Article
Chemistry, Multidisciplinary
Tajrian Chowdhury, Samuel J. Horsewill, Claire Wilson, Joy H. Farnaby
Summary: The unsubstituted bis-hydrotris(I-pyrazolyl)borate) (Tp) ligand framework has been used to synthesise a range of heteroleptic Ln(III) coordination complexes. The complexes were characterised and their solid-state molecular structure was determined by single-crystal X-ray diffraction.
AUSTRALIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Hayam A. Abd A. El Salam, Usama Fathy, Ehab M. Zayed, Mohamed F. El Shehry, Ahmed E. Gouda
Summary: A novel series of heterocyclic compounds pairing hybrids pyrazole, naphthalene and pyrazoline/thiazoldine moieties were synthesized. The structures of the newly synthesized compounds were determined using spectroscopic data and elemental analysis. The cytotoxicity of the selected compounds was evaluated in vitro against three human breast cancer cell lines, and one compound exhibited significant potency with IC(50) values ranging from 4.88 to 10.16 μM. The structure-activity relationship of these compounds was interpreted through molecular docking.
Article
Chemistry, Multidisciplinary
Monireh Ghorbanpour, Behzad Soltani, Ommoleila Molavi, Ali Shayanfar, Elnaz Mehdizadeh Aghdam, Christopher John Ziegler
Summary: Copper-based complexes have diverse applications in pharmaceutical and biochemistry. In this study, four types of bis(pyrazolyl) borate-based ligands and their copper(II) complexes were synthesized and characterized. One of the complexes showed promising anticancer potential and molecular docking studies revealed better binding energy for copper complexes.
Article
Chemistry, Multidisciplinary
Adam A. A. Sulaiman, Saeed Ahmad, Saeed Mujahid Hashimi, Amany Alqosaibi, Abdul Malik Puthan Peedikakkal, Ali Alhoshani, Nasser B. Alsaleh, Anvarhusein A. Isab
Summary: Four novel dinuclear phosphanegold(i) complexes were synthesized and tested for their anticancer activity. They exhibited superior cytotoxicity compared to cisplatin and disrupted the mitochondrial membrane potential, leading to apoptotic cell death.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Monireh Ghorbanpour, Behzad Soltani, Ommoleila Molavi, Elnaz Mehdizadeh Aghdam
Summary: In this study, a series of pyrazole-based metal complexes were synthesized and their antibacterial and anticancer activities were investigated. The results showed that one particular complex exhibited high cytotoxicity and bacterial inhibition. These metal complexes have potential applications for further evaluations in the field of biology.
PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Refaie M. Kassab, Sobhi M. Gomha, Zeinab A. Muhammad, Ahmed S. El-khouly
Summary: This study reported the antimycobacterial activity of imidazole-fused heterocycles for the first time and successfully developed a novel series of bis-imidazole fused heterocycles, with multiple prototypes showing remarkable anti-tubercular and/or potent antitumor activities.
MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Huzaifa Yasir Khan, Sartaj Tabassum, Farukh Arjmand
Summary: The synthesized ionic metallo-NSAID's were found to interact with therapeutic targets, showing high affinity for tRNA and exhibiting higher cytotoxicity than the parent NSAID.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Atikhun Chottiratanachote, Manaswee Suttipong, Umer Rashid, Vudhichai Parasuk, Junko Nomura Kondo, Toshiyuki Yokoi, Ali Alsalme, Chawalit Ngamcharussrivichai
Summary: This study aims to synthesize alpha,beta-unsaturated carbonyl compounds with branched structures via aldol condensation of furfural and 2-butanone using MgAl mixed oxides as catalysts. The most suitable catalyst is LDO3 with a 3:1 Mg:Al atomic ratio. The suitable reaction conditions to produce the branched-chain C9 ketones are 1:5 furfural:2-butanone molar ratio, 5 wt.% catalyst loading, 120 degrees C reaction temperature, and 8 h reaction time.
Article
Chemistry, Multidisciplinary
Huda Alsaeedi, Hilal Ahmad, Malak Faisal Altowairqi, Nouf AbdulRahman Almuryyi, Ali Alsalme
Summary: A graphene oxide (GO/CdS) nanocomposite was synthesized and used for micro solid phase extraction procedure. The nanocomposite selectively extracts Hg(II) ions from different water samples and shows excellent extraction efficiency. The method has a low detection limit, good accuracy and precision, and has been successfully verified using standard reference materials and real samples.
Article
Chemistry, Multidisciplinary
Ali Alsalme, Huda Alsaeedi
Summary: In this study, we used SCAPS-1D to simulate lead (Pb)-free all-perovskite tandem solar cells. Tandem solar cells consist of a top cell and a bottom cell. Methyl ammonium germanium iodide (MAGeI(3)) and FA(0.75)MA(0.25)Sn(0.25)Ge(0.5)I(3) = FAMASnGeI(3) were used as the absorber layers for the top and bottom subcells, respectively. Different electro-transport layers (ETLs) such as titanium dioxide, tin oxide, zinc oxide, tungsten trioxide, and zinc selenide were tested to evaluate their impact on the efficiency of tandem solar cells. The results showed that TiO2 and ZnSe exhibited better band alignment and charge-extraction/transfer properties. The efficiency of the tandem solar cells with TiO2 and ZnSe layers reached 23.18% and 22.4% respectively.
