Article
Biochemistry & Molecular Biology
Eri Shimura, Hajime Suto, Takafumi Numata, Sachiko Yamaguchi, Kazutoshi Harada, Ko Okumura, Katsuko Sudo, Masashi Ikutani, Susumu Nakae
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease with unclear pathogenesis. The study found that the expression of interleukin-25 (IL-25) was significantly increased in a mouse model of oxazolone-induced chronic contact hypersensitivity (CHS), which is similar to human AD. IL-25 plays a crucial role in the development of chronic CHS, although it depends on the genetic background of the mice to some extent.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Dermatology
Satoshi Okuno, Takashi Hashimoto, Yuki Yamazaki, Manami Okuzawa, Takahiro Satoh
Summary: The expression of IL-31 and IL-31RA was increased in PH and PVe. However, PVe did not cause itching, while PH was associated with pathological itching. Many eosinophils and basophils were also present in PH. On the other hand, although IL-31/IL-31RA signaling might contribute to epidermal thickening and dermal fibrosis, it seemed unable to provoke itching in PVe.
JOURNAL OF DERMATOLOGY
(2023)
Article
Immunology
Masashi Mizuno, Rei Nakano, Saki Nose, Moeka Matsumura, Yasuyuki Nii, Kentaro Kurogochi, Hiroshi Sugiya, Masami Uechi
Summary: In this study, it was found that interleukin 1 beta (IL-1 beta) induces the expression of interleukin 8 (IL-8) in canine cardiac fibroblasts through the activation of nuclear factor (NF)-kappa B p65.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Sayaka Shiomitsu, James Gillen, Salvatore Frasca, Domenico Santoro
Summary: This study investigated the expression of IL-17, IL-22, and IL-31 in the skin of healthy and atopic dogs. The results showed no significant difference in the expression of interleukins and their receptors between healthy and atopic skin. Data from both methodologies were similar, but the role and relationship among these proteins in atopic skin remains unclear from the study results.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Immunology
Lidia Sans-de San Nicolas, Ignasi Figueras-Nart, Irene Garcia-Jimenez, Montserrat Bonfill-Orti, Antonio Guilabert, Laia Curto-Barredo, Marta Bertolin-Colilla, Marta Ferran, Esther Serra-Baldrich, Ramon M. Pujol, Luis F. Santamaria-Babi
Summary: This study found that memory T cells from AD patients sensitized to house dust mite produce IL-31, and the production of IL-31 is related to the clinical features of the patients. The production of IL-31 is associated with patient's pruritus intensity, plasma CCL27 levels, and periostin levels. By measuring the levels of sp IgE and total IgE, IL-31 production and related clinical phenotypes can be further determined.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Nermin Ozlen, Deniz Ercetin, Melike Sapmaz-Metin, Ozgur Gunduz
Summary: This study investigated the antipruritic and anti-inflammatory effects of hydrogen sulfide (H2S) in allergic contact dermatitis (ACD). The results showed that sodium sulfide (Na2S) can reduce ear thickness, inhibit the infiltration and proliferation of CD4(+) T lymphocytes, and decrease IL-2 synthesis.
DERMATOLOGICA SINICA
(2023)
Article
Veterinary Sciences
Jason Pearson, Renato Leon, Haley Starr, Sujung Jun Kim, Jonathan E. Fogle, Frane Banovic
Summary: Intradermal administration of IL-31 to healthy dogs caused delayed itch responses, which were reduced by oclacitinib, an oral JAK inhibitor.
VETERINARY SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Raquel Leao Orfali, Valeria Aoki
Summary: Atopic dermatitis (AD) is a chronic inflammatory disease with complex pathogenesis. Treatment is challenging and focuses on reducing immunologic dysfunction, microbiome dysbiosis, and recovering the damaged skin barrier. This review examines the interleukin-31 (IL-31) pathway and its role in AD, discussing clinical studies using monoclonal antibodies to block this cascade. Nemolizumab, an IL-31 receptor antagonist, has shown promise in reducing pruritus and inflammation and repairing the skin barrier in AD patients. Clinical trials have demonstrated its safety and efficacy, particularly when used in combination with topical treatments. Understanding the IL-31 pathway in AD may lead to targeted therapies for AD and other pruritic conditions.
