Article
Rheumatology
Jelena Vojinovic, Ivan Foeldvari, Joke Dehoorne, Violeta Panaviene, Gordana Susic, Gerd Horneff, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Jonathan Akikusa, Tadej Avcin, Cecilia Borlenghi, Edmund Arthur, Svitlana Y. Tatulych, Chuanbo Zang, Vassilis Tsekouras, Bonnie Vlahos, Alberto Martini, Nicolino Ruperto
Summary: CLIPPER2 is an 8-year study on the safety and efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA). The study found that etanercept treatment was well tolerated and effective in these patients.
Article
Medicine, General & Internal
Athimalaipet Ramanan, Pierre Quartier, Nami Okamoto, Ivan Foeldvari, Alberto Spindler, Sarka Fingerhutova, Jordi Anton, Zhongkai Wang, Gabriella Meszaros, Joana Araujo, Ran Liao, Stuart Keller
Summary: Baricitinib demonstrated good efficacy and acceptable safety in the treatment of polyarticular juvenile idiopathic arthritis, extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis, and juvenile psoriatic arthritis.
Article
Rheumatology
Naveen Ravichandran, Shivika Guleria, Namita Mohindra, Amita Aggarwal
Summary: This study assessed the long-term functional outcomes in ERA patients from China and found that delay in diagnosis was the sole predictor of poor functional outcome.
Article
Rheumatology
Joeri W. van Straalen, Roline M. Krol, Gabriella Giancane, Violeta Panaviene, Laura Marinela Ailioaie, Pavla Dolezalova, Marco Cattalini, Gordana Susic, Flavio R. Sztajnbok, Despoina Maritsi, Tamas Constantin, Sujata Sawhney, Marite Rygg, Sheila Knupp Oliveira, Ellen Berit Nordal, Claudia Saad-Magalhaes, Nadina Rubio-Perez, Marija Jelusic, Sytze de Roock, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart
Summary: IBD development in JIA is associated with enthesitis-related arthritis and a family history of autoimmune disease. An increased incidence of IBD was observed with etanercept therapy regardless of concomitant methotrexate use.
Article
Pediatrics
Xuefeng Xu, Xiaohui Liu, Wenjie Zheng, Jihong Xiao, Xiaozhong Li, Ling Wu, Lixia Zou, Qian Ouyang, Yaoyao Shangguan, Kezhao Lin, Xiaomei Dai, Yuanling Chen, Yiping Xu, Jianqiang Wu, Meiping Lu
Summary: This study suggests that the combination of rhTNFR-Fc and MTX significantly improves symptoms and disease activity in children with JIA.
FRONTIERS IN PEDIATRICS
(2022)
Review
Medicine, General & Internal
Shi Huan Tay, Joo Guan Yeo, Jing Yao Leong, Salvatore Albani, Thaschawee Arkachaisri
Summary: Juvenile spondyloarthritis (JSpA) is a diverse spectrum of immune-mediated inflammatory arthritides that typically onset in late childhood and adolescence. It is characterized by a strong association with HLA-B27, enthesitis, and bone resorption.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Arash Maleki, Priya D. D. Patel, C. Steven Foster
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children, with uveitis being the most common extra-articular manifestation. This review covers the epidemiology, risk factors, clinical presentation, laboratory tests, treatment options, and complications of JIA and JIA-associated uveitis. The discussion also includes the course of the disease, functional outcome, and quality of life for patients with JIA and JIA-associated uveitis.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Wojdas, Klaudia Dabkowska, Kornelia Kuznik-Trocha, Grzegorz Wisowski, Iwona Lachor-Motyka, Katarzyna Komosinska-Vassev, Krystyna Olczyk, Katarzyna Winsz-Szczotka
Summary: This study assessed the effects of ETA therapy on ECM metabolism in JIA patients. The results showed that GAGs and TAS concentrations were significantly lower in patients with aggressive JIA, while MMP-1 and MMP-3 levels were significantly higher. Anti-cytokine therapy did not normalize any of the assessed parameters.
