Article
Public, Environmental & Occupational Health
Linus P. Rweyemamu, Gokce Akan, Ismael C. Adolf, Erick P. Magorosa, Innocent J. Mosha, Nazima Dharsee, Lucy A. Namkinga, Sylvester L. Lyantagaye, Abdolrahman S. Nateri, Fatmahan Atalar
Summary: This study revealed heterogeneity in reproductive factors among breast cancer molecular subtypes in Tanzania. Breastfeeding may reduce the likelihood of developing luminal-A, luminal-B, and triple-negative subtypes, while having the first full-term pregnancy after 30 years of age could increase the chance of developing luminal-A subtype.
Article
Oncology
Bo Qin, Riddhi A. Babel, Jesse J. Plascak, Yong Lin, Antoinette M. Stroup, Noreen Goldman, Christine B. Ambrosone, Kitaw Demissie, Chi-Chen Hong, Elisa Bandera, Adana A. M. Llanos
Summary: This study evaluated the association between neighborhood-level socioeconomic status and breast cancer subtypes among Black women, finding that Black women living in socioeconomically disadvantaged neighborhoods have an increased risk of triple-negative breast cancer, particularly in areas with lower proportions of Black residents. The findings suggest that where people live may influence breast tumor biology, highlighting the need for a deeper understanding of multilevel pathways contributing to tumor biology.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Review
Oncology
Xihua Mao, Chioma Omeogu, Shama Karanth, Ashwini Joshi, Clare Meernik, Lauren Wilson, Amy Clark, April Deveaux, Chunyan He, Tisha Johnson, Karen Barton, Samantha Kaplan, Tomi Akinyemiju
Summary: In this systematic review and meta-analysis, the associations between reproductive factors and breast cancer subtypes were summarized. The results showed that later age at menarche and breastfeeding were consistently associated with decreased risk of breast cancer across all subtypes. However, later age at menopause, later age of first childbirth, and nulliparity/low parity were associated with increased risk of specific subtypes. The use of oral contraceptives and hormone replacement therapy showed inconsistent associations with different subtypes. The findings can improve the customization of prevention strategies and the accuracy of risk stratification models.
Article
Oncology
Tara M. Friebel-Klingner, Sarah Ehsan, Emily F. Conant, Despina Kontos, Susan M. Domchek, Anne Marie McCarthy
Summary: The study found that breast density and obesity are strong risk factors for TNBC among Black women. Understanding subtype-specific risk factors for breast cancer among Black women can improve risk assessment.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Chloe M. Beverly Hery, Sarah A. Janse, Kimberly J. Van Zee, Elizabeth Z. Naftalis, Electra D. Paskett, Michelle J. Naughton
Summary: This study examined longitudinal trends and factors associated with insomnia in a cohort of young breast cancer patients over a period of 3 years. It found that insomnia symptoms were most severe closer to diagnosis and treatment, but still persisted for 42% of the patients 3 years after diagnosis. Age, hot flashes, and depressive symptoms were significantly associated with insomnia over time.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, General & Internal
Ryoko Katagiri, Motoki Iwasaki, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Melissa A. Merritt, Ji-Yeob Choi, Aesun Shin, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Xiao-Ou Shu, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yukai Lu, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang
Summary: This study found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These findings from a large pooled study of Asian women add to the growing body of evidence on the association between reproductive factors and endometrial cancer risk.
Article
Oncology
Emma Fontvieille, Mathilde His, Carine Biessy, Anne-Sophie Navionis, Gabriela Torres-Mejia, Angelica Angeles-Llerenas, Isabel Alvarado-Cabrero, Gloria Ines Sanchez, Edgar Navarro, Yorlany Rodas Cortes, Carolina Porras, Ana Cecilia Rodriguez, Maria Luisa Garmendia, Jose Luis Soto, Leonor Moyano, Peggy L. Porter, Ming Gang Lin, Jamie Guenthoer, Isabelle Romieu, Sabina Rinaldi
Summary: This study supports the association between chronic inflammation and breast cancer risk in young women in Latin America. Larger prospective studies are needed to confirm these findings in premenopausal women.
