Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency

Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics

(2017) Anna Chiara Nascimbeni et al.   FEBS Journal

PtdIns3P controls mTORC1 signaling through lysosomal positioning

(2017) Zhi Hong et al.   JOURNAL OF CELL BIOLOGY

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation

(2017) Fergal O’Farrell et al.   NATURE CELL BIOLOGY

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic

(2016) Andrea L Marat et al.   EMBO JOURNAL

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells

(2016) Florian Grahammer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plasticity of the brush border — the yin and yang of intestinal homeostasis

(2016) Delphine Delacour et al.   Nature Reviews Gastroenterology & Hepatology

The renal Fanconi syndrome in cystinosis: pathogenic insights and therapeutic perspectives

(2016) Stephanie Cherqui et al.   Nature Reviews Nephrology

The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells

(2016) Andres E. Perez Bay et al.   Nature Communications

p62 at the crossroad of the ubiquitin-proteasome system and autophagy

(2016) Victoria Cohen-Kaplan et al.   Oncotarget

ER-endosome contact sites: molecular compositions and functions

(2015) C. Raiborg et al.   EMBO JOURNAL

Phosphatidylinositol 3-kinase signaling determines kidney size

(2015) Jian-Kang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

(2015) Samira Alliouachene et al.   Cell Reports

Conditional Knockout of Pik3c3 Causes a Murine Muscular Dystrophy

(2014) Aaron Reifler et al.   AMERICAN JOURNAL OF PATHOLOGY

Time Course of Pathogenic and Adaptation Mechanisms in Cystinotic Mouse Kidneys

(2014) H. P. Gaide Chevronnay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Trafficking to the Apical and Basolateral Membranes in Polarized Epithelial Cells

(2014) E. H. Stoops et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Organization and execution of the epithelial polarity programme

(2014) Enrique Rodriguez-Boulan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo

(2013) Polly E. Mattila et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes

(2013) Wibke Bechtel et al.   Autophagy

Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling

(2013) Kay O. Schink et al.   BIOESSAYS

Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation

(2013) Anne-Christine Hick et al.   DEVELOPMENTAL BIOLOGY

Albumin Is Recycled from the Primary Urine by Tubular Transcytosis

(2013) V. Tenten et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

mVps34 Deletion in Podocytes Causes Glomerulosclerosis by Disrupting Intracellular Vesicle Trafficking

(2013) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vps34 Deficiency Reveals the Importance of Endocytosis for Podocyte Homeostasis

(2013) W. Bechtel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients

(2013) C. M. Gorvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Class III Phosphoinositide 3-Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling

(2013) Sarah Carpentier et al.   TRAFFIC

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis

(2012) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

(2012) N. Jaber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Regulation of autophagy by lysosomal positioning

(2011) Viktor I. Korolchuk et al.   Autophagy

OCRL controls trafficking through early endosomes via PtdIns4,5P2-dependent regulation of endosomal actin

(2011) Mariella Vicinanza et al.   EMBO JOURNAL

Mouse model of proximal tubule endocytic dysfunction

(2011) K. Weyer et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Mammalian Class 3 PI3K (PIK3C3) Is Required for Early Embryogenesis and Cell Proliferation

(2011) Xiang Zhou et al.   PLoS One

SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule

(2010) V. Vallon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ZONAB Promotes Proliferation and Represses Differentiation of Proximal Tubule Epithelial Cells

(2010) W. R. Lima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule

(2010) S. Amsellem et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration

(2010) L. Wang et al.   NEUROSCIENCE

Mapping of the fate of cell lineages generated from cells that express the Wnt4 gene by time-lapse during kidney development☆

(2009) Jingdong Shan et al.   DIFFERENTIATION

Generation of an allele to inactivateWnt4gene function conditionally in the mouse

(2009) Jingdong Shan et al.   GENESIS

Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease

(2009) Heather J. McCrea et al.   PHYSIOLOGY

Sequential Actions of Myotubularin Lipid Phosphatases Regulate Endosomal PI(3)P and Growth Factor Receptor Trafficking

(2008) Canhong Cao et al.   MOLECULAR BIOLOGY OF THE CELL

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Coordinated protein sorting, targeting and distribution in polarized cells

(2008) Ira Mellman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY