Article
Biochemistry & Molecular Biology
Anna Julia Elias, Lajos Balogh, Tomas Branyik, Erzsebet Mak, Eva Csajbokne Csobod, Marta Veresne Balint, Csilla Benedek
Summary: The study aimed to investigate the antitumorigenic potential of a xanthohumol-enriched beer. The results showed that adding xanthohumol to beer did not have a protective effect on tumor growth or enhance plasma antioxidant capacity. However, it had a less harmful effect on the liver compared to an ethanolic solution.
Article
Nanoscience & Nanotechnology
Xiongwei Liu, Kuizhong Shan, Xiaxia Shao, Xianqing Shi, Yun He, Zhen Liu, Joe Antony Jacob, Lichun Deng
Summary: The biomimetic approach of synthesizing silver nanoparticles using Rhizophora apiculata leaf extract showed dose-dependent cytotoxic effects on HEK-293 and HeLa cells, being three times more toxic to HEK-293 cells compared to HeLa cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Marine & Freshwater Biology
Qi Meng, Karen Yeung, King Ming Chan
Summary: Studies have shown that Octocrylene (OC) has toxic effects on zebrafish and zebrafish liver cells, inducing gene expression and affecting hormone synthesis and antioxidant pathways. The findings support banning the use of OC in cosmetics.
AQUATIC TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
V. R. Yenuganti, R. Yadala, R. Azad, S. Singh, V. Chiluka, J. Ahire, P. Reddanna
Summary: The study identified 11 probiotic strains with anticancer effects on human colorectal carcinoma cells, affecting gene expression, some of which induced apoptosis and could be potential candidates for CRC treatment.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Baleva, Ivan Chicherin, Uliana Piunova, Viktor Zgoda, Maxim Patrushev, Sergey Levitskii, Piotr Kamenski
Summary: Protein biosynthesis in mitochondria is closely linked to the assembly of inner membrane complexes and must be coordinated with cytosolic translation. The molecular mechanisms underlying mitochondrial translation regulation are not well understood. This study reveals that PTCD2 functions as a translational regulator of another mitochondrially encoded subunit of cytochrome c oxidase, COIII.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Imran Kazmi, Fahad A. Al-Abbasi, Syed Sarim Imam, Muhammad Afzal, Muhammad Shahid Nadeem, Hisham N. Altayb, Sultan Alshehri
Summary: LPHNPs encapsulated with PPN were developed to overcome the physicochemical limitations of PPN. The optimized PPN-LPHNPs showed small particle size, low polydispersity index, and high positive surface charge. PPN-LPHNPs exhibited excellent cytotoxicity against breast cancer cells and improved intestinal permeation and oral bioavailability compared to the conventional PPN suspension.
Article
Biochemistry & Molecular Biology
N. Sabari Girija, B. Neethi, L. Sakthimanipriya, M. A. Sinekha, P. Shanmugapriya, R. Meenakumari
Summary: This study aimed to evaluate the anti-cancer activity of Nandhi Mezhugu in the HeLa cell line. The results showed that Nandhi Mezhugu can be effectively used as an anti-cancer formulation to treat cervical cancer.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Integrative & Complementary Medicine
Debalina Bose, Amrita Chaudhary, Manchikanti Padmavati, Jyotirmoy Chatterjee, Rintu Banerjee
Summary: This study observed the cytotoxic activity of honey from Litchi chinensis and purified honey protein (PHP) on HeLa cells. Both honey and PHP significantly reduced cancer cell viability and induced apoptosis in a dose-dependent manner. The IC(50) of honey and PHP were found to be 3.5 mg/mL and 4.13 ng/mL, respectively. PHP intervention resulted in more apoptosis compared to honey treatment. These findings provide scientific rationale for the development of effective anti-proliferative agents and endorse the use of lychee honey and PHP as herbal medicines.