Article
Medicine, General & Internal
Rayan Kabirian, Maria Alice Franzoi, Julie Havas, Charles Coutant, Olivier Tredan, Christelle Levy, Paul Cottu, Asma Dhaini Merimeche, Sophie Guillermet, Jean-Marc Ferrero, Sylvie Giacchetti, Thierry Petit, Florence Dalenc, Philippe Rouanet, Sibille Everhard, Anne-Laure Martin, Barbara Pistilli, Matteo Lambertini, Ines Vaz-Luis, Antonio Di Meglio
Summary: This study investigated chemotherapy-related amenorrhea (CRA) among premenopausal women with breast cancer and its association with long-term quality of life (QOL). The study found that most patients experienced CRA from 1 to 4 years after diagnosis, and persistent CRA was associated with worse QOL.
Article
Oncology
Lindsay J. Collin, Deirdre P. Cronin-Fenton, Thomas P. Ahern, Michael Goodman, Lauren E. McCullough, Lance A. Waller, Anders Kjaersgaard, Per Damkier, Peer M. Christiansen, Bent Ejlertsen, Maj-Britt Jensen, Henrik Toft Sorensen, Timothy L. Lash
Summary: This study evaluated the association between early discontinuation of endocrine therapy and breast cancer recurrence in premenopausal women. The results showed a higher rate of recurrence in women who discontinued endocrine therapy compared to those who completed the recommended treatment. These findings emphasize the importance of clinical follow-up and behavioral interventions to support the persistence of adjuvant endocrine therapy in preventing breast cancer recurrence.
CLINICAL CANCER RESEARCH
(2021)
Article
Obstetrics & Gynecology
Fernando Zegers-Hochschild, Javier A. Crosby, Carolina Musri, Maria do Carmo Borges de Souza, A. Gustavo Martinez, Adelino Amaral Silva, Jose Maria Mojarra, Diego Masoli, Natalia Posada
Summary: This study examined the utilization, effectiveness, and safety of assisted reproductive technology (ART) in Latin America in 2019. The results showed an increase in ART utilization and a shift towards frozen-thawed embryo transfers. Selective single-embryo transfer (SET) was found to be important in reducing multiple births.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Oncology
Mark E. Sherman, Thomas de Bel, Michael G. Heckman, Launia J. White, Joshua Ogony, Melody Stallings-Mann, Tracy Hilton, Amy C. Degnim, Robert A. Vierkant, Tanya Hoskin, Matthew R. Jensen, Laura Pacheco-Spann, Jill E. Henry, Anna Maria Storniolo, Jodi M. Carter, Stacey J. Winham, Derek C. Radisky, Jeroen van der Laak
Summary: Serum hormone levels are associated with quantitative features of normal breast tissue. These associations may be modified by parity and tissue composition.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Abduljewad Hussen, Musa Kumbi, Jemal Bedewi, Abate Lette, Shemsu Nuriye
Summary: Breast self-examination practice is low among reproductive-age women in southeast Ethiopia, with only 13.2% of mothers practicing it. Education level, age, and previous breast examination by health professionals are important predictors of breast self-examination practices.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Tess Clendenen, Wenzhen Ge, Karen L. Koenig, Yelena Afanasyeva, Claudia Agnoli, Elizabeth Bertone-Johnson, Louise A. Brinton, Farbod Darvishian, Joanne F. Dorgan, A. Heather Eliassen, Roni T. Falk, Goran Hallmans, Susan E. Hankinson, Judith Hoffman-Bolton, Timothy J. Key, Vittorio Krogh, Hazel B. Nichols, Dale P. Sandler, Minouk J. Schoemaker, Patrick M. Sluss, Malin Sund, Anthony J. Swerdlow, Kala Visvanathan, Mengling Liu, Anne Zeleniuch-Jacquotte
