Hepatocyte-secreted extracellular vesicles modify blood metabolome and endothelial function by an arginase-dependent mechanism

Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice

(2016) Jason M. Aliotta et al.   CARDIOVASCULAR RESEARCH

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

(2016) Petra Hirsova et al.   GASTROENTEROLOGY

Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs

(2015) Hartmut Grasemann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Arterial Hypertension in Rats Due to Age-Related Arginase Activation in Intermittent Hypoxia

(2015) Akina Nara et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus

(2015) J Pernow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cell-derived extracellular vesicles as a platform to identify low-invasive disease biomarkers

(2015) Esperanza González et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension

(2015) Kurt R. Stenmark et al.   JOURNAL OF APPLIED PHYSIOLOGY

Antioxidants and vascular health

(2015) Alessandra Bielli et al.   LIFE SCIENCES

Arginase: an old enzyme with new tricks

(2015) Ruth B. Caldwell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Arginine Metabolic Endotypes in Pulmonary Arterial Hypertension

(2015) Christina C. Kao et al.   Pulmonary Circulation

DERA is the human deoxyribose phosphate aldolase and is involved in stress response

(2014) Lisa Salleron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicity

(2014) Eva Rodríguez-Suárez et al.   Journal of Proteomics

Metabolomic analysis of arginine metabolism in acute hepatic injury in rats

(2014) Wataru Saitoh et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicity

(2014) Eda Ozcelik et al.   Pharmacognosy Magazine

Human liver stem cells and derived extracellular vesicles improve recovery in a murine model of acute kidney injury

(2014) Maria Sanchez et al.   Stem Cell Research & Therapy

Nitric Oxide Deficiency and Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2013) James R. Klinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transcriptome of Extracellular Vesicles Released by Hepatocytes

(2013) Felix Royo et al.   PLoS One

Microparticles and acute lung injury

(2012) Mark McVey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

(2012) Alexey Shemyakin et al.   CIRCULATION

Cellular microparticles in the pathogenesis of pulmonary hypertension

(2012) Nicolas Amabile et al.   EUROPEAN RESPIRATORY JOURNAL

Different patterns of pulmonary vascular disease induced by type 1 diabetes and moderate hypoxia in rats

(2012) Javier Moral-Sanz et al.   EXPERIMENTAL PHYSIOLOGY

Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients With Cirrhosis

(2012) Pierre–Emmanuel Rautou et al.   GASTROENTEROLOGY

Human liver stem cells improve liver injury in a model of fulminant liver failure

(2012) Maria Beatriz Herrera et al.   HEPATOLOGY

A Performance Evaluation of Three Drug-Induced Liver Injury Biomarkers in the Rat: Alpha-Glutathione S-Transferase, Arginase 1, and 4-Hydroxyphenyl-Pyruvate Dioxygenase

(2012) Wendy J. Bailey et al.   TOXICOLOGICAL SCIENCES

Identification of agents that reduce renal hypoxia–reoxygenation injury using cell-based screening: Purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia

(2011) Petra Szoleczky et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity

(2011) Esperanza Gonzalez et al.   Metabolomics

Circulating Microparticles from Pulmonary Hypertensive Rats Induce Endothelial Dysfunction

(2010) Simon Tual-Chalot et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Overview of extracellular microvesicles in drug metabolism

(2010) Javier Conde-Vancells et al.   Expert Opinion on Drug Metabolism & Toxicology

Metabolomics: an integral technique in systems biology

(2010) Wolfram Weckwerth   Bioanalysis

Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats

(2009) M. B. Herrera et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Antioxidant Combination Inhibits Reactive Oxygen Species Mediated Damage

(2008) Nobuya YANAI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

(2008) Javier Conde-Vancells et al.   JOURNAL OF PROTEOME RESEARCH

Arginase blockade protects against hepatic damage in warm ischemia-reperfusion

(2008) Geetha Jeyabalan et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY