Article
Microbiology
Wei-Meng Feng, Pei Liu, Hui Yan, Sen Zhang, Er-Xin Shang, Guang Yu, Shu Jiang, Da-Wei Qian, Jun-Wei Ma, Jin-Ao Duan
Summary: The interaction between plant-microorganism in the rhizosphere is crucial for the accumulation of phthalides in Angelica sinensis. Specific bacteria strains such as Bacillus were identified to potentially influence the phthalides accumulation. Bacillus was found to promote the accumulation of butylidenephthalide while inhibiting the accumulation of ligustilide.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Wei-Meng Feng, Pei Liu, Hui Yan, Guang Yu, Sen Zhang, Shu Jiang, Er-Xin Shang, Da-Wei Qian, Jin-Ao Duan
Summary: The researchers identified enzymes involved in phthalide accumulation in Angelica sinensis and proposed a possible mechanism underlying phthalide transformation and biosynthetic pathways. This study provides valuable information for understanding phthalide accumulation and transformation in A. sinensis.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Oncology
Shouhua Zhang, Hongyan Xu, Weiming Li, Jianfeng Ji, Qifang Jin, Leifeng Chen, Qiang Gan, Qiang Tao, Yong Chai
Summary: MDM2 promotes survival of retinoblastoma (RB) cells by regulating the expression of pVHL and HIF-1 alpha, and targeting MDM2 and/or HIF-1 alpha may represent a promising approach for RB treatment.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Kunhang Du, Lu Wang, Ziling Wang, Hanxianzhi Xiao, Jiying Hou, Ling Hu, Ningke Fan, Yaping Wang
Summary: In this study, researchers found that Angelica Sinensis polysaccharide (ASP) can antagonize the 5-FU-induced injury of mouse spleen and splenocytes, and the underlying mechanism involves the reduction of oxidative stress and apoptosis by activating Nrf2 and PI3K/AKT pathways. The results showed that ASP can restore the spleen weight and function, improve leukocyte and lymphocyte numbers, and regulate cytokine levels, mitochondria swelling, and oxidant accumulation. ASP also downregulated Keap1 expression and promoted the translocation of Nrf2, while activating the PI3K/AKT signaling pathway. This study provides a new protective agent and approach for minimizing spleen injury and improving the prognosis of chemotherapy patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Nan Yang, Xiang Li
Summary: EGCG treatment relieves asthmatic symptoms in mice by suppressing HIF-1 alpha/VEGFA-mediated M2 skewing of macrophages.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hong Ding, Chuanfeng Tang, Wei Wang, Ying Pan, Ruiqing Jiao, Lingdong Kong
Summary: This study found that high fructose intake can lead to oxidative stress and injury in glomerular podocytes. Polydatin, a compound extracted from Chinese herbal medicine, can attenuate this damage by inhibiting the activation of the HIF-1α, NOX4, and SDF-1α/CXCR4 pathways. These findings suggest that polydatin may be a potential therapeutic strategy for protecting podocytes against oxidative stress and injury induced by high fructose intake.
Article
Pharmacology & Pharmacy
Wanfu Lin, Shu Li, Yongbin Meng, Guokai Huang, Shufang Liang, Juan Du, Qun Liu, Binbin Cheng
Summary: This study found that ursodeoxycholic acid (UDCA) can inhibit hypoxic hepatocellular carcinoma (HCC) cell-induced angiogenesis by suppressing HIF-1 alpha/VEGF/IL-8-mediated intercellular signaling.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zichen Xu, Bin Zhang, Zhixin Liao, Shaohua Gou
Summary: The novel drug GEM-5 effectively inhibits tumor growth and improves tumor hypoxia by suppressing HIF-1α expression. This strategy holds great potential for enhancing the anti-tumor effects of chemotherapy drugs.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Bo Zhan, Xiao Dong, Yulin Yuan, Zheng Gong, Bohan Li
Summary: The study reveals that HIF-1α is downregulated in ccRCC, inhibiting cell proliferation, migration, and invasion, which has important biological implications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Fisheries
Qian Ni, Di Wang, Lingli Xie, Hongxing Ge, Zhiguo Dong
Summary: The study shows that clams use HIF-1 alpha gene and antioxidant enzymes to cope with acute hypoxia exposure, which helps increase their adaptation to hypoxic conditions.
AQUACULTURE RESEARCH
(2022)
Article
Engineering, Biomedical
Ying Zhang, Cong Wang, Weishuo Li, Wei Tian, Chunming Tang, Lingjing Xue, Ziming Lin, Guilai Liu, Dongfei Liu, Ying Zhou, Qianqian Wang, Xu Wang, Lutz Birnbaumer, Yong Yang, Xianjing Li, Caoyun Ju, Can Zhang
Summary: The study proposes a general CTC intervention strategy based on neutrophil cyto-pharmaceuticals to suppress CTC colonization and metastasis formation, offering a new perspective for understanding the mechanism of CTC colonization and suggesting targeted intervention as a meaningful treatment for tumor metastasis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Ning Wang, Cheng Zhang, Yu Xu, Hor-Yue Tan, Haiyong Chen, Yibin Feng
Summary: The study demonstrated that berberine can decelerate the progression of diabetic retinopathy by inhibiting insulin-induced neovascularization of retinal endothelial cells. In both experimental type I and type II diabetic mice, berberine effectively suppressed the expression of HIF-1 alpha and VEGF, improving diabetic retinopathy under insulin treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Mingzhu Yu, Qiaoling Pan, Wenbiao Li, Tingting Du, Fei Huang, Hui Wu, Yixin He, Xiaojun Wu, Hailian Shi
Summary: In this study, the researchers found that ISL has anti-gastric cancer activity by inhibiting the growth of gastric cancer and regulating apoptosis-related and metabolism-related protein expression. ISL blocked glucose uptake and suppressed production and secretion of lactic acid, which was accompanied with suppressed mitochondrial oxidative phosphorylation and glycolysis but increased ROS accumulation. Additionally, ISL inhibited the cell viability of gastric cancer by depressing protein expression of c-Myc and HIF-1α, while inducing energy metabolic collapse mediated by PDHK1/PGC-1α.
Article
Medicine, Research & Experimental
Guofu Hu, Zihui Yuan, Jian Wang
Summary: This study aims to investigate the key regulator responsible for autophagy and ferroptosis, and the effects of specific pharmacological inhibitor on macrophages to alleviate atherosclerosis. Autophagy is inhibited and ferroptosis is activated in atherosclerotic lesions. The upregulated expression of HIF-1 alpha is involved in the regulation of autophagy and ferroptosis. The HIF-1 alpha inhibitor PX-478 can attenuate foam cell formation and lessen atherosclerosis by enhancing autophagy and depressing ferroptosis in macrophages.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Tian-Tian Jiang, Chao-Fan Ji, Xiu-Ping Cheng, Shao-Fei Gu, Rui Wang, Yan Li, Jian Zuo, Jun Han
Summary: MAN treatment inhibits aerobic glycolysis in AIA rats, which consequently eases inflammation-related hypoxia, and hampers pathological neovascularization. MAN has inhibitory effects on the migration and tube formation capability of both AIA rats and human umbilical vein endothelial cells.
FRONTIERS IN PHARMACOLOGY
(2021)