Review
Medicine, General & Internal
Yanru Ou, Dandan Zong, Ruoyun Ouyang
Summary: This article explores the relationship between obstructive sleep apnea (OSA) and epigenetics, and provides better diagnostic methods and treatment options. Epigenetic modifications, including post-translational modifications in DNA and histone proteins, and regulation of non-coding RNAs, are involved in the progression of OSA and various multiorgan injuries. This article offers deeper insights into the disease mechanism of OSA and potential applications of targeted diagnosis, treatment, and prognosis in OSA complications.
CHINESE MEDICAL JOURNAL
(2023)
Article
Pediatrics
Yingge Wang, Ying Chen, Wei Lin, Min Huang, Yuanteng Xu, Guohao Chen
Summary: The objective of this study was to evaluate the serum inflammatory markers in children with and without OSAS, including YKL-40, Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), TNF-alpha, and CRP. The ELISA technique was used to measure the concentration of these markers in the serum of 83 children with OSAS and 83 children without OSAS. The results showed that children with OSAS had increased levels of YKL-40, IL-6, IL-8, and IL-10 in their serum. YKL-40 and IL-8 may serve as serum inflammatory markers for the diagnosis of children with OSAS.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Bala S. C. Koritala, Laetitia S. Gaspar, Shweta S. Bhadri, Kyla S. Massie, Yin Yeng Lee, Jiffin Paulose, David F. Smith
Summary: This study aimed to investigate the effects of intermittent hypoxia (IH) on pro-inflammatory mediators in vulnerable organs impacted by obstructive sleep apnea (OSA). The results showed that short-term exposure to IH led to a decrease in immune response pathways in the heart, lung, and liver, while long-term exposure to IH resulted in an increase in inflammatory mediators in the serum, lung, and heart.
Article
Multidisciplinary Sciences
Ji Woon Park, Sujay Mehta, Sandra Fastlicht, Alan A. Lowe, Fernanda R. Almeida
Summary: Oral appliance treatment for obstructive sleep apnea patients with headaches showed significant improvement in headache characteristics, with a higher prevalence of morning headaches in headache responders. The study suggests that oral appliance treatment can be beneficial for OSA patients with headaches, especially those with mild to moderate OSA.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Lu Peng, Xiaodi Wang, Dan Bing
Summary: Our study demonstrated strong associations between immune genes and the development of dyslipidemia in OSA, promoting further research on the molecular mechanisms and potential targets for regulating lipid metabolism in OSA.
FRONTIERS IN GENETICS
(2021)
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
M. Kaminska, M. O'Sullivan, V. P. Mery, A. L. Lafontaine, A. Robinson, P. Gros, J. G. Martin, A. Benedetti, R. J. Kimoff
Summary: This study aimed to investigate the relationship between inflammatory cytokines and brain-derived neurotrophic factor (BDNF) with obstructive sleep apnea (OSA) and Parkinson's disease (PD) symptoms. The results showed that IL-6 levels were associated with OSA severity and PD motor dysfunction. Increasing IL-6 correlated with deterioration of PD symptoms, while increasing BDNF correlated with increasing sleepiness.
