Proceedings Paper
Engineering, Biomedical
Xianle Shi, Jun Liang, Hengyu Zhang, Chunxiao Wan, Rui Xu, Dong Ming
Summary: This study investigated the changes in EEG phase synchronization in stroke patients during alternating ankle movements, finding that patients had lower phase synchronization index compared to healthy individuals, especially in the affected sensory cortex. Furthermore, there was a negative correlation between the recovery of neurons in stroke patients and cortical synchronization.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)
Article
Multidisciplinary Sciences
Jeffrey D. Laurence-Chasen, Callum F. Ross, Fritzie I. Arce-McShane, Nicholas G. Hatsopoulos
Summary: The authors successfully decoded complex tongue deformation from sensorimotor cortex neurons, indicating a cortical representation of 3D tongue shape. They used biplanar x-ray video technology, multi-electrode cortical recordings, and machine-learning-based decoding to explore the cortical representation of lingual deformation.
NATURE COMMUNICATIONS
(2023)
Article
Energy & Fuels
Alexander Karger, Leo Wildfeuer, Deniz Ayguel, Arpit Maheshwari, Jan P. Singer, Andreas Jossen
Summary: This study investigates the modeling methods for capacity fade in lithium-ion batteries during dynamic cyclic aging tests. The results show that the CAP-method accurately models the capacity fade when considering dynamic conditions, while the CCT-method is more accurate in modeling capacity gradient when there is a large difference between actual and reference charge-throughput. The CAP-method assumes path independence through history independence, and the relatively low capacity fade error suggests that capacity fade behaves path-independently in the dynamic cyclic aging tests.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Clinical Neurology
Kristina Denisova
Summary: This is the first English translation of a research article titled "Periodic phenomena in the sleep in children" which was originally published in 1926. The study, conducted by Maria Denisova and Nicholai Figurin, provides the first known data on rapid eye movement (REM) sleep, including observations on respiration, eye and body movements in infants. The study identifies unique sleep state patterns in infants and suggests atonia during REM sleep. Importantly, these findings predate all published studies on REM sleep by about 30 years.
Article
Neurosciences
Jochem van Kempen, Marc A. Gieselmann, Michael Boyd, Nicholas A. Steinmetz, Tirin Moore, Tatiana A. Engel, Alexander Thiele
Summary: Fluctuations in cortical excitability affect sensory processing and behavior. These fluctuations are coordinated across different brain areas, with top-down attention enhancing this coordination. The degree of local state coordination between different areas can predict behavioral performance.
Article
Neurosciences
Tomoki W. Suzuki, Ken-Ichi Inoue, Masahiko Takada, Masaki Tanaka
Summary: The study shows that cortical feedback inputs play a role in modulating neuronal activity in the motor thalamus during goal-directed behavior, especially in primates. Optical stimulation influences thalamic neuron activity, with task-specific effects and non-task-specific changes observed.
Article
Neurosciences
Rania Almajid, Carole Tucker, Emily Keshner, Erin Vasudevan, William Geoffrey Wright
Summary: This study investigated the impact of wearing HMD on kinematic measures in younger and older adults, finding that wearing HMD decreased turning cadence and trunk velocities, and increased the time to complete tasks, especially in older adults. This suggests that the effects of HMD on physical performance should be considered in VR rehabilitation applications.
Article
Neurosciences
Sarah L. West, Justin D. Aronson, Laurentiu S. Popa, Kathryn D. Feller, Russell E. Carter, William M. Chiesl, Morgan L. Gerhart, Aditya C. Shekhar, Leila Ghanbari, Suhasa B. Kodandaramaiah, Timothy J. Ebner
Summary: Motor behavior involves complex exchanges of motor and sensory information across cortical regions. A study using mesoscopic Ca2+ imaging in mice reveals increased activation of the dorsal cerebral cortex during locomotion. The study also found that the functional connectivity of the cortex changes during the transition from rest to locomotion and vice versa, with increased correlations among most nodes. However, once a steady state of locomotion is reached, certain nodes show decreased correlations while others show increased correlations.
Article
Clinical Neurology
Paolo Cardone, Maxime Van Egroo, Daphne Chylinski, Justinas Narbutas, Giulia Gaggioni, Gilles Vandewalle
Summary: Attentional lapses are associated with a transient increase in cortical excitability, but do not lead to detectable changes in subsequent effective connectivity. Despite qualitative differences, age does not significantly affect the TMS-EEG measures.