JOURNAL OF HERBAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Manas Warke, Madeline English, Laura De Marchi, Rohan Deep Sarkar, Srinivas Kannan, Rupali Datta, Smitha Rao
Summary: Arsenic is a highly toxic environmental pollutant that has harmful effects on human health. In order to study its impacts, researchers have attempted to develop in-vitro cell culture models as animal models are costly and time-consuming. However, most studies have not accurately represented realistic environmental exposure conditions. This study exposed human skin cells to water-soluble arsenic extracted from contaminated soil to investigate its effects on cell viability, migration, and protein expression. The results showed that arsenic had a greater impact on HaCaT cells compared to HDFa cells. This methodical approach provides a way to study the effects of toxic elements under realistic environmental conditions and can be adapted for different exposure pathways.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Microbiology
Noha M. M. Ashry, Halla E. K. El Bahgy, Abdelkader Mohamed, Nouf H. H. Alsubhi, Ghadeer I. I. Alrefaei, Najat Binothman, Mona Alharbi, Samy Selim, Mohammed S. S. Almuhayawi, Mohanned T. T. Alharbi, Mohammed K. K. Nagshabandi, Ahmed M. M. Saad, Mohamed T. T. El-Saadony, Basel Sitohy
Summary: This study tested the inhibitory effects of chitosan, graphene oxide, and graphene oxide-chitosan composite on bacterial growth and found that chitosan has antibacterial and anticancer activity. Furthermore, the concentration of chitosan and the ratio of graphene oxide and its composite also affect the antibacterial effect.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Toxicology
Mehmet Evren Ozturk, Anil Yirun, Selinay Basak Erdemli-Kose, Aylin Balci-Ozyurt, Deniz Arca cakir, Didem Oral, Pinar Erkekoglu
Summary: This study evaluated the toxic effects of thimerosal, aluminum, and their combination on SH-SY5Y cells. The results showed that both thimerosal and aluminum can alter the oxidant/antioxidant status, cause DNA damage, and change dopamine and DAT levels. The changes were more pronounced in cells treated with the combined exposure to aluminum and thimerosal.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Materials Science, Ceramics
Sushil Patel, Raj Kumar Samudrala, Srinath Palakurthy, Bramanandam Manavathi, Raghavendra Gujjala, P. Abdul Azeem
Summary: The aim of this study is to evaluate the bioactive and tribological properties of the MgO doped borophosphate glass system. The addition of MgO promotes degradation of the glass and increases its bioactivity. In terms of tribological properties, the glass sample with 3% MgO exhibited the highest hardness and the lowest wear rate. MTT assay confirmed the non-toxic behavior of the glass samples. Therefore, MgO doped borophosphate glass shows potential for bone filling and wound healing applications.
CERAMICS INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Jose Escandell, Filipa Moura, Sofia B. Carvalho, Ricardo J. S. Silva, Ricardo Correia, Antonio Roldao, Patricia Gomes-Alves, Paula M. Alves
Summary: The majority of rAAVs for clinical use are produced using the HEK293 cell line, but this platform has manufacturing bottlenecks such as low product quality and high cost. The HeLa-based stable cell line rAAV production system offers a scalable alternative, but has barriers due to time and complexity. This study developed a more streamlined and efficient process using the HeLaS3-based cell line, achieving high yield and purity of rAAV2.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Engineering, Environmental
Peter R. Tentscher, Beate Escher, Rita Schlichting, Maria Koenig, Nadine Bramaz, Kristin Schirmer, Urs von Gunten
Summary: The study found that both para-benzoquinones and hydroquinones can induce oxidative stress response, and they can react rapidly with components of the incubation medium. However, they do not activate defense against genotoxicity or DNA repair activity.
Article
Microbiology
Rosnani Hanim Mohd Hussain, Mohamed Kamel Abdul Ghani, Naveed Ahmed Khan, Ruqaiyyah Siddiqui, Shafiq Aazmi, Hasseri Halim, Tengku Shahrul Anuar
Summary: This study characterized the pathogenic potential of Acanthamoeba isolated from contact lens paraphernalia and water sources in Malaysia. The findings revealed the presence of multiple isolates with high cytotoxicity levels, adhesion ability, and protease secretion among the T3 and T4 genotypes.
Article
Materials Science, Multidisciplinary
Aniqa Jadoon, Zarshad Ali, W. A. Farooq, Farman Ali, Gareth J. Price, Shaista Taimur, M. Atif, Mona A. AlMutairi, Nafeesah Yaqub, Saira Bibi
Summary: This study explores the feasibility of using 3-aminopropyl triethoxysilane (3-APTES) crosslinked chitosan (Ch)/graphene oxide (GO) membranes for the adsorptive removal of anionic dyes from aqueous medium. The membranes were successfully fabricated through solution casting technique. Strong interactions among the matrix (chitosan), 3-APTES, polyvinylpyrrolidone (PVP) and GO were confirmed by infrared spectroscopy. The addition of graphene oxide improved the thermal stability of the chitosan. The adsorption characteristics of the membranes were evaluated using Congo red (CR) dye, and the results showed that the membranes were capable of removing 80% of CR from aqueous medium following second order kinetics. This study highlights the potential of green membranes for various flow systems.
CURRENT APPLIED PHYSICS
(2022)
Correction
Thermodynamics
Azeem Shahzad, Bushra Habib, Muhammad Nadeem, Muhammad Kamran, Hijaz Ahmad, Muhammad Atif, Shafiq Ahmad
Article
Chemistry, Multidisciplinary
Abdul Raouf Malik, Sadia Sharif, Fozia Shaheen, Mansoor Khalid, Yasir Iqbal, Abrar Faisal, Muhammad Hammad Aziz, Muhammad Atif, Shafiq Ahmad, M. Fakhar-e-Alam, Nazia Hossain, Hijaz Ahmad, Thongchai Botmart
Summary: This study discusses the green chemistry of nanomaterials from synthesis to diverse biomedical applications. The researchers utilized Ocimum basilicum leaves extract as a reducing agent to synthesize ZnO nanoparticles. These green synthesized nanoparticles were then decorated on reduced graphene oxide sheets to form RGO-ZnO nanocomposites. The prepared RGO-ZnO nanocomposites exhibited good performance in antioxidant activity, antibacterial activity, antidiabetic activity, and photocatalytic activity.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Arslan Mahmood, Tariq Munir, M. Fakhar-E-Alam, Muhammad Atif, Kaleem Shahzad, K. S. Alimgeer, Tuan Nguyen Gia, Hijaz Ahmad, Shafiq Ahmad
Summary: Pure and aluminium doped zinc oxide nanoparticles (ZnO-NPs) have extraordinary physical, chemical, and electrical properties, making them essential in various fields. This research aimed to enhance the electrical conductivity and reduce the electrical resistivity of aluminium doped ZnO-NPs. The synthesis of these nanoparticles was done using the co-precipitation method, and their structure, morphology, and functional groups were characterized. The experimental and mathematical analyses showed improved electrical properties, making the aluminium doped ZnO-NPs a promising candidate for optoelectronic devices.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Multidisciplinary Sciences
M. Atif, Saqib Anwar, W. A. Farooq, Muhammad Ali Shar, Bassam Abuamarah, M. S. AlSalhi, V. Masilaimani, Nasser Alarifi, Ibrahim El-Khedr, K. S. Alimgeer, Muhammad Ali Shar
Summary: The experimental reports focused on the structural modification, mechanical properties, and magnetic properties of the Saudi meteorite. Various characterization techniques were employed to study the meteorite specimen. The analysis revealed that the meteorite mainly consisted of an iron-nickel alloy and exhibited soft material properties with a Rockwell hardness of 22.5 HRC. The magnetic measurements showed that the meteorite was a soft ferromagnetic material with a magnetic saturation of 0.701 emu/g at a saturation field of 5025 Oe. Mathematical modeling of hysteresis data was conducted, and a bi-exponential model was proposed as the most suitable model based on goodness of fit parameters.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Shahid Basir, Khurram Saleem Alimgeer, Sajjad Ghauri, Moazam Maqsood, Mubashar Sarfraz, Md Yeakub Ali
Summary: In this paper, a trinotch band MIMO antenna is designed for upper and lower WLAN and satellite X-band. By taking advantage of the placement of notch elements and adding a U-shaped slot, better isolation is achieved.
