Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Yung Hyun Choi, Cheol Park, Cheng-Yung Jin, Chang-Hee Kang, Mi-Hwa Lee, Gi-Young Kim
Summary: The study demonstrates that Fisetin inhibits the activation of the NLRP3 inflammasome by TLR4/MD2 pathway, leading to the elimination of damaged mitochondria through p62-dependent mitophagy.
Article
Immunology
Qi Guo, Meng Zhang, Yonghui Dong, Ke Liu, Desheng Wang, Jia Zheng
Summary: Isobavachalcone (IBC), an active component isolated from Psoralea corylifolia L., has shown potential therapeutic effects on osteoarthritis (OA) by inhibiting inflammation and cartilage degeneration through the NF-KB signaling pathway. These findings suggest that IBC could be a promising therapeutic drug for treating OA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Olga Sokolova, Gunter Maubach, Michael Naumann
Summary: Helicobacter pylori infection induces a strong inflammatory response in gastric mucosa and alters epithelial integrity and function. The activation of NF-κB transcription factors, specifically by the bacterial heptose metabolites, triggers this innate immune response. Our study reveals that the activation of ALPK1-dependent TIFA in H. pylori-infected gastric epithelial cells is followed by TIFA degradation, which is inhibited by proteasomal and lysosomal inhibitors. TRAF2, TRAF6, TAK1, or NEMO are not involved in TIFA degradation, and H. pylori promotes the interaction of TIFA with protein adaptors involved in lysosomal trafficking.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Immunology
Yu Zhu, Shuiliang Ruan, Heping Shen, Qiaobing Guan, Liping Zhai, Yi Yang
Summary: The study found that oridonin protects the liver of NAFLD patients by suppressing ROS production and regulating the M1 polarization of KCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Shasha Liu, Siya Liu, Ziding Yu, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, Jinxuan Hong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang, Ji-Long Chen
Summary: This study reveals that early-stage infection with various viruses, including influenza A virus, leads to IL-6-independent phosphorylation of STAT3 Y705, which is critical for antiviral immunity. Knockin mice with STAT3Y705F/1 mutation show suppressed antiviral response, lung tissue injury, and poor survival upon IAV infection. The phosphorylation of STAT3 Y705 restrains IAV pathogenesis by repressing excessive IFN production, and blocking the phosphorylation enhances IFN expression and potentiates IAV virulence in mice. Knockout of IFNAR1 or IFNLR1 in STAT3Y705F/1 mice protects them from lung injury and reduces viral load.
Article
Medicine, Research & Experimental
Luyao Ma, Wanying Zeng, Zhiyi Tan, Rui Wang, Yi Yang, Shubin Lin, Feng Li, Shuai Wang
Summary: Through studying an experimental colitis mouse model, it was found that the increased systemic exposure of metronidazole in patients with inflammatory bowel diseases might be related to the downregulation of CYP2A5, which is regulated by the inflammatory factor NF-KB. The regulatory effect of colitis on CYP2A5 depends mainly on the disease itself, rather than the inflammatory compound, DSS.
MOLECULAR PHARMACEUTICS
(2022)
Article
Fisheries
Mengjiao Guo, Jiaqi Zhang, Mingtao Li, Xiaorong Zhang, Yantao Wu
Summary: rNLRC3 negatively regulates the NF -KB signaling pathway induced by P. multocida in rabbits by inhibiting the activation of NF -KB, reducing the expression of inflammatory cytokines, and interacting with rTRAF4 and rTRAF6. The NACHT-LRR domain is the functional domain of rNLRC3. These findings provide insights into the important role of rNLRC3 in combating P. multocida infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ok-Joo Sul, Seung Won Ra
Summary: The study revealed that quercetin can reduce oxidative stress and inflammation by suppressing NOX2 production, effectively reducing ROS-induced oxidative stress and inflammation.
Article
Food Science & Technology
Yan Zheng, Xing Wang, Ya-Jing Pan, Xiao-Feng Shi, Lei Yang, Yong-Liang Lou
Summary: In this study, it was found that Ori inhibits the production and activation of osteoclasts induced by RANKL, and reduces intracellular ROS levels by activating ROS-scavenging enzymes. It also downregulates the expression of c-Fos, NFATc1, CTSK, and NFATc2, which are genes and proteins unique to osteoclasts, by inhibiting RANKL-induced NF-κB. In the animal model, Ori therapy restores bone mass and improves microarchitecture.
