The Chinese Medicine Wu-Tou Decoction Relieves Neuropathic Pain by Inhibiting Hippocampal Microglia Activation

Wu-Tou Decoction Inhibits Angiogenesis in Experimental Arthritis by Targeting VEGFR2 Signaling Pathway

(2018) Lianhua He et al.   REJUVENATION RESEARCH

Wu-tou decoction attenuates neuropathic pain via suppressing spinal astrocytic IL-1R1/TRAF6/JNK signaling

(2017) Chao Wang et al.   Oncotarget

Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation

(2017) Qingqing Guo et al.   Frontiers in Pharmacology

Evidence that CA3 is Underling the Comorbidity Between Pain and Depression and the Co-curation by Wu-Tou decoction in Neuropathic Pain

(2017) Chunyan Zhu et al.   Scientific Reports

Are the emergence of affective disturbances in neuropathic pain states contingent on supraspinal neuroinflammation?

(2016) Nathan T. Fiore et al.   BRAIN BEHAVIOR AND IMMUNITY

Depression in patients with chronic pain attending a specialised pain treatment centre

(2016) Lauren Rayner et al.   PAIN

Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats

(2015) Xue-Qin Wang et al.   BMC NEUROSCIENCE

A study on the effective substance of the Wu-tou formula based on the metabonomic method using UPLC-Q-TOF-HDMS

(2015) Tengfei Xu et al.   Molecular BioSystems

Nociception, Pain, Negative Moods, and Behavior Selection

(2015) Marwan N. Baliki et al.   NEURON

Propagation of dysbindin-1B aggregates: Exosome-mediated transmission of neurotoxic deposits

(2015) C.-Y. Zhu et al.   NEUROSCIENCE

The hippocampus and TNF: Common links between chronic pain and depression

(2015) Victoria Fasick et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor

(2015) Elizabeth Gerard et al.   PAIN

Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation

(2015) Yanqiong Zhang et al.   Scientific Reports

Wu-Tou Decoction Inhibits Chronic Inflammatory Pain in Mice: Participation of TRPV1 and TRPA1 Ion Channels

(2015) Chao Wang et al.   Biomed Research International

Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling

(2014) Anna Dellarole et al.   BRAIN BEHAVIOR AND IMMUNITY

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

Metabonomic study of Wu-tou decoction in adjuvant-induced arthritis rat using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

(2014) Yao Qi et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways

(2014) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Altered structure and function in the hippocampus and medial prefrontal cortex in patients with burning mouth syndrome

(2014) Shariq A. Khan et al.   PAIN

Burden of Illness Associated with Peripheral and Central Neuropathic Pain among Adults Seeking Treatment in the United States: A Patient-Centered Evaluation

(2014) Caroline Schaefer et al.   PAIN MEDICINE

Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

(2014) Hong Jiang et al.   Molecular Brain

Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants

(2014) Ana Starcevic et al.   Biomed Research International

Impaired Spatial Memory Performance in a Rat Model of Neuropathic Pain Is Associated with Reduced Hippocampus-Prefrontal Cortex Connectivity

(2013) H. Cardoso-Cruz et al.   JOURNAL OF NEUROSCIENCE

Cognitive and emotional control of pain and its disruption in chronic pain

(2013) M. Catherine Bushnell et al.   NATURE REVIEWS NEUROSCIENCE

Chemical profiling of Wu-tou decoction by UPLC–Q-TOF-MS

(2013) Yao Qi et al.   TALANTA

Abnormalities in Hippocampal Functioning with Persistent Pain

(2012) A. A. Mutso et al.   JOURNAL OF NEUROSCIENCE

Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms

(2012) Regina T. Martuscello et al.   PAIN

Pharmacokinetic determination of ephedrine in HerbaEphedraeand Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry

(2012) Zhijie Zheng et al.   XENOBIOTICA

Primary Microglia Isolation from Mixed Glial Cell Cultures of Neonatal Rat Brain Tissue

(2012) Tami T. Tamashiro et al.   Jove-Journal of Visualized Experiments

Antidepressant-like responses to lithium in genetically diverse mouse strains

(2011) A. Can et al.   GENES BRAIN AND BEHAVIOR

Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABAA receptors

(2011) Guangchen Ji et al.   JOURNAL OF NEUROPHYSIOLOGY

Peripheral Nerve Injury Leads to Working Memory Deficits and Dysfunction of the Hippocampus by Upregulation of TNF-α in Rodents

(2011) Wen-Jie Ren et al.   NEUROPSYCHOPHARMACOLOGY

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Pain perception in relation to emotional learning

(2008) A Vania Apkarian   CURRENT OPINION IN NEUROBIOLOGY

Towards a theory of chronic pain

(2008) A. Vania Apkarian et al.   PROGRESS IN NEUROBIOLOGY