Article
Medicine, General & Internal
Lauren A. Eberly, Lohit Garg, Lin Yang, Timothy M. Markman, Ashwin S. Nathan, Nwamaka D. Eneanya, Sanjay Dixit, Francis E. Marchlinski, Peter W. Groeneveld, David S. Frankel
Summary: This study found that despite increased use of rhythm control strategies for treatment of paroxysmal AF, catheter ablation use remained low and patients from racial/ethnic minority groups and those with lower income were less likely to receive rhythm control treatment, especially catheter ablation. These findings highlight inequities in paroxysmal AF management based on race/ethnicity and socioeconomic status.
Review
Cardiac & Cardiovascular Systems
Yalin Cao, Mingyu Zhou, Huaiyun Guo, Wengen Zhu
Summary: This meta-analysis found an association between the use of antidepressants and an increased risk of atrial fibrillation, but no association with ventricular arrhythmias or sudden cardiac death.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Faye L. Norby, Emelia J. Benjamin, Alvaro Alonso, Sumeet S. Chugh
Summary: Atrial fibrillation (AF) affects at least 60 million individuals globally, with race and ethnicity playing a significant role in its epidemiology, risk prediction, treatment, and outcomes. Most studies have mainly included White populations, with underrepresentation of minority racial and ethnic groups, highlighting the need for more inclusive research to address inequities in treatment and outcomes. Studies must focus on gathering accurate race-based epidemiologic data and evaluating social determinants and genetic factors across multiple races and ethnicities to enhance AF risk prediction, prevention, and management.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jose M. Sanchez, Stacey E. Jolly, Thomas A. Dewland, Zian H. Tseng, Gregory Nah, Eric Vittinghoff, Gregory M. Marcus
Summary: Research shows that American Indian individuals have the highest risk of nonhemorrhagic stroke, both with and without atrial fibrillation (AF). This suggests a need for further study and prompt discussion on guideline-adherent anticoagulation prescribing patterns among American Indian individuals with AF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Matthijs J. M. Cluitmans, Laura R. Bear, Uyen C. Nguyen, Bianca van Rees, Job Stoks, Rachel M. A. ter Bekke, Casper Mihl, Jordi Heijman, Kevin D. Lau, Edward Vigmond, Jason Bayer, Charly N. W. Belterman, Emma Abell, Louis Labrousse, Julien Rogier, Olivier Bernus, Michel Haissaguerre, Rutger J. Hassink, Remi Dubois, Ruben Coronel, Paul G. A. Volders
Summary: This study shows that vulnerability to ventricular fibrillation is related to the steepness of RT gradient and size of early RT areas, rather than markers on the body-surface electrocardiogram. Patients with idiopathic VF have steeper RT gradients and more balanced early versus late RT regions compared to controls.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas Rillig, Katrin Borof, Gunter Breithardt, A. John Camm, Harry J. G. M. Crijns, Andreas Goette, Karl-Heinz Kuck, Andreas Metzner, Panos Vardas, Eik Vettorazzi, Karl Wegscheider, Antonia Zapf, Paulus Kirchhof
Summary: The EAST-AFNET4 study showed that early rhythm control (ERC) can reduce adverse cardiovascular outcomes in patients with recently diagnosed atrial fibrillation and stroke risk factors. However, the effectiveness and safety of ERC in patients with multiple cardiovascular comorbidities is uncertain.
Article
Cardiac & Cardiovascular Systems
Wendy Wang, Faye L. Norby, Michael J. Zhang, Jorge L. Reyes, Amil M. Shah, Elsayed Z. Soliman, Pamela L. Lutsey, Alvaro Alonso, Scott D. Solomon, Riccardo M. Inciardi, Lin Y. Chen
Summary: Black Americans have more atrial fibrillation risk factors but lower atrial fibrillation risk than White Americans. Racial differences in left atrial size and function, as well as atrial tachycardia and premature atrial contractions, may not explain the difference in atrial fibrillation risk between Black and White individuals. Further research is needed to understand why Black individuals with more cardiovascular risk factors have lower atrial tachycardia frequency compared to White individuals.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Andrew E. Radbill, Lucy Y. Lei, Sachin Y. Paranjape, Daniel J. Blackwell, Robert L. Abraham, Derek S. Chew, Satish R. Raj, Bjorn C. Knollmann
Summary: This study aimed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Findings show that rapid pacing trains triggered ventricular ectopy in hypertrophic cardiomyopathy patients, but not controls. However, there were no significant differences observed in surrogate measures for cardiac contractility, suggesting that altered length-dependent myofilament activation may not have significant clinical implications in these patients.
Review
Cardiac & Cardiovascular Systems
Sahil Zaveri, Yongxia Sarah Qu, Mohamed Chahine, Mohamed Boutjdir
Summary: Cardiovascular diseases are the leading cause of disease-related deaths worldwide, with disparities in treatment and outcomes affecting minority populations in the United States. This review focuses on cardiac ion channelopathies and genetic disorders in Asian populations, highlighting differences in research, treatment, and outcomes compared to White populations. The review also addresses unique genetic risk factors in Asians and proposes potential solutions to improve care and reduce disparities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew J. Singleton, Charles A. German, Mercedes Carnethon, Elsayed Z. Soliman, Alain G. Bertoni, Joseph Yeboah
Summary: The study found that obesity is associated with an increased risk of incident atrial fibrillation, with a J-shaped relationship between BMI and AF risk. However, this relationship varies by race/ethnicity, with Chinese-American participants having a more pronounced increased risk of AF with higher BMI, while Black participants have minimal increased risk. Further exploration of the differential effects of BMI by race/ethnicity on cardiovascular outcomes is needed.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
James P. Curtain, Carly Adamson, Toru Kondo, Jawad Butt, Akshay S. Desai, Faiez Zannad, Jean L. Rouleau, Luis E. Rohde, Lars Kober, Inder S. Anand, Dirk J. van Veldhuisen, Michael R. Zile, Martin P. Lefkowitz, Scott D. Solomon, Milton Packer, Mark C. Petrie, Pardeep S. Jhund, John J. McMurray
Summary: This study examined the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) in patients with heart failure and their relationship with mortality. The results showed that VT/VF events were uncommon but strongly associated with mortality in heart failure patients. These events seem to be markers of disease severity rather than risk of sudden death.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
David B. Laslett, Abdullah Haddad, Hardik Mangrolia, Dianna Gaballa, Olivia M. Follis, Chethan Gangireddy, Anuj Basil, Richard M. Greenberg, George A. Yesenosky, Edmond M. Cronin, Joshua M. Cooper, Isaac R. Whitman
Summary: The study retrospectively analyzed 416 patients and found that the incidence of newly detected atrial fibrillation after cryptogenic stroke was significantly lower in nonwhite populations compared to white populations. Blacks and Hispanics had a lower incidence of atrial fibrillation compared to whites.
Article
Medicine, General & Internal
Amalia Ioanna Moula, Iris Parrini, Cecilia Tetta, Fabiana Luca, Gianmarco Parise, Carmelo Massimiliano Rao, Emanuela Mauro, Orlando Parise, Francesco Matteucci, Michele Massimo Gulizia, Mark La Meir, Sandro Gelsomino
Summary: Atrial fibrillation (AF) is the most common arrhythmia, with its incidence increasing with age and comorbidities. Obstructive sleep apnea (OSA) is a chronic sleep disorder more commonly found in older men. Previous studies have shown a link between OSA and AF, although the prevalence of OSA in AF patients remains unknown due to underdiagnosis. This meta-analysis investigated the association between OSA and AF, using data from 54,271 patients. A strong link was found between these two disorders, with the incidence of AF being 88% higher in patients with OSA. Age and hypertension were found to independently strengthen this association, indicating that treating OSA may help reduce AF recurrence. Further research is needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hilmi Alnsasra, Gal Tsaban, Jean Marc Weinstein, Mhamad Nasasra, Tal Ovdat, Roy Beigel, Katia Orvin, Moti Haim
Summary: Among patients with AMI, women are more likely to have atrial fibrillation and HAVB, but lower rates of early ventricular tachyarrhythmia compared to men. Early and late VTAs, AF, and HAVB are associated with increased 30-day mortality, while only late VTA and AF are linked to post-30-day mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Vincent Portero, Thomas Nicol, Svitlana Podliesna, Gerard A. Marchal, Antonius Baartscheer, Simona Casini, Rafik Tadros, Jorien L. Treur, Michael W. T. Tanck, I. Jane Cox, Fay Probert, Tertius A. Hough, Sara Falcone, Leander Beekman, Martina Muller-Nurasyid, Gabi Kastenmuller, Christian Gieger, Annette Peters, Stefan Kaab, Moritz F. Sinner, Andrew Blease, Arie O. Verkerk, Connie R. Bezzina, Paul K. Potter, Carol Ann Remme
Summary: This study identified a mouse line with a high incidence of sudden death at a young age due to a nonsense mutation in the Bcat2 gene, leading to elevated levels of branch chain amino acids. The elevated BCAA levels were found to be positively correlated with arrhythmia-related indices and calcium dysregulation in both mouse models and human cardiomyocytes. The involvement of the mTOR pathway activation was demonstrated in preventing pro-arrhythmic events induced by high BCAA concentrations, suggesting a potential link between elevated BCAAs and arrhythmia in conditions like diabetes and heart failure.
