Article
Pharmacology & Pharmacy
Miao Yan, Lin Guo, Yan Yang, Bikui Zhang, Zhenyan Hou, Yue Gao, Hongmei Gu, Hui Gong
Summary: Glycyrrhetinic acid alleviates ANIT-induced liver injury by regulating bile acid transporters, inflammation, and apoptosis, suggesting its potential as a therapeutic agent for cholestasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Toxicology
Xue Han, Chuyi Lin, Huijie Liu, Shan Li, Bei Hu, Lei Zhang
Summary: In this research, the protective effects and underlying mechanisms of allocholic acid (ACA) against cholestasis were investigated. ACA treatment effectively reduced serum indicators and ameliorated pathological injury caused by cholestasis. ACA primarily regulated BA and salt transport, as well as the signaling pathway associated with bile secretion. ACA pretreatment induced alterations in the liver BA pool, reducing the excessive accumulation of BAs and facilitating the restoration of BA homeostasis. ACA also downregulated the expression of hepatic BA synthase Cyp8b1, while enhancing the expression of hepatic and renal efflux transporters.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Plant Sciences
Mengge Shi, Jie Tang, Tong Zhang, Han Han
Summary: Swertiamarin can alleviate ANIT-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Soraya Salas-Silva, Jocelyn Lopez-Ramirez, Jonatan Barrera-Chimal, Roberto Lazzarini-Lechuga, Arturo Simoni-Nieves, Veronica Souza, Roxana U. Miranda-Labra, Felipe Masso, Marcelo G. Roma, Maria Concepcion Gutierrez-Ruiz, Leticia E. Bucio-Ortiz, Luis Gomez-Quiroz
Summary: This study demonstrates that HGF protects the kidney from damage caused by ANIT-induced cholestasis through its antioxidant properties. It reverses renal damage, decreases tubular cast formation, and controls renal oxidative stress.
Article
Plant Sciences
Jiannan Qiu, Jingyu Yan, Wei Liu, Xinzhu Liu, Jingchao Lin, Zeng Du, Li Qi, Jia Liu, Guoxiang Xie, Ping Liu, Xiaoning Wang
Summary: The study investigated the therapeutic effect of Huangqi decoction (HQD) and astragalosides on alpha-naphthylisothiocyanate (ANIT)-induced cholestasis in rats. The results showed that HQD and astragalosides treatment could alleviate the perturbation of bile acids and free fatty acids, improve liver function, and mitigate liver histopathological damage caused by ANIT.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Zhengyuan Chen, Yuhuan Wu, Bixia Wang, Jiamin Fang, Changlian Gan, Chuanlan Sang, Zhu Dun, Tajie Luosang, Qing Wang, Dawa Zeren, Tianqin Xiong
Summary: Clinical studies have shown a close relationship between intrahepatic cholestasis and intestinal injury, suggesting a disruption in the gut-liver axis. Treatment with Transmetil alleviated liver and gut injuries caused by intrahepatic cholestasis, indicating the importance of bile acids in linking the intestine and liver.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: 18-β-Glycyrrhetinic acid has promising hepatoprotective effects against cholestatic liver injury, improving liver histology and reducing oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis.
Article
Biochemistry & Molecular Biology
Shihong Zheng, Peichang Cao, Zequn Yin, Xuerui Wang, Yuanli Chen, Maoyun Yu, Baocai Xu, Chenzhong Liao, Yajun Duan, Shuang Zhang, Jihong Han, Xiaoxiao Yang
Summary: Apigenin can improve cholestasis induced by DDC by reducing inflammation and oxidative damage, and improving bile acid metabolism, indicating its potential application for cholestasis treatment.
Article
Plant Sciences
FanCheng Meng, Wei Zong, XiaoDong Wei, YunYi Tao, GuoWei Wang, ZhiHua Liao, Min Chen
Summary: This study aimed to investigate the anti-cholestasis effect of Dolomiaea souliei and its potential mechanism against acute intrahepatic cholestasis induced by ANIT. The results demonstrated that D. souliei could exert anti-cholestasis effect by activating FXR-SHP axis, inhibiting bile acid synthesis, increasing bile secretion, and alleviating inflammatory response. Costunolide may be the main active component responsible for these effects, providing a potential therapeutic mechanism for D. souliei as an anti-cholestasis medicine in cholestatic liver diseases.
Article
Cell Biology
Peijie Wu, Ling Qiao, Han Yu, Hui Ming, Chao Liu, Wenjun Wu, Baixue Li
Summary: The study demonstrates that arbutin has a protective effect on cholestatic liver injury induced by ANIT by upregulating FXR and downstream enzymes associated with bile acid homeostasis. Furthermore, the findings suggest that arbutin may be a potential chemical molecule for cholestatic diseases by partly acting through the FXR pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Imran Sohail, Naila Malkani, Nimra Tahir, Ateeb Khalil, Rukset Attar, Sidra Mumtaz
Summary: This study evaluated the anti-cholestatic effect of silymarin against ANIT-induced cholestasis. The results showed that silymarin could alleviate hepatic injury by modulating the expression of genes involved in bile acid homeostasis.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chang Wang, Fei Peng, Bohua Zhong, Ying Shi, Xiaomei Wang, Xueyuan Jin, Junqi Niu
Summary: The study showed that MBT1805 has therapeutic effects on ANIT-induced cholestasis, improving abnormal biochemical indicators, gallbladder enlargement, and histopathological changes. By regulating bile acid synthesis, biotransformation, and transport, MBT1805 helps relieve cholestasis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mega O. Oyovwi, Onome B. Oghenetega, Emojevwe Victor, Falajiki Y. Faith, Joseph Gregory Uchechukwu
Summary: The purpose of this study was to investigate the potential counteractive effects of quercetin on the reproductive capabilities of rats treated with levetiracetam. The study found that quercetin could alleviate the negative effects of levetiracetam on rat reproductive parameters.
Article
Neurosciences
Qingyun Guo, Ichiro Kawahata, Wenbin Jia, Haoyang Wang, An Cheng, Yasushi Yabuki, Norifumi Shioda, Kohji Fukunaga
Summary: This study utilized alpha Syn-derived peptides to validate their effects on alpha Syn neurotoxicity and behavioral impairments in a mouse model of Parkinson's disease. The peptides effectively prevented memory impairment and reduced the phosphorylation of alpha Syn, thereby preventing neuronal death.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Environmental Sciences
Mousa O. Germoush, Maged M. A. Fouda, Mohamed Kamel, Mohamed M. Abdel-Daim
Summary: The study demonstrated the potential therapeutic effect of Spirulina platensis against MC-LR-induced toxic effects in male Wistar rats, by alleviating oxidative damage in liver and kidneys, cardiotoxicity, and neurotoxicity. Spirulina restored normal levels of serum markers and normalized tissue antioxidant biomarkers, mitigating organ toxicities induced by MC-LR.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Xi Li, Yinan Zhang, Lingya Xu, Aoxue Wang, Yejun Zou, Ting Li, Li Huang, Weicai Chen, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang, Joseph Loscalzo, Yi Yang, Yuzheng Zhao
Summary: In this study, a highly sensitive lactate sensor called FiLa was developed, which allows for monitoring subtle lactate fluctuations in living cells and animals. It was found that lactate is highly enriched in mammalian mitochondria and functions as a key hub sensing various metabolic activities. The FiLa sensors also enable direct imaging of elevated lactate levels in diabetic mice and provide a simple, rapid, and sensitive lactate assay for clinical screening. Overall, the FiLa sensors are powerful and broadly applicable tools for studying lactate metabolism in health and disease.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for the quantification of ceramides in liver and small intestine tissues was developed and applied. The method demonstrated good sensitivity and linearity, as well as stable extraction recoveries and precision. The composition of ceramides in the two tissues provides insights for exploring biomarkers and molecular mechanisms of ceramide-related diseases.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Oncology
Zongmei Zheng, Xinxin Hou, Zhaoxiang Bian, Wei Jia, Ling Zhao
Summary: This review explores the crucial role of gut microbiota in the metastasis of colorectal cancer (CRC) and elucidates the molecular mechanisms through which gut microbiota contribute to the formation of a tumor-permissive microenvironment, as well as facilitate malignant transformation and dissemination of tumor cells, thus mediating CRC metastasis.
Article
Biotechnology & Applied Microbiology
Jiaxin Li, Yuqi Chen, Rui Li, Xianglong Zhang, Tao Chen, Fengyi Mei, Ruofan Liu, Meiling Chen, Yue Ge, Hongbin Hu, Rongjuan Wei, Zhenfeng Chen, Hongying Fan, Zhenhua Zeng, Yongqiang Deng, Haihua Luo, Shuiwang Hu, Shumin Cai, Feng Wu, Nengxian Shi, Zhang Wang, Yunong Zeng, Ming Xie, Yong Jiang, Zhongqing Chen, Wei Jia, Peng Chen
Summary: Sepsis, a global public health challenge, lacks effective treatment or intervention. This study reveals that hyodeoxycholic acid (HDCA) has excellent anti-inflammatory properties in sepsis. HDCA administration significantly decreases systemic inflammatory responses and improves the survival of septic mice. The mechanism involves the competitive blockade of lipopolysaccharide binding to TLR4 and MD-2 receptor complex by HDCA. These findings highlight the potential value of HDCA as a therapeutic molecule for sepsis.
