Article
Audiology & Speech-Language Pathology
Catalina Valdes-Baizabal, Lorena Casado-Roman, Edward L. Bartlett, Manuel S. Malmierca
Summary: The inferior colliculus is an important auditory structure where complex coding properties like stimulus-specific adaptation emerge. Studies have shown differences in intrinsic properties between adapting and non-adapting neurons.
Article
Biochemistry & Molecular Biology
Julia E. Manoim, Andrew M. Davidson, Shirley Weiss, Toshihide Hige, Moshe Parnas
Summary: In this study, the authors investigated a neuromodulatory mechanism in fruit flies that is essential for achieving stimulus specificity in learning. They found that cholinergic Kenyon cells, which represent olfactory signals, have axo-axonic connections mediated by the muscarinic type-B receptor. These connections suppress both odor-evoked calcium responses and dopamine-evoked cAMP signals in neighboring cells, contributing to effective and accurate memory formation.
Article
Cell Biology
Alina Peter, Benjamin Johannes Stauch, Katharine Shapcott, Kleopatra Kouroupaki, Joscha Tapani Schmiedt, Liane Klein, Johanna Klon-Lipok, Jarrod Robert Dowdall, Marieke Louise Schoelvinck, Martin Vinck, Michael Christoph Schmid, Pascal Fries
Summary: Repeated visual stimuli can decrease average neuronal responses, but maintain or increase impact through increased synchronization. These effects persist on a minute timescale, and gamma-band synchronization plays an important role in processing repeated stimuli.
Article
Biochemistry & Molecular Biology
Brice Williams, Joseph Del Rosario, Tomaso Muzzu, Kayla Peelman, Stefano Coletta, Edyta K. Bichler, Anderson Speed, Lisa Meyer-Baese, Aman B. Saleem, Bilal Haider
Summary: The visual system responds to changes in luminance with action potentials, where OFF responses dominate in the central visual field and are more balanced in the periphery, possibly influenced by species, experimental techniques, and stimulus properties.
Article
Neurosciences
Xiaohui Wang, Yuanqing Zhang, Siyi Bai, Runze Qi, Hao Sun, Rui Li, Lin Zhu, Xinyuan Cao, Guoqiang Jia, Xinjian Li, Lixia Gao
Summary: This study investigated temporal processing by IC neurons in awake marmosets. The researchers found that 28% of IC neurons exhibited rate representation, contrary to previous beliefs. IC neurons with rate representation also showed distinct response properties compared to those with temporal representation. Additionally, the study revealed that cortico-colliculus projections play a role in temporal processing in the IC.
Article
Multidisciplinary Sciences
Tao Yang, Kai Yu, Xian Zhang, Xiong Xiao, Xiaoke Chen, Yu Fu, Bo Li
Summary: The central amygdala (CeA) is involved in various mental processes, and somatostatin-expressing CeA neurons play a crucial role in generating evaluative signals necessary for learning.
Article
Chemistry, Analytical
Francesca Callegari, Martina Brofiga, Fabio Poggio, Paolo Massobrio
Summary: The present study investigated the effects of low-frequency electrical stimulation on cortical and hippocampal networks. The results showed that cortical assemblies were more reactive than hippocampal ones, and that the response to stimulation was delayed in the cortical assemblies.
Review
Neurosciences
Carlotta Martelli, Douglas Anthony Storace
Summary: It remains an open question how the olfactory system adapts to different stimulus conditions and how this adaptation affects olfactory representations and perception. Although adaptation could allow the olfactory system to adjust sensory representations to the current stimulus conditions, surprisingly little is known about how adaptation changes olfactory representations and affects perception.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Jonas Engert, Kristen Rak, Linda Bieniussa, Miriam Scholl, Rudolf Hagen, Johannes Voelker
Summary: This research project aimed to evaluate the neurogenic potential in the rat inferior colliculus from early postnatal days until adulthood, identifying and characterizing neural stem cells (NSCs) and their age-specific features. The study contributes to a better understanding of the development and plasticity of the auditory pathway, providing insights for potential therapeutic applications.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Audiology & Speech-Language Pathology
Kongyan Li, Vani G. Rajendran, Ambika Prasad Mishra, Chloe H. K. Chan, Jan W. H. Schnupp
Summary: The study found that neural d' values show similar trends with behavioral performance under different conditions, and neural d' correlates better with behavioral performance compared to mutual information (MI). Additionally, when ITD values are encoded as left or right ear leading, results from neural d' and MI are highly correlated.
