Article
Biochemistry & Molecular Biology
Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Toshihiko Toda, Takahiko Shimizu
Summary: The study showed that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis, but did not affect ROS-mediated tissue degeneration in SOD-deficient models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Edurne Tellechea, Aaron C. Asensio, Paula Ciaurriz, Javier Buezo, Pedro Lopez-Gomez, Marina Urra, Jose F. Moran
Summary: This study investigates the characteristics of the recombinant cowpea FeSOD immobilized onto gold nanoparticles (AuNPs) and the effects of NP surface chemistry and biofunctionalization methods on enzyme activity. The results highlight the importance of the biomolecule and AuNP interaction for the functionality of the hybrid and demonstrate the potential of these strategies in biomedical applications.
Article
Cell Biology
Khairun Nisaa, Anat Ben-Zvi
Summary: Muscle proteostasis is regulated by the myogenic transcription factor MyoD. This study demonstrates that MyoD can modulate chaperone expression in terminally differentiated muscle cells, indicating its role in muscle maintenance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyehun Choi, Michael R. Miller, Hong-Ngan Nguyen, Victoria E. Surratt, Stephen R. Koch, Ryan J. Stark, Fred S. Lamb
Summary: TNF alpha activates NADPH oxidase 1, which produces extracellular superoxide anion. The secreted protein ecSOD converts superoxide anion to hydrogen peroxide, playing a role in TNF alpha signaling in vascular smooth muscle cells. Knockdown of ecSOD suppresses downstream TNF alpha signals and reduces expression of TNF alpha receptors.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Giovanna Salbitani, Angela Perrone, Luigi Rosati, Carmen Laezza, Simona Carfagna
Summary: This study investigates the effects of sulfur deprivation on Galdieria sulphuraria and reveals that it leads to a decrease in total protein content and an increase in soluble protein fraction. The glutathione content in Galdieria sulphuraria remains high even under sulfur deprivation.
Article
Biology
ShylajaNaciyar Mohandass, Mangalalakshmi Ragavan, Dineshbabu Gnanasekaran, Uma Lakshmanan, Prabaharan Dharmar, Sushanta Kumar Saha
Summary: Synthetic azo dyes are widely used but their improper discharge poses a threat to the environment. Genetically modified cyanobacteria with enhanced H2O2 accumulation through SOD overexpression can effectively degrade these dyes, suggesting a valuable bioremediation strategy.
Article
Fisheries
Min Yang, Luchuanyang Sun, Yasunosuke Kawabata, Takahiro Maegawa, Shigeto Taniyama, Katsuyasu Tachibana, Katsuya Hirasaka
Summary: Balenine, an endogenous imidazole dipeptide composed of beta-alanine and 3-methyl-l-histidine, is found mainly in muscles and the brain. Studies have shown that balenine exhibits antioxidant activity by increasing SOD activity without affecting other antioxidant enzymes. This suggests that balenine contributes to antioxidant effects through activation of SOD.
Article
Forestry
Ya Chen, Hua Wu, Zhaodong Hao, Liming Zhu, Lu Lu, Jisen Shi, Jinhui Chen
Summary: This study systematically identified and analyzed the SOD gene family of woody plant Liriodendron chinense, and investigated the transcriptional responses of LcSOD genes to abiotic stresses. A total of eight SOD genes were identified and divided into two subgroups. The gene expression analysis revealed the response of LcSOD genes to abiotic stresses, providing potential targets for improving stress tolerance in L. chinense.
Article
Plant Sciences
Chunsong Huo, Linshen He, Ting Yu, Xue Ji, Rui Li, Shunqin Zhu, Fangyuan Zhang, He Xie, Wanhong Liu
Summary: This study systematically characterized the SOD gene family in the tobacco genome, identifying 15 NtSOD genes classified into three subgroups. Functional predictions were consistent with subcellular localization, indicating a protective role against ROS induced by heavy metal stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Lei Cheng, Baolin Yang, Hua Du, Tong Zhou, Yang Li, Jiajie Wu, Zhenxiao Cao, An Xu
Summary: This study explores the nervous responses of Caenorhabditis elegans to moderate-intensity static magnetic fields (SMFs) and finds that these SMFs can induce neurobehavioral disorders and reduction in fat storage by disturbing the secretion of serotonin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lourds M. Fernando, Silwat Adeel, Mohammed Abul Basar, Anna K. Allen, Atanu Duttaroy
Summary: The nematode C. elegans has five sod genes, but only the mitochondrial SOD shows activity in the water-soluble fraction, with lower activity compared to multiple active SODs in D. melanogaster and E. coli.
