Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songuel Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci Ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study aimed to investigate the association between bisphenol A (BPA), 25-hydroxy vitamin D [25(OH)D], and 1 alpha,25 dihydroxy vitamin D [1,25( OH)(2)D] levels in cord blood of newborn babies. The results showed that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but there is no correlation between BPA levels and vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songul Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study investigated the association between BPA, 25(OH)D, and 1,25(OH)(2)D levels in cord blood of newborn babies. The study found that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but BPA levels were not correlated with vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nutrition & Dietetics
Xirui Wang, Xianting Jiao, Ying Tian, Jun Zhang, Yue Zhang, Juan Li, Fan Yang, Mingqing Xu, Xiaodan Yu
Summary: Maternal vitamin D concentrations in each trimester are positively associated with neonatal vitamin D status in cord blood, with the strongest correlation found in the late stage of pregnancy. This suggests that attention to vitamin D nutrition during pregnancy can help prevent vitamin D deficiency in newborns.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Nutrition & Dietetics
Hye Ran Shin, Hyeon Ju Park, Sun Yung Ly
Summary: Vitamin D deficiency is prevalent among young Korean women. This study aimed to determine the optimal vitamin D intake level for maintaining adequate serum 25-hydroxyvitamin D (25[OH]D) levels in young Korean women throughout different seasons. The study identified seasonal factors influencing 25(OH)D levels, calculated the necessary vitamin D intake for sufficient levels, and analyzed the relationship between 25(OH)D and intact parathyroid hormone (iPTH) levels. The results showed that 25(OH)D levels were higher in summertime compared to wintertime, and an increase in vitamin D intake led to a corresponding increase in 25(OH)D levels. The study suggests that increasing UV irradiation time in summertime and consuming vitamin D supplements and foods throughout the year is beneficial for maintaining sufficient levels of 25(OH)D in young Korean women.
Article
Nutrition & Dietetics
Zhiyong Hu, Xueyuan Zhi, Yiming Ma, Jiafu Li, Jinxiu Wang, Jianliang Zhu, Bingyan Li, Zengli Zhang
Summary: Multiple epidemiological studies have suggested an association between low vitamin D levels and an increased risk of type 2 diabetes. This study found a non-linear relationship between serum 25(OH)D concentrations and the risk of type 2 diabetes, as well as additive interactions between serum 25(OH)D and gender, overweight/obesity, and physical activity.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Byoung-Soo Kwon, Kyunghoon Lee, Eun-Sun Kim, Sun-Hee Jun, Sung-Yoon Lim, Myung-Jin Song, Yeon-Wook Kim, Yeon-Joo Lee, Jong-Sun Park, Young-Jae Cho, Ho-Il Yoon, Choon-Taek Lee, Junghan Song, Jae-Ho Lee
Summary: This study compared the vitamin D parameters of patients with NTM-PD to a healthy control group, finding that bioavailable 25-(OH)D concentrations were associated with NTM-PD but not with treatment outcomes. Lower bioavailable 25-(OH)D levels may be a risk factor for NTM-PD.
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
Agnieszka Radom, Andrzej Wedrychowicz, Stanislaw Pieczarkowski, Szymon Skoczen, Przemyslaw Tomasik
Summary: Maintaining optimal vitamin D levels after breast cancer treatment is important for reducing recurrence risk and extending survival time. A study in Polish women after mastectomy found that vitamin D deficiency was more common in this group compared to the general population, highlighting the importance of vitamin D supplementation and monitoring. By providing recommendations and increasing awareness about vitamin D supplementation, there was a significant increase in the number of patients who started supplementing and the average dose of supplements.
Article
Endocrinology & Metabolism
Chun Zhou, Panpan He, Ziliang Ye, Yuanyuan Zhang, Yanjun Zhang, Sisi Yang, Qimeng Wu, Mengyi Liu, Jing Nie, Xianhui Qin
Summary: The study found an inverse association between serum vitamin D levels and new-onset chronic kidney disease in participants with diabetes. However, this association was not observed in participants without diabetes.
Article
Nutrition & Dietetics
Chiara Tuma, Arne Schick, Nele Pommerening, Hans Braun, Mario Thevis
Summary: Vitamin D is crucial for athletes, and personalized supplementation is more effective than standardized supplementation in helping athletes achieve adequate vitamin D levels.