Review
Behavioral Sciences
Peirun Song, Yuying Zhai, Xiongjie Yu
Summary: Rapid detection of novel stimuli is crucial for survival, and stimulus-specific adaptation (SSA) is an important mechanism underlying this. This review discusses recent advances in SSA research, covering the frequency dependence and origin of SSA in the auditory cortex, spatial SSA and its comparison to frequency SSA, feature integration in SSA and its implications in novelty detection, and the functional significance and physiological mechanism of SSA. Despite extensive investigation, there are limited cognitive insights from SSA studies, suggesting a need for future work to bridge these gaps.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Natacha Vanattou-Saifoudine, Chao Han, Renate Krause, Eleni Vasilaki, Wolfger von der Behrens, Giacomo Indiveri
Summary: Stimulus-Specific Adaptation (SSA) is a phenomenon observed in various species and sensory areas, proposed as a computational mechanism for separating behaviorally relevant information. The network details and mechanisms underlying SSA remain unclear, but recent studies suggest a potential association with Population Spikes (PS) in neuronal firing dynamics.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Benjamin J. Stauch, Alina Peter, Heike Schuler, Pascal Fries
Summary: Stimulus repetition can modulate neuronal-gamma band synchronization and induce plastic changes in activated neuronal circuits. These changes are stimulus-specific and persist even after intervening stimuli. The strongest effects are observed in the early visual cortex, where there is an increase in interareal feedforward influences.
Article
Biology
Hannah M. Oberle, Alexander N. Ford, Deepak Dileepkumar, Jordyn Czarny, Pierre F. Apostolides
Summary: Corticofugal projections from the neocortex to evolutionarily ancient subcortical structures are common in mammalian sensory systems, allowing the cortex to control ascending sensory representations predictively or in a feedback manner. This study focused on the projection from the mouse auditory cortex to the inferior colliculus (IC), revealing that although individual synapses were weak, IC neurons integrated inputs from multiple corticofugal axons to generate reliable depolarizations. Descending signals reached the IC within 30 ms of sound onset and were found to nonlinearly amplify IC neurons' acoustic responses.
Article
Multidisciplinary Sciences
Faezeh Tashakori-Sabzevar, Nico Vautrelle, Yiwen Zheng, Paul F. Smith
Summary: This study investigates the effects of electrical stimulation of the peripheral vestibular system on electrophysiological responses in the tail of the rat striatum. Clear triphasic local field potentials (LFPs) were evoked in the bilateral tail of the striatum, with the LFP amplitude increasing with increasing current amplitude. The results suggest a connection between the vestibular system and the tail of the striatum, possibly through the vestibular nucleus or cerebellum and the parafasicular nucleus of the thalamus.
SCIENTIFIC REPORTS
(2023)
Article
Physiology
Juan Francisco Martin-Rodriguez, Victor Dario Ramos-Herrero, Gloria G. Parras, Alvaro Flores-Martinez, Ainara Madrazo-Atutxa, David A. Cano, Agnes Gruart, Jose Maria Delgado-Garcia, Alfonso Leal-Cerro, Rocio Leal-Campanario
Review
Neurosciences
Lauren Harms, Gloria G. Parras, Patricia T. Michie, Manuel S. Malmierca
Summary: Mismatch negativity (MMN) is an electrophysiological signature that occurs in response to unexpected stimuli, often considered a measure of memory-based change detection. The alteration of MMN can reflect conditions where memory is affected, such as Alzheimer's disease, schizophrenia, and healthy aging.
Article
Audiology & Speech-Language Pathology
Catalina Valdes-Baizabal, Lorena Casado-Roman, Edward L. Bartlett, Manuel S. Malmierca
Summary: The inferior colliculus is an important auditory structure where complex coding properties like stimulus-specific adaptation emerge. Studies have shown differences in intrinsic properties between adapting and non-adapting neurons.
Article
Audiology & Speech-Language Pathology
David Perez-Gonzalez, Gloria G. Parras, Camilo J. Morado-Diaz, Cristian Aedo-Sanchez, Guillermo V. Carbajal, Manuel S. Malmierca
Summary: This study investigated neuronal activities in the auditory cortex of animals under the oddball paradigm and found that both fast spiking and regular spiking neurons showed similar levels of deviance detection overall. However, in A1 area, fast spiking neurons exhibited significantly higher levels of deviance detection compared to regular spiking neurons.