INTERNATIONAL JOURNAL OF ANTENNAS AND PROPAGATION
(2022)
Article
Multidisciplinary Sciences
Syed Mujtaba ul Hassan, M. Tariq Siddique, M. Fakhar-e-Alam, M. Atif, Adnan Saifullah, Noreen Marwat, Ahmat Khurshid, Obaidullah Noor, Nazia Hossain, Shafiq Ahmad, K. S. Alimgeer
Summary: This study synthesized dysprosium and holmium-doped zirconium oxide nanoparticles and evaluated their potential as contrast agents in various imaging modalities. The results showed that these nanoparticles exhibited high contrast in X-ray computed tomography and magnetic resonance imaging, and they also demonstrated good biocompatibility.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Tariq Munir, Muhammad Imran, Saima Muzammil, Abdul Ahad Hussain, Muhammad Fakhar-E Alain, Arslan Mahmood, Amjad Sohail, Muhammad Atif, Sulman Shafeeq, Muhammad Afzal
Summary: Graphene oxide nanoparticles (GO-NPs) with excellent physicochemical and biological properties show prominent antimicrobial activities. Coating agents improve the crystallite size, surface morphology, and optical properties of GO-NPs. In vitro experiments demonstrate that polymer-coated GO-NPs exhibit enhanced antimicrobial activities, suggesting their potential application in wound healing.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ghulam Abbas, Akhtar Rasul, M. Fakhar-e-Alam, Malik Saadullah, Saima Muzammil, Omeira Iqbal, M. Atif, Muhammad Hanif, Shahid Shah, Shafiq Ahmad, Sulman Shafeeq, Muhammad Afzal
Summary: The study aimed to formulate nanoparticles of thiolated chitosan with enhanced mucoadhesion and controlled release behavior. Stable nanoparticles were prepared using an ionic gelation method, and their adhesion, swelling, and toxicity were evaluated. Drug release studies of non-thiolated and thiolated nanoparticles showed that the thiolated nanoparticles exhibited better controlled release. Animal experiments confirmed the superior pharmacokinetic properties of the thiolated nanoparticles compared to the marketed formulation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Retraction
Multidisciplinary Sciences
M. Waseem Akram, Muhammad Fakhar-e-Alam, M. Atif, Alvina Rafique Butt, Ali Asghar, Yasir Jamil, K. S. Alimgeer, Zhiming M. Wang
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Tariq Munir, Arslan Mahmood, Shafaq Fatima, Amjad Sohail, Muhammad Fakhar-e-Alam, Muhammad Atif, Noman Rafaqat
Summary: Nanostructured materials play a crucial role in electronic applications and device performance enhancement. Cobalt sulfide, as a transition metal sulfide, has attracted considerable interest in research. In this study, (Al and Zn) doped cobalt sulfide nanoparticles were successfully fabricated using a facile co-precipitation method, and their structural, optical, and electrical properties were analyzed.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Thermodynamics
Salah Tlili, Abdelmadjid Kaddour, Oumr A. Osra, Mustafa Bayram, Muhammad Atif, Hijaz Ahmad, Younes Menni
Summary: This study determined the coldest days in the Djelfa region, Algeria in 2022 by analyzing astronomical and climatic data. The study examined the impact of various factors on the output of a renewable energy converter, including solar radiation intensity, air temperature, and different glass coverings. The findings contribute to energy-efficient designs and renewable integration, aiding in sustainable urban development.
Article
Thermodynamics
Noureddine Kaid, Mustafa Bayram, Jihad Asad, Muhammad Atif, Muataz S. Alhassan, Houari Ameur, Hijaz Ahmad, Younes Menni
Summary: This research paper presents a highly significant study on a new type of static mixer, which employs advanced numerical simulations to assess its mixing efficiency. The findings reveal detailed insights into flow behavior and mixing performance and contribute to applied mechanics and the optimization of industrial mixing processes.
Article
Chemistry, Multidisciplinary
Abdul Raouf Malik, Muhammad Hammad Aziz, Muhammad Atif, Muhammad Sultan Irshad, Hafeez Ullah, Tuan Nguyen Gia, Hijaz Ahmed, Shafiq Ahmad, Thongchai Botmart
Summary: Nanobiotechnology combined with green science holds great potential for the development of novel and important products that benefit human health, climate, and industries. Green synthesized nickel ferrites nanoparticles using biogenic lime peel extract have been investigated and shown to have multiple efficacies, including anticancer effects and antioxidant and antibacterial activities.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2022)
