Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α Production

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

(2014) Sarah L. Rowland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GM-CSF-Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis

(2014) H.-J. Ko et al.   JOURNAL OF IMMUNOLOGY

The BAFF/APRIL system in SLE pathogenesis

(2014) Fabien B. Vincent et al.   Nature Reviews Rheumatology

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

(2013) C. J. Vandenberg et al.   BLOOD

Lupus Nephritis: Treatment of Resistant Disease

(2013) S. Kalloo et al.   Clinical Journal of the American Society of Nephrology

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

Structure-guided design of a selective BCL-XL inhibitor

(2013) Guillaume Lessene et al.   Nature Chemical Biology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

(2013) R. Baccala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

(2013) Paul Koenen et al.   Nature Communications

Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

(2012) D. Merino et al.   BLOOD

BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus

(2012) Fabien B Vincent et al.   IMMUNOLOGY AND CELL BIOLOGY

Resistance to ABT-737 in activated T lymphocytes: molecular mechanisms and reversibility by inhibition of the calcineurin–NFAT pathway

(2012) P E Cippà et al.   Cell Death & Disease

GM-CSF increases cross-presentation and CD103 expression by mouse CD8+ spleen dendritic cells

(2011) Yifan Zhan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prominent Role for Plasmacytoid Dendritic Cells in Mucosal T Cell-Independent IgA Induction

(2011) Hiroyuki Tezuka et al.   IMMUNITY

Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis

(2011) Kate E. Lawlor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Role of Th17 cells in human autoimmune arthritis

(2010) Jan Leipe et al.   ARTHRITIS AND RHEUMATISM

Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy

(2010) Melissa Swiecki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Factors determining the spontaneous activation of splenic dendritic cells in culture

(2010) David Vremec et al.   Innate Immunity

The interferon-α signature of systemic lupus erythematosus

(2010) G. Obermoser et al.   LUPUS

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

(2010) E. M. Carrington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

Cutaneous distribution of plasmacytoid dendritic cells in lupus erythematosus. Selective tropism at the site of epithelial apoptotic damage

(2009) William Vermi et al.   IMMUNOBIOLOGY

Plasmacytoid Dendritic Cells Regulate Autoreactive B Cell Activation via Soluble Factors and in a Cell-to-Cell Contact Manner

(2009) C. Ding et al.   JOURNAL OF IMMUNOLOGY

CTLA4Ig Alters the Course of Autoimmune Disease Development in Lyn-/- Mice

(2009) S. A. Oracki et al.   JOURNAL OF IMMUNOLOGY

The Bcl-2 Family Antagonist ABT-737 Significantly Inhibits Multiple Animal Models of Autoimmunity

(2009) P. D. Bardwell et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

(2008) J. S. Allen et al.   DIABETES

Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment

(2008) Cristina Albanesi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression

(2008) Ou Jin et al.   LUPUS