Article
Psychiatry
Yue Du, Jinxue Wei, Zijian Zhang, Xiao Yang, Min Wang, Yu Wang, Xiongwei Qi, Liansheng Zhao, Yang Tian, Wanjun Guo, Qiang Wang, Wei Deng, Minli Li, Dongtao Lin, Tao Li, Xiaohong Ma
Summary: Metabolomics revealed different metabolic pathway dysfunctions in MDD patients, with 17 metabolic pathways enriched and 23 metabolites hit in these pathways. Glycine and serine metabolism, arginine and proline metabolism, and phenylalanine and tyrosine metabolism were enriched in MDD patients without anxiety. L-glutamic acid was positively correlated with depression severity in MDD patients without anxiety symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yewei Wang, Zeljka Popovic, Georgia Charkoftaki, Rolando Garcia-Milian, TuKiet T. Lam, David C. Thompson, Ying Chen, Vasilis Vasiliou
Summary: This study identifies the impact of knocking down ALDH1B1 on molecular signatures in colon cancer cells through multi-omics analysis. The findings provide new molecular information associated with the cellular functions of ALDH1B1, which will guide future investigations of colon cancer.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, General & Internal
Evan Yi-Wen Yu, Zhewen Ren, Siamak Mehrkanoon, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Maurice P. Zeegers, Anke Wesselius
Summary: This study aimed to investigate the potential mediation role of circulating metabolites in relation to dietary patterns for prediabetes and type 2 diabetes. The findings suggest that adherence to a healthy dietary pattern could affect glucose metabolism status through circulating metabolites, providing novel insights into the biological mechanisms of diet on glucose metabolism and facilitating prevention strategies for type 2 diabetes.
Article
Biochemistry & Molecular Biology
Xue Fan, Ke Li, Xin Guo, Shengyou Liao, Qi Zhang, Yangkai Xu, Hongtu Cui, Lemin Zheng, Mingguo Xu
Summary: In this study, metabolic alterations in Kawasaki disease (KD) were investigated, and it was found that amino acid, lipid, and tryptophan metabolism were significantly disturbed. Changes in tryptophan metabolites were consistent in both patients and a mouse model of KD. Furthermore, analysis of RNA sequencing data revealed the potential involvement of Aryl hydrocarbon receptor in KD. These findings suggest that metabolic indicators could serve as novel diagnostic and therapeutic biomarkers for KD.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, General & Internal
Yingying Ding, Haijiang Lin, Xiaoxiao Chen, Bowen Zhu, Xiaohui Xu, Xiaoyi Xu, Weiwei Shen, Meiyang Gao, Na He
Summary: HIV infection and NCDs are connected through metabolic disturbances, with GPL metabolism being the common link between HIV and NCDs, followed by glutamine and glutamate metabolism.
Article
Neurosciences
Lu Liu, Weizheng Li, Linpeng Wang, Pengyun Gong, Tianli Lyu, Dapeng Liu, Yajie Zhang, Yijie Guo, Xiang Liu, Min Tang, Hongke Hu, Chao Liu, Bin Li
Summary: This study utilized proteomic and metabolomic profiling to reveal that acupuncture treatment can significantly alter metabolic pathways related to migraine, involving energy metabolism and amino acid metabolism. These findings contribute to understanding the pathophysiological changes in migraine and the mechanism of acupuncture treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Raziyeh Abooshahab, Kourosh Hooshmand, Giuseppe Luna, Hani Al-Salami, Crispin R. Dass
Summary: Pigment epithelium-derived factor (PEDF) is a potent inhibitor of tumor progression and proliferation, and it may serve as a therapeutic target for breast cancer. This study used a metabolomics approach to investigate the metabolic changes in breast cancer cells under different glycaemic loads in response to PEDF treatment. The results revealed abnormalities in amino acid metabolism pathways and alterations in lactate and glucose-6-phosphate production, suggesting an influence on the Warburg effect and metabolic reprogramming pathways in cancer cells.
Article
Biochemical Research Methods
Lin Wang, Xi Xing, Xianfeng Zengl, S. RaElle Jackson, Tara TeSlaa, Osama Al-Dalahmah, Laith Z. Samarah, Katharine Goodwin, Lifeng Yang, Melanie R. McReynolds, Xiaoxuan Li, Jeremy J. Wolff, Joshua D. Rabinowitz, Shawn M. Davidson
Summary: Isotope imaging enables quantification of metabolic activity in mammalian tissues with spatial resolution, revealing metabolic heterogeneity in the kidney and brain and spatial gradients in metabolic processes.
Article
Environmental Sciences
Quanwei Li, Jianzhao Liao, Chaiqin Lei, Jian Shi, Hui Zhang, Qingyue Han, Jianying Guo, Lianmei Hu, Ying Li, Jiaqiang Pan, Zhaoxin Tang
Summary: The study found that exposure to copper can lead to significantly increased serum biochemical parameters in pigs, severe structural abnormalities in cardiomyocytes with high copper concentrations exposure, and specific changes in mRNA and protein expression levels in cardiomyocytes at day 80 of the trial.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Microbiology
Haiying Ma, Yujuan Niu
Summary: A study found that highly pathogenic fowl adenovirus serotype 4 (FAdV-4) infection can restore the metabolic networks in host cells, and host cell metabolism plays an important role in virus replication. Furthermore, the production of the virus was significantly reduced when the host cells were cultured in glucose or glutamine-deficient conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Na Sun, Yuchuan Zhang, Jian Dong, Geng Liu, Zhenbin Liu, Jiamin Wang, Zilin Qiao, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiaoming Yang
Summary: This study explores the metabolic differences between MDCK cells with varying proliferative capabilities using untargeted and targeted metabolomics. The findings suggest that fluctuations in metabolite levels, such as choline, tryptophan, and tyrosine, may have a significant impact on cell proliferation.
