Article
Oncology
Lei Chen, Luzeng Chen, Zhenwei Liang, Yuhong Shao, Xiuming Sun, Jinghua Liu
Summary: This study evaluated the diagnostic performance of preoperative contrast-enhanced ultrasound (CEUS) in detecting extracapsular extension (ECE) and cervical lymph node metastasis (LNM) of papillary thyroid carcinoma (PTC) and the added value of CEUS compared to conventional ultrasound (US) in evaluating PTC invasiveness. The results showed that the combination of US and CEUS had higher diagnostic accuracy and is recommended for the detection of ECE and LNM of PTC. CEUS plays an important role in the preoperative evaluation of PTC invasiveness.
FRONTIERS IN ONCOLOGY
(2022)
Article
Hematology
Zhi-Yan Luo, Yu-Rong Hong, Cao-Xin Yan, Yong Wang, Qin Ye, Pintong Huang
Summary: Quantitative CEUS parameters can provide more information to distinguish metastatic from benign LNs in PTC patients; In particular, DT/2 and AUC have a higher sensitivity and accuracy in predicting the presence of metastatic LNs and reduce unnecessary sampling of benign LNs.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2022)
Article
Medicine, General & Internal
Liqing Jiang, Shiyan Guo, Yongfeng Zhao, Zhe Cheng, Xinyu Zhong, Ping Zhou
Summary: This study aimed to establish a novel clinical-radiomics nomogram based on B-mode ultrasound (BMUS) and contrast-enhanced ultrasound (CEUS) for the prediction of extrathyroidal extension (ETE) in papillary thyroid carcinoma (PTC). The results showed that the clinical-radiomics model had the best diagnostic efficiency in both the training set and validation set, and a clinical-radiomics nomogram was established for easier clinical practices.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Zhang, Xia Zhang, Jie Li, Qian Cai, Zhi Qiao, Yu kun Luo
Summary: CEUS is a more valuable and non-invasive imaging modality compared to conventional US in detecting extracapsular extension in papillary thyroid carcinoma. Single capsular invasion was a poor predictor of cervical lymph node metastasis, while extracapsular extension assessments were clinically significant for predicting cervical lymph node metastasis. Among the thyroid papillary carcinoma nodules with differential enhancement, hyper-enhanced nodules had the highest incidence of single capsule invasion (41.9%), while hypo-enhanced ones had a higher incidence of ECE (47.4%).
EUROPEAN RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Wen Li, Shusheng Qiu, Ling Ren, Qiuyang Li, Shaowei Xue, Jie Li, Yan Zhang, Yukun Luo
Summary: This study aimed to investigate the associations between lymph node metastases (LNMs) and primary tumor's ultrasound (US) and contrast-enhanced ultrasound (CEUS) characteristics in papillary thyroid carcinoma (PTC). The results showed that young age, male, large size, calcification, and hyper-enhancement were independent predictors of clinical N1, while young age, large size, and multifocality were independent predictors of microscopic N1.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Fengkai Fang, Yi Gong, Liyan Liao, Fei Ye, Zhongkun Zuo, Xiaodu Li, Qi Zhang, Kui Tang, Yan Xu, Rongsen Zhang, Sijie Chen, Chengcheng Niu
Summary: The aim of this study was to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in distinguishing between benign and malignant cervical lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). The results showed that preoperative CEUS characteristics can serve as a useful tool in identifying malignant cervical LNs from benign ones.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Pengyi Yu, Xinxin Wu, Jingjing Li, Ning Mao, Haicheng Zhang, Guibin Zheng, Xiao Han, Luchao Dong, Kaili Che, Qinglin Wang, Guan Li, Yakui Mou, Xicheng Song
Summary: This study developed a radiomics nomogram based on CT images to predict ETE in PTC patients. The results showed that the nomogram had good performance in both the internal and external test sets, providing utility in identifying ETE.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Liqing Jiang, Zijian Zhang, Shiyan Guo, Yongfeng Zhao, Ping Zhou
Summary: Improving the accuracy of preoperative assessment of lymph node metastasis (LNM) is crucial for determining the scope of PTC surgery and reducing complications. This study demonstrated that radiomics analysis based on contrast-enhanced ultrasound (CEUS) provides incremental value to the prediction and management of LNM in PTC. The developed clinical-radiomics nomogram showed promising value for predicting LNM and can be used as an effective tool for preoperative prediction of LNM.
