Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation

Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm

(2015) Matthew Pahl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells

(2015) L. E. M. Kistemaker et al.   THORAX

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

(2015) Christopher M. Evans et al.   Nature Communications

Interleukin-13-induced MUC5AC expression is regulated by a PI3K–NFAT3 pathway in mouse tracheal epithelial cells

(2014) Fugui Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Secretory Hyperresponsiveness and Pulmonary Mucus Hypersecretion

(2014) Bruce K. Rubin et al.   CHEST

The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

(2014) S. Infantino et al.   Science Signaling

Lyn Mitigates Mouse Airway Remodeling by Downregulating the TGF- 3 Isoform in House Dust Mite Models

(2013) G. Li et al.   JOURNAL OF IMMUNOLOGY

Streptochlorin Suppresses Allergic Dermatitis and Mast Cell Activation via Regulation of Lyn/Fyn and Syk Signaling Pathways in Cellular and Mouse Models

(2013) Seung-Hwan Lee et al.   PLoS One

Sensitivity of MUC5AC to Topical Corticosteroid is Negatively Associated with Interleukin-17A in Patients with Allergic Rhinitis

(2012) Haocheng Tang et al.   American Journal of Rhinology & Allergy

Functions of the Lyn tyrosine kinase in health and disease

(2012) Evan Ingley   Cell Communication and Signaling

Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background

(2012) Maverick Lau et al.   JOURNAL OF AUTOIMMUNITY

Interleukin-13 Induces Mucin 5AC Production Involving STAT6/SPDEF in Human Airway Epithelial Cells

(2011) Hongmei Yu et al.   CELL COMMUNICATION AND ADHESION

Association of Src-Related Kinase Lyn with the Interleukin-2 Receptor and Its Role in Maintaining Constitutive Phosphorylation of JAK/STAT in Human T-Cell Leukemia Virus Type 1-Transformed T Cells

(2011) M. Shuh et al.   JOURNAL OF VIROLOGY

Interleukin-13 Signaling and Its Role in Asthma

(2011) Efren L. Rael et al.   World Allergy Organization Journal

Chemoattractant-Induced Signaling via the Ras-ERK and PI3K-Akt Networks, along with Leukotriene C4 Release, Is Dependent on the Tyrosine Kinase Lyn in IL-5- and IL-3-Primed Human Blood Eosinophils

(2010) Y. Zhu et al.   JOURNAL OF IMMUNOLOGY

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Airway MUC5AC Expression by IL-1  and IL-17A; the NF- B Paradigm

(2009) T. Fujisawa et al.   JOURNAL OF IMMUNOLOGY

Interleukin-4, Interleukin-13, Signal Transducer and Activator of Transcription Factor 6, and Allergic Asthma

(2008) Douglas Kuperman et al.   CURRENT MOLECULAR MEDICINE

Mucus hypersecretion in asthma: causes and effects

(2008) Christopher M Evans et al.   CURRENT OPINION IN PULMONARY MEDICINE

Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma

(2008) M. Kraft et al.   EUROPEAN RESPIRATORY JOURNAL

Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells

(2008) Tomoyuki FUJISAWA et al.   RESPIROLOGY

A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation

(2007) Y. Suzaki et al.   EUROPEAN RESPIRATORY JOURNAL