Article
Biochemistry & Molecular Biology
Eva Cifkova, Radana Brumarova, Magdalena Ovcacikova, Dana Dobesova, Katerina Micova, Ales Kvasnicka, Zuzana Vankova, Jiri Siller, Lukas Sakra, David Friedecky, Michal Holcapek
Summary: The study conducted lipidomic and metabolomic analysis on tumor and surrounding normal tissues of 23 patients with non-small cell lung cancer, identifying and quantifying 500 molecular species. Significant changes were observed in several biochemical pathways related to lung cancer, particularly involving glycerophospholipids, sphingolipids, and cholesteryl esters in lipid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Biochemistry & Molecular Biology
Daniela Grasso, Michela Geminiani, Silvia Galderisi, Gabriella Iacomelli, Luana Peruzzi, Barbara Marzocchi, Annalisa Santucci, Andrea Bernini
Summary: Alkaptonuria is a metabolic disease caused by the accumulation of homogentisic acid, leading to connective tissue pigmentation and the development of osteoarthritis. The molecular mechanisms underlying the severity of the disease are not fully understood, but metabolomics studies have provided insights into the pathways involved and potential biomarkers that can aid in future treatment development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Ling Hong, Yuan Chang Zhu, Su Liu, Tonghua Wu, Yuye Li, Lijun Ye, Lianghui Diao, Yong Zeng
Summary: The deterioration of the endometrial environment is a major cause of recurrent miscarriage (RM). Studies have shown alterations in metabolite profiles, increased levels of autophagy-related proteins, and significant crosstalk between amino acid metabolism and autophagy in RM. These findings suggest a potential link between aberrant crosstalk between amino acid metabolism and autophagy and the impaired endometrial microenvironment in RM.
BIOLOGY OF REPRODUCTION
(2021)
Article
Psychiatry
Laila Gbaoui, Melanie Fachet, Marian Lueno, Gabriele Meyer-Lotz, Thomas Frodl, Christoph Hoeschen
Summary: The study demonstrates that the combination of non-targeted breathomics analysis with high-throughput sensitive analytical technologies and advanced computational tools offers new insights into peripheral biochemical changes in patients with MDD.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Bernd Moosmann, Mario Schindeldecker, Parvana Hajieva
BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Marius W. Baeken, Bernd Moosmann, Parvana Hajieva
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Fazilet Bekbulat, Daniel Schmitt, Anne Feldmann, Heike Huesmann, Stefan Eimer, Thomas Juretschke, Petra Beli, Christian Behl, Andreas Kern
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Review
Cell Biology
Donat Koegel, Benedikt Linder, Andreas Brunschweiger, Silvia Chines, Christian Behl
Editorial Material
Cell Biology
Andreas Kern, Christian Behl
Article
Biochemistry & Molecular Biology
Anna S. Besemer, Joanna Maus, Mirjam D. A. Ax, Anna Stein, Stella Vo, Christian Freese, Karsten Nalbach, Christian von Hilchen, Ines F. Pfalzgraf, Ingrid Koziollek-Drechsler, Beate Silva, Heike Huesmann, Fatima Boukhallouk, Luise Florin, Andreas Kern, Christian Behl, Albrecht M. Clement
Summary: The study identifies a novel role of RME-8/DNAJC13 in cellular protein homeostasis by modulating ATG9A trafficking and autophagy processes to maintain cellular balance.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Elona Jankauskaite, Anna Maria Ambroziak, Parvana Hajieva, Monika Oldak, Katarzyna Tonska, Magdalena Korwin, Ewa Bartnik, Agata Kodron
JOURNAL OF APPLIED GENETICS
(2020)
Article
Biochemistry & Molecular Biology
Sascha Kunath, Mario Schindeldecker, Antonio De Giacomo, Theresa Meyer, Selina Sohre, Parvana Hajieva, Clemens von Schacky, Joachim Urban, Bernd Moosmann
Article
Cell Biology
Marius W. Baeken, Katja Weckmann, Philip Diefenthaler, Jan Schulte, Kamran Yusifli, Bernd Moosmann, Christian Behl, Parvana Hajieva
Article
Biochemistry & Molecular Biology
Jana Schepers, Christian Behl
Summary: Recent studies have found a close connection between lipid droplet dynamics and the regulation of autophagy, which may provide insights into the induction mechanisms of autophagy and various diseases associated with lipid droplet dysregulation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marius W. Baeken, Christian Behl
Summary: The BAG protein family, particularly BAG3, plays a crucial role in cellular protein homeostasis, with BAG3 being important in macroautophagy. Studies across different species have provided insights into the functions and regulations of BAG3 and other BAG proteins, but there is still a lack of research on the evolution of BAG3 and its phylogenetic position within the BAG family.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Cell Biology
Marius W. Baeken, Mario Schwarz, Andreas Kern, Bernd Moosmann, Parvana Hajieva, Christian Behl
Summary: The SIRT protein family plays a crucial role in gene and metabolic regulation by removing acyl groups from lysine residues in proteins. Maintaining a fine-tuned homeostasis of SIRTs is vital for cell function and survival.
CELL DEATH DISCOVERY
(2021)