Summary: This study found positive associations between AMH and age at menarche and parity, and negative associations with hysterectomy/partial oophorectomy. Women who were obese, currently used oral contraceptives, or were current/former smokers had lower AMH concentrations. Interestingly, higher AMH concentrations were observed in women who had a benign breast biopsy, especially in women over 40 years old.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Anushri Chitkara, Ines Mesa-Eguiagaray, Sarah H. Wild, Peter S. Hall, David A. Cameron, Andrew H. Sims, Jonine D. Figueroa
Summary: This study investigated the relationship between reproductive risk factors and molecular subtypes of breast cancer in women aged <= 50 years. The findings revealed differences in number of births and time since last birth among different molecular subtypes of breast cancer. The study suggests that analyzing routine electronic medical records linked to tumor pathology data can help explore the etiology and prognosis of cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Nursing
Go-Un Kim, Hae Kyoung Son, Mi-Young Kim
Summary: This study found that individual and community level factors affect suicidal ideation among pre- and postmenopausal women, with factors such as religion, alcohol use, and mental health having a greater impact on premenopausal women. Mental health nurses can help reduce suicidal ideation among these women by providing targeted interventions and promoting the use of community resources.
JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
(2021)
Article
Endocrinology & Metabolism
Angela Jaramillo-Ospina, Paola Casanello, Maria Luisa Garmendia, Ross Andersen, Robert D. Levitan, Michael J. Meaney, Patricia Pelufo Silveira
Summary: This study analyzed the interaction between polygenic risk score (PRS) for plasma docosahexaenoic fatty acid (DHA) concentration, body composition, and eating behavior in childhood. The results showed that there were interactions between PRS and body fat on eating behavior in childhood, and interactions between PRS and eating behavior on body fat later in childhood, suggesting that genetic profile and eating behavior influence the development of adiposity at later ages.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Oncology
Constanza Lesser, Veronica Mericq, Marcela Reyes, Maria Luisa Garmendia, John A. Shepherd, Karin B. Michels, Camila Corvalan, Ana Pereira
Summary: The study found that girls who consumed higher amounts of total phytoestrogens and isoflavones during puberty until 2 years after menarche onset had significantly lower fibroglandular volume in the breasts.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Letter
Nutrition & Dietetics
B. Marcela Araya, Juan Pedro Kusanovic, Camila Corvalan, Maria Luisa Garmendia
REVISTA CHILENA DE NUTRICION
(2022)
Article
Oncology
Emma Fontvieille, Mathilde His, Carine Biessy, Anne-Sophie Navionis, Gabriela Torres-Mejia, Angelica Angeles-Llerenas, Isabel Alvarado-Cabrero, Gloria Ines Sanchez, Edgar Navarro, Yorlany Rodas Cortes, Carolina Porras, Ana Cecilia Rodriguez, Maria Luisa Garmendia, Jose Luis Soto, Leonor Moyano, Peggy L. Porter, Ming Gang Lin, Jamie Guenthoer, Isabelle Romieu, Sabina Rinaldi
Summary: This study supports the association between chronic inflammation and breast cancer risk in young women in Latin America. Larger prospective studies are needed to confirm these findings in premenopausal women.
