Article
Medicine, General & Internal
Cheng-Ming Hsu, Hui-Chen Su, Ming-Yu Yang, Yao-Te Tsai, Ming-Shao Tsai, Yao-Hsu Yang, Ching -Yuan Wu, Shun -Fu Chang
Summary: This study aimed to investigate the potential anticancer effects of 6-shogaol, a major ginger derivative, on head and neck squamous cell carcinomas (HNSCCs) and the underlying mechanisms. The results showed that 6-shogaol significantly induced G2/M phase arrest and apoptosis in HNSCC cells, thereby inhibiting tumor cell survival. These responses could be regulated by the ERK1/2 and p38 signaling pathways. Additionally, 6-shogaol was found to enhance the cytotoxicity of cisplatin in HNSCC cells.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Yang Kai, Li Shugen, Zhang Tianyu, Dong Panpan, Zeng Qingqi
Summary: The study demonstrated that RJ extract can partially reverse OAT induced by ORN, maintain spermatogenesis through regulating ERK signaling and vimentin expression.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Article
Immunology
Yuna Du, Huiqing Zhang, Yujie Guo, Kuangyu Song, Lifeng Zeng, Yiguo Chen, Zhengyu Xie, Rong Li
Summary: The study found that CD38(-/-) mice injected with Escherichia coli resulted in more severe pulmonary injuries and higher levels of cytokine mRNA expressions. CD38 deficiency increased the expressions of IL-1 beta and MCP-1 and aggravated pulmonary injury through the TLR4/ERK/NF-kB signaling pathway in sepsis.
MICROBES AND INFECTION
(2021)
Article
Oncology
Kayla R. Getz, Emily Bellile, Katie R. Zarins, Cailey Rullman, Steven B. Chinn, Jeremy M. G. Taylor, Laura S. Rozek, Gregory T. Wolf, Alison M. Mondul
Summary: The study identified a significant inverse association between statin use and overall death, disease-specific death, and recurrence in untreated HNSCC patients. This protective effect was particularly pronounced in patients with HPV-positive disease.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Otorhinolaryngology
Elise Rowinski, Nicolas Magne, Jerome Fayette, Elisabeth Daguenet, Severine Racadot, Pascal Pommier, Benoite Mery, Alexis Vallard, Fabien Tinquaut, Eve-Marie Neidhardt-Berard, Philippe Cassier, Valery Attignon, Daniel Pissaloux, Qing Wang, Emilie Sohier, David Perol, Jean-Yves Blay, Olivier Tredan
Summary: In head and neck squamous cell carcinoma patients, PIK3CA mutation, genomic instability in MAP kinase pathway, and instability in apoptosis pathway were found to be prognostic factors for loco-regional relapse or complete response after radiotherapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Oncology
Dominic H. Moon, David J. Sher
Summary: Up to 40% of patients with metastatic head and neck squamous cell carcinoma have oligometastatic disease, which is associated with improved overall survival. Local ablative therapy and radiation therapy have shown promise in improving outcomes. Stereotactic ablative radiotherapy is a less invasive alternative to surgical resection, but more research is needed to determine its role.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Susanne Flach, Karen Howarth, Sophie Hackinger, Christodoulos Pipinikas, Pete Ellis, Kirsten McLay, Giovanni Marsico, Tim Forshew, Christoph Walz, Christoph A. Reichel, Olivier Gires, Martin Canis, Philipp Baumeister
Summary: This study demonstrates the potential of ctDNA as a biomarker for detecting minimal residual disease and recurrence in HNSCC and shows the feasibility of personalized ctDNA assays for disease detection prior to clinical recurrence.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel, Sven Perner
Summary: This study investigated the clinical implications of CDK7 and pMED1 as potential biomarkers in head and neck squamous-cell cancer (HNSCC). The results showed that high levels of CDK7 were associated with lower survival rates and disease-free survival rates in HNSCC patients. Additionally, CDK7 expression was significantly elevated in immune cell infiltrated tumors. In vitro studies also demonstrated the potential of CDK7 inhibition as a therapeutic target.