Article
Engineering, Environmental
Shunyao Wang, Peter J. Gallimore, Carolyn Liu-Kang, Kirsten Yeung, Steven J. Campbell, Battist Utinger, Tengyu Liu, Hui Peng, Markus Kalberer, Arthur W. H. Chan, Jonathan P. D. Abbatt
Summary: This study reports the unique chemical and toxicological metrics of biomass burning organic aerosols (BBOA) from pine wood smoldering during multiphase aging by gas-phase hydroxyl radicals (OH). Both the fresh and OH-aged BBOA show activity relevant to adverse health outcomes. Short-term aging initiated by OH radicals can produce biomass burning particles with a higher particle-bound reactive oxygen species (ROS) generation capacity, posing a greater exposure hazard for residents in large population centers close to wildfire regions than previously studied fresh biomass burning emissions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Kanika Bansal, Javier Garcia, Cody Feltch, Christopher Earley, Ryan Robucci, Nilanjan Banerjee, Justin Brooks
Summary: This study investigates the relationship between leg movements and cortical arousals during sleep using a novel leg movement monitor and polysomnography. The results show that the capacitive displacement measures are more closely related to cortical arousals than inertial measurements. The neuro-extremity analysis reveals a temporally evolving connectivity pattern, supporting a model in which brainstem dysfunction leads to leg movements during sleep and cortical arousals.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Fu-Jung Hsiao, Wei-Ta Chen, Li-Ling Hope Pan, Hung-Yu Liu, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Gianluca Coppola, Shuu-Jiun Wang
Summary: This study compares neuronal excitability in the brainstem and primary somatosensory region between different phases of migraine attacks and finds that migraine is a cyclic excitatory disorder involving the somatosensory system, starting in the brainstem and subsequently spanning to the S1 area, which contributes to a better understanding of the pathophysiology of migraine.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Computer Science, Information Systems
Chenyang Sun, Kaiya Chu, Qing Miao, Li Ping, Wenjuan Zhong, Shichen Qi, Mingming Zhang
Summary: This study investigated bilateral force production and control in dynamic tasks, revealing significant asymmetry in force output between bilateral hands. The results show that force difference between two hands decreased with the increase of the target force, while the sensitivity to moving directions differed.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Energy & Fuels
Jizhao Xu, Cheng Zhai, P. G. Ranjith, Shuxun Sang, Xu Yu, Yong Sun, Yuzhou Cong, Yangfeng Zheng, Wei Tang
Summary: The study found that coal affected by liquid CO2 exhibited more complex destruction patterns, larger fractal dimensions, and greater structure degradation. The affected coals showed diverse mechanical responses, with temperature shock and CO2 adsorption potentially leading to crack growth and strength deterioration, ultimately destroying the coal with smaller yield strength.
Article
Cell Biology
Yaroslav Sych, Aleksejs Fomins, Leonardo Novelli, Fritjof Helmchen
Summary: By training mice in a tactile discrimination task, we found that the functional networks in the brain undergo dynamic reorganization and establish mesoscale network dynamics suitable for goal-oriented behavior.
Article
Engineering, Biomedical
Lazar I. Jovanovic, Milos R. Popovic, Cesar Marquez-Chin
Summary: This study evaluated the effectiveness of using band-pass filters in reducing stimulation interference during BCI-FEST. Results showed that SNR values increased for all participants across different types of movements after filtering.
Article
Clinical Neurology
Ke Zeng, Ghazaleh Darmani, Anton Fomenko, Xue Xia, Stephanie Tran, Jean-Francois Nankoo, Yazan Shamli Oghli, Yanqiu Wang, Andres M. Lozano, Robert Chen
Summary: Transcranial ultrasound stimulation (TUS) has been shown to effectively induce cortical plasticity in human subjects, with the potential for neuromodulation treatment for neurological and psychiatric disorders, as well as advancing neuroscience research. This study demonstrated the efficacy of TUS in increasing corticospinal excitability and modulating intracortical inhibition and facilitation in the motor cortex.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Kaviraja Udupa, Amitabh Bhattacharya, Robert Chen
Summary: This article reviews the findings of motor cortical excitability, plasticity, and evoked potentials in dystonia. The studies suggest that there are alterations in cortical excitability and plasticity in dystonia, and different treatments such as deep brain stimulation can modulate these changes.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2022)
Article
Chemistry, Analytical
Milad Alizadeh-Meghrazi, Gurjant Sidhu, Saransh Jain, Michael Stone, Ladan Eskandarian, Amirali Toossi, Milos R. Popovic
Summary: This study developed textile electrodes as an alternative to traditional gel electrodes for recording electromyography (EMG) signals, and compared their performance and washability. The results showed that the textile electrodes performed comparably to gel electrodes in signal recording, and were able to successfully control a myoelectric prosthetic hand.
Article
Computer Science, Information Systems
Yupeng Tian, Muammar Kabir, Mohammad Abdizadeh, Behnaz Poursartip, Amin Mahnam, Presish Bhattachan, Ladan Eskandarian, Milad Alizadeh Meghrazi, Idir Mellal, Milos R. Popovic, Milad Lankarany
Summary: This paper presents an approach to generating noisy textile ECG signals and creating a Textile-like ECG dataset with 108 trials. Additionally, the authors provide a Python code for generating textile-like ECG signals with variable SNR online.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Letter
Clinical Neurology
Can Sarica, Anton Fomenko, Jean-Francois Nankoo, Ghazaleh Darmani, Artur Vetkas, Kazuaki Yamamoto, Andres M. Lozano, Robert Chen
Biographical-Item
Engineering, Biomedical
Lana Popovic-Maneski, Strahinja Dosen, Milos R. Popovic, Christine Azevedo, Thierry Keller, Simona Ferrante, Vance Bergeron, Matija Milosevic
Article
Neurosciences
Zhitang Chen, Zheng Dou, Hui Xu, Zhenghua Wang, Suhua Zeng, Xiangyu Yang, Eiki Takahashi, Milos R. Popovic, Lihui Wang, Weidong Li
Summary: This study aimed to decompose the abnormal characteristics of encoding and maintenance in patients with recurrent major depressive disorder (MDD). The results showed lower performance in depression than the controls. However, the retention performance of the depression group did not further suffer from the short encoding time, unlike the control group.
Article
Physics, Multidisciplinary
Mohammad R. Rezaei, Reza Saadati Fard, Milos R. Popovic, Steven A. Prescott, Milad Lankarany
Summary: This study investigates how an ensemble of homogeneous neurons enables synchrony-division multiplexing (SDM) in response to mixed stimuli. The results show that both synchronous and asynchronous spikes can encode different features of the stimulus, providing insight into the mechanisms of neural multiplexing.
Article
Neurosciences
Kai -Hsiang Stanley Chen, Tzu-Kang Hung, Rupesh Kumar Chikara, Yu-Ting Kuo, Yi-Ping Liu, Yan-Siou Dong, Yih-Ru Wu, Li -Wei Ko, Ying-Zu Huang, Robert Chen
Summary: Based on the theory of coordinated reset (CR) stimulation, the noninvasive coordinated multifocal burst stimulation (COMBS) was developed to modulate the target frequency in the primary motor cortex. The results showed an increase in a-band power and low I3-band power during the finger-tapping task, and a reduction in low I3-band event-related desynchronization after COMBS. However, there were no significant changes in cortical excitability measured by various parameters.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Talyta Grippe, Alfonso Fasano, Robert Chen
Summary: This article describes an unusual case involving a combination of slow orthostatic tremor, orthostatic myoclonus, and parkinsonism. The case highlights the importance of utilizing electrophysiology for precise characterization of physical findings in order to establish a diagnosis.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Yazan Shamli Oghli, Talyta Grippe, Tarun Arora, Tasnuva Hoque, Ghazaleh Darmani, Robert Chen
Summary: In this study, the mechanisms of transcranial ultrasound stimulation (TUS) in human primary motor cortex were investigated by administering different drugs to healthy subjects. The results showed that all study drugs reduced the plasticity effects of tbTUS on motor cortex excitability. The conclusion is that tbTUS may induce NMDA-dependent synaptic plasticity and is influenced by increased GABAA receptor activity and blockers of voltage-gated Na+ and Ca2+ channels.
Article
Engineering, Biomedical
Rizaldi A. Fadli, Yuki Yamanouchi, Lazar Jovanovic, Milos R. Popovic, Cesar Marquez-Chin, Taishin Nomura, Matija Milosevic
Summary: This study evaluated the effectiveness of brain-computer interface (BCI)-controlled functional electrical stimulation (FES) in upper limb motor recovery. The findings showed that both M1 and PFC BCI-FES interventions had approximately 80% success rate, but M1 intervention was faster in detecting the activity. Furthermore, only the M1 intervention effectively elicited changes in corticospinal excitability, while cortical excitability measures did not indicate changes after either M1 or PFC BCI-FES.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Stephanie Tran, Calaina Brooke, Young Joon Kim, Stephen D. Perry, Jean-Francois Nankoo, Cricia Rinchon, Tarun Arora, Luc Tremblay, Robert Chen
Summary: People with Parkinson's disease show impaired visual and vestibular perception, but relatively preserved visual-vestibular integration during gait.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Talyta Grippe, Robert Chen
Summary: Many studies have shown that botulinum toxin (BoNT) can be an effective option for treating both motor and non-motor symptoms in Parkinson's disease (PD) and parkinsonian syndromes. BoNT has advantages over oral medications as it has localized action and a low incidence of systemic side effects, which is crucial in treating neurodegenerative diseases. However, most of the evidence for the use of BoNT in parkinsonism is based on open-label studies and there is a lack of randomized, controlled trials. Further research is needed to provide more evidence of its efficacy and determine the optimal injection protocols for different symptoms.