Letter
Oncology
Connor J. Kinslow, Arreum Kim, Gloria I. Sanchez, Simon K. Cheng, Lisa A. Kachnic, Alfred I. Neugut, David P. Horowitz
Article
Public, Environmental & Occupational Health
Maria F. Mujica-Coopman, Camila Corvalan, Marcela Flores, Maria Luisa Garmendia
Summary: This study aims to describe the design, methods, and preliminary findings of the Chilean Maternal & Infant Cohort Study II (CHiMINCs-II), which examines the health consequences for mothers and infants in the COVID-19 era. The study includes two nested studies focused on breast cancer risk assessment and the impact of COVID-19 on maternal and infant health and nutrition.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Sebastian Sole, Sergio Becerra, Claudia Carvajal, Piero Bettolli, Hernan Letelier, Alejandro Santini, Lorena Vargas, Alexander Cifuentes, Francisco Larsen, Natalia Jara, Jorge Oyarzun, Eva Bustamante, Benjamin Martinez, David Rosenberg, Tomas Galvan
Summary: This study investigates the clinical impact of Dentoxol(R) use in severe oral mucositis and shows that it has important clinical relevance in reducing the severity of oral mucositis. The results justify the incorporation of Dentoxol(R) mouth rinse into clinical protocols to prevent and/or treat oral mucositis secondary to cancer therapy.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
D. Navarro-Rosenblatt, T. Benmarhnia, P. Bedregal, S. Lopez-Arana, L. Rodriguez-Osiac, M. -L. Garmendia
Summary: This study assessed the impact of extended maternity leave, a pay for performance exclusive breastfeeding strategy, and the COVID-19 pandemic on breastfeeding inequalities in Chile. The results showed no impact of extended maternity leave on breastfeeding inequalities. The pay for performance strategy was effective in increasing breastfeeding rates, with a stronger effect in poorer areas. During COVID-19, wealthier areas had slightly higher breastfeeding rates. Limited healthcare access in poorer areas may explain breastfeeding inequalities.
Article
Medicine, General & Internal
Mary Luz Rol, Maria Alejandra Picconi, Annabelle Ferrera, Gloria Ines Sanchez, Maria de la Luz Hernandez, Joana Lineros, Ana Peraza, Marisol Brizuela, Laura Mendoza, Pamela Mongelos, Yessy Cabrera, Margarita Rodriguez de la Pena, Rita Mariel Correa, Carolina Teran, Deisy Colque Reynaga, Laura Garcia, Arianis Tatiana Ramirez, Pilar Hernandez-Nevarez, Franco Doimi, Maria Ramon, Javier Arias-Stella, Michael Zuniga, Veronica Villagra, Maria Liz Bobadilla, Lucia Cardinal, Joan Valls, Eric Lucas, Armando Baena, Laura Fleider, Gino Venegas, Aurelio Cruz-Valdez, Guillermo Rodriguez, Alejandro Calderon, Carolina Wiesner, Silvana Luciani, Nathalie Broutet, Rolando Herrero, Maribel Almonte
Summary: This study describes the process of implementing HPV testing in 12 laboratories across 9 Latin American countries, assessing their readiness and continuity capacity. The results show that although seven laboratories had high readiness, only two were able to maintain good quality HPV testing over time. Based on gained expertise, five laboratories have become part of national screening programs. Therefore, in addition to readiness, establishing a culture of quality and effective monitoring and quality assurance systems are essential for successful implementation of HPV-based cervical screening.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Martha I. Gonzalez-Ramirez, Yurley T. Cardona, Maria C. Agudelo, Carolina Lopez, Juan J. Florez-Acosta, Samuel Agudelo-Gamboa, Jone Garai, Li Li, Carlos A. Orozco-Castano, Jovanny Zabaleta, Gloria I. Sanchez
Summary: Biomarkers are needed to identify women at risk of cervical cancer among those with high-risk HPV infection. In this study, miRNAs were identified as potential markers for distinguishing high and low grade cervical lesions. Several miRNAs were found to have inverse correlations with mRNA targets related to HPV-induced carcinogenesis, and two miRNAs, miR-143-5p and miR-29a-3p, were able to predict CIN2+ and CIN3+ in hrHPV-positive women.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Joan Valls, Armando Baena, Gino Venegas, Marcela Celis, Mauricio Gonzalez, Carlos Sosa, Jorge Luis Santin, Marina Ortega, Ana Soilan, Elmer Turcios, Jacqueline Figueroa, Margarita Rodriguez de la Pena, Alicia Figueredo, Andrea Veronica Beracochea, Natalia Perez, Josefina Martinez-Better, Oscar Lora, Julio Yamil Jimenez, Diana Gimenez, Laura Fleider, Yuly Salgado, Sandra Martinez, Yenny Bellido-Fuentes, Bettsy Flores, Silvio Tatti, Veronica Villagra, Aurelio Cruz-Valdez, Carolina Teran, Gloria Ines Sanchez, Guillermo Rodriguez, Maria Alejandra Picconi, Annabelle Ferrera, Laura Mendoza, Alejandro Calderon, Raul Murillo, Carolina Wiesner, Nathalie Broutet, Silvana Luciani, Carlos Perez, Teresa M. Darragh, Jose Jeronimo, Rolando Herrero, Maribel Almonte
Summary: This study aimed to evaluate the performance of colposcopy in detecting cervical precancer and cancer in HPV-positive women. The results showed that colposcopy has high sensitivity and suitability in detecting CIN3+ in HPV-positive women.
