The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

(2016) Xinlai Cheng et al.   Molecular Oncology

Molecular basis of resistance to proteasome inhibitors in hematological malignancies

(2015) Denise Niewerth et al.   DRUG RESISTANCE UPDATES

Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4

(2015) Xinlai Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers

(2015) Xinlai Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

TP53 loss creates therapeutic vulnerability in colorectal cancer

(2015) Yunhua Liu et al.   NATURE

Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome

(2015) Iqbal Dulloo et al.   NATURE CELL BIOLOGY

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells

(2014) Xinlai Cheng et al.   Molecular Cancer

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Combination of TRAIL with Bortezomib Shifted Apoptotic Signaling from DR4 to DR5 Death Receptor by Selective Internalization and Degradation of DR4

(2014) Maxim L. Bychkov et al.   PLoS One

7,7′-Diazaindirubin—A small molecule inhibitor of casein kinase 2 in vitro and in cells

(2013) Xinlai Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

p53 regulates a non-apoptotic death induced by ROS

(2013) J Montero et al.   CELL DEATH AND DIFFERENTIATION

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Indirubin Derivatives Modulate TGFβ/BMP Signaling at Different Levels and Trigger Ubiquitin-Mediated Depletion of Nonactivated R-Smads

(2012) Xinlai Cheng et al.   CHEMISTRY & BIOLOGY

Proteasome Inhibitors Induce p53-Independent Apoptosis in Human Cancer Cells

(2011) Bulbul Pandit et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

The current landscape of locally advanced rectal cancer

(2011) Mebea Aklilu et al.   Nature Reviews Clinical Oncology

Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib

(2010) Siquan Chen et al.   CANCER RESEARCH

p53-family proteins and their regulators: hubs and spokes in tumor suppression

(2010) L Collavin et al.   CELL DEATH AND DIFFERENTIATION

Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells

(2010) L. Roger et al.   JOURNAL OF CELL SCIENCE

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE