Article
Chemistry, Multidisciplinary
Yanfang Hu, Yonglong Li, Linfeng Yu, Yuying Zhang, Yuming Lai, Wei Zhang, Wei Xie
Summary: A universal assembly methodology for preparing hetero-superstructures is introduced in this study, enabling the assembly of building block materials without the need for molecular linkers and utilizing surface property modulation to achieve self-organization. The resulting superstructures exhibit superior photocatalytic activity and Raman scattering performance.
Article
Polymer Science
Peng Ding, Lusha Chen, Cheng Wei, Wenjuan Zhou, Chendan Li, Jiahua Wang, Mingwei Wang, Xuhong Guo, Martien A. Cohen Stuart, Junyou Wang
Summary: A novel strategy for preparing stable coacervate nanoparticles, termed electrostatic assembly directed polymerization (EADP), is proposed in this study. The nanoparticles exhibit high salt stability and scalability, with tunable size and properties, allowing for scaled-up production.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Qamar A. Alshammari, Rajasekharreddy Pala, Ayan K. Barui, Saud O. Alshammari, Andromeda M. Nauli, Nir Katzir, Ashraf M. Mohieldin, Surya M. Nauli
Summary: This study integrates spectral imaging technology with AI-driven analysis to achieve high-resolution detection and identification of nanoparticles. By simultaneously analyzing 45 spectral points, the core and shell of nanoparticles can be distinguished, providing a new approach for nanoparticle localization and identification in biological samples.
Article
Chemistry, Multidisciplinary
Carsten Donau, Fabian Spaeth, Michele Stasi, Alexander M. Bergmann, Job Boekhoven
Summary: This study describes a model based on a complex coacervate gel, which regulates the affinity and liquidity of droplets in membraneless organelles by controlling the chemical reaction cycle. The findings reveal the regulatory mechanism of subcompartments in membraneless organelles, providing new insights into the importance of active processes inside cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Reece W. Lewis, Benjamin Klemm, Mariano Macchione, Rienk Eelkema
Summary: This study demonstrates the use of a chemical reaction network to drive the coacervation of macromolecular species, resulting in the assembly and disassembly of chemical triggered complex coacervates. Unlike other systems, this chemical reaction network operates at constant physiological pH without the need for complex biomolecules.
Article
Food Science & Technology
Chun-Ru Su, Yu-Yan Huang, Qi-Hui Chen, Meng-Fan Li, Hao Wang, Guo-Yan Li, Yang Yuan
Summary: In this study, a novel complex coacervate between gliadin and sodium alginate was formed and successfully loaded with curcumin, demonstrating spherical particles with good homogeneity and dispersion. The formation of coacervates at different pH induced by electrostatic interaction reduced the release speed of curcumin, leading to better encapsulation and controlled release properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Inge Bos, Eline Brink, Lucile Michels, Joris Sprakel
Summary: Studied the dynamics of single stranded DNA in complex coacervate droplets and micelles. Found that the diffusion coefficient of DNA depends more strongly on DNA length than predicted by traditional models, which can be partly explained by changes in complex coacervate density and other factors. Also discovered that chain length polydispersity is the main cause of a broad distribution of exchange rates in micelles, and dye interactions significantly affect micelle exchange rates.
Review
Chemistry, Multidisciplinary
M. P. Pileni
Summary: This article describes the water-soluble superstructures of hydrophobic nanocrystals that have been developed recently, highlighting their properties and potential applications as nanoheaters. The first structure discussed is called cluster structures, which are hydrophobic 3D superlattices of Co or Au nanocrystals covered with organic molecules. These structures retain their magnetic and optical properties when dispersed in aqueous solution. The second structure is based on liquid-liquid instabilities and involves Fe3O4 nanocrystal shells filled or unfilled with Au 3D superlattices, known as colloidosomes and supraballs, respectively.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Youcef Chakib Hacene, Alexis Loiseau, Vanessa Dos Passos Maio, Philippe Grenier, Elodie Boisselier, Nicolas Bertrand
Summary: This study presents an immunoprecipitation method using AntiPEG antibodies to extract different types of PEGylated systems, showcasing its potential and unique perspective in understanding the interactions of nanoparticles with biological systems.
Review
Chemistry, Physical
Xibo Yan, Julien Bernard, Francois Ganachaud
Summary: Polymeric nanoparticles are important functional nanomaterials with various shapes and inner morphologies, which can be precisely controlled using the nanoprecipitation technique. This technique allows for the fabrication of a wide range of polymeric nanostructures, including equilibrium and out-of-equilibrium morphologies, as well as core-shell structures. New directions are proposed to further expand the scope and potential achievements of this process.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Oncology
Chuan Li, Wen-Yang Lin, Hira Rizvi, Hongchen Cai, Christopher D. McFarland, Zoe N. Rogers, Maryam Yousefi, Ian P. Winters, Charles M. Rudin, Dmitri A. Petrov, Monte M. Winslow
Summary: This study used a multiplexed and quantitative experimental platform with robust statistical methods to explore the complex relationship between tumor genotypes and therapeutic responses, uncovering significant resistance or sensitivity in over 20% of possible interactions. Known and novel interactions were identified, highlighting the broad impact of tumor suppressor genotype on treatment responses.
