Onset of disorder and protein aggregation due to oxidation-induced intermolecular disulfide bonds: case study of RRM2 domain from TDP-43

Simple MD-based model for oxidative folding of peptides and proteins

(2017) Sergei A. Izmailov et al.   Scientific Reports

The TDP-43 N-terminal domain structure at high resolution

(2016) Miguel Mompeán et al.   FEBS Journal

Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains

(2016) Fuyuki Kametani et al.   Scientific Reports

An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice

(2015) Adam K. Walker et al.   HUMAN MOLECULAR GENETICS

Mechanisms of amyloid formation revealed by solution NMR

(2015) Theodoros K. Karamanos et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity

(2015) Quan Li et al.   Nature Communications

Transient misfolding dominates multidomain protein folding

(2015) Alessandro Borgia et al.   Nature Communications

Identification of disulfide cross-linked tau dimer responsible for tau propagation

(2015) Dohee Kim et al.   Scientific Reports

Compensatory Adaptations of Structural Dynamics in an Intrinsically Disordered Protein Complex

(2014) Dennis Kurzbach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

pH-dependent random coil 1H, 13C, and 15N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements

(2014) Gerald Platzer et al.   JOURNAL OF BIOMOLECULAR NMR

Thiol–Disulfide Exchange in Signaling: Disulfide Bonds As a Switch

(2013) Joris Messens et al.   ANTIOXIDANTS & REDOX SIGNALING

Sulfenic acid chemistry, detection and cellular lifetime

(2013) Vinayak Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

(2013) Chung-ke Chang et al.   FEBS LETTERS

BEST-TROSY experiments for time-efficient sequential resonance assignment of large disordered proteins

(2013) Zsofia Solyom et al.   JOURNAL OF BIOMOLECULAR NMR

Theoretical Size Distribution in Linear Step-Growth Polymerization for a Small Number of Reacting Species

(2013) Sándor Kéki et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reduced Native State Stability in Crowded Cellular Environment Due to Protein–Protein Interactions

(2013) Ryuhei Harada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43

(2013) Peter J Lukavsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Understanding the pKa of Redox Cysteines: The Key Role of Hydrogen Bonding

(2012) Goedele Roos et al.   ANTIOXIDANTS & REDOX SIGNALING

Noncovalent Dimerization of Ubiquitin

(2011) Zhu Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Factors Affecting Protein Thiol Reactivity and Specificity in Peroxide Reduction

(2011) Gerardo Ferrer-Sueta et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

(2011) Todd J Cohen et al.   EMBO JOURNAL

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43

(2009) Takashi Nonaka et al.   HUMAN MOLECULAR GENETICS

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

(2009) G. S. Pesiridis et al.   HUMAN MOLECULAR GENETICS

Expression of TDP-43 C-terminal Fragmentsin VitroRecapitulates Pathological Features of TDP-43 Proteinopathies

(2009) Lionel M. Igaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

(2009) P.-H. Kuo et al.   NUCLEIC ACIDS RESEARCH

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

(2009) C. M. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation

(2008) Matthew J. Winton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants of the cellular localization and shuttling of TDP-43

(2008) Y. M. Ayala et al.   JOURNAL OF CELL SCIENCE