Review
Cell Biology
That Minh Pham, Julie Ladeby Erichsen, Justyna Magdalena Kowal, Soren Overgaard, Hagen Schmal
Summary: Patients with intra-articular fractures have significantly elevated pro-inflammatory cytokines in synovial fluid after injury, along with increased levels of anti-inflammatory cytokines. However, concentrations of IL-13, CTX-II, and aggrecan did not show significant differences between compared cohorts. Further standardized studies focusing on the ratio of pro- and anti-inflammatory cytokines at different time points are needed to better understand the inflammatory responses in intra-articular fractures.
Article
Biochemistry & Molecular Biology
Cristian Navarrete, Alejandro Riquelme, Natalia Baksai, Romina Perez, Claudia Gonzalez, Maria Michea, Hans von Muhlenbrock, Emilio A. Cafferata, Rolando Vernal
Summary: During orthodontic treatment, the production of certain substances in the periodontal tissues of teeth can affect alveolar bone remodeling and teeth movement. This study examined the production levels of certain substances in periodontal tissues of patients with reduced periodontal support undergoing orthodontic treatment. The results showed that the specific orthodontic treatment based on low-intensity intermittent forces was well tolerated by the compromised teeth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Bianka Karshikoff, Jenny Astrom, Linda Holmstrom, Mats Lekander, Mike K. Kemani, Rikard K. Wicksell
Summary: This study found that multimodal therapy significantly improved pain interference and psychological inflexibility in chronic pain patients, but did not have a significant effect on pain intensity. The levels of inflammatory cytokines in the blood plasma did not change during the treatment, but higher baseline inflammation levels were associated with less improvement in psychological inflexibility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Xiaoping Yuan, Song Wang, Yudong Shi, Yating Yang, Yulong Zhang, Lei Xia, Kai Zhang, Huanzhong Liu
Summary: This study found that chronic use of clozapine has a greater effect on the immune function of female patients with schizophrenia, resulting in abnormal expression of serum cytokines. Serum IL-2 levels were lower in female patients compared to male patients, and there was a positive correlation between serum IL-2 levels and clozapine daily dosage in female patients.
PSYCHOPHARMACOLOGY
(2022)
Article
Veterinary Sciences
Sheeba Thomas, David Francis Lappin, David Bennett, Christopher Nile, Marcello Pasquale Riggio
Summary: This study found that Feline odontoclastic resorptive lesion (FORL) can be divided into two subgroups, with FORL-1 subgroup having a less diverse oral microbiome and higher levels of proinflammatory cytokines and chemokines, which may be associated with the severity and activity of the disease.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Immunology
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'Dowd, Laura O'Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Summary: Clinical outcomes of SARS-CoV-2 infection show a wide range, from asymptomatic cases to severe pneumonia and death. This variability is influenced by differences in the immune response to the virus. A study measured inflammatory markers in patients with acute COVID-19 and found that most pro-inflammatory markers were significantly elevated, and specific markers were associated with disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Isadora de Fatima Braga Magalhaes, Ana Leticia Marinho Figueiredo, Elizeu Mendes da Silva, Adryan Adam Batalha de Miranda, Claudia Quintino da Rocha, Katia da Silva Calabrese, Fernando Almeida-Souza, Ana Lucia Abreu-Silva
Summary: A study focuses on the anti-inflammatory potential of Passovia ovata extract, which contains high levels of flavonoids. The results demonstrate significant reduction in inflammatory markers both in cell experiments and animal models. This study indicates the potential of Passovia ovata extract as a new agent for suppressing inflammatory responses.
Article
Biochemistry & Molecular Biology
Aakanksha Jha, Joseph Larkin III, Erika Moore
Summary: This study introduces a PEGDA hydrogel platform to investigate the utilization of SOCS1-KIR as a macrophage phenotype manipulating peptide. Results from immunocytochemistry, cytokine secretion assays, and gene expression analysis demonstrate a reduction in M1 activation due to SOCS1-KIR treatment. The retention of SOCS1-KIR in the hydrogel and the unaffected swelling ratio of the hydrogel are also demonstrated.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Microbiology
Marina Nosik, Konstantin Ryzhov, Irina Rymanova, Alexandr Sobkin, Alexey Kravtchenko, Ulyana Kuimova, Vadim Pokrovsky, Vitaly Zverev, Oxana Svitich
Summary: Coinfection with HIV/TB suppresses both Th1 and Th2 immune responses, leading to delayed immune recovery and potentially providing IL-6 as a potential marker for early detection of TB infection in HIV-infected individuals, with IL-1Ra emerging as a potential predictive biomarker for TB-IRIS development and treatment outcomes.
Article
Immunology
Chaolai Jiang, Zubin Zhou, Yiwei Lin, Haojie Shan, Wenyang Xia, Fuli Yin, Nan Wang, Lihui Zhou, Youshui Gao, Xiaowei Yu
Summary: AS-IV effectively alleviates ON-FH by repolarizing macrophages from M1-like phenotype to M2-like phenotype, promoting survival of osteocytes, reducing arthritic symptoms, and decreasing inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiuhua Yang, Yingying Tian, Linlin Zheng, Thanh Luu, Joanne Kwak-Kim
Summary: Recurrent pregnancy losses (RPL) is a common reproductive disorder with various underlying etiologies. Recent research has shown that the immune response, particularly the imbalance of cytokines in the maternal-fetal interface, plays a crucial role in RPL. The increased NK1/NK2 ratio in decidual NK (dNK) cells of RPL patients contributes to a pro-inflammatory cytokine milieu and increased NK cell cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Eva Biener-Ramanujan, Florian Rosier, Simon G. Coetzee, Dermot D. P. McGovern, Dennis Hazelett, Stephan R. Targan, Rivkah Gonsky
Summary: RNASET2 gene variants are associated with risk for autoimmune diseases like Crohn's disease. There is a relationship between RNASET2, T cell activation, mucosal inflammation, and disease severity. The variants are associated with decreased mRNA expression and clinical characteristics of severe Crohn's disease. The study found that the variants affect transcriptional and post-transcriptional mechanisms, and overexpression or treatment with RNASET2 can reduce IFN-gamma secretion. Preoperative RNASET2 protein levels are decreased in severe Crohn's disease patients and increase post-operatively after removal of the inflamed region.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christophe Magaud, Thomas Harnois, Stephane Sebille, Aurelien Chatelier, Jean-Francois Faivre, Patrick Bois, Guylene Page, Barnabas Gellen
Summary: This study investigates the internalization of TTR aggregates in cardiac fibroblasts and their effects on the secretion of inflammatory factors. The results show that TTR aggregates can induce the secretion of Brain Natriuretic Peptide (BNP), N-terminal pro B-type Natriuretic Peptide (NT-proBNP), interleukin-6 (IL-6), and interleukin-8 (IL-8) by cardiac fibroblasts. However, the levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remain unchanged. These findings suggest that IL-6 and IL-8 play important roles in the development of ATTR-wt and could be potential therapeutic targets.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Wu, Shanshan Li, Ran Li, Xuejiao Chen, Lingzi Guo, Ying Zheng
Summary: This research aimed to quantify pro-inflammatory cytokines from dental pulp tissue exudates to aid in the diagnosis of pulpitis and provide the foundation for vital pulp therapy. Samples were collected from different stages of chronic pulpitis and analyzed for cytokine levels. The results showed that normal pulps had low levels of IL-18 and IL-8, while TNF and IL-6 were almost undetectable.
Article
Biology
Lisa Bauer, Laurine C. Rijsbergen, Lonneke Leijten, Feline F. W. Benavides, Danny Noack, Mart M. Lamers, Bart L. Haagmans, Rory D. de Vries, Rik L. de Swart, Debby van Riel
Summary: Influenza infection leads to high levels of systemic inflammation, which contribute to morbidity and mortality. Endothelial cells play a crucial role in systemic inflammatory responses during severe influenza A virus (IAV) infections, despite being rarely infected in humans.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biochemistry & Molecular Biology
Francesco Borriello, Valentina Poli, Ellen Shrock, Roberto Spreafico, Xin Liu, Novalia Pishesha, Claire Carpenet, Janet Chou, Marco Di Gioia, Marisa E. McGrath, Carly A. Dillen, Nora A. Barrett, Lucrezia Lacanfora, Marcella E. Franco, Laura Marongiu, Yoichiro Iwakura, Ferdinando Pucci, Michael D. Kruppa, Zuchao Ma, Douglas W. Lowman, Harry E. Ensley, Etsuro Nanishi, Yoshine Saito, Timothy R. O'Meara, Hyuk-Soo Seo, Sirano Dhe-Paganon, David J. Dowling, Matthew Frieman, Stephen J. Elledge, Ofer Levy, Darrell J. Irvine, Hidde L. Ploegh, David L. Williams, Ivan Zanoni
Summary: The physical properties of microbial ligands determine the outcome of the immune response and can be utilized for vaccine development.
Article
Veterinary Sciences
Yulia Makusheva, Soo-Hyun Chung, Aoi Akitsu, Natsumi Maeda, Takumi Maruhashi, Xiao-Qi Ye, Tomonori Kaifu, Shinobu Saijo, Haiyang Sun, Wei Han, Ce Tang, Yoichiro Iwakura
Summary: Clec1A, a member of the C-type lectin receptor family, plays an important role in host defense against Aspergillus fumigatus by recognizing melanin on the fungal surface. This study found that Clec1a(-/-) mice developed milder symptoms in an animal model for multiple sclerosis, suggesting a novel function of Clec1A in the immune system. The reduced production of inflammatory cytokines may be responsible for the amelioration of the disease in Clec1a(-/-) mice.
EXPERIMENTAL ANIMALS
(2022)
Article
Biotechnology & Applied Microbiology
Tomoyuki Shimazu, Mai Suzuki, Ryo Takasaki, Asuka Besshi, Yuna Suzuki, Yoichiro Iwakura
Summary: This study investigated the relationship between lactic acid bacteria (LAB) and innate immune receptors. The researchers found that C-type lectin receptors (CLRs) are involved in the immune-stimulating function of LAB. The interaction between LAB and CLRs can reduce the levels of certain cytokines and is only observed in heat-killed LAB. These findings contribute to a better understanding of the immunomodulatory effects of LAB.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Eitoyo Kokubu, Yuichiro Kikuchi, Kazuko Okamoto-Shibayama, Kazuyuki Ishihara
Summary: This study investigated the effects of T. denticola virulence factors dentilisin and Msp on epithelial cells. The results showed that T. denticola disrupts the function of epithelial cells by hydrolyzing intercellular junction proteins and focal adhesion proteins, inhibiting cell migration and healing.
BULLETIN OF TOKYO DENTAL COLLEGE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yuri Miyai-Murai, Kazuko Okamoto-Shibayama, Toru Sato, Yuichiro Kikuchi, Eitoyo Kokubu, Jan Potempa, Kazuyuki Ishihara
Summary: The Msp protein complex and the serine protease dentilisin are the best-characterized virulence factors in Treponema denticola, the major etiological agent of chronic periodontitis. In addition, the cysteine protease dentipain also contributes to pathogenicity, but its secretion, processing, cellular localization, and role in T. denticola virulence are not fully understood. This study found that dentipain is located in the outer sheath derived from T. denticola dentilisin- and Msp-deficient mutants, suggesting that dentilisin and Msp are involved in the secretion and maturation of dentipain. Inactivation of the dentipain gene slowed the growth of T. denticola, and the mutant strain showed altered gene expression, increased hydrophobicity, reduced autoaggregation activity, and decreased adhesion to IgG.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Article
Toxicology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: In the study of polymicrobial sepsis, pro-inflammatory cytokines play a vital role in regulating hepatic drug transporter expression. The research found that both CLP and LPS can reduce the expression of drug transporters, but IL-6 is the major factor in the downregulation of hepatic multidrug transporters caused by polymicrobial sepsis.
