Article
Biochemistry & Molecular Biology
Praphatson Malat, Tipaya Ekalaksananan, Chukkris Heawchaiyaphum, Supawadee Suebsasana, Sittiruk Roytrakul, Yodying Yingchutrakul, Chamsai Pientong
Summary: Andrographolide inhibits the reactivation of Epstein-Barr virus in EBV-positive cancer cells by inhibiting EBV lytic genes, possibly through histone modifications.
Review
Immunology
Cong Sun, Xin-chun Chen, Yin-feng Kang, Mu-sheng Zeng
Summary: EBV is a common human herpesvirus associated with infectious mononucleosis, malignancies, and autoimmune diseases. Despite efforts to develop a prophylactic vaccine, there is currently no EBV vaccine in clinical use. Insights from the COVID-19 pandemic and global vaccine development offer opportunities for designing an effective prophylactic EBV vaccine to control worldwide EBV infection and associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yiran Qu, Bingyang Zhang, Yingli Wang, Shuang Yin, Jordan L. Pederick, John B. Bruning, Yan Sun, Anton Middelberg, Jingxiu Bi
Summary: The study investigated the relationship between insertion sites in ferritin (N-terminus and C-terminus) and immune responses, finding that C-terminus insertion resulted in a stronger cell-mediated immune response than N-terminus insertion. This research provides new insights into the development of ferritin nanoparticle vaccines.
Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Article
Biochemistry & Molecular Biology
Deeksha Tiwari, Gaurava Srivastava, Omkar Indari, Vijay Tripathi, Mohammad Imran Siddiqi, Hem Chandra Jha
Summary: Recent reports suggest that persistent Epstein-Barr virus infection could lead to the formation of proteinaceous plaques in the brain, a hallmark of Alzheimer's disease. The apolipoprotein E (ApoE), a major genetic risk factor for AD, may also affect the outcome of EBV infection. This study investigates the interactions between ApoE and various EBV proteins, and finds possible stable interactions between the C-terminal domain of ApoE3 and EBV proteins EBNA1 and BZLF1. These interactions may interfere with the clearance of amyloid fragments from the brain, contributing to the development of AD.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Immunology
Elshafa Hassan Ahmed, Eric Brooks, Shelby Sloan, Sarah Schlotter, Frankie Jeney, Claire Hale, Charlene Mao, Xiaoli Zhang, Eric McLaughlin, Polina Shindiapina, Salma Shire, Manjusri Das, Alexander Prouty, Gerard Lozanski, Admasu T. Mamuye, Tamrat Abebe, Lapo Alinari, Michael A. Caligiuri, Robert A. Baiocchi
Summary: Epstein-Barr virus (EBV) is a common herpes virus that infects the majority of the world's population and is associated with cancer development. Immune suppression may increase the risk of EBV-driven cancers, particularly in post-organ transplant patients prone to PTLD. Vaccines could potentially enhance EBV-specific immunity and prevent PTLD.
Article
Virology
Jaeyeun Lee, Jennifer Stone, Prashant Desai, John G. Kosowicz, Jun O. Liu, Richard F. Ambinder
Summary: Research found that As2O3 can increase EBV Zta gene expression while blocking late lytic gene expression and virion production. Additionally, the effects of As2O3 on EBV gene expression may be mediated by pathways other than the ISR signaling pathway.
Article
Biology
Victor Omoboyede, Ochapa Ibrahim, Haruna Isiyaku Umar, Taye Bello, Ayodeji Adeola Adedeji, Aqsa Khalid, Emmanuel Sunday Fayojegbe, Adunola Blessing Ayomide, Prosper Obed Chukwuemeka
Summary: The study aimed to develop a multiepitope-based polyvalent vaccine against EBV-associated tumors using an immunoinformatics approach. Thirty viable B-cell and T-cell epitopes were selected and conjugated to form the vaccine construct, showing desirable properties based on in silico evaluation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xubing Long, Jing Yang, Xiaolin Zhang, Ziwei Yang, Yang Li, Fan Wang, Xiaojuan Li, Ersheng Kuang
Summary: The study reveals that Epstein-Barr virus lytic replication inhibits inflammasome activation through the immediate-early protein BRLF1, leading to altered immune responses in T cells and NK cells.
Article
Biology
Wesley Soo I. Hoo, Kaylie Higa, Alison A. McCormick
Summary: This study successfully developed a mouse B cell line expressing latent membrane protein 1 and demonstrated that vaccination protected mice against B cell tumors expressing latent membrane protein 1. This research provides a potential for studying vaccine immunotherapy in cancer patients.
Article
Virology
Devin N. Fachko, Yan Chen, Rebecca L. Skalsky
Summary: It has been found that EBV miR-BHRF1-3 can suppress lytic replication by directly inhibiting Zta expression. Moreover, nucleotide variants that impact the function of miR-BHRF1-3 have been identified, which may contribute to specific EBV pathologies.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera
Summary: This study demonstrated that Decitabine treatment can reduce the 5mC levels in the EBV genome and increase the amount of open chromatin in gastric cancer cell lines. It also revealed the presence of heterogeneous epigenetic states within the EBV genome, which are disrupted by Decitabine. These findings emphasize the importance of 5mC in maintaining EBV genomic chromatin structure and latency.
Review
Biochemistry & Molecular Biology
Paul J. Farrell, Robert E. White
Summary: The incidence of diseases associated with EBV infection varies greatly in different parts of the world, which may be influenced by the variation in the virus genome. This article describes the main forms of EBV genome sequence variation and the potential contribution of these variations to disease development. Polymorphisms or deletions in the EBV genome can also serve as useful markers for disease monitoring. If certain strains of EBV are proven to be more pathogenic than others, immunization against these pathogenic strains may be valuable.
Review
Virology
Chung-Pei Lee, Mei-Ru Chen
Summary: The nuclear envelope of eukaryotic cells plays a crucial role in maintaining the structural integrity of the nucleus and supporting various cellular processes. Viral proteins from Epstein-Barr virus, such as BGLF4 kinase and the nuclear egress complex BFRF1/BFRF2, have been found to regulate and modulate the nuclear envelope structure in different ways. This review highlights the impact of viral lytic gene expression on nuclear envelope structure and its related cellular processes.
Review
Immunology
Jing Cai, Bodou Zhang, Yuqi Li, Wanfang Zhu, Toshihiro Akihisa, Wei Li, Takashi Kikuchi, Wenyuan Liu, Feng Feng, Jie Zhang
Summary: The lack of approved EBV vaccines can be attributed to the complexity of the virus life cycle, the absence of suitable animal models, and limited understanding of adjuvant selection and immune responses. Continuous research and trials show that combined immunization could be crucial for the future success in developing EBV vaccines.
Article
Medical Informatics
Mohammad Faizal Ahmad Fauzi, Michael Pennell, Berkman Sahiner, Weijie Chen, Arwa Shana'ah, Jessica Hemminger, Alejandro Gru, Habibe Kurt, Michael Losos, Amy Joehlin-Price, Christina Kavran, Stephen M. Smith, Nicholas Nowacki, Sharmeen Mansor, Gerard Lozanski, Metin N. Gurcan
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2015)
Letter
Surgery
Cuneyt Kucur, Kasim Durmus, Enver Ozer, Habibe Kurt, Martha M. Yearsley
JOURNAL OF CRANIOFACIAL SURGERY
(2015)
Article
Pathology
Habibe Kurt, Christina A. Arnold, Jason E. Payne, Michael J. Miller, Roman J. Skoracki, O. Hans Iwenofu
Article
Pathology
Nicholas Mackrides, German Campuzano-Zuluaga, Yvan Maque-Acosta, Adrienne Moul, Nouf Hijazi, Francis Offiong Ikpatt, Ronald Levy, Ramiro E. Verdun, Kranthi Kunkalla, Yasodha Natkunam, Izidore S. Lossos, Francisco Vega, Jennifer Chapman
Article
Anatomy & Morphology
Richard L. Price, Lualhati Harkins, Ennio A. Chiocca, Paul J. Zhang, Habibe Kurt, Obiajulu H. Iwenofu
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2017)
Editorial Material
Hematology
Habibe Kurt, Joseph D. Khoury, L. Jeffrey Medeiros, Yang O. Huh
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Editorial Material
Hematology
Habibe Kurt, L. Jeffery Medeiros, Joseph D. Khoury, Ellen J. Schlette
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Review
Hematology
Habibe Kurt, Jeffrey L. Jorgensen, Hesham M. Amin, Keyur P. Patel, Sa A. Wang, Pei Lin, Rashmi Kanagal-Shamanna, Sanam Loghavi, Beenu Thakral, Haitham A. Khogeer, Elias J. Jabbour, Shaoying Li, C. Cameron Yin, L. Jeffrey Medeiros, Joseph D. Khoury
EUROPEAN JOURNAL OF HAEMATOLOGY
(2018)
Article
Pathology
Habibe Kurt, Lan Zheng, Hagop M. Kantarjian, Guilin Tang, Farhad Ravandi-Kashani, Guillermo Garcia-Manero, Zimu Gong, Hesham M. Amin, Sergej N. Konoplev, Mark J. Routbort, Xin Han, Wei Wang, L. Jeffery Medeiros, Shimin Hu
Editorial Material
Hematology
Habibe Kurt, Karen A. Ferreira
Letter
Hematology
Kirill A. Lyapichev, Habibe Kurt, Narittee Sukswai, Sergej Konoplev, Carlos E. Bueso-Ramos, Joseph D. Khoury, Yang O. Huh
ANNALS OF HEMATOLOGY
(2019)
Article
Pathology
Habibe Kurt, Carlos E. Bueso-Ramos, Joseph D. Khoury, Mark J. Routbort, Rashmi Kanagal-Shamanna, Umang V. Patel, Jeffrey L. Jorgensen, Sa A. Wang, Farhad Ravandi, Courtney DiNardo, Rajyalakshmi Luthra, L. Jeffrey Medeiros, Keyur P. Patel
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2018)
Meeting Abstract
Pathology
Habibe Kurt, Yuan Miao, Suyang Hao, Xinyan Lu, Pei Lin
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2017)
Meeting Abstract
Hematology
Habibe Kurt, Carlos E. Bueso-Ramos, Joseph D. Khoury, Mark Routbort, Rashmi Kanagal-Shamanna, Jeffrey L. Jorgensen, Courtney D. DiNardo, Farhad Ravandi, Hagop M. Kantarjian, Raja Luthra, Jeffrey Medeiros, Keyur Patel