Article
Multidisciplinary Sciences
Hsin-Ya Tang, Wang-Sheng Ko, Yuan-Horng Yan, Su-Chen Yu, Ya-ling Chiou
Summary: Shift nurses in Taiwan often experience 25(OH)D deficiency, sleep disturbances, depression, and fatigue. However, no significant correlation was found between 25(OH)D levels and mental health.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Mehmet Emin Arayici, Sila Ovgu Korkut-Uysal, Asim Leblebici, Zeynep Akcali, Deniz Tuna Edizer, Seher Kabul, Dilek Cimrin, Ender Berat Ellidokuz
Summary: The aim of this study was to evaluate the change in 25-hydroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic. The study found that restrictions, partial or complete closures, and curfews can significantly affect individuals' 25(OH)D levels during the COVID-19 outbreak. There is a need for multicenter studies with larger populations covering different regions to strengthen and support the results.
Article
Biochemical Research Methods
Danchen Wang, Songlin Yu, Qi Zhang, Qian Cheng, Shaowei Xie, Yuanyuan Zhang, Xiuzhi Guo, Yutong Zou, Yicong Yin, Jialei Yu, Honglei Li, Liangyu Xia, Ling Qiu, Weibo Xia
Summary: This study successfully developed a robust and accurate method for simultaneous measurement of serum 25(OH)D, 1,25(OH)(2)D, and 24,25(OH)(2)D by LC-MS/MS with efficient separation of 3-epi analogs, 23R,25(OH)(2)D-3, and 4 beta,25(OH)(2)D-3.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Nutrition & Dietetics
Xiaoyun Shan, Xiayu Zhao, Siran Li, Pengkun Song, Qingqing Man, Zhen Liu, Yichun Hu, Lichen Yang
Summary: This study aims to analyze the associations between serum 25(OH)D levels and the risk of metabolic syndrome (MetS) and its components in non-diabetic women of childbearing age in China, considering both genetic and non-genetic factors. The findings suggest significant associations between insufficient serum 25(OH)D and components of MetS, including elevated waist circumference, triglycerides, and reduced high-density lipoprotein cholesterol. However, no independent associations were found between 25(OH)D levels and MetS, hypertension, and hyperglycemia.
Article
Rheumatology
Felix Kartnig, Daniel Mrak, Elisabeth Simader, Selma Tobudic, Helga Radner, Peter Mandl, Lisa Goeschl, Nikolaus Hommer, Margareta Mayer, Philipp Hofer, Thomas Hummel, Thomas Deimel, Irina Gessl, Antonia Puchner, Andreas Kerschbaumer, Renate Thalhammer, Alessandra Handisurya, Renate Kain, Stefan Winkler, Josef S. Smolen, Karin Stiasny, Thomas Perkmann, Helmuth Haslacher, Judith H. Aberle, Daniel Aletaha, Leonhard X. Heinz, Daniela Sieghart, Michael Bonelli
Summary: This clinical trial evaluated the immunogenicity and safety of a third COVID-19 vaccination in patients with immune-mediated inflammatory diseases (IMIDs). The results showed that the third vaccination had good immunogenicity and safety in these patients, but the effects of immunomodulatory therapy should be considered.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Daniel Mrak, Felix Kartnig, Daniela Sieghart, Elisabeth Simader, Helga Radner, Peter Mandl, Lisa Goeschl, Philipp Hofer, Thomas Deimel, Irina Gessl, Renate Kain, Stefan Winkler, Josef S. Smolen, Thomas Perkmann, Helmuth Haslacher, Daniel Aletaha, Leonhard X. Heinz, Michael Bonelli
Summary: A study found that patients under immunosuppression experienced a rapid decline in antibodies after the third COVID-19 vaccine dose, and it remains unclear whether immunosuppressive therapy affects immune responses. Monitoring the immune response and adverse events in 50 immunosuppressed patients and 42 healthy controls, it was observed that immunosuppressed patients had significantly lower antibody levels, suggesting the need for an early fourth vaccination.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Virology
Thomas Perkmann, Patrick Mucher, Darlene Oesze, Antonia Mueller, Nicole Perkmann-Nagele, Thomas Koller, Astrid Radakovics, Ines Flieder, Manuela Repl, Rodrig Marculescu, Michael Wolzt, Oswald F. Wagner, Christoph J. Binder, Helmuth Haslacher
Summary: This study investigated the comparability of WHO standard referenced commercial SARS-CoV-2 antibody tests after three doses of BNT162b2 vaccine for up to 14 months. The results showed systematic differences between the results of the three antibody binding assays, but the differences decreased over time. IgG-based assays had better agreement with each other but were not interchangeable with the Roche assay. In conclusion, standardization of SARS-CoV-2 antibody binding assays needs improvement for reliable longitudinal analysis.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Martin Riesenhuber, Christian Nitsche, Christoph J. Binder, Eva S. Schernhammer, Tanja Stamm, Friedrich Jakse, Elaaha Anwari, Fardin Hamidi, Helmuth Haslacher, Thomas Perkmann, Christian Hengstenberg, Thomas A. Zelniker
Summary: This study aimed to estimate and compare the prevalence of anti-SARS-CoV-2 N antibodies in healthcare workers and patients. The results showed that healthcare workers and patients had similar and higher seroprevalence compared to confirmed cases in Austria throughout the pandemic. There was no significant difference in seroprevalence between pediatric and adult patients at different time periods.
