Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy

Adenosine contribution to normal renal physiology and chronic kidney disease

(2017) Carlos Oyarzún et al.   MOLECULAR ASPECTS OF MEDICINE

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

(2016) Pier Andrea Borea et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Reduced Adenosine Uptake and Its Contribution to Signaling that Mediates Profibrotic Activation in Renal Tubular Epithelial Cells: Implication in Diabetic Nephropathy

(2016) Catalina Kretschmar et al.   PLoS One

Increased levels of adenosine and ecto 5′-nucleotidase (CD73) activity precede renal alterations in experimental diabetic rats

(2015) C. Oyarzún et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin signaling

(2015) Richard Coward et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium

(2015) Francisco Westermeier et al.   FASEB JOURNAL

Adenosine receptors and diabetes: Focus on the A2B adenosine receptor subtype

(2015) Stefania Merighi et al.   PHARMACOLOGICAL RESEARCH

Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets

(2015) Marçal Pastor-Anglada et al.   Frontiers in Pharmacology

The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters

(2015) Jaya Aseervatham et al.   PLoS One

Adenosine, type 1 receptors: role in proximal tubule Na+reabsorption

(2014) W. J. Welch   Acta Physiologica

The role of adenosine receptors A2A and A2B signaling in renal fibrosis

(2014) Veena S. Roberts et al.   KIDNEY INTERNATIONAL

The Selective A 3 AR Antagonist LJ-1888 Ameliorates UUO-Induced Tubulointerstitial Fibrosis

(2013) Jiyoun Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats

(2013) J. Lamontagne et al.   DIABETES

Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model

(2012) C. Martinez-Garcia et al.   Disease Models & Mechanisms

Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney

(2012) Rodrigo Gatica et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice

(2012) Almut Grenz et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversal of diabetic nephropathy: lessons from pancreas transplantation

(2012) Paola Fioretto et al.   JOURNAL OF NEPHROLOGY

Adenosine A2B receptor-mediated VEGF induction promotes diabetic glomerulopathy

(2012) Angel Cárdenas et al.   LABORATORY INVESTIGATION

Gestational Diabetes Reduces Adenosine Transport in Human Placental Microvascular Endothelium, an Effect Reversed by Insulin

(2012) Carlos Salomón et al.   PLoS One

Podocytopathy in Diabetes: A Metabolic and Endocrine Disorder

(2011) Ana Diez-Sampedro et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Insulin Restores Gestational Diabetes Mellitus-Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium

(2011) F. Westermeier et al.   DIABETES

Temporal Trends in the Prevalence of Diabetic Kidney Disease in the United States

(2011) Ian H. de Boer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A2B Adenosine Receptor-Mediated Induction of IL-6 Promotes CKD

(2011) Y. Dai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity

(2011) Akira Mima et al.   KIDNEY INTERNATIONAL

Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients

(2010) Jian-Fei Xia et al.   CLINICAL BIOCHEMISTRY

Do Adenosine Receptors Offer New Therapeutic Options for Diabetic Nephropathy?

(2009) Rody Martin et al.   Current Vascular Pharmacology

Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats

(2009) H. Roa et al.   FEBS LETTERS

Ultraviolet and tandem mass spectrometry for simultaneous quantification of 21 pivotal metabolites in plasma from patients with diabetic nephropathy

(2009) Jian-Fei Xia et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

(2008) T. Tejada et al.   KIDNEY INTERNATIONAL

Adenosine A2B receptor mediates an increase on VEGF-A production in rat kidney glomeruli

(2007) D. Valladares et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS