Article
Biochemistry & Molecular Biology
Maria Jose Gonzalez-Riquelme, Fernando Lucas-Ruiz, Caridad Galindo-Romero, Raquel Boia, Antonio Francisco Ambrosio, Manuel Vidal-Sanz, Ana Raquel Santiago, Marta Agudo-Barriuso
Summary: This study compares retinal organotypic cultures (ROCs) with in vivo models to study retinal ganglion cell (RGC) death and glial activation. The results show that there are significant differences in glial activation between ROCs and in vivo models, with earlier and different morphological activation in ROCs. Additionally, microglial cell density in ROCs is consistently lower than in vivo. ROCs can be used for proof-of-concept studies on neuroprotection, but long-term experiments should be performed in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Kyoung In Jung, Jeong-Sun Han, Chan Kee Park
Summary: Nicotinamide plays a neuroprotective role in diabetic retinal neurodegeneration by reducing oxidative DNA damage and supporting DNA repair.
Article
Cell Biology
Ben Mead, Alicia Kerr, Naoki Nakaya, Stanislav I. Tomarev
Summary: This study aimed to characterize the miRNA profile of purified retinal ganglion cells (RGC) from healthy and diseased rat retina. Over 100 different miRNAs were identified in diseased retina compared to healthy retina. Manipulating candidate mRNAs after retinal injury revealed significant neuroprotection and neuritogenesis effects in RGC.
Article
Medicine, Research & Experimental
Julia Oswald, Evgenii Kegeles, Tomas Minelli, Pavel Volchkov, Petr Baranov
Summary: The study demonstrates successful transplantation of mouse induced pluripotent stem cell (miPSC)/mouse embryonic stem cell (mESC)-derived retinal ganglion cells (RGCs) into mouse retinas, with high success rate and long-term survival of donor cells. The transplanted RGCs were able to polarize and form axonal processes within the host retinas, showing potential therapeutic effects.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
Review
Medicine, Research & Experimental
Jieru Shen, Wenqing San, Yangyang Zheng, Shuping Zhang, Danyi Cao, Yun Chen, Guoliang Meng
Summary: Diabetes mellitus is a metabolic disease that results from disorders in insulin secretion and utilization, leading to vascular endothelial cell damage. Cell death is a key factor in diabetic endothelial dysfunction, and regulated cell death involves various forms of cell death.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Yaqiong An, Haibo Li, Mengxiao Wang, Zhaohua Xia, Lexi Ding, Xiaobo Xia
Summary: This study investigates the protective effect of tert-Butylhydroquinone (TBHQ) against glutamate excitotoxicity-induced retinal cell damage. It suggests that TBHQ activates the Nrf2 signaling pathway, reduces oxidative stress and inflammation, and inhibits NF-Kappa B activation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Neurosciences
Jennifer H. Pham, Dorota L. Stankowska
Summary: Glaucoma is a leading cause of blindness worldwide and is commonly associated with elevated intraocular pressure. Recent studies suggest that mitochondrial dysfunction plays a crucial role in glaucomatous neurodegeneration. The retina, especially the retinal ganglion cells (RGCs), relies heavily on mitochondrial energy for signal transduction, making them vulnerable to oxidative damage. Mitochondrial dysfunction and ER stress have been observed in RGCs in glaucoma models, and the potential cross-signaling and roles of MAMs need to be further investigated.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Mengya Zhao, Kenichi Toma, Benyam Kinde, Liang Li, Amit K. Patel, Kong-Yan Wu, Matthew R. Lum, Chengxi Tan, Jody E. Hooper, Arnold R. Kriegstein, Anna La Torre, Yaping Joyce Liao, Derek S. Welsbie, Yang Hu, Ying Han, Xin Duan
Summary: Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, aRGCs and intrinsically photosensitive RGCs (ipRGCs) preferentially survive glaucomatous conditions, similar to findings in the retina subject to axotomy. This study reveals the role of Spp1 in mediating neuronal resiliency in glaucoma, as Spp1 overexpression can protect susceptible RGC subclasses.
Article
Cell & Tissue Engineering
Maria Norte-Munoz, Alejandro Gallego-Ortega, Fernando Lucas-Ruiz, Maria J. Gonzalez-Riquelme, Yazmin Changa-Espinoza, Caridad Galindo-Romero, Peter Ponsaerts, Manuel Vidal-Sanz, David Garcia-Bernal, Marta Agudo-Barriuso
Summary: This study compares the response of the mouse retina to different modes of MSC transplantation and finds that different transplantation modes lead to varying degrees of anatomical and functional changes, with xenotransplants being the most detrimental. This finding is of great importance for preclinical studies.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Fei Yao, Xuan Zhang, Xueyan Yao, Xiaohua Ren, Xiaobo Xia, Jian Jiang, Lexi Ding
Summary: This study revealed that activation of PPAR alpha by FA can promote RGC survival, alleviate thinning of the ganglion cell complex, and reduce the latency of positive waves in FVEPs after IR injury. Additionally, FA treatment significantly increased the expression of endogenous PPAR alpha and suppressed GFAP and COX2 expression.
FRONTIERS IN MEDICINE
(2021)
Review
Ophthalmology
Won-Kyu Ju, Guy A. Perkins, Keun-Young Kim, Tonking Bastola, Woo-Young Choi, Soo-Ho Choi
Summary: Glaucoma is a leading cause of irreversible blindness, involving the degeneration of retinal ganglion cells (RGCs) and their axons. Intraocular pressure (IOP) is a treatable risk factor, but lowering IOP alone is not sufficient to prevent disease progression. Understanding the structural and functional impairment of mitochondria in RGCs and their axons is an important area of research, as oxidative phosphorylation stress-mediated mitochondrial dysfunction is associated with glaucomatous neurodegeneration.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Review
Cell Biology
Xiao-yu Wu, Wen-Wen Xu, Xiang-kun Huan, Guan-nan Wu, Gang Li, Yu-Hong Zhou, Masoud Najafi
Summary: Resistance of cancer cells to anti-tumour agents is a major challenge in cancer treatment. Metformin, an antidiabetic drug, can enhance cell death mechanisms and play a key role in inducing cell death, thereby increasing the therapeutic efficiency of anti-cancer therapy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chun-Lei Deng, Cheng-Biao Hu, Sheng-Tao Ling, Na Zhao, Li-Hui Bao, Feng Zhou, Ye-Cheng Xiong, Tao Chen, Bing-Dong Sui, Xiao-Rui Yu, Cheng-Hu Hu
Summary: The study revealed the therapeutic effects and mechanisms of mesenchymal stem cell transplantation and exosomal transplantation on photoreceptor injuries, with a focus on miR-21 mediation for photoreceptor viability. These methods demonstrated long-lasting efficacy in treating retinal degenerative diseases, highlighting their potential as a therapeutic approach.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Lorena Olivares-Gonzalez, Sheyla Velasco, Isabel Campillo, Regina Rodrigo
Summary: Inherited retinal dystrophies (IRDs) are a group of retinal disorders that lead to progressive vision loss due to retinal cell death, predominantly photoreceptor cells. The treatment of IRDs is complicated by genetic and clinical heterogeneity, but reducing retinal inflammation has emerged as an effective approach to slowing disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Andreas Koller, Susanne Maria Brunner, Julia Preishuber-Pfluegl, Daniela Mayr, Anja-Maria Ladek, Christian Runge, Herbert Anton Reitsamer, Andrea Trost
Summary: The endosomal-lysosomal system (ELS), essential for cell homeostasis, is responsible for cellular waste degradation. Modulating autophagic flux is a strategy to remove damaging cell waste. In this study, CysLTR1 antagonist application was shown to increase autophagic flux. Furthermore, inhibition of CysLTR1 resulted in decreased levels of autophagosomes, late endosomes/lysosomes, aggregated proteins, and reactive oxygen species (ROS) in ARPE-19 cells.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Jung Hwan Ji, Soong June Bae, Seul-Gi Kim, Min Hwan Kim, Gun-Min Kim, Joohyuk Sohn, Joon Jeong, Jee Hung Kim, Sung Gwe Ahn
Summary: This study investigated the impact of different doses of carboplatin on pathologic complete response rate, grade 3/4 anaemia occurrence, and transfusion rate in patients treated with neoadjuvant TCHP. The results showed that carboplatin at AUC5 has comparable cytotoxic effects to carboplatin at AUC6 and is associated with fewer complications related to anaemia in HER2+ breast cancer patients.
Article
Environmental Sciences
Yu-Jin Jeong, Chang-Ung Kim, Kyung-Soo Lee, Ji Hyung Kim, Seo Young Park, Ahn Young Jeong, Jun Bong Lee, Doo-Jin Kim, Young-Jun Park, Moo-Seung Lee
Summary: In this study, it was found that PM-isolated Pseudomonas stutzeri (PMPS) induces higher levels of inflammatory responses in lung epithelial cells, alveolar cells, and macrophages compared to Pseudomonas stutzeri (PS). The pathogenicity of PMPS is mediated by Toll-like receptors (TLRs) signaling pathways, which also regulate the expression of the antibiotic peptide beta-defensin 3 (BD3) that suppresses PMPS proliferation. Furthermore, pretreatment with PM enhances inflammatory responses and tissue damage caused by PMPS, while reducing BD3 expression.
ENVIRONMENTAL POLLUTION
(2023)
Article
Fisheries
Sib Sankar Giri, Sang Guen Kim, Kang Jeong Woo, Won Joon Jung, Sung Bin Lee, Young Min Lee, Su Jin Jo, Mae Hyun Hwang, JaeHong Park, Ji Hyung Kim, V Sukumaran, Se Chang Park
Summary: This study investigated the effects of Bougainvillea glabra leaf as a feed supplement on the growth, immune response, and disease resistance of carp. The results showed that a dietary supplementation with 40g/kg BG leaf significantly improved the growth performance, immune response, and disease resistance of carp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yeonjin Je, Kyungdo Han, Jaeyoung Chun, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jong Pil Im, Joo Sung Kim
Summary: Abdominal obesity is associated with an increased risk of developing Crohn's disease, but not ulcerative colitis, according to a population-based cohort study in Korea.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Changsoo Woo, Kwan Hyeong Jo, Beomseok Sohn, Kisung Park, Hojin Cho, Won Jun Kang, Jinna Kim, Seung-Koo Lee
Summary: A machine learning model was developed and tested to classify the HPV status of OPSCC patients using 18F-FDG PET-derived parameters and an appropriate combination of machine learning methods. The model utilized PET parameters, clinical features, and their combination, and employed various techniques like feature transforms, feature selection, and oversampling for training. The model outperformed those using only PET or clinical parameters in predicting HPV status.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Cell Biology
Audrey Le Floc'h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Dharani Ajithdoss, Kaitlyn Gayvert, Annabel Romero Hernandez, Olivier Herbin, Amanda Tay, Pamela Farrales, Chandrashekhar K. Korgaonkar, Hao Pan, Sweta Shah, Vishal Kamat, Ishita Chatterjee, Jon Popke, Adelekan Oyejide, Wei Keat Lim, Jee H. Kim, Tammy Huang, Matthew Franklin, William Olson, Thomas Norton, Lorah Perlee, George D. Yancopoulos, Andrew J. Murphy, Matthew A. Sleeman, Jamie M. Orengo
Summary: The study generated an antibody called REGN7257, which can bind to IL-2RG with high affinity and effectively block signaling of all gamma c cytokines, thus inhibiting T cell-mediated diseases. By using REGN7257, the researchers found that gamma c cytokines play a key role in mouse models of graft-versus-host disease (GVHD) and multiple sclerosis, suggesting that inhibition of gamma c cytokine signaling is a potential strategy for the management of T cell-mediated diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yuna Kim, Sung Hwan Yoo, Jaeyoung Chun, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This study found that exposing patients to virtual reality (VR) prior to endoscopic procedures can reduce their anxiety levels, leading to less discomfort and incomplete procedures, as well as decreased use of sedative medication. The proportion of patients with high anxiety significantly decreased in the VR group compared to the control group, and patients in the VR group reported higher satisfaction with sedation.
YONSEI MEDICAL JOURNAL
(2023)
Article
Nutrition & Dietetics
Mi Jung Kwon, Jae Yong Park, Sung Gyun Kim, Jwa-Kyung Kim, Hyun Lim, Joo-Hee Kim, Ji Hee Kim, Seong-Jin Cho, Eun Sook Nam, Ha Young Park, Nan Young Kim, Ho Suk Kang
Summary: Using nationwide data from the Korean National Health Insurance Service-Health Screening Cohort database, this study aimed to explore the link between gout and incident osteoporosis/osteoporotic fractures. The results showed that gout patients had a slightly higher risk of developing osteoporosis compared to controls, but no significant association was found between gout and incident osteoporotic fractures. This study provides insights into the health implications of gout in the Korean population.
