Journal
CARTILAGE
Volume 6, Issue 2, Pages 13S-29SPublisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1947603515571002
Keywords
mesenchymal stem cells; synovial cells; articular cartilage; animal models; biomaterials
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Funding
- New Energy and Industrial Technology Development Organization, Japan
- Japan Society for the Promotion of Science
- Alberta Innovates Health Solutions Osteoarthritis Team Grant
- Alberta Innovates [201200838] Funding Source: researchfish
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Because of its limited healing capacity, treatments for articular cartilage injuries are still challenging. Since the first report by Brittberg, autologous chondrocyte implantation has been extensively studied. Recently, as an alternative for chondrocyte-based therapy, mesenchymal stem cell-based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation. This review summarizes latest development of stem cell therapies in cartilage repair with special attention to scaffold-free approaches.
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