Article
Virology
Mohammad Farahmand, Somayeh Jalilvand, Arash Arashkia, Shohreh Shahmahmoodi, Atefeh Afchangi, Yaghoub Mollaei-Kandelous, Zabihollah Shoja
Summary: This study aimed to evaluate human genetic susceptibility to rotavirus gastroenteritis in Iran. The phylogenetic analysis showed that all rotavirus strains in Iran belonged to P[II], with P[8] being the most common genotype. The P[8] genotype was found to be associated with secretor and Lewis positive status.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Dandi Li, Mengxuan Wang, Jianxun Qi, Qing Zhang, Hong Wang, Lili Pang, Xiaoman Sun, Zhaojun Duan
Summary: This study investigated the glycan binding and structural characteristics of human P[25] rotavirus, revealing its ability to recognize type A histo-blood group antigen and sharing a similar structure with P[14]. These findings provide insights into the infection, prevalence, and host range of P[III] rotaviruses.
Article
Multidisciplinary Sciences
Shenyuan Xu, Kristen Rose McGinnis, Yang Liu, Pengwei Huang, Ming Tan, Michael Robert Stuckert, Riley Erin Burnside, Elsa Grace Jacob, Shuisong Ni, Xi Jiang, Michael A. Kennedy
Summary: The study revealed the diversity and host ranges of RVs in different human and animal hosts, suggesting that the evolution of P[II] RVs is influenced by HBGAs receptor selection. These findings help explain disease burden, species barriers, and vaccine efficacy, and have the potential to impact future vaccine strategy design.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Yu Liang, Wei Bu Wang, Jing Zhang, Jun Wei Hou, Fang Tang, Xue Feng Zhang, Li Fang Du, Ji Guo Su, Qi Ming Li
Summary: Norovirus (NoV) is the major pathogen causing outbreaks of viral gastroenteritis worldwide, with GII.4 being the predominant genotype in recent decades. The evolution-induced changes in HBGA-binding affinity for GII.4 NoV variants have been investigated, revealing a molecular mechanism behind the increased binding affinities during evolution.
Article
Microbiology
Lydie Masson, Laure Barbe, Fanny Henaff, Tasnuva Ahmed, Beatrice Le Moullac-Vaidye, Cecile Peltier, Sarah S. Marchand, Pauline Scherdel, Marie-Anne Vibet, Nathalie Ruvoen-Clouet, Narcisse Elenga, Berthe-Marie Imbert-Marcille, Christele Gras-Le Guen, Jacques Le Pendu
Summary: The null alleles of ABO, FUT2, and FUT3 genes provide protection against rotavirus gastroenteritis. A study in France and French Guiana found that the FUT2 and FUT3 null phenotypes offer nearly complete protection against P[8]-3 strains of rotavirus gastroenteritis in infants, and blood group O also provides some protection in Metropolitan France.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Bianca F. Middleton, Margie Danchin, Nigel A. Cunliffe, Mark A. Jones, Karen Boniface, Carl D. Kirkwood, Sarah Gallagher, Lea -Ann Kirkham, Caitlyn Granland, Monica McNeal, Celeste Donato, Nada Bogdanovic-Sakran, Amanda Handley, Julie E. Bines, Thomas L. Snelling
Summary: Most Australian Aboriginal children have positive secretor and Lewis antigen statuses. However, it seems that HBGA status cannot fully explain the underperformance of rotavirus vaccines among these children.
Article
Immunology
Julien Racle, Philippe Guillaume, Julien Schmidt, Justine Michaux, Amede Larabi, Kelvin Lau, Marta A. S. Perez, Giancarlo Croce, Raphael Genolet, George Coukos, Vincent Zoete, Florence Pojer, Michal Bassani-Sternberg, Alexandre Harari, David Gfeller
Summary: In this study, a dataset of 627,013 unique MHC-II ligands identified by mass spectrometry was collected and curated, allowing for precise determination of binding motifs for 88 MHC-II alleles across different species. Further analysis revealed a reverse-binding mode in HLA-DP ligands, and a machine-learning framework was developed to accurately predict binding specificities and ligands of any MHC-II allele.
Article
Virology
Sonja Jacobsen, Sandra Niendorf, Roswitha Lorenz, C. -Thomas Bock, Andreas Mas Marques
Summary: A study conducted in Germany shows that RVA-positive AGE in children after vaccination is not necessarily associated with the vaccine strain. The study also provides a reliable workflow to distinguish vaccine strains from wild-type strains.
Article
Immunology
Clayton Faua, Samira Fafi-Kremer, Pierre Gantner
Summary: HIV infection is directly associated with antigen-specific cells, including both HIV-specific cells and other pathogen-specific cells. The mechanisms involved in preferential infection and selection include HIV entry and restriction, cell exhaustion, survival, self-renewal, and immune escape. Further research is needed to study the role of other pathogens, viral genome intactness, inducibility, and phenotypic features.
JOURNAL OF VIRUS ERADICATION
(2023)
Article
Gastroenterology & Hepatology
Cliff A. Magwira, Duncan Steele, M. L. Seheri
Summary: The study found that harboring high levels of histo-blood group antigen-expressing Enerobactero cloacae is a risk factor for norovirus diarrhea. Infants with norovirus diarrhea had significantly higher counts of E. cloacae compared to non-diarrheic infants, and harboring higher counts of E. cloacae poses a significant risk for norovirus diarrhea.
Article
Biotechnology & Applied Microbiology
Suvrotoa Mitra, Mahadeb Lo, Ritubrita Saha, Alok K. Deb, Falguni Debnath, Shin-Ichi Miyoshi, Shanta Dutta, Mamta Chawla-Sarkar
Summary: This study investigated the prevalence rates and epidemiological patterns of major viral agents causing gastroenteritis among children under 5 years old in eastern India. The study found that GARV remained the predominant viral agent, although its prevalence rates decreased significantly compared to previous years. The study provides important insights into the current burden of viral gastroenteritis in this region.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Su-Kyung Lee, Su Jin Oh, Seoheui Choi, Soo Han Choi, Seon-Hee Shin, Eun Jin Lee, Eun-Jung Cho, Jungwon Hyun, Hyun Soo Kim
Summary: The study investigated the relationship between rotavirus genotype and HBGA-Lewis blood type in Korean children, revealing the predominance of the rotavirus P[6] strain in Korean neonates. The unique VP8* sequence of Korean P[6] strains and amino acid substitutions may be contributing factors to this predominance. This information may be beneficial for future neonatal vaccine development.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Ningbo Liao, Mengxuan Tang, Lili Chen, Peng Tian, Dapeng Wang, Dongqing Cheng, Guoping Wu
Summary: This study discovered a substance called SEPS-SC015, found on the surface of lettuce, that enhances the survival and adherence of foodborne norovirus. SEPS-SC015 also increases the resistance of the virus to heat and bleach treatment, but is ineffective against UV inactivation.
Article
Gastroenterology & Hepatology
Lauren Perieres, Aldiouma Diallo, Fabienne Marcellin, Marie Libelee Nishimwe, El Hadji Ba, Marion Coste, Gora Lo, Philippe Halfon, Coumba Toure Kane, Gwenaelle Maradan, Patrizia Carrieri, Assane Diouf, Yusuke Shimakawa, Cheikh Sokhna, Sylvie Boyer
Summary: The prevalence of HBsAg was found to be low in children in rural Senegal, meeting the WHO's 2020 target, but high in young adults aged 15-34 years. To achieve national and WHO hepatitis elimination goals, there is a need for general population testing, care, and treatment scale-up, particularly for adolescents and young adults.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Oncology
Kelly L. Harms, Lili Zhao, Bryan Johnson, Xiaoming Wang, Shannon Carskadon, Nallasivam Palanisamy, Daniel R. Rhodes, Rahul Mannan, Josh N. Vo, Jae Eun Choi, May P. Chan, Douglas R. Fullen, Rajiv M. Patel, Javed Siddiqui, Vincent T. Ma, Steven Hrycaj, Scott A. McLean, Tasha M. Hughes, Christopher K. Bichakjian, Scott A. Tomlins, Paul W. Harms
Summary: The study classified Merkel cell carcinoma (MCC) tumors into virus-positive (VP) and virus-negative (VN) types, each displaying distinct sets of prognostic molecular biomarkers. MCPyV status was found to be an independent prognostic factor for MCC, with tumor genome, transcriptome, and microenvironment features modifying prognosis in a manner specific to viral status.
CLINICAL CANCER RESEARCH
(2021)
Article
Clinical Neurology
Kayluz F. Boligan, Johanna Oechtering, Christian W. Keller, Benjamin Peschke, Robert Rieben, Nicolai Bovin, Ludwig Kappos, Richard D. Cummings, Jens Kuhle, Stephan von Gunten, Jan D. Luenemann
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2020)
Review
Biochemistry & Molecular Biology
Alexander Tuzikov, Alexander Chinarev, Nadezhda Shilova, Elena Gordeeva, Oxana Galanina, Tatyana Ovchinnikova, Marcel Schaefer, Nicolai Bovin
Summary: Polyacrylamide conjugates of glycans are widely used in glycobiology for immobilizing glycans and as multivalent inhibitors. The biotin tag allows quantitative immobilization on any surface and acts as a tracer for detecting carbohydrate-binding proteins. Additionally, this review covers less common but significant applications, as well as details on the glycopolymers themselves and their interactions with proteins.
GLYCOCONJUGATE JOURNAL
(2021)
Article
Medicine, Research & Experimental
Kira Dobrochaeva, Nailya Khasbiullina, Nadezhda Shilova, Yuriy Knirel, Polina Obukhova, Alexey Nokel, Roman Kunetskiy, Svetlana Tsygankova, Daniel Bello-Gil, Cristina Costa, Rafael Manez, Nicolai Bovin
Summary: The study compared the specificity of alpha-Gal antibodies in mice and humans, finding that the mouse model recognizes a broader range of human blood group B epitopes and glycans without the alpha-galactosyl residue compared to human antibodies, which show a preference for binding bacterial polysaccharides. This suggests caution should be exercised in using the mouse model in xenotransplantation experiments when epitope specificity is critical.
XENOTRANSPLANTATION
(2021)
Article
Hematology
Radhika Nagappan, Willy A. Flegel, Kshitij Srivastava, Eleanor C. Williams, Ivan Ryzhov, Alexander Tuzikov, Oxana Galanina, Nadezhda Shilova, Gennady Sukhikh, Holly Perry, Nicolai V. Bovin, Stephen M. Henry
Summary: This study evaluated the feasibility of using SARS-CoV-2 peptide Kode Technology-modified red cells to develop an assay for detecting SARS-CoV-2 antibodies. The results showed that C19-kodecytes have high specificity and sensitivity on routine serologic platforms, making them suitable for serological testing related to COVID-19.
Article
Microbiology
Adrien Breiman, Nathalie Ruvoen-Clouet, Marie Deleers, Tiffany Beauvais, Nicolas Jouand, Jezabel Rocher, Nicolai Bovin, Nathalie Labarriere, Hanane El Kenz, Jacques Le Pendu
Summary: The study reveals that COVID-19 patients have significantly lower levels of anti-Tn antibodies compared to non-infected individuals, indicating both quantitative and qualitative differences. The anti-Tn antibodies are correlated with the development of specific antiviral response and are also lower in individuals with blood types A and B.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Developmental Biology
Momal Sharif, Karl Kerns, Peter Sutovsky, Nicolai Bovin, David J. Miller
Summary: Studies have shown that progesterone-induced sperm release requires active CatSper channels and proteasomal degradation, indicating that hyperactivation and proteolysis are vital parts of the mechanism for sperm movement.
Article
Chemistry, Organic
Alexey V. Nizovtsev, Nicolai V. Bovin
Summary: A new convenient synthetic route for 2-aminopropane-1,2,3-tricarboxylic acid is described, involving two initial steps conducted in a one-pot procedure. The successful synthesis is achieved through the cyclization of hippuric acid and subsequent hydrolysis with HCl.
SYNTHESIS-STUTTGART
(2021)
Article
Immunology
Marina M. Ziganshina, Nadezhda Shilova, Nailia R. Khasbiullina, Anastasia Terentyeva, Elena L. Dolgopolova, Alexey Yu Nokel, Ekaterina L. Yarotskaya, Roman G. Shmakov, Nicolai Bovin, Gennady T. Sukhikh
Summary: A possible mechanism of immune tolerance in pregnancy is the production of blocking antibodies in the placenta, which protect the fetus from the mother's immune system. The specificity and nature of these antibodies are still unknown. However, the study found that the repertoire of placental antibodies is less variable and qualitatively different from those in the peripheral blood, and this repertoire is narrower in women with pre-eclampsia compared to healthy pregnancy. Some antibodies are found exclusively in the placenta, while others are only found in the placenta of healthy women.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
E. Slivka, A. B. Tuzikov, S. Khaidukov, V. A. Komarova, S. M. Henry, N. Bovin, E. M. Rapoport
Summary: This study compared the properties of three synthetic analogs and found that they have similar localization patterns and can be interchanged when studying the incorporation/release processes. However, there are some differences in the insertion process and release kinetics.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2022)
Review
Nanoscience & Nanotechnology
A. Yu Nokel, N. Bovin, N. Shilova
Summary: The review discusses the main methods for modifying plastic as a functional material for manufacturing biochips, including physical, chemical, and physical-chemical methods for introducing functional groups and achieving effective immobilization of biomolecules. The advantages and disadvantages of existing approaches are discussed in terms of their applicability to various tasks.
NANOBIOTECHNOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sabrina Leoty-Okombi, Florence Gillaizeau, Sebastien Leuillet, Benoit Douillard, Sophie Le Fresne-Languille, Thomas Carton, Alessandra De Martino, Philippe Moussou, Catherine Bonnaud-Rosaye, Valerie Andre
Summary: This study found that skin physiology disruption induced by SLS patch can alter skin microbiota composition, relative abundance, and diversity, leading to increased skin redness, decreased stratum corneum hydration, and skin barrier function impairment. The experiment also showed changes in the relative abundance of potential pathogens and beneficial bacteria in the skin.
Article
Biochemistry & Molecular Biology
N. Shilova, I. M. Ryzhov, M. M. Ziganshina, A. S. Rakitko, M. E. Huflejt, N. Bovin
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Polina Obukhova, Svetlana Tsygankova, Alexander Chinarev, Nadezhda Shilova, Alexey Nokel, Paul Kosma, Nicolai Bovin
Correction
Biochemistry & Molecular Biology
Polina Obukhova, Svetlana Tsygankova, Alexander Chinarev, Nadezhda Shilova, Alexey Nokel, Paul Kosma, Nicolai Bovin
Article
Virology
Dmitry K. L'vov, Elena Burtseval, Lyudmila Kolobukhinal, Irina T. Fedyakina, Nikolay Bovin, Anna Ignatjeva, Kirill G. Krasnoslobodtsev, Elena L. Feodoritova, Svetlana Trushakoval, Nataliya Breslav, Liliya N. Merkulova, Evgeniya A. Mukasheva, Irina N. Khlopova, Olga L. Voronina, Ekaterina Aksyonova, Marina S. Kunda, Natalia N. Ryzhova, Raisa V. Vartanjan, Lidiya B. Kistenyova, Ilja M. Kirillov, Elena S. Proshina, Alexandra G. Rosatkevich, Irina S. Kruzhkova, Andrey L. Zaplatnikov, Marina Bazarova, Svetlana Smetanina, Mikhail Kharlamov, Nikolay L. Karpov, Alexander Shikhin
VOPROSY VIRUSOLOGII
(2020)