Article
Veterinary Sciences
Mennat-Allah Abdelsalam, Wael Felefel, Sabreen Fadl, Mohamed Bessat
Summary: This study provides the first molecular evidence of Babesia, Theileria, and Anaplasma infections in sheep and goat populations in the North Coast region of Egypt. 73% of the samples were found to be infected with at least one of the three blood pathogenic organisms through microscopic examination. 43% of the small ruminants were infected with at least one of these pathogens according to molecular diagnosis.
BMC VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Alejandro Garcia, M. Estrella Santamaria, Isabel Diaz, Manuel Martinez
Summary: The study reveals that transcriptomic meta-analysis is an effective approach to uncover physiological processes in plant responses to herbivores. Analysis of Arabidopsis-thaliana interactions with pests highlights key issues in plant responses, such as the specificity of perception and signaling pathways, and the variability in secondary metabolic pathways.
SCIENTIFIC REPORTS
(2021)
Article
Fisheries
Zhuoxin Lai, Wei Zhao, Yingying Lu, Lingjun Wu, Chuangye Yang, Qingheng Wang
Summary: This study characterized the cDNA of the AP-1 gene in Pinctada fucata martensii and found that it is highly expressed in multiple tissues and during specific developmental stages. The gene also shows significantly high expression under cold tolerance stress. SNP and haplotype analysis revealed that genetic variations in PmAP-1 are associated with cold tolerance in P. f. martensii.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leonardo Garcia-Murillo, Eliana Valencia-Lozano, Nicolas Alberto Priego-Ranero, Jose Luis Cabrera-Ponce, Fatima Patricia Duarte-Ake, Juan Carlos Vizuet-de-Rueda, Diana Marcela Rivera-Toro, Humberto Herrera-Ubaldo, Stefan de Folter, Raill Alvarez-Venegas
Summary: With the continual degradation of arable land caused by a growing population, improving crops and crop protection plays a crucial role in maintaining and increasing crop productivity. Alternatives to pesticide use include biological control agents, the creation of resistant crop varieties, the application of plant activator agrochemicals, and the utilization of gene editing techniques such as CRISPR-Cas. In this study, it was demonstrated that editing tomato plants using CRISPR activation (CRISPRa) can activate defense genes and enhance resistance against pathogen infection.
Article
Immunology
Yulong Wei, Timothy C. Davenport, Jack A. Collora, Haocong Katherine Ma, Delia Pinto-Santini, Javier Lama, Ricardo Alfaro, Ann Durr, Ya-Chi Ho
Summary: Understanding the proliferation and persistence of HIV-1-infected cells is crucial for eradicating HIV-1. By examining the transcription factor accessibility, transcriptome, surface proteins, HIV-1 DNA, and HIV-1 RNA of single CD4+ memory T cells, we identified specific transcription factor accessibility in latent and transcriptionally active HIV-1-infected cells. Additionally, a proliferation program was found to promote the survival of transcriptionally active HIV-1-infected cells. Different epigenetic programs were also involved in driving the heterogeneous cellular states of HIV-1-infected cells, including activation, cytotoxic effector differentiation, migration, and cell death.
Article
Chemistry, Multidisciplinary
Mustapha Najih, Audrey Basque, Ha Tuyen Nguyen, Mariama Diawara, Luc J. Martin
Summary: Gap junctions, mainly formed by Gja1, are important in the regulation of spermatogonia proliferation and differentiation. The expression of Gja1 is regulated through various processes, including gene transcription, mRNA maturation, protein synthesis, post-translational modifications, plasma membrane integration, and protein degradation. Abnormal decrease in Gja1 expression is observed in testicular germ cell tumors, suggesting a loss of cooperation between AP-1 factors. Jun and Fosl2 cooperate to activate the Gja1 promoter, and protein kinase A and calcium-calmodulin protein kinase I improve the cooperation between AP-1 factors.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Lizhi He, Henry Pratt, Mingshi Gao, Fengxiang Wei, Zhiping Weng, Kevin Struhl
Summary: YAP and TAZ are recruited by JUNB and STAT3 in addition to TEAD, and they interact with AP-1 proteins to stimulate transcriptional activation. Different classes of YAP/TAZ target sites are associated with distinct gene functions, and YAP-specific or TAZ-specific target sites have different sequence motifs and gene classes compared to shared YAP/TAZ target sites. Genes with YAP/TAZ sites of the AP-1 or TEAD class are linked to poor survival in breast cancer patients with triple-negative breast cancer.
Review
Oncology
Fengjuan Fan, Klaus Podar
Summary: Transcription factors like the Activator Protein-1 (AP-1) family play crucial roles in cell physiology and disease pathogenesis, including hematologic malignancies like multiple myeloma. Targeting AP-1 TFs has emerged as a promising approach for anti-MM therapy, with potential inhibitors and modifiers being explored for therapeutic purposes.