Article
Chemistry, Physical
Juchan Lee, Myung Joon Kim, InverstigationByeong Geun Jeong, Chan Kwon, Yumin Cha, Soo Ho Choi, Ki Kang Kim, Mun Seok Jeong
Summary: The study investigates the effect of sulfur vacancies on the electrical properties of MoS2. After generating sulfur vacancies through treatment with hydrazine, the density of shallow traps increased by a factor of 4, whereas that of deep-level traps increased by a factor of 200. These results indicate that sulfur vacancies induce both deep- and shallow-level traps, with a higher trap density at the deep level.
APPLIED SURFACE SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Hyo-Joon Yang, Young-Il Kim, Ji Yong Ahn, Kee Don Choi, Sang Gyun Kim, Seong Woo Jeon, Jie-Hyun Kim, Sung Kwan Shin, Hyuk Lee, Wan Sik Lee, Gwang Ha Kim, Jae Myung Park, Woon Geon Shin, Il Ju Choi
Summary: This study validated the effectiveness of the eCura system in undifferentiated-type early gastric cancer, and found that close follow-up without additional treatment can be considered for low-risk patients, while additional surgery is recommended for intermediate- and high-risk patients.
Article
Surgery
So Young Han, Hong Jin Yoon, Jie-Hyun Kim, Hye Sun Lee, Jaeyoung Chun, Young Hoon Youn, Hyojin Park
Summary: By analyzing the characteristics of patients with early gastric cancer who underwent ESD, we developed a nomogram to predict the risk of non-CR. This nomogram includes endoscopic features, radiologic findings, and pathology results, and it showed good predictive performance in the external validation.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Cell & Tissue Engineering
Youn Keong Cho, Hyun-Kyung Kim, Soon Sung Kwon, Su-Hee Jeon, June-Won Cheong, Ki Taek Nam, Han-Soo Kim, Sinyoung Kim, Hyun Ok Kim
Summary: To address the blood shortage issue, scientists have been exploring the use of human-induced pluripotent stem cells (hiPSCs) to generate red blood cells (RBCs) in vitro. In this study, hiPSCs were established from peripheral blood, cord blood, and bone marrow, and it was found that peripheral blood and cord blood were the most reliable sources for RBC production in vitro. These findings will aid in the selection of optimal hiPSC lines for clinical RBC production in the future.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Oh Chan Kwon, See Young Lee, Jaeyoung Chun, Kyungdo Han, Yuna Kim, Ryul Kim, Min-Chan Park, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This population-based cohort study in Korea found that patients with immune-mediated inflammatory diseases (IMIDs) had a lower risk of all-cause mortality compared to individuals without IMIDs. The risks of cancer-specific and cardiovascular disease-specific mortalities were also lower in IMID patients.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Oh Chan Kwon, Yuna Kim, Jaeyoung Chun, Kyungdo Han, Min-Chan Park, Ryul Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
Summary: This study aimed to assess whether the presence of immune-mediated inflammatory diseases (IMIDs) confers a higher risk of depression and anxiety in patients with type 2 diabetes (T2DM). The results showed that the existence of gut, joint, and skin IMIDs was associated with a higher risk of depression and anxiety. Patients with multiple IMIDs had a higher risk than those with only one.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Chang Gon Kim, Min Hwan Kim, Jee Hung Kim, Seul-Gi Kim, Gun Min Kim, Tae Yeong Kim, Won-Ji Ryu, Jee Ye Kim, Hyung Seok Park, Seho Park, Young Up Cho, Byeong Woo Park, Seung Il Kim, Joon Jeong, Joohyuk Sohn
Summary: This study analyzed data from postmenopausal women with HR-positive, HER2-negative ABC who were treated with CDK4/6 inhibitors and found that on-treatment dNLR predicted progression-free survival (PFS). Flow cytometry analysis revealed potential systemic immune responses induced by CDK4/6 inhibitors, including prevention of T cell exhaustion and reduction of myeloid-derived suppressor cell frequency.
BREAST CANCER RESEARCH
(2023)