Article
Biochemistry & Molecular Biology
Bala Murali Krishna Vasamsetti, Kyongmi Chon, Chang-Young Yoon, Juyeong Kim, Ji-Yeong Choi, Sojeong Hwang, Kyeong-Hun Park
Summary: In this study, a zebrafish model was used to investigate the molecular pathways associated with the developmental toxicity of Etridiazole. The analysis of the transcriptome revealed differentially expressed genes related to sensory perception, visual perception, organ development, and visual system development, as well as involvement in various signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Mingrui Yuan, Wenhua Li, Peng Xiao
Summary: In this study, exposure to BIX was found to induce cardiac toxicity in zebrafish embryos, leading to cardiac dysplasia and dysfunction. This toxicity was associated with decreased expression of erythropoiesis-related and cardiac development-related genes in response to BIX treatment. These findings highlight the potential environmental risks of BIX exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Xin Chen, Tiantong Qiu, Mengjun Pan, Peng Xiao, Wenhua Li
Summary: In this study, the influence of fluxapyroxad on hematopoietic development was evaluated using zebrafish embryos. The results showed that fluxapyroxad treatment led to abnormal distribution and decreased levels of hemoglobin, as well as reduced transcription levels of genes involved in erythropoiesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Shanshan Guo, Yaqing Wu, Wenhua Li, Peng Xiao
Summary: This study aimed to investigate the toxicity of tralomethrin in zebrafish. Results showed that tralomethrin exposure caused cardiovascular dysplasia and dysfunction, as well as developmental abnormalities and oxidative stress in embryos. The dysregulation of crucial genes responsible for cardiovascular development was also observed. These findings highlight the cardiovascular and developmental toxicity of tralomethrin in zebrafish, and their significance for assessing the environmental risk of tralomethrin in aquatic ecosystems.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wannakarn Kitipaspallop, Siwapech Sillapaprayoon, Preecha Phuwapraisirisan, Woo-Keun Kim, Chanpen Chanchao, Wittaya Pimtong
Summary: Sesamolin, a major active compound in sesame seeds, has been found to have various pharmaceutical activities. This study showed that sesamolin may have potential toxicity to zebrafish embryonic development, including inducing malformations and reducing heart rates. It also affected genes related to angiogenesis and erythropoiesis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Raquel Martin-Folgar, Monica Torres-Ruiz, Mercedes de Alba, Ana Isabel Canas-Portilla, M. Carmen Gonzalez, Monica Morales
Summary: Plastics, especially nano-sized plastic particles, have negative health effects on living beings and the environment. These particles can be found in various ecosystems and exposure to them can occur through air, water, food, and personal care products. The toxicity mechanisms of these nanomaterials are currently unknown, emphasizing the need for further studies on their effects at the molecular and cellular levels.
Article
Engineering, Environmental
Yanping Zhao, Ruxia Qiao, Siyuan Zhang, Guoxiang Wang
Summary: The study found that microplastic fibers can cause intestinal damage and toxicity in zebrafish, with longer fibers producing more serious effects. Metabolomics analysis revealed that microplastic fibers can up-regulate glycerophospholipids metabolism, exacerbating oxidative damage and inflammation, while down-regulating fatty acyls metabolism related to nutritional deficiency.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Multidisciplinary Sciences
Min Luo, Dan Xie, Ziyuan Lin, Huaqin Sun, Yanyan Liu
Summary: The potential risks of hydroxychloroquine (HCQ) treatment include various side effects and potential genetic defects. This study used zebrafish embryos to investigate the effects of HCQ overdose and found that high concentrations can lead to mortality, malformation, and abnormal differentiation of vital organs.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Johannes Pohl, Oksana Golovko, Gunnar Carlsson, Stefan Orn, Monika Schmitz, Ehsan Pashay Ahi
Summary: Exposure to ozonated carbamazepine (CBZ) was found to result in cardiovascular-related malformations and reduced heart rate in zebrafish embryos, along with a lack of swim bladder inflation. Through gene co-expression analysis, two co-expression networks and their upstream transcription regulators were identified, offering mechanistic explanations for the observed toxicity phenotypes. The study presents a novel application of gene co-expression analysis elucidating potential toxicity mechanisms of an ozonated pharmaceutical with environmental relevance.
Article
Environmental Sciences
Young Sang Kwon, Chang-Beom Park, Seung-Min Lee, Seonggeun Zee, Go-Eun Kim, Yeong-Jin Kim, Hee-Jung Sim, Jong-Hwan Kim, Jong-Su Seo
Summary: This study investigated the protein profiles in zebrafish embryos exposed to BB using mass spectrometry. A total of 83 differentially expressed proteins were identified, and their biological functions were categorized into different functional groups. The research provides insights into the molecular basis of the ecotoxicity of BB in aquatic ecosystems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Anton Vremere, Carmine Merola, Federico Fanti, Manuel Sergi, Monia Perugini, Dario Compagnone, Milena Mikhail, Stefano Lorenzetti, Michele Amorena
Summary: This study compared the effects of bisphenol A (BPA) with cytochromes P450 (CYPs)-modulating chemicals on oxysterols levels in zebrafish embryos at 8 and 24 hours post fertilization. The results showed that BPA, similar to CYPs-modulating chemicals, caused a dose-dependent increase in total oxysterols at 24 hpf.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Huiting Yang, Xiaohong Gu, Huihui Chen, Qingfei Zeng, Zhigang Mao, Miao Jin, Hongmin Li, You Ge, Jinmiao Zha, Christopher J. Martyniuk
Summary: This study investigates the effects of chronic exposure to different concentrations of SER on zebrafish and reveals its potential toxicity mechanisms, including oxidative stress and neurotoxicity. Transcriptomics analysis suggests that the circadian system may play a role in SER-induced neurotoxicity in the central nervous system.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Bala Murali Krishna Vasamsetti, Kyongmi Chon, Juyeong Kim, Jin-A Oh, Chang-Young Yoon, Hong-Hyun Park
Summary: This study investigated the effects of Thiram on the development of zebrafish embryos and found that Thiram is highly toxic, causing deformities and cardiac-related issues in zebrafish embryos.
Article
Pharmacology & Pharmacy
Xiaofang Che, Yong Huang, Tianzhu Shen, Keyuan Zhong, You Wei, Guoqiang Fan, Kun Jia, Wei Yuan, Huiqiang Lu
Summary: This study revealed the toxicity of Mon in notochord development in zebrafish. Mon exposure led to reduced body length, decreased heart rate and hatchability, and induced notochord deformity. Histological staining and molecular biology experiments showed that Mon exposure also affected the internal structure and gene expression levels of the notochord. Therefore, this research suggests that the use of Mon may pose risks to the ecological environment and human health.
Review
Immunology
Michal Stosik, Beata Tokarz-Deptula, Wieslaw Deptula
Summary: This review presents Danio rerio as a model organism for studying hematopoiesis in vertebrates and discusses the development of this process in fish and mammals, as well as the impact of microenvironmental factors.
FRONTIERS IN IMMUNOLOGY
(2022)