FOOD SCIENCE & NUTRITION
(2023)
Article
Immunology
Xiangyu Wang, Quanbo Ji, Wenhao Hu, Zhifa Zhang, Fanqi Hu, Shiqi Cao, Qi Wang, Yongyu Hao, Meng Gao, Xuesong Zhang
Summary: Our study demonstrates that isobavachalcone (ISO) can prevent osteoporosis by inhibiting the activation of ERK and NF-KB signaling pathways, as well as M1 polarization of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yingxiang Li, Chengdong Liu, Luke Rolling, Veronica Sikora, Zhimin Chen, Jack Gurwin, Caroline Barabell, Jiandie Lin, Cunming Duan
Summary: We investigated the reactivation of quiescent cells through a zebrafish model and observed an increase in mitochondrial membrane potential in the reactivated cells. Genetic and pharmacological perturbations revealed that elevated mitochondrial metabolism and ATP synthesis are crucial for cell reactivation. Further analysis showed that the elevated mitochondrial metabolism leads to increased mitochondrial ROS levels, which induce the expression of Sgk1 in the mitochondria. Sgk1, in turn, promotes S phase entry in human breast cancer cells by coordinating mitochondrial activity with ATP synthesis through phosphorylating F1Fo-ATP synthase.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Daishui Yang, Yejun Tan, Xi Xie, Wenbiao Xiao, Jin Kang
Summary: This study aimed to explore the pharmacological properties of zingerone (ZO) in attenuating osteoclast-mediated periprosthetic osteolysis and how ZO modulates osteoclas-togenesis. The results showed that ZO has an obvious inhibitory effect on osteoclastogenesis and bone resorption in a dose-dependent manner by mainly suppressing the activation of NF-KB signaling pathways. Furthermore, ZO administration successfully attenuated titanium (Ti) particle-stimulated periprosthetic osteolysis and osteoporosis by regulating osteoclast formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Fisheries
Xiaomeng Ren, Han Zhang, Xiaolong Yan, Yuena Sun, Tianjun Xu
Summary: The study found that NOP56 acts as a negative regulator of the MyD88-mediated NF-KB signaling pathway by inhibiting MyD88 protein expression, providing new insights into the regulatory mechanism in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Ana Sofia Martelli Chaib Saliba, Alan Giovanini de Oliveira Sartori, Pollyanna Souza Batista, Jose Eduardo Pedroso Gomes do Amaral, Namuhell Oliveira da Silva, Masaharu Ikegaki, Pedro Luiz Rosalen, Severino Matias de Alencar
Summary: This study aimed to investigate the impact of gastrointestinal digestion/Caco-2 cell transport on the biological activities and toxicity of ethanolic extract of organic propolis from southern Brazil (EEOP1). The results demonstrated that EEOP1 deactivated reactive oxygen species and attenuated the activation of transcription factors, while also reducing the release of pro-inflammatory cytokines. Additionally, the phytochemical profile of EEOP1 changed after digestion, and antimicrobial activity was only observed in the non-digested form.
Article
Biochemistry & Molecular Biology
Shuye Lin, Hongyun Ruan, Lin Qin, Cong Zhao, Meng Gu, Ziyu Wang, Bin Liu, Haichao Wang, Jinghui Wang
Summary: This study investigated the epigenetic effects of MUC17 in acquired drug-resistant cells of EGFR-TKIs. In gefitinib/osimertinib-resistant (GR/OR) cells, downregulation of MUC17 was mediated by promoter methylation promoted by the DNMT1/UHRF1 complex, leading to activation of NF-kappa B activity. MUC17 acted as an epigenetic sensor for monitoring resistance to EGFR-TKIs in GR/OR cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Olga Kim, Jung Hwan Yoon, Won Suk Choi, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Jung Young Lee, Won Sang Park
Article
Oncology
Jung Hwan Yoon, Won Suk Choi, Olga Kim, Byung Joon Choi, Suk Woo Nam, Jung Young Lee, Won Sang Park
Article
Oncology
Olga Kim, Jung Hwan Yoon, Won Suk Choi, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Jung Young Lee, Won Sang Park
Article
Oncology
Jung Hwan Yoon, In-Hye Ham, Olga Kim, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Jung Young Lee, Hoon Hur, Won Sang Park
Article
Gastroenterology & Hepatology
Jung Hwan Yoon, Yeon Soo Lee, Olga Kim, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Won Sang Park
WORLD JOURNAL OF GASTROENTEROLOGY
(2019)
Review
Oncology
Jaeyeon Kim, Eun Young Park, Olga Kim, Jeanne M. Schilder, Donna M. Coffey, Chi-Heum Cho, Robert C. Bast
Article
Genetics & Heredity
Olga Kim, Eun Young Park, David L. Klinkebiel, Svetlana D. Pack, Yong-Hyun Shin, Zied Abdullaev, Robert E. Emerson, Donna M. Coffey, Sun Young Kwon, Chad J. Creighton, Sanghoon Kwon, Edmund C. Chang, Theodore Chiang, Alexander N. Yatsenko, Jeremy Chien, Dong-Joo Cheon, Yang Yang-Hartwich, Harikrishna Nakshatri, Kenneth P. Nephew, Richard R. Behringer, Facundo M. Fernandez, Chi-Heum Cho, Barbara Vanderhyden, Ronny Drapkin, Robert C. Bast, Kathy D. Miller, Adam R. Karpf, Jaeyeon Kim
Article
Multidisciplinary Sciences
Olga Kim, Eun Young Park, Sun Young Kwon, Sojin Shin, Robert E. Emerson, Yong-Hyun Shin, Francesco J. DeMayo, John P. Lydon, Donna M. Coffey, Shannon M. Hawkins, Lawrence A. Quilliam, Dong-Joo Cheon, Facundo M. Fernandez, Kenneth P. Nephew, Adam R. Karpf, Martin Widschwendter, Anil K. Sood, Robert C. Bast, Andrew K. Godwin, Kathy D. Miller, Chi-Heum Cho, Jaeyeon Kim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Oncology
Alice Ranjan, Ying Pang, Madison Butler, Mythili Merchant, Olga Kim, Guangyang Yu, Yu-Ting Su, Mark R. Gilbert, David Levens, Jing Wu
Summary: Inhibiting CDK9 can impact cancer cell survival pathways and may improve clinical outcomes, especially in highly resistant cancers like glioblastoma.
