Article
Medicine, General & Internal
Yan Lu, Jianfeng Hua, Fengqin Yan, Chuner Jiang, Yongfeng Piao, Zhimin Ye, Zhenfu Fu, Haitao Jiang, Fangzheng Wang, Yangming Jiang
Summary: In elderly patients aged 65 years and older with nasopharyngeal carcinoma, the combination of radiation therapy and chemotherapy resulted in longer overall survival compared to radiation therapy alone. Additionally, this combination treatment showed a better correlation with overall survival and cancer-specific survival in patients with stage T3 or N2 or stage III.
Article
Oncology
Jiyi Hu, Qingting Huang, Jing Gao, Weixu Hu, Jing Yang, Xiyin Guan, Xianxin Qiu, Wenna Zhang, Lin Kong, Jiade J. Lu
Summary: The study demonstrated that the combination of IMRT with CIRT boost therapy provides excellent disease control and favorable toxicity profile for patients with non-metastatic nasopharyngeal carcinoma. The results suggest that this mixed treatment strategy is safe and well-tolerated, with promising outcomes in terms of disease control.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jie Wu, Yu-Chen Wang, Wen-Jie Luo, Bo-Dai, Ding-Wei Ye, Yi-Ping Zhu
Summary: Surgery for non-metastatic PUC patients provides a survival advantage, with better 5-year survival rates and lower cancer-specific mortality rates for patients who undergo surgery at the primary site.
Article
Oncology
Huifang Zuo, Min-Min Li
Summary: This study establishes and validates two prognostic nomograms for assessing long-term overall survival and cancer-specific survival in non-metastatic nasopharyngeal carcinoma patients and investigates treatment options based on risk stratification subgroups. The results demonstrate the potential of the nomograms for prognosis assessment and individualized treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Bassel Nazha, Chao Zhang, Zhengjia Chen, Camille Ragin, Taofeek K. Owonikoko
Summary: The study found that previous androgen deprivation therapy in prostate cancer patients is associated with longer survival when they subsequently develop lung cancer. These findings indicate a potential role of the androgen receptor in lung cancer.
Article
Surgery
Lingyu Han, Weixing Dai, Shaobo Mo, Wenqiang Xiang, Qingguo Li, Ye Xu, Guoxiang Cai, Renjie Wang
Summary: The study found that patients with metastatic colorectal cancer demonstrated a substantial increase in conditional survival over time. Factors affecting survival may change gradually, and nomograms based on survival time can accurately predict survival for patients with mCRC.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Oncology
Jie Zhou, Zhenyu Jiang, Yunhao Li, Xuwen Shao, Haihong Liao
Summary: Although NPC remains the leading cause of death after NPC diagnosis, other non-NPC causes of death represent an increased number of death in NPC patients. These findings support the involvement of multidisciplinary care for follow-up strategy in NPC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Benedikt Hoeh, Christoph Wuernschimmel, Rocco S. Flammia, Benedikt Horlemann, Gabriele Sorce, Francesco Chierigo, Zhe Tian, Fred Saad, Markus Graefen, Michele Gallucci, Alberto Briganti, Carlo Terrone, Shahrokh F. Shariat, Derya Tilki, Luis A. Kluth, Philipp Mandel, Felix K. H. Chun, Pierre I. Karakiewicz
Summary: Chemotherapy was associated with improved overall survival for metastatic prostate cancer patients in a real-world population-based cohort, although the magnitude of survival benefit was not comparable to phase 3 trials.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuan Zhou, Dan Wang, Fengbo Tan, Zhongyi Zhou, Lilan Zhao, Cenap Guengoer, Qian Pei, Yuqiang Li, Wenxue Liu
Summary: The role of radiotherapy in rectal cancer metastasis is associated with the site of metastasis, and it may only provide survival benefit for patients with rectal liver-limited metastasis.
Article
Medicine, Research & Experimental
Yali Xu, Taoyuan Huang, Min Mao, Jinming Zhai, Jinhai Chen
Summary: The study evaluated prognostic factors and distant metastatic patterns in de novo metastatic nasopharyngeal carcinoma patients, with liver metastasis identified as an independent predictor for poor cancer-specific survival and overall survival.
Article
Oncology
Jeremiah Wala, Paul Nguyen, Mark Pomerantz
Summary: The Oncology Grand Rounds series aims to provide clinical context for original reports published in the Journal of Clinical Oncology. This article discusses the use of androgen deprivation therapy (ADT) and the recent advancements in treatment for metastatic hormone-sensitive prostate cancer (mHSPC). The addition of second-generation oral androgen-receptor pathway inhibitors (ARPIs) or docetaxel to ADT has shown improved outcomes, and studies are also examining the role of radiotherapy (RT) in mHSPC.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Zhen-Chong Yang, Mei-Juan Luo, Xue-Song Sun, Li-Ting Liu, Qiu-Yan Chen, Hai-Qiang Mai, Shan-Shan Guo
Summary: This study evaluated the suitability of radiation therapy and liver local therapy for patients with lmNPC. The results showed that radiation therapy may be beneficial for lmNPC patients regardless of the tumor response after chemotherapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Lara Franziska Stolzenbach, Giuseppe Rosiello, Marina Deuker, Thomas Martin, Sophie Knipper, Zhe Tian, Alberto Briganti, Kevin C. Zorn, Fred Saad, Felix K. H. Chun, Markus Graefen, Pierre I. Karakiewicz
Summary: The study indicates that metastatic prostate cancer patients with intermediate life expectancy and low PSA levels may benefit from external beam radiation therapy (EBRT) in reducing overall mortality, especially in M1a and M1b sub-stages. It is suggested to consider EBRT treatment more in these patients, but study limitations should be taken into account until clinical trials confirm the potential benefits.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Jing Jia, Wenming Chen
Summary: This study evaluated the role of radiation therapy (RT) in primary tonsil diffuse large B cell lymphoma (PT-DLBCL) using the SEER database, finding a favorable survival outcome in early stages rather than advanced stages. A prognostic model was established to identify high-risk patients and improve prognosis.
RADIATION ONCOLOGY
(2021)
Article
Urology & Nephrology
Jiafeng Shou, Qi Zhang, Dahong Zhang
Summary: The study investigated the impact of different distant metastases patterns on the survival of patients with stage IV bladder cancers. The results showed that bone was the most common site of single metastasis, while patients with liver metastasis had worse survival outcomes compared to other distant metastases. Understanding these differences can help guide pre-treatment evaluation and interventions for bladder cancer.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guang Ma, Bingxin Gu, Jiyi Hu, Lin Kong, Jiangang Zhang, Zili Li, Yangbo Xue, Jiade Lu, Junning Cao, Jingyi Cheng, Yingjian Zhang, Shaoli Song, Zhongyi Yang
Summary: The study examined the value of pretreatment F-18-FDG uptake heterogeneity in predicting the prognosis of locally recurrent nasopharyngeal carcinoma (LRNPC) patients treated with carbon ion radiotherapy (CIRT). Results showed that F-18-FDG uptake heterogeneity, particularly with a HI>=0.81, was significantly associated with poorer LRFS and PFS outcomes, indicating its potential as an independent predictor for LRNPC patients undergoing CIRT.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shubing Jia, Jian Chen, Ningyi Ma, Jingfang Zhao, Jingfang Mao, Guoliang Jiang, Jiade Lu, Kailiang Wu
Summary: This study demonstrates the dosimetric benefits of adaptive carbon ion radiotherapy (CIRT) for locally advanced non-small cell lung cancer (LANSCLC) and compares the differences between patients with and without adaptive plans. The results show that adaptive plans can ensure target coverage and reduce spinal cord dose. Patients with adaptive plans have larger tumor volumes and greater volume changes. iGTV volume changes and iGTV center movements are the main factors influencing adaptive planning.
