Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation

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Digging deep to reveal how the mutational dynamics of CLL might inform patient management

(2016) David Killock   Nature Reviews Clinical Oncology

An ultra-deep sequencing strategy to detect sub-clonal TP53 mutations in presentation chronic lymphocytic leukaemia cases using multiple polymerases

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Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

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A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

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Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer

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A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients

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SubClonal Hierarchy Inference from Somatic Mutations: Automatic Reconstruction of Cancer Evolutionary Trees from Multi-region Next Generation Sequencing

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Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

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Reproducibility of Variant Calls in Replicate Next Generation Sequencing Experiments

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Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

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Cancer Evolution: Mathematical Models and Computational Inference

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Physical Biology in Cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography

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Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

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Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

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Clonal competition with alternating dominance in multiple myeloma

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Comprehensive molecular portraits of human breast tumours

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Fast and accurate long-read alignment with Burrows–Wheeler transform

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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

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Tumor heterogeneity: Causes and consequences

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