LANCET GLOBAL HEALTH
(2023)
Article
Oncology
Carlos Andres Ossa Gomez, Maria Isabel Achatz, Mabel Hurtado, Maria Carolina Sanabria-Salas, Yasser Sullcahuaman, Yanin Chavarri-Guerra, Julie Dutil, Sarah M. Nielsen, Edward D. Esplin, Scott T. Michalski, Sara L. Bristow, Kathryn E. Hatchell, Robert L. Nussbaum, Daniel E. Pineda-Alvarez, Patricia Ashton-Prolla
Summary: This study reports on pathogenic germline variants detected among individuals undergoing genetic testing for hereditary breast and/or ovarian cancer from Latin America and compares them with self-reported Hispanic individuals from the United States.
JCO GLOBAL ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Carlos Barrios, Guillermo Sanchez-Vanegas, Cynthia Villarreal-Garza, Andres Ossa, Milton A. Lombana, Angelica Monterrosa-Blanco, Ana S. Ferrigno, Carlos Alberto Castro
Summary: This study describes the barriers and facilitators for providing multidisciplinary care (MDC) to breast cancer patients in Latin America. Experts recognized that most oncology practices in Latin America do not apply a multidisciplinary approach for breast cancer patients. The main barriers for MDC include fragmentation of health services, being understaffed, inadequate infrastructure, and geographic disparities. Addressing regional issues and identifying specific local needs is necessary to encourage the adoption of an effective multidisciplinary approach.
LANCET REGIONAL HEALTH-AMERICAS
(2022)
Article
Oncology
Sarah Ward, Anya Burton, Rulla M. Tamimi, Ana Pereira, Maria Luisa Garmendia, Marina Pollan, Norman Boyd, Isabel dos-Santos-Silva, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martin Lajous, Ruy Lopez-Ridaura, Kimberly Bertrand, Ava Kwong, Giske Ursin, Eunjung Lee, Huiyan Ma, Sarah Vinnicombe, Sue Moss, Steve Allen, Rose Ndumia, Sudhir Vinayak, Soo-Hwang Teo, Shivaani Mariapun, Beata Peplonska, Agnieszka Bukowska-Damska, Chisato Nagata, John Hopper, Graham Giles, Vahit Ozmen, Mustafa Erkin Aribal, Joachim Schuez, Carla H. Van Gils, Johanna O. P. Wanders, Reza Sirous, Mehri Sirous, John Hipwell, Jisun Kim, Jong Won Lee, Caroline Dickens, Mikael Hartman, Kee-Seng Chia, Christopher Scott, Anna M. Chiarelli, Linda Linton, Anath Arzee Flugelman, Dorria Salem, Rasha Kamal, Valerie McCormack, Jennifer Stone
Summary: Late age at menarche is positively associated with higher mammographic density, while taller stature is also related to higher mammographic density. The study reveals a complex relationship between growth and development, mammographic density, and breast cancer risk.
BREAST CANCER RESEARCH
(2022)