FREE RADICAL RESEARCH
(2021)
Article
Fisheries
JaiGopal Sharma, Amarjeet Singh, Ajima Begum, Sonia, Vungarala Hari Krishna, Rina Chakrabarti
Summary: This study evaluated the effects of feeding Achyranthes aspera seeds and leaves on the immune system of magur Clarias batrachus challenged with Aeromonas hydrophila in pond conditions. The results showed that the inclusion of A. aspera in the diet improved the immune system of the fish, reduced mortality rates, and promoted growth. Additionally, the feeds also lowered oxidative stress levels and increased antioxidant levels in the fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Cell Biology
Danial Khayatan, Seyed Mehrad Razavi, Zahra Najafi Arab, Yasamin Hosseini, Amirhossein Niknejad, Saeideh Momtaz, Amir Hossein Abdolghaffari, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Prashant Kesharwani, Amirhossein Sahebkar
Summary: In recent years, the prevalence of neurodegenerative diseases (NDD) has significantly increased, placing a burden on the community health system due to high healthcare costs. Superoxide dismutase (SOD) is a metalloenzyme that protects the body from oxidative stress through antioxidants. SOD supplementation can activate the body's natural antioxidant mechanism and neutralize excessive free radicals. Excessive reactive oxygen species (ROS) and reactive nitrogen species (RNS) can damage DNA and RNA, leading to mitochondrial dysfunction and oxidative stress-related diseases like NDD. Curcumin (Cur) has been shown to possess anti-inflammatory and neuroprotective properties, making it a potential therapeutic agent for NDD, possibly through its interaction with SOD.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Eun-Nam Kim, Ga-Ram Kim, Jae Sik Yu, Ki Hyun Kim, Gil-Saeng Jeong
Summary: The study found that BAG can inhibit osteoclast differentiation and ROS production, restore the expression of antioxidant enzymes, suppress the phosphorylation of MAPKs and translocation of NF-kappa beta, and restore the mineralization of lost osteoblasts, suggesting its potential as a new natural product-derived treatment for bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Ahmed B. M. Ibrahim, Ghada Abd-Elmonsef Mahmoud, David B. Cordes, Alexandra M. Z. Slawin
Summary: In this study, four new complexes were synthesized and tested for their antifungal activity. The results showed that all four complexes had significant inhibitory effects on the growth of Cladosporium sphaerospermum, resulting in a reduction in fungal dry mass and sugar consumption. Additionally, the antioxidant activities of the complexes varied depending on their concentrations.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Alexander M. Horspool, Jeffrey W. Schertzer
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Alexander M. Horspool, Howard C. Chang
Article
Multidisciplinary Sciences
Howard C. Chang, Jennifer Paek, Dennis H. Kim
Article
Multidisciplinary Sciences
Howard Chia-Hao Chang, Douglas N. Dimlich, Takakazu Yokokura, Ashim Mukherjee, Mark W. Kankel, Anindya Sen, Vasanthi Sridhar, Tudor A. Fulga, Anne C. Hart, David Van Vactor, Spyros Artavanis-Tsakonas
Article
Multidisciplinary Sciences
Lesley Emtage, Howard Chang, Rebecca Tiver, Christopher Rongo
Article
Genetics & Heredity
Maria Dimitriadi, James N. Sleigh, Amy Walker, Howard C. Chang, Anindya Sen, Geetika Kalloo, Jevede Harris, Tom Barsby, Melissa B. Walsh, John S. Satterlee, Chris Li, David Van Vactor, Spyros Artavanis-Tsakonas, Anne C. Hart
Article
Microbiology
Courtney E. Chandler, Alexander M. Horspool, Preston J. Hill, Daniel J. Wozniak, Jeffrey W. Schertzer, David A. Rasko, Robert K. Ernst
JOURNAL OF BACTERIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Alexander M. Horspool, Ting Wang, Young-Sun Scaringella, Mitchell E. Taub, Tom S. Chan
DRUG METABOLISM AND DISPOSITION
(2020)
Article
Multidisciplinary Sciences
Chun-Ying Yu, Howard C. Chang
Summary: Glutamate transmission plays a role in the behavioral response and plasticity of Caenorhabditis elegans to Pseudomonas aeruginosa. Glutamate receptor GLR-1 and superoxide dismutase SOD-1 are involved in the downstream neuronal network. This study provides insights into the link between glutamate signaling and oxidative stress in the nervous system.
Article
Cell Biology
HCH Chang, C Rongo
JOURNAL OF CELL SCIENCE
(2005)
Article
Cell Biology
DR Glodowski, T Wright, K Martinowich, HCH Chang, D Beach, C Rongo
MOLECULAR BIOLOGY OF THE CELL
(2005)