Article
Clinical Neurology
Hiwa Mohammadi, Ardalan Aarabi, Mohammad Rezaei, Habibolah Khazaie, Serge Brand
Summary: The study found that individuals with OSAS have significantly lower spindle density in N3 and shorter spindle duration in N2 compared to healthy controls. Furthermore, individuals with mild OSAS showed sleep spindle characteristics more similar to healthy controls, unlike those with moderate and severe OSAS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Engineering, Biomedical
Xin-Xue Lin, Phone Lin, En-Hau Yeh, Gi-Ren Liu, Wan-Ching Lien, Yuguang Fang
Summary: In this paper, an AI-based framework called RAPIDEST is proposed to detect OSA. The framework only requires EEG signals, simplifying the signal collection process and reducing the complexity of severity determination for apnea and hypopnea.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Otorhinolaryngology
Diogo Raposo, Marco Menezes, Joao Rito, Mafalda Trindade-Soares, Cristina Adonis, Helena Cristina Loureiro, Filipe Freire
Summary: DISE findings varied between surgically naive children and those with persistent obstructive sleep apnea after adenotonsillectomy. Increased obstruction at the tongue base and multilevel obstruction predicted a lower saturation nadir in children with persistent obstructive sleep apnea after adenotonsillectomy.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, General & Internal
Amalia Ioanna Moula, Iris Parrini, Cecilia Tetta, Fabiana Luca, Gianmarco Parise, Carmelo Massimiliano Rao, Emanuela Mauro, Orlando Parise, Francesco Matteucci, Michele Massimo Gulizia, Mark La Meir, Sandro Gelsomino
Summary: Atrial fibrillation (AF) is the most common arrhythmia, with its incidence increasing with age and comorbidities. Obstructive sleep apnea (OSA) is a chronic sleep disorder more commonly found in older men. Previous studies have shown a link between OSA and AF, although the prevalence of OSA in AF patients remains unknown due to underdiagnosis. This meta-analysis investigated the association between OSA and AF, using data from 54,271 patients. A strong link was found between these two disorders, with the incidence of AF being 88% higher in patients with OSA. Age and hypertension were found to independently strengthen this association, indicating that treating OSA may help reduce AF recurrence. Further research is needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ana L. Vega-Jasso, Luis M. Amezcua-Guerra, Hector Gonzalez-Pacheco, Julio Sandoval-Zarate, Cesar A. Gonzalez-Diaz, Jennifer Escobar-Alvarado, Jennifer D. Manzano-Luna, Malinalli Brianza-Padilla
Summary: This study investigated the involvement of adipokines in AMI patients, and found that both AMI patients and AMI patients with OSA exhibited elevated levels of adipokines. AMI patients with concomitant OSA also showed greater cardiac damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yi-An Lu, Chao-Jan Wang, Yen-Ting Chiang, Hsueh-Yu Li
Summary: This study examined the association between tongue dimensions and obstructive sleep apnea (OSA), and proposed whole tongue treatment using coblation ablation tongue (CAT) for OSA patients. The study found that tongue length is associated with the severity of OSA, and CAT can significantly decrease tongue volume. The volumetric reduction of 0.38 cm(3) per ablation may be useful in optimizing tongue reduction for OSA. Additionally, surgical success is higher in patients with non-hypertrophic lingual tonsils.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Silvia Conde, Fatima O. Martins, Sara S. Dias, Paula Pinto, Cristina Barbara, Emilia C. Monteiro
Summary: This study investigated the effect of caffeine consumption on patients with obstructive sleep apnea (OSA) and found that higher caffeine consumption does not alter the variables related to the disease.
Article
Pediatrics
Ryan Kahanowitch, Hector Aguilar, Miriam Weiss, Jenny Lew, Qi Pan, Maria Camila Ortiz-Vergara, Oscar Rodriguez, Gustavo Nino
Summary: This study aimed to explore the age-related differences in sleep architecture and obstructive sleep apnea (OSA) severity between children with Down syndrome (DS) and euploid individuals. The main findings showed a higher prevalence of severe OSA in the DS group, especially in young children and adolescents. Additionally, children with DS had disturbances in sleep architecture characterized by a longer REM sleep onset latency and elevated arousal indexes. These findings offer clinically relevant insights to guide anticipatory guidance for infants, children, and adolescents with DS.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Joel Reiter, Maya Ramagopal, Alex Gileles-Hillel, Erick Forno
Summary: Asthma and sleep disorders are common in children and often coexist, with one potentially influencing the other. Children with asthma may experience complaints of poor sleep quality, insomnia, and daytime sleepiness, while also having higher rates of parasomnias. The bidirectional interaction between sleep-related breathing disorders and asthma may worsen each condition, emphasizing the importance of considering both when managing asthma in children.
PEDIATRIC PULMONOLOGY
(2022)
Article
Respiratory System
Olga Mediano, Nicolas Gonzalez Mangado, Josep M. Montserrat, M. Luz Alonso-Alvarez, Isaac Almendros, Alberto Alonso-Fernandez, Ferran Barbe, Eduardo Borsini, Candelaria Caballero-Eraso, Irene Cano-Pumarega, Felix de Carlos Villafranca, Carmen Carmona-Bernal, Jose Luis Carrillo Alduenda, Eusebi Chiner, Jose Aurelio Cordero Guevara, Luis de Manuel, Joaquin Duran-Cantolla, Ramon Farre, Carlos Franceschini, Carles Gaig, Pedro Garcia Ramos, Francisco Garcia-Rio, Onintza Garmendia, Teresa Gomez Garcia, Silvia Gonzalez Pondal, M. Blanca Hoyo Rodrigo, Albert Lecube, Juan Antonio Madrid, Lourdes Maniegas Lozano, Jose Luis Martinez Carrasco, Juan Fernando Masa, Maria Jose Masdeu Margalef, Merce Mayos Perez, Enrique Mirabet Lis, Carmen Monasterio, Nieves Navarro Soriano, Erika Olea de la Fuente, Guillermo Plaza, Francisco Javier Puertas Cuesta, Claudio Rabec, Pilar Resano, David Rigau, Alejandra Roncero, Concepcion Ruiz, Neus Salord, Adriana Saltijeral, Gabriel Sampol Rubio, M. Angeles Sanchez Quiroga, Oscar Sans Capdevila, Carlos Teixeira, Francisco Tinahones Madueno, Sonia Maria Togeiro, Maria Fernanda Troncoso Acevedo, Leslie Katherine Vargas Ramirez, Joao Winck, Nerea Zabala Urionaguena, Carlos Egea
Summary: The aim of this international consensus document is to provide guidelines for healthcare professionals in the care of adult patients with obstructive sleep apnea based on a critical analysis of the latest literature. The document was developed by an expert working group consisting of scientific societies, specialists, and a methodology expert, and includes systematic literature searches for each section. The document does not cover pediatric patients or the management of patients receiving chronic non-invasive mechanical ventilation.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Pediatrics
Joel Reiter, Oded Breuer, Malena Cohen-Cymberknoh, Erick Forno, Alex Gileles-Hillel
Summary: Cystic fibrosis (CF) is a chronic multisystem disease with manifestations from birth, involving the entire respiratory system and leading to intestinal malabsorption. Sleep quality and efficiency are often impaired in children with CF, with potential associations between sleep disturbances and respiratory outcomes. Further research is needed to better understand the impact of sleep disorders on pulmonary status in these children.
PEDIATRIC PULMONOLOGY
(2022)
Article
Pediatrics
Oren Biro, Alex Gileles-Hillel, Talia Dor-Wollman, Eli M. Eisenstein, Yackov Berkun
Summary: The study found a higher prevalence of ADHD, learning disabilities, headaches, and febrile seizures in children with FMF. Headaches and febrile seizures were significantly more common in children with FMF compared to their siblings. ADHD and learning disabilities were associated with poor adherence to colchicine treatment. Overall, it highlights the importance of addressing neurodevelopmental aspects in children with FMF for better disease management.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Editorial Material
Clinical Neurology
Alex Gileles-Hillel, Tehila Dahan
Article
Pediatrics
Tomer Israeli, Iris Eisenstadt, David Shoseyov, Shoshana Armoni, Alex Gileles-Hillel, Galit Cremisi, Malena Cohen-Cymberknoh, Oded Breuer
Summary: In this study, we present the physiotherapy management of two patients with severe cystic fibrosis (CF) lung disease and upper limb deep vein thrombosis (DVT). By implementing a set of precautions and restrictions, the patients maintained sufficient airway clearance for respiratory improvement without major adverse events.
PEDIATRIC PULMONOLOGY
(2022)
Article
Genetics & Heredity
Dustin J. Wcisel, Alex Dornburg, Sean C. McConnell, Kyle M. Hernandez, Jorge Andrade, Jill L. O. de Jong, Gary W. Litman, Jeffrey A. Yoder
Summary: Multiple novel immunoglobulin-like transcripts (NILTs) have been identified in salmon, trout, and carp, but a definitive framework of NILT diversity is still lacking. In this study, the researchers identified five NILT loci in the Atlantic salmon genome, defined 86 NILT Ig domains in zebrafish chromosome 1, and described 41 NILT Ig domains in an alternative haplotype for the same genomic region. They found an unprecedented diversity of Ig domain sequences and combinations for NILTs within a single species. The results suggest that this gene family likely plays multiple roles in host immunity.