Article
Immunology
Jutamas Suwanpradid, Min Jin Lee, Peter Hoang, Jeffery Kwock, Lauren P. Floyd, Jeffrey S. Smith, Zhinan Yin, Amber R. Atwater, Sudarshan Rajagopal, Ross M. Kedl, David L. Corcoran, Jennifer Y. Zhang, Amanda S. MacLeod
Summary: The crosstalk between T cells, dendritic cells, and macrophages in leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. It was found that macrophages produce IL-27 which induces IL-15 production from other cells within leukocyte clusters, enhancing the survival of skin T cells. Blocking the IL-27 pathway in CHS mice led to decreased expression of the T cell survival gene BCL2, resulting in a decline in dermal CD8(+) T cells and T cell cluster numbers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Evangeline Cowell, Hawraa Jaber, Luke P. Kris, Madeleine G. Fitzgerald, Valeria M. Sanders, Aidan J. Norbury, Nicholas S. Eyre, Jillian M. Carr
Summary: The expression of Vav proteins is associated with inflammatory responses during dengue virus infection, and blocking Vav signaling pathways does not compromise control of viral replication but may influence host responses.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Anna Strzepa, Cody J. Gurski, Landon J. Dittel, Marian Szczepanik, Kirkwood A. Pritchard, Bonnie N. Dittel
Summary: The study found that MPO plays a dual role in the pathogenesis of CHS. During the induction phase, MPO promotes IL-1 beta production in the skin, affecting migratory DC and effector T cells. In the elicitation phase, inhibiting MPO significantly reduces ear swelling and vascular permeability, indicating that MPO could potentially be a therapeutic target for ACD treatment in humans.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Puja Upadhaya, Felipe F. Lamenza, Suvekshya Shrestha, Peyton Roth, Sushmitha Jagadeesha, Hasan Pracha, Natalie A. Horn, Steve Oghumu
Summary: Berries and their active constituents have potential therapeutic effects in mitigating contact hypersensitivity (CHS). This study demonstrated that black raspberry extract (BRB-E) and certain natural compounds found in berries can inhibit the activation of dendritic cells (DCs) and reduce the production of proinflammatory cytokines, suggesting potential novel approaches for alleviating CHS.
Article
Food Science & Technology
Karolina Swierczynska, Piotr K. Krajewski, Danuta Nowicka-Suszko, Rafal Bialynicki-Birula, Magdalena Krajewska, Jacek C. Szepietowski
Summary: This study investigates the role of interleukin-31 (IL-31) in the pathogenesis of itch in patients undergoing maintenance hemodialysis (HD). The results show that IL-31 serum levels are significantly higher in patients with pruritus compared to those without pruritus. There is also a marginal association between IL-31 levels and itch intensity.
Review
Dermatology
Chie Tamamoto-Mochizuki, Thierry Olivry
Summary: In canine atopic dermatitis (AD) skin lesions, the peak expression of IL-31 occurs at 24 hours or 48 hours post-allergen provocation, decreasing at 96 hours. There is no significant correlation between IL-31 expression scores, serum IL-31 concentrations, and skin lesion scores. The majority of IL-31-positive cells are CD3 and CD4 positive, indicating they are helper T cells. IL-31RA is visualised on keratinocytes and a small proportion of dermal nerves.
VETERINARY DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Sung-Hyun Hwang, Yeseul Yang, Yeji Jeong, Yongbaek Kim
Summary: The study demonstrated that ovalicin extracted from Cordyceps militaris has the potential to suppress inflammation and pruritic responses associated with atopic dermatitis, offering a promising alternative to commonly used steroidal drugs for AD treatment. Ovalicin significantly alleviated allergic symptoms in an AD mouse model by reducing the expression of downstream genes and decreasing the number of infiltrated macrophages and mast cells in the dermis. This research provides insights into the anti-atopic mechanism of ovalicin, highlighting its therapeutic potential in AD management.
JOURNAL OF BIOMEDICAL RESEARCH
(2021)
Article
Allergy
Marek Jutel, Maria J. Torres, Oscar Palomares, Cezmi A. Akdis, Thomas Eiwegger, Eva Untersmayr, Domingo Barber, Magdalena Zemelka-Wiacek, Anna Kosowska, Elizabeth Palmer, Stefan Vieths, Vera Mahler, Walter G. Canonica, Kari Nadeau, Mohamed H. Shamji, Ioana Agache
Summary: Immune modulation is a crucial treatment approach for allergic diseases, asthma, and autoimmunity. The COVID-19 vaccine has the potential to combat the global pandemic, but its administration needs to be considered in conjunction with allergen immunotherapy and biologicals.
Editorial Material
Allergy
Hideaki Morita, Hirohisa Saito, Kenji Matsumoto
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Masayuki Akashi, Daisuke Hayashi, Naoki Kajita, Misako Kinoshita, Tomo Ishii, Yuki Tsumura, Kenta Horimukai, Koichi Yoshida, Takao Takahashi, Hideaki Morita
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Letter
Allergy
Mariko Hara, Noriko Morimoto, Takahisa Watabe, Takeshi Inoue, Natsuki Takada, Yasunobu Amari, Hideaki Morita, Kenji Matsumoto
Article
Allergy
Ayako Yamada, Takanori Hasegawa, Mikiya Fujieda, Hideaki Morita, Kenji Matsumoto
Summary: Early food introduction induces tolerance, but epicutaneous exposure promotes IgE sensitization. This study suggests that two protease-digested egg-white products have the potential to be optimal for early introduction to prevent egg allergy.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Dermatology
Harutaka Seshimo, Chizu Egusa, Tatsuo Maeda, Takafumi Numata, Yukari Okubo, Kazutoshi Harada, Tomonobu Ito
Summary: Atopic dermatitis (AD) is an allergic disease mediated by Th2 cells. IMT, a drug that suppresses vascular permeability, showed potential as a therapeutic agent for AD. In a murine AD model, IMT significantly reduced ear thickness, Evans blue leakage, and scratch onset. IMT also inhibited inflammatory cell infiltration and the expression of cytokines associated with AD. It also suppressed TSLP expression in primary mouse keratinocytes. These findings suggest that IMT could be a new treatment for AD.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Allergy
Ichiro Takeuchi, Kumiko Yanagi, Shuji Takada, Toru Uchiyama, Arisa Igarashi, Kenichiro Motomura, Yuka Hayashi, Naoko Nagano, Ryo Matsuoka, Hiroki Sugiyama, Takako Yoshioka, Hirohisa Saito, Toshinao Kawai, Yumiko Miyaji, Yusuke Inuzuka, Yoichi Matsubara, Yukihiro Ohya, Toshiaki Shimizu, Kenji Matsumoto, Katsuhiro Arai, Ichiro Nomura, Tadashi Kaname, Hideaki Morita
Summary: A novel gain-of-function variant in the STAT6 gene has been identified in a patient with early-onset multiple allergic diseases. This variant leads to upregulation of STAT6 transcriptional activity and may be a potential cause of primary atopic disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Letter
Dermatology
Risa Suzuki, Takafumi Numata, Junichiro Hiruma, Tatsuo Maeda, Ryoji Tsuboi, Kazutoshi Harada
JOURNAL OF DERMATOLOGY
(2023)
Article
Veterinary Sciences
Shuntaro Urayama, Akane Tanaka, Kanichi Kusano, Hiroaki Sato, Masanori Muranaka, Hiroshi Mita, Tsuyoshi Nagashima, Hiroshi Matsuda
Summary: This study compared the effects of meloxicam (MX) and flunixin meglumine (FM) on the treatment of horses with SIRS/endotoxemia, and found that MX has a similar analgesic effect and ability to suppress inflammatory response as FM, with fewer adverse effects. Therefore, MX may be more beneficial in the clinical application for horses with SIRS/endotoxemia.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2023)
Article
Allergy
Saori Nagashima, Mayu Yamamoto, Yusuke Inuzuka, Makoto Irahara, Yumiko Miyaji, Hiromi Tadaki, Shuichi Ito, Shizuka Masuda, Yoshiyuki Ito, Yuri Saito, Saeko Kobayashi, Hideaki Morita, Takako Yoshioka, Hirotaka Shimizu, Katsuhiro Arai, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto, Ichiro Nomura
Summary: The Rainbow Elimination Diet (ED) was well-tolerated and safe for pediatric patients with non-EoE EGIDs, and it showed effectiveness in reducing symptoms and improving nutritional status.
ALLERGOLOGY INTERNATIONAL
(2023)
Letter
Dermatology
Hisami Imawari, Kazuki Fujimori, Jun-ichiro Hiruma, Takafumi Numata, Noriyasu Sakai, Hidemitsu Tsutsui, Kazutoshi Harada
JOURNAL OF DERMATOLOGY
(2023)
Article
Immunology
Kenichiro Motomura, Hideaki Morita, Naoko Okada, Akio Matsuda, Susumu Nakae, Mikiya Fujieda, Haruhiko Sago, Hirohisa Saito, Kenji Matsumoto
Summary: This study comprehensively analyzed the expression of functional pattern recognition receptors in a primary syncytiotrophoblast (STB) model. The results showed that the STB predominantly expressed dsRNA receptors and played a key role in immune response. Understanding the mechanisms underlying these defense processes can enhance our understanding of viral infections during pregnancy.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Kenichiro Motomura, Mariko Hara, Ikuyo Ito, Hideaki Morita, Kenji Matsumoto
Summary: The immune system in pregnancy protects both the mother and the fetus from pathogenic microorganisms while also tolerating the semi-allogenic fetus. Trophoblasts, fetal-derived placental cells, play a crucial role in this process by expressing pattern recognition receptors (PRRs) and participating in the innate immune response in the placenta.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Editorial Material
Immunology
Heidi Makrinioti, Hideaki Morita, Eleni Nastouli, Tuomas Jartti
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Allergy
Yusuke Okubo, Yu Kuwabara, Sakura Sato, Masafumi Sakashita, Hayashi Yuka, Hideaki Morita