Review
Pharmacology & Pharmacy
Dragan Primorac, Martin Cemerin, Vid Matisic, Vilim Molnar, Marko Strbad, Lenart Girandon, Lucija Zenic, Miomir Knezevic, Stephen Minger, Denis Polancec
Summary: The COVID-19 pandemic has had a significant impact globally and the overaggressive immune reaction in response to the virus can lead to ARDS. Mesenchymal stromal cell therapy presents a potential treatment option for severe patients.
Review
Biochemistry & Molecular Biology
Jacques Hernigou, Pascale Vertongen, Joanne Rasschaert, Philippe Hernigou
Summary: Different approaches for treating osteoarthritis, including intra-articular injections, subchondral implantation, and scaffolds loaded with bone marrow aspirate concentrate, have shown improvement in patients. However, studies suggest that using bone marrow concentrates in combination with scaffolds or in subchondral bone injection is superior to intra-articular injections for long-term results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Kamal Hezam, Chen Wang, Enze Fu, Manqian Zhou, Yue Liu, Hui Wang, Lihong Zhu, Zhibo Han, Zhong-Chao Han, Ying Chang, Zongjin Li
Summary: This study used PGE2 to prime MSCs and investigated their therapeutic potential in ALI models. The results showed that PGE2-MSCs effectively ameliorated lung injury and reduced total cell numbers, neutrophils, macrophages, and protein levels in BALF. Furthermore, PGE2 priming improved the therapeutic efficacy of MSCs through M2 macrophage polarization and cytokine production regulation.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Yutong Huang, Qiang Wu, Paul Kwong Hang Tam
Summary: Mesenchymal stem cells (MSCs) have multiple properties, including self-renewal, immunomodulation, and regenerative medicine, making them a potential therapeutic strategy for immune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Paulius Valiukevicius, Justinas Maciulaitis, Dalia Pangonyte, Vitalija Sirataviciute, Katarzyna Kluszczynska, Ugne Kuzaityte, Ruta Insodaite, Ieva Ciapiene, Ramune Grigaleviciute, Vilma Zigmantaite, Astra Vitkauskiene, Romaldas Maciulaitis
Summary: This study investigates the therapeutic potential of human placental mesenchymal stem cells (P-MSCs) and their extracellular vesicles (EVs) in a murine model of acute respiratory distress syndrome (ARDS). The results show that both P-MSC and EV therapy can reduce lung injury, decrease neutrophil infiltration, and improve alveolar barrier integrity. Analyses of cytokines and gene expression reveal that both treatments accelerate inflammation resolution in lung tissue. Biodistribution studies indicate that the therapeutic effects of intraperitoneal P-MSC therapy are mainly mediated by soluble factors.
Article
Cell Biology
Ju -Pi Li, Kang-Hsi Wu, Wan-Ru Chao, Yi-Ju Lee, Shun-Fa Yang, Yu-Hua Chao
Summary: Immune-mediated hematopoietic destruction plays a major role in idiopathic severe aplastic anemia. Mesenchymal stem cells (MSCs) have important immunomodulatory functions in the bone marrow niche. Dysfunction of MSCs is believed to be a major cause of immunological changes in SAA bone marrow.
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Review
Cell & Tissue Engineering
Xiangling Li, Yanjun Guan, Chaochao Li, Tieyuan Zhang, Fanqi Meng, Jian Zhang, Junyang Li, Shengfeng Chen, Qi Wang, Yi Wang, Jiang Peng, Jinshu Tang
Summary: The article summarizes the interactions between MSCs, immune cells, and inflammatory cytokines following PNI, with a focus on the immunosuppressive role of MSCs. Additionally, the immunomodulatory potential of MSC-derived extracellular vesicles as a cell-free treatment for PNI is discussed.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Medicine, General & Internal
Qian Hu, Shu Zhang, Yue Yang, Jia-Qi Yao, Wen-Fu Tang, Christopher J. Lyon, Tony Ye Hu, Mei-Hua Wan
Summary: “Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common and life-threatening lung diseases associated with acute and severe inflammation. Study on extracellular vesicles (EVs) has shown their potential role in regulating pulmonary inflammation, including ALI/ARDS, and predicting the development of these diseases.”
MILITARY MEDICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Katia Nunes da Silva, Priscila Carvalho Guedes Pinheiro, Andre Luiz Nunes Gobatto, Rogerio da Hora Passos, Bruno Diaz Paredes, Luciana Souza de Arago Franca, Carolina Kymie Vasques Nonaka, Beatriz Barreto-Duarte, Mariana Araujo-Pereira, Rafael Tiburcio, Fernanda Ferreira Cruz, Gabriele Louise Soares Martins, Bruno B. Andrade, Hugo Caire de Castro-Faria-Neto, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza
Summary: This case report demonstrated the reduction of both lung inflammation and fibrosis in a critically ill COVID-19 patient after MSC therapy, leading to significant clinical improvement and discharge from the hospital.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Wu Duan, Huajie Zou, Nan Zang, Dongxia Ma, Bo Yang, Lin Zhu
Summary: Bone marrow adipose tissue (MAT) can have both local and systemic effects on metabolic homeostasis. The effects of metformin, a first-line drug for type 2 diabetes, on MAT and bone marrow mesenchymal stem cell (BM-MSC) differentiation are conflicting. In vivo and in vitro experiments showed that metformin increased MAT in mice tibia and promoted both osteogenic and lipogenic gene expression in mouse bone marrow. However, metformin inhibited lipogenesis and promoted osteogenesis of MSC in vitro. The increased MAT may be attributed to the filling of adipose tissue after metformin-induced apoptosis of bone marrow stromal cells.
Article
Medicine, General & Internal
Jesus A. Perez, Juan J. Parcero Valdes, Ruben Corral Moreno, Leonardo I. Gomez Cuevas, Jose J. Lopez, Thomas Ichim, Kristen McGreevy, Feng Lin, Santosh Kesari, Souvik Datta
Summary: The use of umbilical cord-derived MSCs (UC-MSCs) in treating COVID-19-induced ARDS showed promising results in a case series study. Longitudinal analysis revealed decreased inflammatory markers and stabilized pulmonary function in the majority of patients after intravenous administration of UC-MSCs. UC-MSCs possess immunomodulatory and anti-inflammatory properties, making them a potential treatment option for ARDS.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Multidisciplinary Sciences
Luisa Nathalia Fonseca, Santiago Bolivar-Mona, Tatiana Agudelo, Liz Daniela Beltran, Daniel Camargo, Nestor Correa, Maria Alexandra Del Castillo, Sebastian Fernandez de Castro, Valeria Fula, Gabriela Garcia, Natalia Guarnizo, Valentina Lugo, Liz Mariana Martinez, Veronica Melgar, Maria Clara Pena, Wilfran Arbey Perez, Nicolas Rodriguez, Andres Pinzon, Sonia Luz Albarracin, Mercedes Olaya, Maria Lucia Gutierrez-Gomez
Summary: This study reviewed the literature to determine the surface markers for human MSCs associated with skeletal tissue. The most widely used markers were CD105, CD90, and CD73, but they do not represent true stemness. Most studies did not evaluate the characteristics of self-renewal and differentiation, which are necessary to distinguish between stem cells and progenitor populations.
Article
Pharmacology & Pharmacy
Ilenia Mastrolia, Andrea Giorgini, Alba Murgia, Pietro Loschi, Tiziana Petrachi, Valeria Rasini, Massimo Pinelli, Valentina Pinto, Francesca Lolli, Chiara Chiavelli, Giulia Grisendi, Maria Cristina Baschieri, Giorgio De Santis, Fabio Catani, Massimo Dominici, Elena Veronesi
Summary: In this study, a rabbit model was established to mimic human osteonecrosis of the femoral head (ONFH) and evaluate the autologous MSC-based treatment. Results showed that implantation of autologous BM-MSCs could restore the damaged tissue in rabbit femurs. Furthermore, the study found that osteonecrosis did not affect the behavior of MSCs.
Article
Materials Science, Multidisciplinary
Ran Li, Jiansheng Lin, Feng Zheng
Summary: Stem cell therapy provides a new approach for reconstructing central nervous system function and nerve regeneration. This study investigates the impact of autologous bone marrow mesenchymal stem cell transplantation on neural repair in an animal model of spinal cord injury. The combined treatment of graphene nanomaterials and autologous BMSC transplantation shows significant effects on neuropathic pain caused by spinal cord injury.
MATERIALS & DESIGN
(2022)
Article
Critical Care Medicine
Avi Benov, Margaux M. Salas, Helit Nakar, Ben Antebi, Bader Tarif, Avraham Yitzhak, Elon Glassberg
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2017)
Article
Critical Care Medicine
Avi Benov, Margaux M. Salas, Helit Nakar, Ben Antebi, Bader Tarif, Avraham Yitzhak, Elon Glassberg
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2017)
Article
Cell & Tissue Engineering
J. S. McDaniel, B. Antebi, M. Pilia, B. J. Hurtgen, S. Belenkiy, C. Necsoiu, L. C. Cancio, C. R. Rathbone, A. I. Batchinsky
STEM CELLS INTERNATIONAL
(2017)
Article
Cell & Tissue Engineering
Ben Antebi, Luis A. Rodriguez, Kerfoot P. Walker, Amber M. Asher, Robin M. Kamucheka, Lucero Alvarado, Arezoo Mohammadipoor, Leopoldo C. Cancio
STEM CELL RESEARCH & THERAPY
(2018)
Article
Cell & Tissue Engineering
Ben Antebi, Kerfoot P. Walker, Arezoo Mohammadipoor, Luis A. Rodriguez, Robbie K. Moore, Leopoldo C. Cancio, Andriy I. Batchinsky
REGENERATIVE MEDICINE
(2019)
Article
Cell Biology
Luis A. Rodriguez, Arezoo Mohammadipoor, Lucero Alvarado, Robin M. Kamucheka, Amber M. Asher, Leopoldo C. Cancio, Ben Antebi
Article
Cell & Tissue Engineering
Amy L. Xu, Luis A. Rodriguez, Kerfoot P. Walker, Arezoo Mohammadipoor, Robin M. Kamucheka, Leopoldo C. Cancio, Andriy Batchinsky, Ben Antebi
STEM CELLS TRANSLATIONAL MEDICINE
(2019)
Article
Medicine, Research & Experimental
Ben Antebi, Amber M. Asher, Luis A. Rodriguez, Robbie K. Moore, Arezoo Mohammadipoor, Leopoldo C. Cancio
JOURNAL OF TRANSLATIONAL MEDICINE
(2019)
Article
Ophthalmology
Sumin Gu, Sondip Biswas, Luis Rodriguez, Zhen Li, Yuting Li, Manuel A. Riquelme, Wen Shi, Ke Wang, Thomas W. White, Matthew Reilly, Woo-Kuen Lo, Jean X. Jiang
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)