Article
Respiratory System
Carolina Cubillos-Zapata, Miguel Angel Martinez-Garcia, Elena Diaz-Garcia, Sara Garcia-Tovar, Francisco Campos-Rodriguez, Manuel Sanchez-de-la-Torre, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernandez Blasco, Esther Pastor, Jorge Abad-Capa, Josep Maria Montserrat, Valentin Cabriada-Nuno, Irene Cano-Pumarega, Jaime Corral-Penafiel, Eva Arias, Olga Mediano, Maria Somoza-Gonzalez, Joan Dalmau-Arias, Isaac Almendros, Ramon Farre, David Gozal, Francisco Garcia-Rio
Summary: In patients with obstructive sleep apnoea (OSA), high levels of paraspeckle component (PSPC)1 are associated with increased tumor aggressiveness in cutaneous melanoma. Intermittent hypoxia and soluble PSPC1 play a role in promoting epithelial-mesenchymal transition (EMT) and acquisition of cancer stem cell (CSC)-like features in melanoma cells. These findings suggest a potential link between OSA severity, PSPC1 levels, and melanoma aggressiveness.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Pediatrics
Alex Gileles-Hillel, Limor Yochi Harpaz, Oded Breuer, Joel Reiter, Reuven Tsabari, Eitan Kerem, Malena Cohen-Cymberknoh, Patrick Stafler, Meir Mei-Zahav, Yazeed Toukan, Lea Bentur, David Shoseyov
Summary: This multicenter retrospective analysis suggests that bronchoscopy has a significant impact on treatment decisions for patients with cystic fibrosis, with a considerable proportion of patients experiencing a change in their treatment regimen. There were no serious adverse events reported, indicating that bronchoscopy is a safe procedure. Further studies should explore whether bronchoscopy-guided decision-making can also lead to improvements in clinical outcomes for patients with cystic fibrosis.
PEDIATRIC PULMONOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Constanca Junior, Anna Ulldemolins, Maria Narciso, Isaac Almendros, Ramon Farre, Daniel Navajas, Javier Lopez, Mar Eroles, Felix Rico, Nuria Gavara
Summary: The extracellular matrix (ECM) of the lung, composed mainly of collagens, elastin, and proteoglycans, provides support to lung cells. Aberrant increased deposition of ECM in lung fibrosis changes filament organization and stiffens the ECM, leading to the profibrotic profile of pulmonary cells. The study examines changes in ECM properties during fibrosis development and identifies potential pharmacological targets to hinder its progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Tehila Adler-Haltovsky, Alex Gileles-Hillel, Ira Erlichman, Smadar Eventov-Friedman
Summary: A retrospective study investigated the changes in ventilation modes in preterm neonates over the last decade and their impact on the prevalence of BPD. The study found an increase in noninvasive ventilation rates, but no decrease in the use of invasive ventilation or the prevalence of BPD. The high prevalence of BPD in extreme prematurity remains a significant problem, suggesting the need for additional interventions.
PEDIATRIC PULMONOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ramon Farre, Isaac Almendros, Miguel-Angel Martinez-Garcia, David Gozal
Summary: This review focuses on the experimental models used to study the consequences of sleep apnea (SA), including cell culture systems, animal models, and human SA models. The advantages, limitations, and relevant findings of these models are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Clinical Neurology
J. Reiter, H. Abuelhija, M. Slae, P. Millman, Z. Davidovics, E. Chaimov, A. Gileles-Hillel, M. Wilschanski
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
Malena Cohen-Cymberknoh, Maya Lehavi, Ohad Atia, Alex Gileles-Hillel, Joel Reiter
Meeting Abstract
Pediatrics
I Sadras, O. Breuer, E. Kerem, A. Ta-Shma, M. Cohen-Cymberknoh, A. Gileles-Hillel
PEDIATRIC PULMONOLOGY
(2022)