Article
Biochemistry & Molecular Biology
Jinming Peng, Guiqiang Liang, Wenjun Wen, Zihui Qiu, Wenye Huang, Qin Wang, Gengsheng Xiao
Summary: This study prepared Penta-O-galloyl-beta-D-glucose (PGG) from tannic acid methanolysis products and investigated its protective effects and mechanism on glucose-induced glycation for the first time. PGG was found to have strong anti-AGEs effects in bovine serum albumin (BSA)-glucose (Glu) and BSA-methylglyoxal (MGO) glycation systems. It inhibits AGEs formation by blocking glycated intermediates, eliminating radicals, and chelating metal ions. Mechanism analysis showed that PGG prevents BSA from glycation by hindering amyloid fibril accumulation, stabilizing BSA secondary structures, and binding partial glycation sites. PGG also displays effective trapping capacities on MGO reactive intermediate. This research suggests PGG as a potential functional ingredient in food materials for preventing diabetic syndrome.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Sauradipta Banerjee
Summary: The study characterized MG-modified myoglobin in a time-dependent manner, with mass spectrometric studies indicating modifications at Lys-87 and Lys-133. Far-UV CD studies revealed alterations in protein structure and surface hydrophobicity as a result of MG modification. These findings suggest that MG-derived AGE adducts significantly impact the structure of Mb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Zhaoqing Tian, Shasha Chen, Yiheng Shi, Panpan Wang, Yongning Wu, Guoliang Li
Summary: Advanced glycation end products (AGEs) are formed through chemical reactions of amino acids, peptides, proteins, and ketones at normal or heated non-enzymatic conditions. The intake of dietary AGEs is linked to the development of various chronic diseases, and their safety and health risks have garnered significant attention. This review provides an overview of the production, bio-transport, detection technologies, and physiological toxicity of dietary AGEs, as well as discusses strategies to inhibit their generation. Future opportunities and challenges in the detection, toxicity, and inhibition of dietary AGEs are also highlighted.
Article
Agriculture, Multidisciplinary
Tobias Jost, Christian Henning, Thomas Heymann, Marcus A. Glomb
Summary: This study investigated the manufacturing process of wheat bread rolls and found that the AGE profile was significantly expanded, providing comprehensive mechanistic insights. Analysis of five major German bread types revealed high AGE contents, with major lysine protein modifications including carboxymethyl, carboxyethyl, and formyl lysine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiaodi Zhang, Casper G. Schalkwijk, Kristiaan Wouters
Summary: The immune system plays a crucial role in protecting the body against pathogens. MGO and MGO-derived AGEs have been implicated in the development of insulin resistance, type 2 diabetes, and other inflammatory diseases. However, MGO may also have beneficial effects as a defense mechanism during infections and diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Advanced glycation end products (AGEs) are compounds formed by nonenzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. These AGEs can alter protein structure and activate the receptor for advanced glycation end products (RAGE). RAGE is expressed by various cells and plays a role in chronic inflammatory autoimmune disorders. Soluble RAGE (sRAGE) acts as a decoy and inhibits pro-inflammatory processes mediated by RAGE. AGE overproduction, low sRAGE concentrations, and certain RAGE polymorphisms are associated with rheumatic diseases and cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi
Summary: Advanced glycation end products (AGEs) can suppress STING/TBK1/IRF3 signaling and the effect depends on the type and concentration of carbonyl compounds. Lysine modification appears to be involved in the suppressive effect, and one of the AGEs can enhance signaling activation through toll-like receptor 4.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Bednarska, Izabela Fecka
Summary: The unfermented rooibos extract showed a higher ability to trap methylglyoxal and glyoxal and inhibit the formation of advanced glycation end products (AGEs) than the fermented rooibos extract, mainly due to its higher content of dihydrochalcones. Compounds found in rooibos tea, such as aspalathin and vitexin, were able to trap methylglyoxal and glyoxal, and isovitexin showed the strongest inhibition of AGE formation. In addition to its other health benefits, rooibos tea could potentially be used as an alpha-dicarbonyl trapping agent and AGE inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Dianwei Zhang, Pei Zhu, Luxuan Han, Xiaomo Chen, Huilin Liu, Baoguo Sun
Summary: Pyrraline, a type of advanced glycation end product, can be inhibited by phenolic compounds extracted from highland barley and vinasse. The antioxidant activity of the extracts and their regulation on pyrraline formation were studied using UPLC-PAD-MS/MS. The results suggest that highland barley and its by-products have the potential to be used as functional foods to regulate pyrraline formation during food processing.
Article
Nutrition & Dietetics
Yantao Zhao, Yao Tang, Shengmin Sang
Summary: The study found that dietary quercetin significantly reduced MGO and AGEs concentrations in the plasma and tissues of mice, inhibiting AGE formation by trapping MGO and regulating the MGO detoxification systems.
JOURNAL OF NUTRITION
(2021)
Article
Chemistry, Applied
Yin He, Zhijun Yang, Jingwen Pi, Tiange Cai, Ying Xia, Xiangyu Cao, Jianli Liu
Summary: This study found that EGCG can attenuate MGO-induced nerve damage by regulating MAPK and downstream pathways, as well as inhibiting the formation of AGEs.
Article
Endocrinology & Metabolism
Sarah C. Shuck, Peter Achenbach, Bart O. Roep, John S. Termini, Carlos Hernandez-Castillo, Christiane Winkler, Andreas Weiss, Anette-Gabriele Ziegler
Summary: The study found that serum levels of MG-AGEs were associated with the rate of progression to stage 3 type 1 diabetes, with lower levels increasing the risk of progression. This provides a potential new clinical biomarker for determining the rate of disease progression and points to contributing metabolic pathways.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Marcus Thierig, Eva Siegel, Thomas Henle
Summary: Honey from the Manuka tree in New Zealand contains antibacterial MGO. The reactions of MGO with honey proteins during storage were studied, and the formation of protein-bound MRPs was analyzed. The results showed that the contents of CEL and MG-H1 increased with MGO content, and the lysine modification increased with storage independently from the MGO concentration.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Biochemistry & Molecular Biology
Lory Sthephany Rochin-Hernandez, Lory Jhenifer Rochin-Hernandez, Luis Bernardo Flores-Cotera
Summary: Endophytes, microorganisms that live in plants, have the potential to produce bioactive compounds, including anti-aging compounds. This study discusses the importance and challenges of using endophytes as a source of anti-aging compounds, focusing on 26 plant compounds and derivatives that have been reported as endophytic metabolites.
Review
Biochemistry & Molecular Biology
Gulam Rabbani, Ejaz Ahmad, Abrar Ahmad, Rizwan Hasan Khan
Summary: Microbial lipases are excellent biocatalysts that can catalyze various reactions in both aqueous and non-aqueous media. This review focuses on microbial lipases from different sources (psychrophiles, mesophiles, and thermophiles), highlighting the structural diversity in temperature adaptation and industrial applications. Understanding the molecular mechanisms of temperature adaptation in lipases is of great interest, as extremophilic lipases are widely used in biotransformation reactions with higher yields and unique products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Editorial Material
Genetics & Heredity
Saheem Ahmad, Firoz Akhter, Khurshid Ahmad, Saif Khan
FRONTIERS IN GENETICS
(2023)
Review
Plant Sciences
Mudasir Ahmad Bhat, Awdhesh Kumar Mishra, Saima Jan, Mujtaba Aamir Bhat, Mohammad Azhar Kamal, Safikur Rahman, Ali Asghar Shah, Arif Tasleem Jan
Summary: Plants are affected by various environmental stresses, which can disrupt their functioning and impact their growth and productivity. Plant growth-promoting rhizobacteria (PGPR), through their association with plant roots, help plants adapt and survive under changing environmental conditions and become more resilient to stress. They aid in nutrient acquisition, regulation of water content, osmotic balance, and ion homeostasis, contributing to stress alleviation and promoting plant growth and development. This review examines the use of PGPR in increasing plant tolerance to different stresses and their effects on crop yield and food security.
Article
Chemistry, Analytical
Mazin Zamzami, Samer Alamoudi, Abrar Ahmad, Hani Choudhry, Mohammad Imran Khan, Salman Hosawi, Gulam Rabbani, El-Sayed Shalaan, Bassim Arkook
Summary: This study presents an electrochemical method for directly identifying unlabeled Gram-negative bacteria without the need for additional substances. The design of the electrode geometry plays a crucial role in the detection sensitivity of Gram-negative bacteria. The aim is to find the most suitable electrode geometry to detect and quantify bacterial cells in normal saline solutions.
Article
Economics
Syed Tauseef Ali, Joseph H. H. Zhang, Farman Ali, Misraku Molla Ayalew, Muhammad Ullah
Summary: This study adopts the imprinting theory to examine the influence of ideologically imprinted board chairs on corporate innovation. Through analyzing Chinese listed manufacturing firms from 2003 to 2016, the study finds that firms with board chairs who were socialized during the hardline communist regime demonstrate enhanced corporate innovation. The positive effect on corporate innovation is more prominent in firms where board chairs have greater power, but is weakened by their industry experience. These findings contribute to the understanding of the lasting impact of intense political environments on individuals' imprints and shed light on the dynamics of ideological decay and persistence.
JOURNAL OF THE KNOWLEDGE ECONOMY
(2023)
Article
Biochemistry & Molecular Biology
Roshan Vaid, Akram Mendez, Ketan Thombare, Rebeca Burgos-Panadero, Remy Robinot, Barbara F. Fonseca, Nikhil R. Gandasi, Johan Ringlander, Mohammad Hassan Baig, Jae-June Dong, Jae Yong Cho, Bjorn Reinius, Lisa A. Chakrabarti, Kristina Nystrom, Tanmoy Mondal
Summary: Research reveals that SARS-CoV-2 variants infection leads to the loss of m(6)A in cellular RNAs, accompanied by abnormal localization of METTL3. Furthermore, down-regulation of transcripts with m(6)A modification is observed postinfection. Inhibition of XPO1 restores METTL3 localization, m(6)A modification, and mRNA expression, as well as stress granule formation, resulting in reduced viral infection in vitro.
Article
Biochemistry & Molecular Biology
Shahid Ali, Khurshid Ahmad, Sibhghatulla Shaikh, Hee Jin Chun, Inho Choi, Eun Ju Lee
Summary: Myostatin is an inhibitory factor that influences muscle development and metabolism. Inhibition of myostatin improves insulin sensitivity, increases glucose uptake, and reduces body fat. The downregulation of Mss51 in response to myostatin inhibition suggests it as a potential target for the treatment of obesity and type 2 diabetes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Neurosciences
Mohd Imran Khan, Park Taehwan, Yunseong Cho, Marcus Scotti, Renata Priscila Barros de Menezes, Fohad Mabood Husain, Suliman Yousef Alomar, Mohammad Hassan Baig, Jae-June Dong
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting a large population worldwide. This study used machine learning modeling to search for potential drug candidates that inhibit acetylcholinesterase, providing a new approach for the treatment of AD.
FRONTIERS IN NEUROSCIENCE
(2023)
Editorial Material
Genetics & Heredity
Prachi Srivastava, Anshul Tiwari, Khurshid Ahmad, Neha Srivastava, Prekshi Garg
FRONTIERS IN GENETICS
(2023)
Article
Multidisciplinary Sciences
Zeeshan Rafi, Mohammad Hassan Baig, Fohad Mabood Husain, Suliman Yousef Alomar, Jae-June Dong, Mohd Sajid Khan
Summary: This study achieved the facile synthesis of gold nanoparticles (AuNPs) and their bioconjugation with herbal drug garcinol (G) in order to enhance the antiglycative, antidiabetic, and anticancer efficacy. The results showed that G-AuNPs were more effective in inhibiting glycation reactions and preventing the formation of early glycation adducts and AGEs. Additionally, G-AuNPs induced apoptosis in cancer cells, leading to cell death.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alaa Eldin M. A. Morshdy, Karima M. E. Abdallah, Heba E. Abdallah, Fahad D. Algahtani, Mohamed Tharwat Elabbasy, Suleman Atique, Khursheed Ahmad, Mohammad A. A. Al-Najjar, Hossam M. Abdallah, Abdallah Fikry A. Mahmoud
Summary: This study found a high prevalence of Staphylococcus aureus in chicken meat samples from Egyptian markets, with a majority of the isolates being multidrug-resistant. The study also demonstrated the potential of certain natural phenolic compounds, particularly hydroquinone, as alternative antibacterial agents against these drug-resistant bacteria.
Review
Agriculture, Dairy & Animal Science
Syed Sayeed Ahmad, Hee Jin Chun, Khurshid Ahmad, Sibhghatulla Shaikh, Jeong Ho Lim, Shahid Ali, Sung Soo Han, Sun Jin Hur, Jung Hoon Sohn, Eun Ju Lee, Inho Choi
Summary: Cultured meat is a sustainable food produced through in vitro myogenesis of muscle satellite (stem) cells. Growth factors and hormones play crucial roles in the proliferation and differentiation of these cells during cultured meat production.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shahid Ali, Sibhghatulla Shaikh, Khurshid Ahmad, Inho Choi
Summary: This study used a combined approach of machine learning and structure-based virtual screening to identify potential DPP4 inhibitors for type 2 diabetes. Two ML models were trained and showed good accuracy. The compounds Z-614 and Z-997 were found to have high binding affinity and specificity for DPP4. The study suggests that Z-997 has the potential to be a therapeutic option for T2DM.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Medicine, Research & Experimental
Khurshid Ahmad, Sibhghatulla Shaikh, Jeong Ho Lim, Syed Sayeed Ahmad, Hee Jin Chun, Eun Ju Lee, Inho Choi
Summary: This review discusses the role of skeletal muscle (SM) in insulin resistance and type 2 diabetes (T2D), as well as the pharmacological targets and potential modulators/inhibitors associated with SM metabolism. The review highlights the importance of SM in metabolic disorders and the therapeutic potential of natural compounds in targeting SM-associated T2D targets.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Environmental Sciences
Saima Jan, Awdhesh Kumar Mishra, Mujtaba Aamir Bhat, Mudasir Ahmad Bhat, Arif Tasleem Jan
Summary: Water is a vital resource for life on earth, but it is being polluted at an alarming rate due to human activities, leading to concerns about water shortage worldwide. Toxic contaminants negatively impact aquatic and terrestrial organisms and cause serious diseases in humans. Therefore, water treatments that can eliminate toxins are crucial. However, traditional wastewater treatment technologies are expensive and inefficient, highlighting the need for advanced sustainable approaches.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)