TOXICOLOGY LETTERS
(2023)
Article
Microbiology
Yukiko Yamaguchi-Kuroda, Yuichiro Kikuchi, Eitoyo Kokubu, Kazuyuki Ishihara
Summary: This study investigated the effect of diffusible signaling molecules from P. gingivalis on F. nucleatum and revealed that these molecules induce metabolic changes in F. nucleatum, including an increase in polysaccharide synthesis and a reduction in de novo synthesis of purine and pyrimidine. These changes may accelerate biofilm formation by F. nucleatum with P. gingivalis and could serve as potential therapeutic targets for preventing dysbiosis.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Correction
Oncology
Chunyan Yu, Xiulong Niu, Yongrui Du, Yan Chen, Xiaomei Liu, Lingling Xu, Yoichiro Iwakura, Xiaoxia Ma, Yan Li, Zhi Yao, Weimin Deng
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: Sepsis affects drug metabolism and the expression of cytochrome P450s. The study shows that cecal ligation and puncture (CLP) induces the expression of proinflammatory cytokines and leads to decreased survival in IL-6(-/-) mice. CLP also downregulates the expression of Cyp2c and Cyp3a11 genes, but this effect is abolished by IL-6 depletion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takehisa Nakanishi, Shohei Iida, Junko Maruyama, Hayato Urushima, Masako Ichishi, Yoshiaki Matsushima, Kento Mizutani, Yuichi Nakayama, Kyoko Sugioka, Mai Nishimura, Ai Umaoka, Yoichiro Iwakura, Makoto Kondo, Koji Habe, Daisuke Tsuruta, Osamu Yamamoto, Yasutomo Imai, Keiichi Yamanaka
Summary: The skin is a major immune organ that produces inflammatory cytokines in response to stimuli, leading to systemic inflammation. Inflammatory skin diseases like psoriasis and atopic dermatitis can cause vascular disorders like arteriosclerosis. However, the mechanism of arteriosclerosis in dermatitis and the role of cytokines are not fully understood. This study investigates the pathophysiology of arteriosclerosis and treatment options for inflammatory skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S. P. Viall, Christa S. Zerbe, Elise M. N. Ferre, Monica M. Schmitt, Tom DiMaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, Michail S. Lionakis
Summary: The study explores the immune protection mechanisms against subcutaneous phaeohyphomycosis caused by viral particles. The researchers found that CLEC7A gene mutations are associated with susceptibility to the disease. Animal experiments further confirmed the importance of this gene in immune defense against phaeohyphomycosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Dermatology
S. Iida, T. Nakanishi, F. Momose, M. Ichishi, K. Mizutani, Y. Matsushima, A. Umaoka, M. Kondo, K. Habe, Y. Hirokawa, M. Watanabe, Y. Iwakura, Y. Miyahara, Y. Imai, K. Yamanaka
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Meeting Abstract
Respiratory System
A. Jonckheere, B. Steelant, S. Seys, T. Decaesteker, J. Cremer, E. Dilissen, D. Schols, Y. Iwakura, J. Vanoirbeek, L. Dupont, D. Bullens
EUROPEAN RESPIRATORY JOURNAL
(2022)
Letter
Dermatology
Keiichiro Mine, Xin Tun, Shinya Hatano, Naoto Noguchi, Yoichiro Iwakura, Shinichiro Sawa, Seiho Nagafuchi, Yasunobu Yoshikai, Gaofeng Wang, Jianshi Yu, Maureen A. Kane, Luis A. Garza
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Immunology
Mari T. Iwasawa, Hideaki Miyachi, Seiichiro Wakabayashi, Takashi Sugihira, Reika Aoyama, Seitaro Nakagawa, Yuki Katayama, Mitsutoshi Yoneyama, Hiromitsu Hara, Yoichiro Iwakura, Masanori Matsumoto, Naohiro Inohara, Hanako Koguchi-Yoshioka, Manabu Fujimoto, Gabriel Nunez, Hiroyuki Matsue, Yuumi Nakamura, Shinobu Saijo
Summary: This study found that IL-17A and IL-17F play critical and redundant roles in host defense against C. albicans in the epidermis through their production by ILC3s. Furthermore, clearance of C. albicans in the epidermis is independent of innate immune receptors or these receptors act redundantly in fungal recognition and clearance.
INTERNATIONAL IMMUNOLOGY
(2022)