Article
Chemistry, Physical
Sushil Swaroop Pathak, Gotluru Kedarnath, Leela S. Panchakarla
Summary: It has been demonstrated that CdS quantum dots can be synthesized and self-assembled into complex superstructures without the use of templates. These superstructures exhibit Stokes-shifted photoluminescence and a single-exponential decay behavior, indicating the presence of trap states within a narrow range. The formation of liquid crystal phases is proposed as the growth mechanism for these superstructures, supported by small-angle X-ray scattering analysis.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Verner Hakonsen, Gurvinder Singh, Jose A. De Toro, Peter S. Normile, Erik Wahlstrom, Jianying He, Zhiliang Zhang
Summary: Through a comprehensive Monte Carlo investigation, this study demonstrates how the mechanical properties of self-assembled magnetic nanocubes can be intrinsically controlled by the nanoparticle magnetocrystalline anisotropy (MA), as well as by the superstructure shape anisotropy. Low MA-to-dipolar energy ratio favors isotropic mechanical superstructure stabilization, while a high ratio yields magnetically blocked nanoparticle macrospins.
Article
Biochemistry & Molecular Biology
Chunlei Zhou, Qibing Lin, Yulong Ren, Jie Lan, Rong Miao, Miao Feng, Xin Wang, Xi Liu, Shengzhong Zhang, Tian Pan, Jiachang Wang, Sheng Luo, Jinsheng Qian, Wenfan Luo, Changling Mou, Thanhliem Nguyen, Zhijun Cheng, Xin Zhang, Cailin Lei, Shanshan Zhu, Xiuping Guo, Jie Wang, Zhichao Zhao, Shijia Liu, Ling Jiang, Jianmin Wan
Summary: This study reveals a CYP78As-SMG4-COPII regulatory pathway that controls grain size in rice. SMG4 encodes a MATE transporter, which interacts with COPII components and CYP78As to regulate grain size.
Review
Chemistry, Physical
Sachit Shah, Lorraine Leon
Summary: PEC micelles, formed by self-assembly of oppositely charged polyelectrolytes conjugated to neutral polymeric blocks, are highly modular systems with stimuli-responsive and targeting properties, making them smart platforms for biomedical applications. This review discusses the mechanisms involved in their assembly and disassembly, as well as their structural and functional changes in response to solution conditions, highlighting their impactful applications in the treatment of various human diseases.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Article
Urology & Nephrology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias M. Heck, Thomas Horn, Tobias Maurer
Summary: This study evaluated the oncological outcomes of salvage PSMA-RGS in patients with recurrent oligometastatic prostate cancer and identified predictive preoperative factors for improved outcomes. The results showed that the 3-month and 2-year tumor survival rates were 32% and 58%, respectively. Preoperative PSA, number of PSMA-avid lesions, and localization of lesions were independent predictors of biochemical recurrence after PSMA-RGS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Samaneh Azargoshasb, Imke Boekestijn, Meta Roestenberg, Gijs H. KleinJan, Jos A. van der Hage, Henk G. van der Poel, Daphne D. D. Rietbergen, Matthias N. van Oosterom, Fijs W. B. van Leeuwen
Summary: This study investigates the impact of signal-to-background ratios (SBR) on surgical performance using kinematics analysis. The results show that below SBR 1.5, task completion time, time spent in fluorescence-imaging mode, and total pathlength increase significantly, and handling errors become more frequent. The values of Dx and DM indicate that proficiency can only be achieved at SBR> 1.55.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nikolas Duszenko, Danny M. van Willigen, Anton Bunschoten, Aldrik H. Velders, Meta Roestenberg, Fijs W. B. van Leeuwen
Summary: This study demonstrates that pathogen immunogenicity can be enhanced by complexing an adjuvant onto the surface of a poorly immunogenic bacterium. The adjuvanted bacteria were able to stimulate a stronger immune response and could potentially be used as a treatment modality to boost the immune system's response to pathogenic microbes.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jean-Pierre Pouget, Mark Konijnenberg, Uta Eberlein, Gerhard Glatting, Pablo Minguez Gabina, Ken Herrmann, Soren Holm, Lidia Strigari, Fijs W. B. van Leeuwen, Michael Lassmann
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Review
Oncology
Imke Boekestijn, Matthias N. van Oosterom, Paolo Dell'Oglio, Floris H. P. van Velden, Martin Pool, Tobias Maurer, Daphne D. D. Rietbergen, Tessa Buckle, Fijs W. B. van Leeuwen
Summary: Molecular imaging technologies are increasingly important in the diagnosis, monitoring, and treatment of cancer. The relevance and accessibility of surgical targets, as well as the selection of the correct combination of imaging agents for visualizing disease sites with high affinity and specificity are crucial. Developments within engineering/imaging physics continue to drive image-guided surgery, enhancing sensitivity and spatial resolution to ensure cancer sites are not overlooked during surgery.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anne-Claire Berrens, Matthias N. van Oosterom, Leon J. Slof, Fijs W. B. van Leeuwen, Henk G. van der Poel, Tessa Buckle
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Chemistry, Physical
Laura M. I. Schijven, Vittorio Saggiomo, Aldrik H. Velders, Johannes H. Bitter, Constantinos V. Nikiforidis
Summary: Researchers have discovered that solid or hollow microparticles can be formed using proteins with different aggregate sizes. By mixing proteins with CaCl2 and Na2CO3 solutions, and then adding Au3+ ions, solid and hollow protein microparticles with embedded gold nanoparticles can be fabricated. This method has a broader range of applications, including biomaterial preparation and multimodal imaging.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Anne-Claire Berrens, Maarten L. Donswijk, Esther M. K. Wit, Fijs W. B. van Leeuwen, Pim J. van Leeuwen, Henk G. van der Poel
JOURNAL OF UROLOGY
(2023)
Review
Parasitology
Clarize Maria de Korne, Lisette van Lieshout, Fijs Willem Bernhard van Leeuwen, Meta Roestenberg
Summary: Imaging technology is essential for diagnosing parasitic diseases and has played a crucial role in developing antiparasitic strategies. The advancement of novel imaging technologies has revolutionized various fields of medicine and has also provided new ways to visualize parasites.
TRENDS IN PARASITOLOGY
(2023)
Article
Medicine, Research & Experimental
Marco Erreni, Francesca D'Autilia, Roberta Avigni, Evangelia Bolli, Sana M. Arnouk, Kiavash Movahedi, Pieterjan Debie, Achille Anselmo, Raffaella Parente, Cecile Vincke, Fijs W. B. van Leeuwen, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Sophie Hernot, Jo A. Van Ginderachter
Summary: Nanobodies (Nbs) have been identified as an elegant alternative to conventional monoclonal antibodies for cancer therapy, but there is a lack of detailed microscopic insight into the in vivo pharmacokinetics of different Nb formats in tumor-bearers, especially for the targeting of pro-tumoral tumor-associated macrophages (TAMs) located in less penetrable tumor regions.
Article
Cell & Tissue Engineering
M. M. Welling, K. Warbroek, C. Khurshid, M. N. van Oosterom, D. D. D. Rietbergen, M. G. J. de Boer, R. G. H. H. Nelissen, F. W. B. van Leeuwen, B. G. Pijls, T. Buckle
Summary: In this study, the ability of a bacteria-specific hybrid tracer (99mTc-UBI29-41-Cy5) to visualize the bacterial load on femoral implants using clinical-grade image guidance methods was evaluated. The results showed that this hybrid tracer allowed effective bacterial staining and combined qualitative real-time fluorescence guidance with nuclear imaging for quantitative monitoring of the effectiveness of cleaning strategies.
BONE & JOINT RESEARCH
(2023)
Article
Multidisciplinary Sciences
M. Victoria Gomez, Sander Baas, Aldrik H. Velders
Summary: Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique for molecular characterization and quantification, but is limited by poor sensitivity and expensive hardware. In this study, a microfluidic NMR-chip with a single planar-spiral microcoil and photochemically induced hyperpolarization is used for multidimensional and heteronuclear NMR experiments on picomole quantities of material. This chip significantly improves sensitivity and reduces cost and hardware complexity compared to traditional instruments.
NATURE COMMUNICATIONS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthias N. van Oosterom, Samaneh Azargoshasb, Leon J. Slof, Fijs W. B. van Leeuwen
Summary: With the increasing use of robotic platforms in laparoscopic surgery, radioguidance has the potential to play a crucial role in improving surgical precision. Although there are challenges and limitations, recent developments have shown progress in integrating radioguidance with robotic laparoscopic surgery.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Article
Surgery
Matthias N. van Oosterom, Sven van Leeuwen, Elio Mazzone, Paolo Dell'Oglio, Tessa Buckle, Florian van Beurden, Michael Boonekamp, Huybert van de Stadt, Kevin Bauwens, Herve Simon, Pim J. van Leeuwen, Henk G. van der Poel, Fijs W. B. van Leeuwen
Summary: This study engineered a 'click-on' fluorescence detector that transforms standard robotic instruments into molecular sensing devices, enabling the detection of near-infrared fluorescence in a white-light setting. The detector showed promising performance in detecting blood vessels, assessing vascularization, and localizing lymph nodes during robotic surgery in pigs and human specimen evaluation.
JOURNAL OF ROBOTIC SURGERY
(2023)