Article
Substance Abuse
Stephan Listabarth, Benjamin Vyssoki, Rodrig Marculescu, Andreas Gleiss, Magdalena Groemer, Armin Trojer, Christine Harrer, Sabine Weber, Daniel Koenig
Summary: This study aimed to compare the effect of two best practice thiamine substitution regimens on thiamine blood levels and cognitive function. The results showed that increases in thiamine levels were associated with pronounced improvements of cognitive function, and oral and intravenous substitution seemed to be equally effective.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Nutrition & Dietetics
Viktoria Knaze, Heinz Freisling, Paz Cook, Katy Heise, Johanna Acevedo, Marcos Cikutovic, Karl-Heinz Wagner, Rodrig Marculescu, Catterina Ferreccio, Rolando Herrero, Jin Young Park
Summary: This study aimed to evaluate the association between salt intake and gastric atrophy (GA) in Chilean adults. The analysis of population-based samples from two sites found little evidence for an association between salt intake and GA risk.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Benedikt Simbrunner, Esther Caparros, Teresa Neuwirth, Philipp Schwabl, Philipp Koenigshofer, David Bauer, Rodrig Marculescu, Michael Trauner, Bernhard Scheiner, Georg Stary, Mattias Mandorfer, Thomas Reiberger, Ruben Frances
Summary: In patients with advanced chronic liver disease (ACLD), bacterial translocation (BT) leads to systemic inflammation and circulatory dysfunction, but there is no clear correlation between BT markers and portal hypertension and circulatory dysfunction.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Adam Taleb, Peter Willeit, Shahzada Amir, Thomas Perkmann, Maria Ozsvar Kozma, Martin L. Watzenboeck, Christoph J. Binder, Joseph L. Witztum, Sotirios Tsimikas
Summary: This study shows that high levels of IgM antibodies to oxidation-specific epitopes (OSEs) may be protective against acute myocardial infarction (AMI) in humans. The levels of IgM OSEs were significantly lower in AMI patients compared to controls. These findings provide important clinical information and support the hypothesis that IgM OSEs have a protective effect against AMI.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Hematology
Dino Mehic, Jennifer Machacek, Theresa Schramm, Lisbeth Buresch, Alexandra Kaider, Beate Eichelberger, Helmuth Haslacher, Michael Fillitz, Barbara Dixer, Tanja Flasch, Theresa Anderle, Anja Rath, Alice Assinger, Cihan Ay, Ingrid Pabinger, Johanna Gebhart
Summary: This study found that the bleeding phenotype in ITP patients is heterogeneous and usually mild. Platelet reactivity may be one of the factors underlying the mild phenotype.
THROMBOSIS RESEARCH
(2023)
Article
Oncology
Maximilian J. Mair, Agnieszka Maj-Hes, Alina Nussbaumer-Proell, Rainer Puhr, Agnieszka Christenheit, Marlene Troch, Hannah C. Puhr, Angelika M. Starzer, Ariane Steindl, Sabine Eberl, Helmuth Haslacher, Thomas Perkmann, Christoph Minichsdorfer, Gerald W. Prager, Wolfgang W. Lamm, Anna S. Berghoff, Barbara Kiesewetter, Markus Zeitlinger, Matthias Preusser, Markus Raderer
Summary: This study aimed to investigate the preventive effect of azithromycin on COVID-19 infection in cancer patients, but due to low acceptance and low incidence of infection, the study was prematurely closed. Nevertheless, azithromycin had a favorable side effect profile in cancer patients.
INFECTIOUS AGENTS AND CANCER
(2023)
Article
Medicine, General & Internal
Selma Tobudic, Elisabeth Simader, Thomas Deimel, Jennifer Straub, Felix Kartnig, Leonhard X. Heinz, Peter Mandl, Helmuth Haslacher, Thomas Perkmann, Lisa Schneider, Thomas Nothnagl, Helga Radner, Florian Winkler, Heinz Burgmann, Karin Stiasny, Gottfried Novacek, Walter Reinisch, Daniel Aletaha, Stefan Winkler, Stephan Blueml
Summary: This study aimed to evaluate the duration of humoral responses after two doses of SARS-CoV-2 mRNA vaccines in patients with inflammatory joint diseases and IBD, and to analyze the factors influencing immune response. The results showed that patients receiving b/tsDMARDs had lower antibody levels and neutralizing antibody titers compared to healthy controls or patients receiving csDMARDs. The decline in antibody levels was faster in patients with b/tsDMARDs, indicating a significantly reduced duration of vaccine-induced immunity. Furthermore, they displayed a reduced response to a booster vaccination, highlighting the need for earlier booster strategies in these patients.
FRONTIERS IN MEDICINE
(2023)
Article
Rheumatology
Markus Mueller, Michael E. Gschwandtner, Wolfgang Emminger, Hans Kiener, Sebastian Schnaubelt, Georgiana-Aura Giurgea, Robin Ristl, Thomas Perkmann, Renate Koppensteiner, Oliver Schlager
Summary: The objective of this study was to characterize the associations between individual nailfold capillary aberrations and autoantibodies in children and adults with Raynaud's phenomenon (RP). Nailfold capillaroscopy and laboratory tests were conducted on consecutive RP patients without previously known connective tissue disease. The prevalence of nailfold capillary aberrations and antinuclear antibodies (ANA) was assessed and analyzed separately for children and adults, revealing a less pronounced association between nailfold capillary aberrations and ANA in children. Further studies are needed to validate these observations in children with RP.
Article
Virology
Thomas Perkmann, David N. Springer, Patrick Mucher, Michael Wolzt, Lukas Weseslindtner, Helmuth Haslacher
Summary: This study investigated whether breakthrough infection with SARS-CoV-2 Omicron increases antibody levels in individuals who received three doses of wild-type-based BNT162b2 vaccine. The results suggest that breakthrough infection efficiently boosts wild-type antibodies in vaccinated individuals, while antibody levels decrease in those who received only three doses of the vaccine.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Sebastian Schnaubelt, Julia Oppenauer, Mathias Bader, Na DU, Felix Eibensteiner, Calvin L. Kienbacher, Enrico Baldi, Markus Mueller, Thomas Perkmann, Helmuth Haslacher, Wolfgang Schreiber, Alexander Niessner, Oliver Schlager, Hans Domanovits, Patrick Sulzgruber
Summary: Pulse-wave velocity (PWV) is a non-invasive measurement that can predict cardiovascular pathologies and PCI complexity in patients with acute coronary syndrome (ACS). This study found that pathological PWV was associated with high-risk prediction scores, cardiac enzymes, and three-vessel disease. Additionally, PWV was also related to the complexity of coronary angiography and PCI procedures.
Article
Immunology
Daniela Sieghart, Christian Konrad, Sascha Swiniarski, Helmuth Haslacher, Daniel Aletaha, Guenter Steiner
Summary: This study aimed to investigate the diagnostic performance of anti-CCP2 and anti-CCP3 IgG and IgA assays in patients with early RA, with a focus on the prognostic value of IgA ACPA. The results showed that the anti-CCP2 IgG and IgA assays had high specificity but low sensitivity. The anti-CCP3.1 assay had slightly higher sensitivity but lower specificity compared to the anti-CCP2 IgG assay.
FRONTIERS IN IMMUNOLOGY
(2023)