Article
Oncology
Guangyang Yu, Ying Pang, Mythili Merchant, Chimene Kesserwan, Vineela Gangalapudi, Abdalla Abdelmaksoud, Alice Ranjan, Olga Kim, Jun S. Wei, Hsien-Chao Chou, Xinyu Wen, Sivasish Sindiri, Young K. Song, Liqiang Xi, Rosandra N. Kaplan, Terri S. Armstrong, Mark R. Gilbert, Kenneth Aldape, Javed Khan, Jing Wu
Summary: The study found that TMB was not correlated with immune score in IDH-mutant gliomas, while in IDH-wildtype tumors, TMB was positively correlated with expressed neoantigens but inversely correlated with immune score. The Antigen Processing and Presentation (APP) score may have potential as a biomarker for immune therapy response in gliomas.
Article
Oncology
Samyukta Sah, Xin Ma, Andro Botros, David A. Gaul, Sylvia R. Yun, Eun Young Park, Olga Kim, Samuel G. Moore, Jaeyeon Kim, Facundo M. Fernandez
Summary: This study investigated the serum metabolomic and spatial lipidomic profiles of an ovarian cancer mouse model, revealing temporal trends of lipid classes, amino acids, and TCA cycle metabolites associated with HGSC progression. The results highlight the critical role of lipid and fatty acid metabolism, amino acid biosynthesis, TCA cycle, and ovarian steroidogenesis in the onset and development of HGSC.
Article
Oncology
Mythili Merchant, Margarita Raygada, Ying Pang, Martha Quezado, Mark Raffeld, Liqiang Xi, Jung Kim, Manoj Tyagi, Zied Abdullaev, Olga Kim, Zach Sergi, Tina Pillai, Byram Ozer, Kareem Zaghloul, John D. Heiss, Terri S. Armstrong, Mark R. Gilbert, Kenneth Aldape, Jing Wu
Summary: Most tumors, including brain tumors, occur sporadically. However, there is a small subset of central nervous system tumors that are associated with Lynch Syndrome. This report presents a rare case of an oligodendroglioma with a PMS2 mutation associated with Lynch Syndrome. The limited literature on germline PMS2 mutations and oligodendrogliomas highlights the importance of genetic testing in neuro-oncology.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samyukta Sah, Sylvia R. Yun, David A. Gaul, Andro Botros, Eun Young Park, Olga Kim, Jaeyeon Kim, Facundo M. Fernandez
Summary: In this study, a targeted microchip CE-HRMS method was developed to analyze multiple metabolites in mouse serum samples, revealing metabolic alterations during the development and progression of high-grade serous carcinoma.
Article
Oncology
Ying Pang, Guangyang Yu, Madison Butler, Sivasish Sindiri, Young K. Song, Jun S. Wei, Xinyu Wen, Hisen-Chao Chou, Martha Quezado, Svetlana Pack, Liqiang Xi, Zied Abdullaev, Olga Kim, Alice Ranjan, Mythili Merchant, Ramya Antony, Lisa Boris, Orwa Aboud, David Kamson, Rosandra Kaplan, Megan Mackey, Kevin Camphausen, Kareem Zaghloul, Terri S. Armstrong, Mark R. Gilbert, Kenneth Aldape, Matthias Holdhoff, Javed Khan, Jing Wu
JCO PRECISION ONCOLOGY
(2021)