Article
Crystallography
Ali Alsalme, Huda Alsaeedi
Summary: The determination of hydrazine is important due to its hazardous nature. In this study, a hydrazine electrochemical sensor was designed and fabricated using two-dimensional molybdenum diselenide (MoSe2) synthesized via the sol-gel method. The synthesized MoSe2 was characterized for its phase purity, surface morphology, and elemental composition. A glassy carbon electrode was modified with the prepared MoSe2 and used as the working electrode for hydrazine sensing. The MoSe2-GC electrode exhibited excellent sensing performance with high sensitivity, low detection limit, and good selectivity.
Review
Chemistry, Inorganic & Nuclear
Claudio Pettinari, Alessia Tombesi
Summary: Metal organic frameworks (MOFs) are crystalline porous materials with ordered structures and large surface areas, which have attracted much attention for their potential applications in energy electrochemical conversion and storage devices. This review summarizes the recent research on the use of MOFs in fuel cells, solar cells, supercapacitors, and batteries. The different applications of MOFs in Li-ion, Na-ion, and other metal ion batteries are differentiated. The review also provides an overview of the water splitting reaction catalyzed by MOFs.
Article
Chemistry, Medicinal
Daphne Romani, Fabio Marchetti, Corrado Di Nicola, Massimiliano Cuccioloni, Chunmei Gong, Anna Maria Eleuteri, Agustin Galindo, Farzaneh Fadaei-Tirani, Massimo Nabissi, Riccardo Pettinari
Summary: A series of Ga(Q(n))(3) coordination compounds were synthesized and characterized through various techniques. Cytotoxicity studies showed interesting results in terms of selectivity and toxicity values compared with cisplatin. Mechanistic investigations revealed that the gallium(III) complexes induced cancer cell death through ferroptosis, triggering various cell death signals and altering cell redox homeostasis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Polymer Science
Yury A. Belousov, Mikhail T. Metlin, Darya A. Metlina, Mikhail A. Kiskin, Ilya A. Yakushev, Trofim A. Polikovskiy, Ilya V. Taydakov, Andrei A. Drozdov, Fabio Marchetti, Claudio Pettinari
Summary: A new strategy for the easy polymerization of anionic [Ln(Q(cy))(4)](-) into two-dimensional layers of [AgLn(Q(cy))(4)](n) is proposed by binding the single molecular anions [Ln(Q(cy))(4)](-) to silver cations through coordination. The luminescent properties of [AgLn(Q(cy))(4)](n) have been studied, and it was found that LMCT quenching is effectively suppressed in the heterometallic [AgEu(Q(cy))(4)](n) polymer, explaining the low PLQY in [Eu(Q(cy))(4)](-). Sensibilization coefficients for H3O[Eu(Q(cy))(4)], [AgEu(Q(cy))(4)](n), and H3O[Sm(Q(cy))(4)] complexes were estimated via theoretical analysis and PLQY measurements.
Article
Biochemistry & Molecular Biology
Sonila Xhafa, Laura Olivieri, Corrado Di Nicola, Riccardo Pettinari, Claudio Pettinari, Alessia Tombesi, Fabio Marchetti
Summary: In this study, a new synthetic protocol based on microwave-assisted synthesis was used to prepare higher yields of zinc and copper in MOFs with different ligands. The antibacterial activity of these MOFs was tested against Gram-negative and Gram-positive bacteria, and the results showed that they exhibited broad-spectrum activity and strong efficiency in inhibiting bacterial growth. The mechanism of action was found to be based on the surface contact of MOF particles with bacterial cells and the generation of reactive oxygen species.
Article
Polymer Science
Huda Alsaeedi, Hilal Ahmad, Malak Faisal Altowairqi, Afnan Abdullah Alhamed, Ali Alsalme
Summary: Cellulose nanoparticles were synthesized and covalently functionalized with multi-functional group for their excellent application in environmental remediation technology. The hybrid material demonstrated excellent adsorption properties for simultaneous extraction of multiple metal ions. The sorbent exhibited a sorption capacity in the range of 1.8-2.2 mmol/g. The method was successfully employed for simultaneous extraction and determination of Pb(II), Cd(II) and Cu(II) from real-world samples, with a preconcentration limit of 0.7 ppb and a detection limit of 0.4 ppb.
Article
Biochemistry & Molecular Biology
Syed Ghazanfar Ali, Uzma Haseen, Mohammad Jalal, Rais Ahmad Khan, Ali Alsalme, Hilal Ahmad, Haris Manzoor Khan
Summary: In this study, copper oxide nanoparticles were synthesized using the leaves of Aegle marmelos plant and characterized by various techniques. The nanoparticles showed a crystalline structure and exhibited antimicrobial activity and photocatalytic degradation of organic dyes.
Article
Chemistry, Multidisciplinary
Corrado Di Nicola, Fabio Marchetti, Alessia Tombesi, Sonila Xhafa, Patrizio Campitelli, Marco Moroni, Simona Galli, Riccardo Pettinari, Claudio Pettinari
Summary: Novel copper(ii) coordination polymers were synthesized and their thermal behavior and structural features were investigated. The nanoparticles showed potential antibacterial activity through a contact kill mechanism involving ROS production.
NEW JOURNAL OF CHEMISTRY
(2023)