CARDIOVASCULAR RESEARCH
(2022)
Article
Medicine, General & Internal
Kathleen Kearney, Sonja Ellingson, Karen Stout, Kristen K. Patton
AMERICAN JOURNAL OF MEDICINE
(2015)
Review
Cardiac & Cardiovascular Systems
David G. Rosenthal, Paco E. Bravo, Kristen K. Patton, Zachary D. Goldberger
CLINICAL CARDIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
David Slotwiner, Niraj Varma, Joseph G. Akar, George Annas, Marianne Beardsall, Richard I. Fogel, Nestor O. Galizio, Taya V. Glotzer, Robin A. Leahy, Charles J. Love, Rhondalyn C. McLean, Suneet Mittal, Loredana Morichelli, KristenK. Patton, Merritt H. Raitt, Renato Pietro Ricci, John Rickard, Mark H. Schoenfeld, Gerald A. Serwer, Julie Shea, Paul Varosy, Atul Verma, Cheuk-Man Yu
Editorial Material
Cardiac & Cardiovascular Systems
Kristen K. Patton
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2015)
Article
Pharmacology & Pharmacy
Lingtak-Neander Chan, Yvonne S. Lin, Jessica C. Tay-Sontheimer, Dorothy Trawick, Brant K. Oelschlager, David R. Flum, Kristen K. Patton, Danny D. Shen, John R. Horn
Article
Clinical Neurology
Hooman Kamel, Traci M. Bartz, W. T. Longstreth, Peter M. Okin, Evan L. Thacker, Kristen K. Patton, Phyllis K. Stein, Rebecca F. Gottesman, Susan R. Heckbert, Richard A. Kronmal, Mitchell S. V. Elkind, Elsayed Z. Soliman
Article
Cardiac & Cardiovascular Systems
Paola Gilsanz, Stefan Walter, Eric J. Tchetgen Tchetgen, Kristen K. Patton, J. Robin Moon, Benjamin D. Capistrant, Jessica R. Marden, Laura D. Kubzansky, Ichiro Kawachi, M. Maria Glymour
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2015)
Article
Cardiac & Cardiovascular Systems
Kristen K. Patton, Patrick T. Ellinor, Michael Ezekowitz, Peter Kowey, Steven A. Lubitz, Marco Perez, Jonathan Piccini, Mintu Turakhia, Paul Wang, Sami Viskin
Article
Cardiac & Cardiovascular Systems
Rajat Deo, Faye L. Norby, Ronit Katz, Nona Sotoodehnia, Selcuk Adabag, Christopher R. DeFilippi, Bryan Kestenbaum, Lin Y. Chen, Susan R. Heckbert, Aaron R. Folsom, Richard A. Kronmal, Suma Konety, Kristen K. Patton, David Siscovick, Michael G. Shlipak, Alvaro Alonso
Meeting Abstract
Cardiac & Cardiovascular Systems
Daniel J. Friedman, Craig Parzynski, Jeptha Curtis, Paul Varosy, Andrea Russo, Jordan Prutkin, Kristen Patton, Ali Mithani, Sana Al-Khatib
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Daniel J. Friedman, Craig S. Parzynski, Paul D. Varosy, Jordan M. Prutkin, Kristen K. Patton, Ali Mithani, Andrea M. Russo, Jeptha P. Curtis, Sana M. Al-Khatib
Article
Health Care Sciences & Services
Jill M. Steiner, Kristen K. Patton, Jordan M. Prutkin, James N. Kirkpatrick
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Kristen K. Patton
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
David G. Rosenthal, Richard K. Cheng, Bradley J. Petek, Sofia Carolina Masri, Carmen Mikacenic, Ganesh Raghu, Kristen K. Patton
AMERICAN JOURNAL OF CARDIOLOGY
(2020)