Article
Endocrinology & Metabolism
Fei Ye, Yi Gong, Kui Tang, Yan Xu, Rongsen Zhang, Sijie Chen, Xiaodu Li, Qi Zhang, Liyan Liao, Zhongkun Zuo, Chengcheng Niu
Summary: This study evaluated the diagnostic value of lymph node ultrasonography in distinguishing between benign and malignant central cervical lymph nodes in patients with papillary thyroid carcinoma. The results showed that ultrasonography features and clinical features can help differentiate between malignant and benign lymph nodes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiaojiao Ma, Yuan Wang, Xuehua Xi, Jiajia Tang, Linping Wang, Liangkai Wang, Di Wang, Xiaolong Liang, Bo Zhang
Summary: A targeted microbubble was successfully designed and prepared for the specific ultrasound imaging diagnosis of highly aggressive papillary thyroid cancer. The targeted microbubbles showed good stability, biosafety, and high targeting specificity, significantly improving the tumor signal-to-noise ratio of highly invasive PTC and facilitating accurate diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen Li, Yi Li, Mei Long, Jie Li, Jun Ma, Yukun Luo
Summary: In this study, the prognostic value of vascularity in papillary thyroid cancer (PTC) was investigated using contrast-enhanced ultrasound (CEUS). Hypervascularity depicted by CEUS was found to be independently associated with structural recurrence in patients with classic PTC.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Fengkai Fang, Yi Gong, Liyan Liao, Fei Ye, Zhongkun Zuo, Zhang Qi, Xiaodu Li, Chengcheng Niu
Summary: The study found that compared to benign nodular goiters, PCPTCs more frequently presented with calcification, hypoechogenicity of the solid part, hypoenhancement, heterogeneous enhancement, centrifugal perfusion, among other ultrasound and CEUS characteristics.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lingli Xiao, Jianhua Zhou, Wen Tan, Ying Liu, Haoming Zheng, Guanying Wang, Wei Zheng, Xiaoqing Pei, Ankui Yang, Longzhong Liu
Summary: This study demonstrated that the postvascular phase of CEUS with perfluorobutane had excellent performance in diagnosing suspicious small lateral cervical LNs in patients with PTC. It showed improved diagnostic value compared to traditional ultrasonography alone. Overall, this study highlights the importance of utilizing contrast-enhanced US for better diagnosis of metastatic LNs in PTC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Peidi Zhang, Haijing Liu, Xiao Yang, Lina Pang, Fen Gu, Jiani Yuan, Lei Ding, Jun Zhang, Wen Luo
Summary: This study compared the contrast-enhanced ultrasound (CEUS) features of inflammatory thyroid nodules and papillary thyroid carcinomas using time-intensity curve (TIC) analysis. The results showed that the heterogeneous hypo-enhancement CEUS pattern was predominant in inflammatory nodules, while the concentric hypo-enhancement pattern was identified as a valuable predictive pattern for papillary carcinomas. TIC parameters revealed that inflammatory nodules had a lower peak intensity and a smaller maximum slope rate of the ascending curve, compared with papillary carcinomas.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Endocrinology & Metabolism
Sijie Chen, Chengcheng Niu, Qinghai Peng, Kui Tang
Summary: This study evaluated the sonographic characteristics of papillary thyroid carcinoma (PTC) with Hashimoto's thyroiditis (HT) and found that factors like patient age, nodule size, shape, calcification, and vascularity were associated with central lymph node metastasis (CLNM). Preoperative ultrasound characteristics can help predict CLNM in PTCs with coexistent HT.
FRONTIERS IN ENDOCRINOLOGY
(2021)