Article
Multidisciplinary Sciences
Ana I. Fernandez-Marino, Xiao-Feng Tan, Chanhyung Bae, Kate Huffer, Jiansen Jiang, Kenton J. Swartz
Summary: The study reveals the structure and functional mechanisms of the Kv2.1 voltage-activated potassium channel, providing insights into how mutations affect channel activity. Inactivation in Kv2.1 is found to be caused by dynamic alterations in electromechanical coupling, which suggests a conserved mechanism in voltage-activated cation channels and its relevance for regulating neuron firing.
Article
Multidisciplinary Sciences
Nicholas C. Vierra, Samantha C. O'Dwyer, Collin Matsumoto, L. Fernando Santana, James S. Trimmer
Summary: In mammalian brain neurons, membrane depolarization triggers Ca2+ influx through voltage-gated Ca2+ channels, leading to diverse cellular responses, including gene expression. The L-type Ca2+ channels in neuronal soma and dendrites play a key role in this process. The organization of signaling complexes by Kv2.1 at endoplasmic reticulum-plasma membrane junctions enhances the clustering and activity of Cav1.2 channels, impacting somatic Ca2+ signals and excitation-transcription coupling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Kristina Haer, Natalia N. Lysenko, Daniela Dimitrova, Torsten Schlueter, Olga Zavaritskaya, Andrej G. Kamkin, Mitko Mladenov, Olaf Grisk, Ralf Koehler, Hristo Gagov, Rudolf Schubert
Summary: Vascular smooth muscle Kv2 channels contribute to myogenic autoregulation by fine-tuning the myogenic response. Specifically, Kv2.1 channels are predominantly expressed in smooth muscle cells and provide a negative feedback mechanism by preventing vasomotion and safeguarding the myogenic response. The Kv2 channel inhibitor stromatoxin induces vasomotion in some vessels, leading to disturbances in the myogenic response.
Article
Biochemistry & Molecular Biology
Yuchen Zhang, Xuefeng Zhang, Cuiyun Liu, Changlong Hu
Summary: The study identified differences in the hydrogen bond controls for slow inactivation between mammalian Kv channels and Shaker channels, indicating the crucial role of the inter-subunit hydrogen bond formed by W366 and Y376 in regulating the K+ conductance in mammalian Kv2.1, Kv2.2, and Kv1.2 channels.
Article
Biochemical Research Methods
Zhen Xu, Saif Khan, Nicholas J. Schnicker, Sheila Baker
Summary: This study used X-ray crystallography to determine the structure of the human Kv2.1 T1 domain and found that it forms a pentamer, different from other Kv T1 domains. The study also demonstrated the importance of zinc binding for the stability of the Kv2.1 T1 domain.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Bishwajyoti Purkayastha, Tanmoy Bhattacharya
Summary: This article proposes a scheme to use time-multiplexing for transmitting the sensed data of a modular multilevel converter. The mathematical analysis of the data transmission system and its influence on closed-loop performance is studied, and the proposed scheme is experimentally verified in the laboratory.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2022)
Article
Engineering, Electrical & Electronic
Venkata Ramesh Naganaboina, Satish Bonam, Mariappan Anandkumar, Atul Suresh Deshpande, Shiv Govind Singh
Summary: In this study, a highly selective methane gas sensor is fabricated using Ce-HEC as a sensing material, and a humidity compensation model is developed using multivariate polynomial regression techniques to reduce the interference of humidity on sensing response.
IEEE ELECTRON DEVICE LETTERS
(2022)
Article
Engineering, Electrical & Electronic
Fangxing Hou, Yuxin Zhang, Lei Sheng
Summary: The study shows that using adhesive patterning liquid metal flexible electrodes can effectively improve the efficiency of external defibrillators and electrocardiogram measurements, while reducing energy input and avoiding skin burns.
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Yuval Ben-Abu
Summary: This article explores the application of quantum mechanics in the study of ion channels, focusing on the time required for ions to cross two gates.
BIOPHYSICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jeffrey Z. Nie, James W. Nie, Na-Teng Hung, R. James Cotton, Marc W. Slutzky
Summary: Arm movement kinematics may provide a more sensitive way to assess neurorehabilitation outcomes than existing metrics. Two open-source methods using inertial measurement units and virtual reality sensors accurately measured wrist position with respect to the shoulder during reaching movements in people with stroke. Both methods showed high accuracy and strong correlation in estimating kinematics in chronic stroke patients, making them potentially useful for evaluating stroke rehabilitation outcomes in laboratory and clinical settings.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Artur de Araujo Silva, Claudio Floridia, Joao Batista Rosolem
Summary: This study explores the experimental application of current and voltage polarization sensors in a medium voltage distribution grid, utilizing a 90-degree polarization degree for compensation to improve measurement accuracy.
Article
Biochemistry & Molecular Biology
Verena Schmid, Alexander Wurzel, Christian H. Wetzel, Karolina Ploessl, Astrid Bruckmann, Patricia Luckner, Bernhard H. F. Weber, Ulrike Friedrich
Summary: Retinoschisin interacts directly with the retinal Na/K-ATPase and Kv2.1 and Kv8.2 channel subunits to form a macromolecular complex at the photoreceptor inner segments. Deficiency of retinoschisin leads to mislocalization of the complex and decreased expression of Kv2.1 and Kv8.2 proteins. This may be a crucial step in the pathogenesis of X-linked juvenile retinoschisis (XLRS).
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Analytical
Yiling Meng, Delu Zhao, Xingye Yang, Yixuan Li, Bohui Liu, Zijie Zhang, Shuyue Cui, Fulan Wei
Summary: A near-infrared ratiometric hemicyanine-based pH fluorescence probe was designed and synthesized for reliable and safe monitoring of bone resorption in orthodontic treatment. In vitro and in vivo experiments demonstrated that the probe had high sensitivity, excellent photostability, reversibility, and strong resistance to interference. The probe could detect bone resorption through fluorescence imaging and quantitative monitoring of pH. Therefore, it has great clinical potential for real-time monitoring of bone resorption in orthodontic treatment and as a reference for other bone resorption-related diseases.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Ying Hou, Jianyu Fu, Chao Liu, Qiong Zhou, Wanjin Feng, Peng Huang, Dapeng Chen
Summary: This paper investigates the measurement errors in multi-pixel thermopile sensors with networked arrangement through mathematical modeling and experimental study. The results indicate that the actual response voltage, resistance, and array size of adjacent pixels have an impact on the measurement error. The study also demonstrates that solving the actual response voltage of each pixel without introducing more equations is challenging.
IEEE SENSORS JOURNAL
(2021)
Review
Engineering, Industrial
Nathan A. Edwards, Maria K. Talarico, Ajit Chaudhari, Cody J. Mansfield, James Onate
Summary: This systematic review examines the use of accelerometers and inertial measurement units in quantifying movement patterns of tactical athletes. The study found that accelerometers were the most commonly used sensor type, and physical activity was the primary outcome variable. However, research on firefighters, emergency medical services, and law enforcement officers was limited. Future research should focus on making quantified movement data more accessible and user-friendly for non-research personnel.
APPLIED ERGONOMICS
(2023)
Article
Developmental Biology
Glenn Regnier, Elke Bocksteins, Waleed F. Marei, Isabel Pintelon, Jean-Pierre Timmermans, Jo L. M. R. Leroy, Dirk J. Snyders
REPRODUCTION FERTILITY AND DEVELOPMENT
(2017)
Meeting Abstract
Biophysics
Evelyn Martinez-Morales, Laura C. Coonen, Dieter V. Van de Sande, Dirk J. Snyders, Alain J. Labro
BIOPHYSICAL JOURNAL
(2018)
Article
Pharmacology & Pharmacy
Dieter V. Van de Sande, Ivan Kopljar, Ard Teisman, David J. Gallacher, Dirk J. Snyders, Hua Rong Lu, Alain J. Labro
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Biophysics
Laura Coonen, Evy Mayeur, Nicolas De Neuter, Dirk J. Snyders, Luis G. Cuello, Alain J. Labro
BIOPHYSICAL JOURNAL
(2020)
Article
Multidisciplinary Sciences
Lena Moller, Glenn Regnier, Alain J. Labro, Rikard Blunck, Dirk J. Snyders
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Pharmacology & Pharmacy
Kenny M. Van Theemsche, Dieter V. Van de Sande, Dirk J. Snyders, Alain J. Labro
FRONTIERS IN PHARMACOLOGY
(2020)
Letter
Multidisciplinary Sciences
Lena Moller, Glenn Regnier, Alain J. Labro, Dirk J. Snyders, Rikard Blunck
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Dieter V. van de Sande, Ivan Kopljar, Alaerts Maaike, Ard Teisman, David J. Gallacher, Loeys Bart, Dirk J. Snyders, Luc Leybaert, Hua Rong Lu, Alain J. Labro
Summary: Human-induced pluripotent stem cell and stem cell-derived cardiomyocytes exhibit a more hyperpolarized resting membrane potential when interconnected in a syncytium, likely due to an increased pool of active Kir2.1 channels. This finding highlights the importance of considering the cellular environment when studying electrophysiological characteristics of these cells.
Article
Biochemistry & Molecular Biology
Rohit Arora, Kenny M. Van Theemsche, Samuel Van Remoortel, Dirk J. Snyders, Alain J. Labro, Jean-Pierre Timmermans
Summary: Members of the MRGPRs, a subfamily of GPCRs, are involved in regulating inflammation, with MRGPRD releasing IL-6 upon stimulation by beta-alanine through the IKK/NF-kappa B signaling pathway. Inhibitors can block IL-6 release. FBS dependency affects the basal activity of MRGPRD in an in vitro system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Laura Coonen, Evelyn Martinez-Morales, Dieter V. Van De Sande, Dirk J. Snyders, D. Marien Cortes, Luis G. Cuello, Alain J. Labro
Summary: This study found that the conductive state of the Shaker-IR-W434F-P475D mutant becomes loose and noncationic specific during the recovery from inactivation.
Article
Biochemistry & Molecular Biology
Kenny M. Van Theemsche, Joni G. Heymans, Nikola Z. Popovic, Evelyn Martinez-Morales, Dirk J. Snyders, Alain J. Labro
Summary: A cluster of charged residues at the top of S1 and the beginning of the S1-S2 linker are found to be close enough to S4 and offset (polarize) the electric field sensed by S4, contributing to the voltage dependence of channel activation.
Meeting Abstract
Biophysics
Laura Coonen, Evelyn Martinez-Morales, Luis G. Cuello, Dirk J. Snyders, Alain J. Labro
BIOPHYSICAL JOURNAL
(2022)
Meeting Abstract
Biophysics
Lena Moeller, Alain J. Labro, Dirk J. Snyders, Rikard Blunck
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Rohit Arora, Samuel Van Remoortel, Geert Van Raemdonck, Geert Baggerman, Roeland Buckinx, Dirk J. Snyders, Alain J. Labro, Jean-Pierre Timmermans
Article
Medicine, Research & Experimental
Nejia Tounsi, Alain J. Labro, Emna Kerkeni, Mohamed Habib Grissa, Imen Trabelsi, Imen Gannoun, Abbi Van Tilborg, Nasri Bzeouich, Kamel Monastiri, Dirk J. Snyders, Semir Nouira
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2018)