Article
Oncology
Fangzhu Wan, Haojiong Zhang, Jiyi Hu, Li Chen, Shikai Geng, Lin Kong, Jiade J. Lu
Summary: This study identified miR-125a as highly expressed in normal nasopharyngeal epithelial tissue compared to nasopharyngeal carcinoma. It demonstrated that miR-125a inhibits the migration and vasculogenic mimicry (VM) formation in nasopharyngeal carcinoma cells, targeting TAZ. Additionally, artificial engineering of mesenchymal stem cells (MSCs) allowed the generation of miR-125a-overexpressing exosomes which attenuated VM formation and migration in nasopharyngeal carcinoma, providing a potential therapeutic approach.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ophthalmology
Jingli Guo, Xianxin Qiu, Wenyi Tang, Gezhi Xu, Michael F. Moyers, Wei Ren, Ying Xing, Jin Gao, Jiayao Sun, Jiade Lu, Lin Kong, Wei Liu
Summary: The study demonstrates that PBI combined with IVC may help promote regression and closure of polyps in PCV, reduce central macular thickness, and improve BCVA with good safety profile after 12 months. Hence, PBI may be a useful adjuvant therapy for patients with refractory or recurrent PCV.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Oncology
Dong Yang, Weiwei Wang, Jiyi Hu, Weixu Hu, Xiyu Zhang, Xiaodong Wu, Jiade J. Lu, Lin Kong
Summary: This study investigated the feasibility of lattice radiotherapy (LRT) using proton or carbon-ion beams in the treatment of sinonasal malignancies. The results showed that proton and carbon-ion LRT plans can better protect critical organs compared to photon LRT plans, despite minimal differences in PVDR.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Robert L. Foote, Hirohiko Tsujii, Reiko Imai, Hiroshi Tsuji, Eugen B. Hug, Tatsuaki Kanai, Jiade J. Lu, Juergen Debus, Rita Engenhart-Cabillic, Anita Mahajan
Summary: As of December 31, 2020, there were 12 facilities in Asia and Europe providing carbon ion radiotherapy (CIRT) for cancer patients, with a total of 37,548 patients treated worldwide. The absence of CIRT facilities in the U.S. limits access to this treatment for American cancer patients and prevents their inclusion in phase III clinical trials, which are essential for FDA approval and insurance coverage. Overcoming this barrier would require establishing a limited number of CIRT facilities in the U.S.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaofeng Xu, Peiru Zhang, Yangle Huang, Weizhong Shi, Jingfang Mao, Ningyi Ma, Lin Kong, Lin Guo, Jinlong Liu, Jian Chen, Renquan Lu
Summary: This study found that the levels of METTL3 and its mediated m6A modification were elevated in non-small-cell lung cancer (NSCLC) cells treated with carbon-ion radiotherapy. Knockdown of METTL3 impaired cell proliferation, migration, invasion, and enhanced DNA damage repair and cell survival.
Article
Cell Biology
Vivek Kumar, Mohit Vashishta, Lin Kong, Jiade J. Lu, Xiaodong Wu, Bilikere S. Dwarakanath, Chandan Guha
Summary: Photon-based radiotherapy and carbon ion radiotherapy have different effects on Notch signaling in glioma cells. Carbon ion radiotherapy regulates the expression of Notch signaling and reduces stemness and cell migration. These findings may contribute to reducing tumor regrowth and disease dissemination.
Article
Cell Biology
Qilin Zhang, Lijiang Fei, Rui Han, Ruofan Huang, Yongfei Wang, Hong Chen, Boyuan Yao, Nidan Qiao, Zhe Wang, Zengyi Ma, Zhao Ye, Yichao Zhang, Weiwei Wang, Ye Wang, Lin Kong, Xuefei Shou, Xiaoyun Cao, Xiang Zhou, Ming Shen, Haixia Cheng, Zhenwei Yao, Chao Zhang, Guoji Guo, Yao Zhao
Summary: By performing single-cell RNA sequencing, we revealed the cellular hierarchies of skull base chordoma (SBC) and identified potential targets and drugs for the treatment of SBC.
Article
Immunology
Wanzun Lin, Jing Gao, Haojiong Zhang, Li Chen, Xianxin Qiu, Qingting Huang, Jiyi Hu, Lin Kong, Jiade J. Lu
Summary: This study classified lower-grade glioma (LGG) into inflammation-, low, -mid, and -high subtypes based on the inflammatory response, which have distinct clinicopathologic features, prognosis, and tumor microenvironment. An inflammation-related prognostic model was also established with strong predictive power for prognosis assessment.
INFLAMMATION AND REGENERATION
(2022)
