Identification of Interleukin-1β-Producing Monocytes That Are Susceptible to Pyronecrotic Cell Death in Patients With Neonatal-Onset Multisystem Inflammatory Disease

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies

(2013) Susannah D. Brydges et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiple Interferon Regulatory Factor and NF- B Sites Cooperate in Mediating Cell-Type- and Maturation-Specific Activation of the Human CD83 Promoter in Dendritic Cells

(2013) M. F. Stein et al.   MOLECULAR AND CELLULAR BIOLOGY

Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: A cohort study to determine three- and five-year outcomes

(2012) Cailin H. Sibley et al.   ARTHRITIS AND RHEUMATISM

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome: Results of an international multicenter collaborative study

(2011) Naoko Tanaka et al.   ARTHRITIS AND RHEUMATISM

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: Results from two sequential placebo-controlled studies

(2008) Hal M. Hoffman et al.   ARTHRITIS AND RHEUMATISM

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY