Article
Biochemistry & Molecular Biology
Guillermo H. Jimenez Aleman, Venkatesh P. Thirumalaikumar, Georg Jander, Alisdair R. Fernie, Aleksandra Skirycz
Summary: The oxylipin 12-oxo-phytodienoic acid (OPDA) is a biosynthetic precursor of the plant hormone jasmonic acid, but also functions as a signaling molecule independent of jasmonates. OPDA is involved in various biological processes across plant species, including defense and stress responses, growth regulation, and development. This article summarizes what is known about OPDA metabolism and signaling, discussing its jasmonate dependent and independent roles, as well as open questions regarding the OPDA protein interactome and biological roles of OPDA conjugates.
Review
Cell Biology
Tautvydas Paskevicius, Rabih Abou Farraj, Marek Michalak, Luis B. Agellon
Summary: Calnexin is an integral ER membrane protein with distinct domains in the ER lumen and cytosol. It acts as a chaperone for folding and quality control of proteins, similar to calreticulin. Recent studies have shown that the cytosolic domain of calnexin undergoes post-translational modifications and interacts with various proteins, suggesting its role in coordinating ER functions with cytosolic events.
Editorial Material
Biochemistry & Molecular Biology
Richard Huskey
Summary: Gossip is more than just trash talk, it can influence behavior, foster cooperation, and increase group affiliation.
Review
Engineering, Chemical
Stefan Kittler, Mihail Besleaga, Julian Ebner, Oliver Spadiut
Summary: Highly specific drugs known as antibodies have become dominant in the biopharmaceutical market over the past 30 years, with recombinant production facing challenges. Affinity ligands, particularly proteins A, G, and L, are crucial in the downstream process but face challenges in application. There is a need for better process analytical tools to monitor and control production processes effectively.
Article
Biochemistry & Molecular Biology
Matrone Carmela
Summary: Neurodegenerative diseases refer to the progressive decline of neuronal function in multiple brain areas, resulting in cognitive, psychiatric, or motor deficits due to the atrophy of specific neuronal populations. These diseases commonly share pathological mechanisms such as protein misfolding, oxidative stress, and impaired autophagy.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Editorial Material
Biochemistry & Molecular Biology
Sarah Mundt, Annika Keller, Melanie Greter
Summary: Recent research has found an active neuroimmune exchange at brain border regions, challenging the concept of the immune-privileged central nervous system; dural sinuses serve as a conduit for brain-derived antigens to interact with the immune system, allowing in situ immune surveillance.
Review
Immunology
Le Xiong, Stephen L. L. Nutt, Cyril Seillet
Summary: Innate lymphoid cells (ILCs) serve as a link between sensory cells and effector cells, contributing to tissue homeostasis and adaptation to changing environmental conditions. Studying the non-canonical functions of these cells provides insights into their regulation and adaptability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Pascal Leblanc, Ina Maja Vorberg
Summary: Neurodegenerative diseases are fatal neurological diseases that may be associated with viral infections, which can lead to neuroinflammation and disruption of neuronal protein quality control, affecting the formation and spread of diseases.
Editorial Material
Oncology
Song Chen, Andrew D. Luster
Summary: The study identifies that histamine released during allergic reactions and from tumor cells weakens the response to immunotherapy. Histamine H-1-receptor signaling induces a suppressive phenotype in tumor-associated macrophages and increases VISTA expression, thereby suppressing CD8(+) T cell function. Anti-histamines can reverse these effects and improve the efficacy of immunotherapy.
Editorial Material
Biotechnology & Applied Microbiology
Madhvi J. Venkatesh, Alexandra R. Elchert, Bolutife Fakoya, Francisco Fernandez, Andrew C. Kwong, Yue J. Liu, Peter Lotfy, David D. Lowe, Christopher A. Petty, Alejandra Rodriguez-delaRosa, Bryan O. Seguinot, Yingxiao Shi, Joseph J. Loparo
Summary: Integrating community building into graduate classrooms can help students develop professional identities and establish connections between students and faculty.
NATURE BIOTECHNOLOGY
(2021)
Article
Oncology
Saisai Guo, Linna Zhang, Na Li
Summary: This article reviews the role of ANO1 in various malignant tumors, including replication, proliferation, invasion, and apoptosis. The expression of ANO1 is controlled by various molecules and stimuli, with different regulatory mechanisms in different tumor cells. Studies have shown that ANO1 exerts its effects through multiple pathways and signaling pathways, and has functions in resisting apoptosis and promoting immune escape. Further research on the channels and protein activity mechanism of ANO1, as well as the development of ANO1 inhibitors, is of great significance for revealing its tumor-promoting mechanism.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Matthias W. Laschke, Thomas Spaeter, Michael D. Menger
Summary: Adipose tissue-derived microvascular fragments have the ability to rapidly reassemble into microvascular networks, exhibit angiogenic activity, and serve as a source of endothelial progenitor cells and multipotent mesenchymal stromal cells. They also play a crucial role in tissue integration of implanted biomaterials.
TRENDS IN BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Joerg Wilting, Juergen Becker
Summary: Despite the long history of research on the lymphatic vascular system, there is still much unknown about its structure, function, development, and evolution. The functions of lymphatic endothelial cells are more diverse than previously thought, with implications for various physiological processes.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Elis Cristina Araujo Eleutherio, Rayne Stfhany Silva Magalhaes, Aline de Araujo Brasil, Jose Raphael Monteiro Neto, Luan de Holanda Paranhos
Summary: During cellular respiration, radicals like superoxide can cause cell damage, but cells use the enzyme Cu/Zn Superoxide Dismutase (SOD1) to convert superoxide into oxygen and hydrogen peroxide. In addition to its primary function, SOD1 also plays other roles, such as activating gene transcription or functioning as an RNA binding protein.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Editorial Material
Hematology
Bethany T. Samuelson Bannow
Summary: In the largest meta-analysis to date on the topic, Valeriani et al identified 4 clear benefits of using anticoagulation to treat splanchnic vein thrombosis (SVT), including increased recanalization, decreased thrombosis progression, decreased major bleeding, and decreased mortality.
Article
Neurosciences
Brad T. Casali, Angela W. Corona, Monica M. Mariani, J. Colleen Karlo, Kaushik Ghosal, Gary E. Landreth
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Kaushik Ghosal, Scott P. Naples, Alexander R. Rabe, Kathleen A. Killian
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2010)
Article
Neurosciences
Kenneth L. Pitter, Ilaria Tamagno, Xi Feng, Kaushik Ghosal, Nduka Amankulor, Eric C. Holland, Dolores Hambardzumyan
Article
Biology
Kaushik Ghosal, Mohit Gupta, Kathleen A. Killian
JOURNAL OF EXPERIMENTAL BIOLOGY
(2009)
Article
Geriatrics & Gerontology
Kaushik Ghosal, Sanjay W. Pimplikar
NEUROBIOLOGY OF AGING
(2011)
Article
Clinical Neurology
Kaushik Ghosal, Andrea Stathopoulos, Dustin Thomas, David Phenis, Michael P. Vitek, Sanjay W. Pimplikar
NEURODEGENERATIVE DISEASES
(2013)
Article
Multidisciplinary Sciences
Kaushik Ghosal, Daniel L. Vogt, Man Liang, Yong Shen, Bruce T. Lamb, Sanjay W. Pimplikar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