Article
Medicine, General & Internal
Nicolino Ruperto, Hermine Brunner, Olga Synoverska, Tracy Ting, Carlos Abud Mendoza, Alberto Spindler, Yulia Vyzhga, Katherine Marzan, Lyudmila Grebenkina, Irit Tirosh, Lisa Imundo, Rita Jerath, Daniel J. Kingsbury, Betul Sozeri, Sheetal S. Vora, Sampath Prahalad, Elena Zholobova, Yonatan Butbul Aviel, Vyacheslav Chasnyk, Melissa Lerman, Kabita Nanda, Heinrike Schmeling, Heather Tory, Yosef Uziel, Diego O. Viola, Holly B. Posner, Keith S. Kanik, Ann Wouters, Cheng Chang, Richard Zhang, Irina Lazariciu, Ming-Ann Hsu, Ricardo M. Suehiro, Alberto Martini, Daniel J. Lovell
Summary: The trial showed that tofacitinib is an effective treatment for patients with polyarticular course JIA. New oral therapies are particularly relevant for children and adolescents, who might prefer to avoid injections.
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Gerd Horneff, Kirsten Minden, Catherine Rolland, Ana C. Hernandez Daly, Cecilia Borlenghi, Nicolino Ruperto
Summary: In this systematic literature review, tumor necrosis factor inhibitors were found to be effective and well tolerated in the treatment of juvenile idiopathic arthritis (JIA). However, more research is needed, especially in terms of head-to-head studies and longer-term follow-up, to provide additional evidence.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Rheumatology
Umang Bhardwaj, Narendra K. Bagri, Rakesh Lodha, Sushil K. Kabra, Thirumurthy Velpandian, Ravindra M. Pandey
Summary: This study aimed to evaluate the efficacy and safety of pulse dexamethasone therapy in children with treatment-naive non-systemic JIA. The results showed that the addition of pulse dexamethasone to standard treatment may not have any advantage in improving ACR-Pedi 70 scores at medium-term follow-up.
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Radiology, Nuclear Medicine & Medical Imaging
Floris Verkuil, Robert Hemke, E. Charlotte van Gulik, Anouk M. Barendregt, Amara Nassar-Sheikh Rashid, Dieneke Schonenberg-Meinema, Koert M. Dolman, Eline E. Deurloo, Kees F. van Dijke, J. Michiel den Harder, Taco W. Kuijpers, J. Merlijn van den Berg, Mario Maas
Summary: This study compared double inversion recovery (DIR) MRI to conventional contrast-enhanced (CE) MRI in delineating synovium and assessing synovial thickness in children with juvenile idiopathic arthritis (JIA). The results showed that DIR MRI adequately delineated the synovium and enabled synovial thickness measurement similar to that of CE-MRI.
INSIGHTS INTO IMAGING
(2022)
Article
Rheumatology
Hermine I. Brunner, Nicolino Ruperto, Zbigniew Zuber, Ruben Cuttica, Vladimir Keltsev, Ricardo M. Xavier, Ruben Burgos-Vargas, Inmaculada Calvo Penades, Earl D. Silverman, Graciela Espada, Manuel Ferrandiz Zavaler, Yukiko Kimura, Carolina Duarte, Chantal Job-Deslandre, Rik Joos, Wendy Douglass, Sunethra Wimalasundera, Kamal N. Bharucha, Chris Wells, Daniel J. Lovell, Alberto Martini, Fabrizio de Benedetti
Summary: This study aimed to report the 2-year efficacy and safety of tocilizumab (TCZ) in patients with polyarticular-course juvenile idiopathic arthritis (JIA). The results showed high-level disease control for up to 2 years in patients treated with TCZ for polyarticular-course JIA, with a safety profile consistent with previous reports.
ARTHRITIS & RHEUMATOLOGY
(2021)