Article
Multidisciplinary Sciences
Gloria G. Parras, Catalina Valdes-Baizabal, Lauren Harms, Patricia T. Michie, Manuel S. Malmierca
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Lorena Casado-Roman, Guillermo V. Carbajal, David Perez Gonzalez, Manuel S. Malmierca
Article
Biochemistry & Molecular Biology
Mario Diaz, Fernando Lobo, Dacil Hernandez, Angel Amesty, Catalina Valdes-Baizabal, Ana Canerina-Amaro, Fatima Mesa-Herrera, Kevin Soler, Alicia Boto, Raquel Marin, Ana Estevez-Braun, Fernando Lahoz
Summary: Tamoxifen is a widely used selective estrogen receptor modulator for breast cancer treatment, but it has undesirable effects on uterine tissues. FLTX2, a derivative of tamoxifen, shows promising antiestrogen properties and induces apoptotic cell death in MCF7 cells through photosensitization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Neurosciences
Manuel S. Malmierca
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Gloria G. Parras, Lorena Casado-Roman, Erich Schroeger, Manuel S. Malmierca
Summary: The study found functional specialization in different fields of the rat auditory cortex, with the posterior auditory field showing the largest prediction error effects and other fields dominantly affected by repetition suppression effects. Results suggest that different AC fields have varying roles in context-dependent processing and being sensitive to stimulus-dependent effects in deviance detection.
Article
Biochemistry & Molecular Biology
Lucas Taoro-Gonzalez, Daniel Pereda, Catalina Valdes-Baizabal, Miriam Gonzalez-Gomez, Jose A. Perez, Fatima Mesa-Herrera, Ana Canerina-Amaro, Herminia Perez-Gonzalez, Covadonga Rodriguez, Mario Diaz, Raquel Marin
Summary: Recent findings suggest that changes in brain lipid composition during aging can affect the integrity and protein signaling of lipid rafts, leading to memory impairment. However, a n-3 LCPUFA-enriched diet has been shown to improve cognitive function and stabilize the lipid composition of hippocampal lipid rafts in aged mice. These findings suggest that n-3 LCPUFA supplementation may have a rejuvenating effect on the microenvironment of lipid rafts, enhancing cognitive performance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Neurosciences
Diego Elgueda, Yaneri A. Ayala, Paul H. Delano
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Gloria G. Parras, Rocio Leal-Campanario, Juan C. Lopez-Ramos, Agnes Gruart, Jose M. Delgado-Garcia
Summary: Classical conditioning of nictitating membrane/eyelid responses has been used as a model to study how the brain organizes the acquisition, storage, and retrieval of motor abilities. Multiple brain areas have been found to be involved in this type of learning. This study specifically focuses on the functional roles of three brain structures involved in the acquisition and performance of eyelid conditioned responses, as well as three other brain structures related to non-motor aspects of the acquisition process.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Ana B. Lao-Rodriguez, Karol Przewrocki, David Perez-Gonzalez, Artoghrul Alishbayli, Evrim Yilmaz, Manuel S. Malmierca, Bernhard Englitz
Summary: Prediction is crucial for survival, and cognitive studies indicate that the brain can make multilevel predictions. However, neuronal evidence for predictions has been difficult to find due to the challenge of separating neural activity related to predictions from stimulus responses. In this study, we recorded single-neuron activity from auditory regions in both anesthetized and awake animals and observed reliable responses to omitted tones, providing empirical evidence for the implementation of predictive processes.
Article
Neurosciences
Antonio Criscuolo, Michael Schwartze, Luis Prado, Yaneri Ayala, Hugo Merchant, Sonja A. Kotz
Summary: Many animal species have the ability to detect basic rhythms and produce rhythmic behavior, but the ability to process complex rhythms and synchronize rhythmic behavior seems to be species-specific. This study investigates whether our closest ancestors, macaque monkeys, show similar innate tendencies to sample the acoustic environment without task instructions and training. The results show that both macaque monkeys and humans have neural oscillations that encode and track the timing of auditory events, indicating convergence in temporal regularity processing in the acoustic environment.
PROGRESS IN NEUROBIOLOGY
(2023)