Article
Immunology
Yuan Gao, Zhenlu Xu, Ximeng Li, Zhuangzhuang Liu, Wenjing Li, Yuan Kang, Xiaoyu Zhang, Yun Qi
Summary: Resibufogenin (RBG), one of the major active components in toad venom, has significant anti-inflammatory activity by reducing inflammatory mediators and inhibiting NF-kappa B and AP-1 signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hideki Furuya, Yuka Sasaki, Runpu Chen, Rafael Peres, Kanani Hokutan, Kaoru Murakami, Nari Kim, Owen T. M. Chan, Ian Pagano, Lars Dyrskjot, Jorgen B. Jensen, Per-Uno Malmstrom, Ulrika Segersten, Yijun Sun, Abolfazl Arab, Hani Goodarzi, Steve Goodison, Charles J. Rosser
Summary: The extracellular activity of Plasminogen activator inhibitor-1 (PAI-1) is well described, but recent studies have revealed its role in promoting human cancers by regulating angiogenesis and tumor cell survival. This study found that PAI-1 expression levels correlated with tumor grade, stage, and overall survival in bladder cancer. Further investigation showed that nuclear PAI-1 can influence gene expression programs and support malignancy.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Eunji Kim, Akash Ahuja, Mi-Yeon Kim, Jae Youl Cho
Summary: Epigenetic regulation plays a crucial role in disease development and progression, as well as in controlling anti-inflammatory and anti-tumor responses. The study highlights the involvement of the activator protein-1 (AP-1) signaling pathway in various cellular processes, and the diverse ways in which methyltransferases modulate AP-1 activities.
Article
Biochemistry & Molecular Biology
Nan Wang, Yao Deng, Lisha Zhang, Yingchun Wan, Ting Lei, Yimin Yang, Can Wu, Hai Du, Ping Feng, Wuzhong Yin, Guanghua He
Summary: A rice mutant, osuge1, lacking UDP-glucose epimerase activity, exhibited delayed tapetum degradation and abnormal pollen development. OsUGE1 was found to participate in the TIP2/bHLH142-TDR-EAT1/DTD transcriptional regulatory cascade, in which TIP2 and TDR regulate OsUGE1 expression while OsUGE1 regulates EAT1 expression. Moreover, OsUGE1 was shown to regulate its own gene expression by directly binding to an E-box element in its promoter. These findings demonstrate that OsUGE1 has moonlighting functions as a transcriptional activator in addition to its role as a UDP-glucose epimerase.
Article
Biochemistry & Molecular Biology
Dhiraj Kumar Sah, Pham Ngoc Khoi, Shinan Li, Archana Arjunan, Jae-Uk Jeong, Young Do Jung
Summary: EGCG can inhibit the invasion ability of bladder cancer cells induced by IL-1β by suppressing the expression of uPAR through the inhibition of ERK1/2, JNK, AP-1, and NF-κB activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jung Sun Park, In Ae Jung, Hong Sang Choi, Dong-Hyun Kim, Hoon In Choi, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: The study demonstrated that inhibiting the overexpression of PAI-1 and CTGF with the glycogen synthase kinase-3p inhibitor 6-BIO reduced kidney fibrosis in a rat model and in vitro experiments. This treatment regulated signaling pathways and transcription factors, such as SMAD and MAPK, leading to anti-fibrotic effects on kidney cells.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Rocio Morales-Barcenas, Yesennia Sanchez-Perez, Miguel Santibanez-Andrade, Yolanda Chirino, Ernesto Soto-Reyes, Claudia M. Garcia-Cuellar
Summary: This study demonstrates that exposure to PM10 enhances the activity of c-Jun, Jun B, and Fra-1, increases the expression of MMP-9, and promotes cell invasion in lung epithelial cells through the AhR pathway. Furthermore, the activity of Fos B and C-Fos is downregulated by PM10. These findings highlight the potentially toxic effects of the PM10 mixture in lung epithelial cells.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Ornithology
Anna C. B. Prinz, Vikas K. Taank, Vincent Voegeli, Eric L. Walters
JOURNAL OF FIELD ORNITHOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Shovan Dutta, Michael J. Celestine, Supreet Khanal, Alexis Huddleston, Colin Simms, Jessa Faye Arca, Amlan Mitra, Loree Heller, Piotr J. Kraj, Michel Ledizet, John F. Anderson, Girish Neelakanta, Alvin A. Holder, Hameeda Sultana
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2018)
Article
Multidisciplinary Sciences
Supreet Khanal, Hameeda Sultana, John D. Catravas, Jason A. Carlyon, Girish Neelakanta
Article
Multidisciplinary Sciences
Ashish Vora, Vikas Taank, Sucharita M. Dutta, John F. Anderson, Durland Fish, Daniel E. Sonenshine, John D. Catravas, Hameeda Sultana, Girish Neelakanta
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Vikas Taank, Shovan Dutta, Amrita Dasgupta, Tanner K. Steeves, Durland Fish, John F. Anderson, Hameeda Sultana, Girish Neelakanta
SCIENTIFIC REPORTS
(2017)
Article
Parasitology
Vikas Taank, Wenshuo Zhou, Xuran Zhuang, John F. Anderson, Utpal Pal, Hameeda Sultana, Girish Neelakanta
PARASITES & VECTORS
(2018)
Article
Infectious Diseases
Jeremy W. Turck, Vikas Taank, Girish Neelakanta, Hameeda Sultana
TICKS AND TICK-BORNE DISEASES
(2019)
Article
Genetics & Heredity
Ellango Ramasamy, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta
Article
Biochemistry & Molecular Biology
Supreet Khanal, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta
Summary: This study provides evidence for the first time that Anaplasma phagocytophilum modulates the arthropod circadian gene for its transmission to the vertebrate host. The results suggest that the circadian modulation of tick gene expression plays an important role in arthropod blood feeding and transmission of pathogens from vector to the vertebrate host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Multidisciplinary
BK Bajaj, V Taank, RL Thakur
JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH
(2003)