Review
Pharmacology & Pharmacy
Kenneth Chat Pan Cheung, Ma Jiao, Xingxuan Chen, Jia Wei
Summary: This article discusses the potential of extracellular vesicles in the treatment of osteoporosis, and introduces their characteristics and application prospects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zhao
Summary: This study evaluated the effect of cinnamon extract on bowel symptoms in rat models of irritable bowel syndrome with diarrhea (IBS-D). It found that cinnamon extract reduced defecation frequency and visceral hyperalgesia in the rat models, and the efficacy was comparable to a positive drug. Furthermore, cinnamon extract directly inhibited the expression of Tph1 and controlled serotonin synthesis, providing a scientific viewpoint for the traditional use of cinnamon in treating IBS.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Yu Pi, Yujun Wu, Xiangyu Zhang, Dongdong Lu, Dandan Han, Jiangchao Zhao, Xiaojiao Zheng, Shiyi Zhang, Hao Ye, Shuai Lian, Yu Bai, Zhenyu Wang, Shiyu Tao, Dongjiao Ni, Xinhua Zou, Wei Jia, Guolong Zhang, Defa Li, Junjun Wang
Summary: In this study, the difference in fecal microbiome and bile acid (BA) profiles between low birth weight (LBW) and normal birth weight (NBW) piglets were investigated. Fecal microbiota transplantation confirmed the link between microbial BA metabolism and intestinal inflammation. The therapeutic potential of ursodeoxycholic acid (UDCA) was evaluated and it was found to alleviate intestinal inflammation through M2 macrophage polarization and suppression of inflammatory cytokines.
Article
Microbiology
Lepeng Zhou, Wen Qiu, Jie Wang, Aihua Zhao, Chuhui Zhou, Tao Sun, Ziyu Xiong, Peihua Cao, Wei Shen, Jingfen Chen, Xiaolu Lai, Liu-hong Zhao, Yue Wu, Meng Li, Feng Qiu, Yanhong Yu, Zhenjiang Zech Xu, Hongwei Zhou, Wei Jia, Yan Liao, Ravi Retnakaran, Daniel Krewski, Shi Wu Wen, Jose C. Clemente, Tianlu Chen, Ri-hua Xie, Yan He
Summary: The microbiomes of cesarean-born infants differ from vaginally delivered infants and are associated with increased disease risks. Vaginal microbiota transfer (VMT) to newborns may reverse C-section-related micro biome disturbances. In this study, VMT was found to be safe and had positive effects on infant neurodevelopment, gut microbiota maturation, and fecal metabolites.
CELL HOST & MICROBE
(2023)
Review
Immunology
Kenneth C. P. Cheung, Jiao Ma, Rodrigo Azevedo Loiola, Xingxuan Chen, Wei Jia
Summary: Bile acid-activated receptors have important roles in regulating microbiota-host immunity and may influence the development of metabolic disorders. This perspective provides a summary of regulatory pathways and mechanisms of these receptors, their impact on immune system, cell proliferation, and signaling in inflammatory diseases. It also discusses new therapeutic approaches and clinical projects on bile acids for disease treatment.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D'Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Summary: An essential function of the epidermis is to provide a physical barrier that prevents water loss. Alteration of ceramides, cholesterol, and very long chain fatty acids, mediators of this barrier function, causes human pathologies. A study shows that genetic deletion of ZFP750 in mice leads to the loss of epidermal barrier function due to a reduction in ceramides. ZFP750 directly and/or indirectly regulates the expression of enzymes involved in ceramide biosynthesis, contributing to our understanding of skin disease pathogenesis.
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Article
Biochemistry & Molecular Biology
Claire L. K. Boulange, Helle K. Pedersen, Francois-Pierre Martin, Lea Siegwald, Albert Palleja C. Caro, Aron C. Eklund, Wei Jia, Huizhen Zhang, Bernard Berger, Norbert G. Sprenger, Ralf G. Heine, CINNAMON Study Investigator Grp
Summary: Cow's milk protein allergy (CMPA) is a common food allergy in infants and young children. A study was conducted on non-breastfed infants with CMPA to assess the effects of a whey-based extensively hydrolyzed formula (EHF) supplemented with 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) on the fecal microbiome and metabolome. The supplementation of human milk oligosaccharides (HMO) enriched bifidobacteria in the gut microbiome and delayed the shift of the microbiome composition towards an adult-like pattern. HMO supplementation partially corrected the dysbiosis commonly observed in infants with CMPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Siu Leung Chau, Aihua Zhao, Wei Jia, Lu Wang
Summary: This study presents a method for rapidly detecting pesticide residues and mycotoxins in Pu-erh tea. The results showed no pesticide residues and mycotoxins detected in the collected samples, all of which were below the legal limits.
Article
Nutrition & Dietetics
Hung N. Luu, Chi Thi-Du Tran, Renwei Wang, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Huy Vu, Nam Chi Bui, Hien Thi-Thu Ha, Dung Tuan Trinh, Claire E. Thomas, Jennifer Adams-Haduch, Liudmilla Velikokhatnaya, Robert E. Schoen, Guoxiang Xie, Wei Jia, Paolo Boffetta, Jose C. Clemente, Jian-Min Yuan
Summary: The study found that colorectal advanced adenoma is associated with alterations in ileal juice bile acids. The concentrations of hyodeoxycholic acid (HCA) species in ileal juice were significantly higher in advanced adenoma patients compared to controls. The relative abundance of ursodeoxycholic acid (UDCA) in total bile acids was significantly reduced in cases than controls.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for quantifying ceramides and dihydroceramides in animal tissues has been developed. The results indicate significant differences in ceramide and dihydroceramide levels between liver and small intestine tissues, which may be related to the compositional features of ceramides.
ANALYTICAL BIOCHEMISTRY
(2023)