Article
Cell Biology
Jianmin Tang, Zheng Wu, Xiaohang Wang, Yanli Hou, Yongrui Bai, Ye Tian
Summary: This study reveals that the long non-coding RNA (lncRNA) USP2-AS1 can serve as a potential therapeutic target in head and neck squamous cell carcinoma (HNSCC). The level of USP2-AS1 is closely associated with the development and prognosis of HNSCC, and it promotes cell proliferation and invasion by interacting with DCAF13.
Article
Oncology
Yang Yang, Jaeil Ahn, Rekha Raghunathan, Bhaskar V. Kallakury, Bruce Davidson, Zuzana Brnakova Kennedy, Joseph Zaia, Radoslav Goldman
Summary: The sulfation of heparan sulfate proteoglycans (HSPG) plays a crucial role in regulating growth factor receptor signaling. The enzyme Sulf-2 (SULF2) has a significant impact on modifying the 6-O-sulfation of HSPG, affecting downstream signaling pathways. High SULF2 expression in HNSCC tumors is associated with poor clinical outcomes and survival rates, suggesting its potential as a prognostic factor or therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Moran Amit, Chuan Liu, Jobran Mansour, Frederico O. Gleber-Netto, Samantha Tam, Erez N. Baruch, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Kenneth Tsai, Elsa R. Flores, Michael R. Migden, Deborah A. Silverman, Goujun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study showed that elective neck dissection (END) did not improve survival rates for patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck and no evidence of regional metastasis. Further research is needed to clarify the role of END in patients with advanced disease.
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Medical Laboratory Technology
Donna C. Ferguson, Mitra Mehrad, Kim A. Ely, Justin R. Shinn, James S. Lewis
Summary: According to the research, pathologists continue to deviate significantly from the testing guideline for human papillomavirus in everyday practice, suggesting further education and discussion may be needed regarding the appropriate handling of head and neck cancer specimens.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Nicholas J. Gadsden, Cory D. Fulcher, Daniel Li, Nitisha Shrivastava, Carlos Thomas, Jeffrey E. Segall, Michael B. Prystowsky, Nicolas F. Schlecht, Evripidis Gavathiotis, Thomas J. Ow
Summary: Inhibition of CDK4/6 leads to senescence in HPV- HNSCC, which can be effectively eliminated by combining palbociclib and navitoclax. This combination therapy decreases cell survival and increases apoptosis levels in HPV- HNSCC cell lines.
MOLECULAR CANCER RESEARCH
(2021)
Article
Cell Biology
Nargess Farhangdoost, Cynthia Horth, Bo Hu, Eric Bareke, Xiao Chen, Yinglu Li, Mariel Coradin, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Summary: Chromatin dysregulation plays a key role in oncogenesis, and mutations in the histone methyltransferase gene NSD1 have been identified in head and neck squamous cell carcinomas. Loss of NSD1 leads to alterations in chromatin modifications, affecting gene expression. This study sheds light on the downstream effects of NSD1 loss and provides insights into the role of chromatin modifications in cancer.
Article
Biochemistry & Molecular Biology
Atsushi Kasamatsu, Katsuhiro Uzawa, Fumihiko Hayashi, Akihiro Kita, Yasuhiko Okubo, Tomoaki Saito, Yasushi Kimura, Isao Miyamoto, Noritoshi Oka, Masashi Shiiba, Chizuru Ito, Kiyotaka Toshimori, Takashi Miki, Mitsuo Yamauchi, Hideki Tanzawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Letter
Dentistry, Oral Surgery & Medicine
K. Uzawa, A. L. Amelio, H. Tanzawa, M. Yamauchi
JOURNAL OF DENTAL RESEARCH
(2019)
Article
Oncology
Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa
EXPERIMENTAL CELL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Katsuhiro Uzawa, Antonio L. Amelio, Atsushi Kasamatsu, Tomoaki Saito, Akihiro Kita, Megumi Fukamachi, Yuki Sawai, Yuriko Toeda, Keitaro Eizuka, Fumihiko Hayashi, Ikuko Kato-Kase, Masataka Sunohara, Manabu Iyoda, Kazuyuki Koike, Dai Nakashima, Katsunori Ogawara, Yosuke Endo-Sakamoto, Masashi Shiiba, Yuichi Takiguchi, Mitsuo Yamauchi, Hideki Tanzawa
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Toshiaki Ando, Atsushi Kasamatsu, Kohei Kawasaki, Kazuya Hiroshima, Reo Fukushima, Manabu Iyoda, Dai Nakashima, Yosuke Endo-Sakamoto, Katsuhiro Uzawa
Summary: Circular RNAs (circRNAs) are covalently closed loop structures that have longer circulatory half-lives compared to linear RNAs, and can regulate miRNA and target gene expression as competing endogenous RNAs. The down-regulation of circRNA-102450 is identified as a novel tumor suppressor in oral squamous cell carcinoma, potentially serving as a marker for regional lymph node metastasis.
Article
Oncology
Kohei Kawasaki, Atsushi Kasamatsu, Toshiaki Ando, Tomoaki Saito, Takafumi Nobuchi, Ryunosuke Nozaki, Manabu Iyoda, Katsuhiro Uzawa
Summary: PAFR is a therapeutic target for modulating CDDP sensitivity in oral squamous cell carcinoma (OSCC) cells. The specific inhibitor of PAFR, ginkgolide B (GB), can enhance chemosensitivity to CDDP and promote apoptosis. GB may serve as a novel drug to enhance combination chemotherapy with CDDP for OSCC patients.
Article
Biochemistry & Molecular Biology
Tomoaki Saito, Shunichi Asai, Nozomi Tanaka, Nijiro Nohata, Chikashi Minemura, Ayaka Koma, Naoko Kikkawa, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: This study utilized ChIP-Seq to analyze active enhancers and identified genes associated with drug resistance and prognosis in oral squamous cell carcinoma, providing crucial genetic information for improving treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Masashi Shiiba, Takao Baba, Keitaro Eizuka, Atsushi Kasamatsu, Katsuhiro Uzawa, Yuichi Takiguchi, Hideki Tanzawa
ORAL SCIENCE INTERNATIONAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Aika Tanzawa, Masashi Shiib, Tomoaki Saito, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Masataka Sunohara, Katsuhiro Uzawa, Yuichi Takiguchi, Hideki Tanzawa, Hiroshi Shirasawa
ORAL SCIENCE INTERNATIONAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Jun-Ichiro Yamamoto, Atsushi Kasamatsu, Morihiro Higo, Yosuke Endo-Sakamoto, Katsunori Ogawara, Masataka Sunohara, Masashi Shiiba, Katsuhiro Uzawa, Hideki Tanzawa
ORAL SCIENCE INTERNATIONAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Manabu Iyoda, Kazuyuki Koike, Tomoaki Saito, Dai Nakashima, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Masataka Sunohara, Masashi Shiiba, Katsuhiro Uzawa, Hideki Tanzawa
ORAL SCIENCE INTERNATIONAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Yutaro Kase, Atsushi Kasamatsu, Tomoaki Saito, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Yosuke Endo-Sakamoto, Masataka Sunohara, Masashi Shiiba, Katsuhiro Uzawa, Hideki Tanzawa
ORAL SCIENCE INTERNATIONAL
(2019)
Article
Oncology
Keitaro Eizuka, Dai Nakashima, Noritoshi Oka, Sho Wagai, Toshikazu Takahara, Tomoaki Saito, Kazuyuki Koike, Atsushi Kasamatsu, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa
Article
Dentistry, Oral Surgery & Medicine
Isao Miyamoto, Yosuke Endo-Sakamo, Yukio Yamano, Atsushi Kasamatsu, Katsuhiro Uzawa, Hideki Tanzawa
ORAL SCIENCE INTERNATIONAL
(2019)
Article
Oncology
Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa