Article
Biology
Georges Raad, Fabrizio Serra, Luc Martin, Marie-Alix Derieppe, Jerome Gilleron, Vera L. Costa, Didier F. Pisani, Ez-Zoubir Amri, Michele Trabucchi, Valerie Grandjean
Summary: Research shows that maintaining a paternal Western diet feeding for five consecutive generations in mice leads to an increase in fat mass and related metabolic diseases over generations, but progenies from these multigenerational Western-diet-fed males develop a healthy overweight phenotype characterized by normal glucose metabolism and without fatty liver, which persists for four subsequent generations. Sperm RNA is suggested to be sufficient for the establishment but not for long-term maintenance of epigenetic inheritance of metabolic pathologies.
Article
Biochemistry & Molecular Biology
Andreu Gual-Grau, Maria Guirro, Noemi Boque, Lluis Arola
Summary: Genetic factors and sex can influence the gut microbiota composition and obesity status of rats fed a CAF diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Thais Helena Figueiredo do Bonfim, Renata Leite Tavares, Maria Helena Araujo de Vasconcelos, Mirela Gouveia, Polyana Campos Nunes, Nais Lira Soares, Raquel Coutinho Alves, Jader Luciano Pinto de Carvalho, Adriano Francisco Alves, Ramon de Alencar Pereira, Glebia Alexa Cardoso, Alexandre Sergio Silva, Jailane de Souza Aquino
Summary: This study compared the effectiveness of western and cafeteria diets as obesity-inducing protocols, finding that the cafeteria diet was more effective in inducing obesity and causing a greater number of obesity-related metabolic and neurobehavioral disorders in the evaluated rats.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Food Science & Technology
Michael D. Kendig, Sarah-Jane Leigh, Kyoko Hasebe, Nadeem O. Kaakoush, R. Fred Westbrook, Margaret J. Morris
Summary: This study aimed to investigate the effects of diet cycling on cognition and fecal microbiota. The results showed that switching to a regular diet for at least 11 days could reduce the impairment in place recognition memory caused by a high-fat, high-sugar cafeteria diet. Moreover, longer cycles of unhealthy diet exposure worsened cognitive deficits and led to larger shifts in gut microbiota composition. The results suggest that at least a week of healthy diet is necessary for recovery of cognitive deficits.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, General & Internal
Armin Rashidi, Fei Gao, David N. Fredricks, Steven A. Pergam, Marco Mielcarek, Filippo Milano, Brenda M. Sandmaier, Stephanie J. Lee
Summary: This cohort study identified antibiotics and antibiotic exposure timeframes associated with hazard of acute graft-vs-host disease (aGVHD) after allogeneic hematopoietic cell transplantation. The study highlights the importance of considering antibiotic choices and schedules in the early stages of transplantation in order to reduce aGVHD rates.
Article
Nutrition & Dietetics
Paolo De Marco, Ana C. Henriques, Rui Azevedo, Susana I. Sa, Armando Cardoso, Bruno Fonseca, Joana Barbosa, Sandra Leal
Summary: The study found that consumption of sugary drinks and CAFD in early rat life alters the gut microbial community structure, affects metabolic activity, increases white adipose tissue, and has long-lasting negative effects on metabolic function. Unhealthy diet-fed groups also showed higher levels of glucose, total cholesterol, and creatinine serum compared to the control group.
Article
Endocrinology & Metabolism
Daniela Diaz-Catalan, Gema Alcarraz-Vizan, Carlos Castano, Sara de Pablo, Julia Rodriguez-Comas, Antonio Fernandez-Perez, Mario Vallejo, Sara Ramirez, Marc Claret, Marcelina Parrizas, Anna Novials, Joan -Marc Servitja
Summary: The study found that inhibition of BACE2 in a model of diet-induced obesity leads to exacerbated body weight gain, hyperinsulinemia, and insulin resistance. This suggests that inhibition of BACE2 may worsen the adverse metabolic effects associated with obesity.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Thomas Guerbette, Martin Beaumont, Mireille Andriamihaja, Vincent Ciesielski, Jean-Baptiste Perrin, Regis Janvier, Gwenaelle Randuineau, Patricia Leroyer, Olivier Loreal, Vincent Rioux, Gaelle Boudry, Annaig Lan
Summary: Obesity is associated with inflammation, intestinal imbalance, and dysbiosis of the microbiota. This study aimed to investigate the effect of an obesogenic diet on mitochondrial function in colonic epithelial cells (CEC) of mice. The results showed that mice on the obesogenic diet developed obesity, intestinal hyperpermeability, and increased endotoxemia. Mitochondrial dysfunction, characterized by decreased respiration and lower ATP production, was observed in CEC of these mice. Additionally, increased sulfide production and altered bile acid concentrations were found in the colonic content of obese mice. Chronic treatment of control mouse colon organoids with sodium sulfide induced similar mitochondrial dysfunction, while acute exposure of isolated mitochondria from control mice to sodium sulfide decreased complex IV activity. These findings suggest that dysbiosis-induced sulfide production impairs mitochondrial function in CEC of obese mice.
Article
Food Science & Technology
Michael D. Kendig, Kyoko Hasebe, Aynaz Tajaddini, Nadeem O. Kaakoush, R. Frederick Westbrook, Margaret J. Morris
Summary: This study examines the effects of a diet switch intervention in a rat model of maternal obesity. The results show that the intervention leads to reductions in body weight and adiposity, improvements in place recognition memory, and changes in gut microbiota composition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Nutrition & Dietetics
Alice Zaramella, Diletta Arcidiacono, Daniele Nucci, Federico Fabris, Clara Benna, Salvatore Pucciarelli, Matteo Fassan, Alberto Fantin, Valli De Re, Renato Cannizzaro, Stefano Realdon
Summary: Esophageal adenocarcinoma (EAC) is a consequence of long-term gastroesophageal reflux, which leads to inflammation and could cause Barrett's esophagus (BE), the main risk factor for EAC development. The study aims to explore the esophageal microbial profile in patients with different stages of BE and EAC, and develop a score to predict cancer risk.
Article
Pharmacology & Pharmacy
Maria Chiara Valerii, Silvia Turroni, Carla Ferreri, Michela Zaro, Anna Sansone, Alessandro Dalpiaz, Giada Botti, Luca Ferraro, Renato Spigarelli, Irene Bellocchio, Federica D'Amico, Enzo Spisni
Summary: Studies have shown that D-Limonene can improve metabolic parameters in obese mice via various mechanisms, including modulation of intestinal microbiota. Administering a food supplement containing D-Limonene adsorbed on dietary fibers to mice on a high-fat diet led to decreased weight gain and improved metabolic profile, highlighting the potential non-toxic and effective use of this supplement in combating obesity.
Review
Medicine, Research & Experimental
Dan Li, Yujuan Li, Shengjie Yang, Jing Lu, Xiao Jin, Min Wu
Summary: The prevalence of metabolic diseases, such as obesity, type 2 diabetes, and nonalcoholic fatty liver disease, is closely related to environmental factors like diet and gut microbiota, as well as epigenetic modifications. Dietary components and habits can regulate the changes in gut microbiota, while microbiota-derived metabolites may play a role in the regulation of epigenetic modifications. These epigenetic changes mediated by microbial metabolites participate in metabolic disorders through alterations in intestinal permeability, immune responses, inflammatory reactions, and insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Penghao Sun, Mengli Wang, Zhuoni Li, Jingjing Wei, Feng Liu, Wei Zheng, Xiaoyan Zhu, Xuejun Chai, Shanting Zhao
Summary: This study investigates the effects of an obesogenic diet on adolescents and explores the role of Eucommiae cortex polysaccharides in mitigating the diet-induced behavioral dysfunction. The study reveals that the supplementation of polysaccharides improves cognitive and social behavior by modulating gut microbiota and tryptophan metabolism in adolescent mice fed with the obesogenic diet.
Review
Microbiology
Jack Jansma, Sahar El Aidy
Summary: Through in silico simulation methods based on flux balance analysis, interactions within the complex microbiota community in the human gut can be better investigated, aiding in understanding the intricate relationship between microbiota and the host. This approach can help researchers study the effects of various perturbations on different bacterial species in a shared metabolic environment, ultimately leading to improvements in human health.
Article
Food Science & Technology
Xinyue Dong, Yueyue Liu, Xingbin Yang, Ting Li
Summary: The gut microbiome, influenced by genetic and dietary factors, plays a critical role in human health and disease. miRNAs, both derived from diet and the host, can affect the growth of gut microbes through extracellular vesicles (EVs). This has potential implications for precision nutrition, disease management, and personalized treatment.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Md Mustahsan Billah, Saroj Khatiwada, Virginie Lecomte, Margaret J. Morris, Christopher A. Maloney
Summary: This study investigated the effects of an antioxidant-based micronutrient supplement on sperm and testicular oxidative damage in male rats fed a high-fat diet. The results suggest that the supplement may reduce oxidative damage in sperm and testis and improve testicular antioxidant capacity.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Craig Haifer, Laurence Don Wai Luu, Sudarshan Paramsothy, Thomas J. Borody, Rupert W. Leong, Nadeem O. Kaakoush
Summary: This study characterized the differences in gut microbiota between two FMT donors and found that donor microbiota stability and species evenness were associated with therapeutic efficacy in UC. These findings have important implications for improving FMT donor selection.
Article
Food Science & Technology
Michael D. Kendig, Kyoko Hasebe, Aynaz Tajaddini, Nadeem O. Kaakoush, R. Frederick Westbrook, Margaret J. Morris
Summary: This study examines the effects of a diet switch intervention in a rat model of maternal obesity. The results show that the intervention leads to reductions in body weight and adiposity, improvements in place recognition memory, and changes in gut microbiota composition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Josephine Yu, D. Ross Laybutt, Neil A. Youngson, Margaret J. Morris
Summary: This study aimed to investigate the effects of betaine supplementation on the metabolic consequences of high fat diet-induced obesity in mice. The results showed that betaine supplementation combined with exercise significantly reduced body weight and adiposity, improved glucose tolerance, and enhanced insulin sensitivity in obese mice. Additionally, betaine exerted modest effects on fatty acid metabolism genes in skeletal muscle, while its effects on hepatic lipid metabolism were limited.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Ecology
Hamza Anwer, Dominic Mason, Susanne Zajitschek, Daniel Hesselson, Daniel W. A. Noble, Margaret J. Morris, Malgorzata Lagisz, Shinichi Nakagawa
Summary: The obesity epidemic and its impact on cognition and behavior is a cause for concern. This study investigates the intergenerational effects of obesogenic diets on zebrafish cognition and anxiety. Results suggest that the negative effects of obesity on aversive learning can be carried across generations, with offspring from both obese parents performing poorly. However, offspring with only one obese parent performed the best. There were no significant differences in anxiety behaviors between groups. This study highlights the importance of investigating the effects of obesity on cognitive function and provides insights into intergenerational effects.
ECOLOGY AND EVOLUTION
(2022)
Article
Microbiology
Maryanne O'Donnell, Scott B. Teasdale, Xin-Yi Chua, Jamie Hardman, Nan Wu, Jackie Curtis, Katherine Samaras, Patrick Bolton, Margaret J. Morris, Cyndi Shannon Weickert, Tertia Purves-Tyson, Fatima El-Assaad, Xiao-Tao Jiang, Georgina L. Hold, Emad El-Omar
Summary: This study characterized the gut microbiota in patients with first-episode psychosis, antipsychotic naive or quasi-naive patients, and patients with established schizophrenia receiving clozapine therapy using an exploratory proof-of-concept approach. The study found that a 12-week lifestyle intervention led to significant increases in microbiota diversity in patients with established schizophrenia. This suggests that lifestyle interventions may have a positive impact on gut microbial diversity in patients with established illness.
Review
Biochemistry & Molecular Biology
Bruna Panizzutti, David Skvarc, Sylvia Lin, Sarah Croce, Alcy Meehan, Chiara Cristina Bortolasci, Wolfgang Marx, Adam J. Walker, Kyoko Hasebe, Bianca E. Kavanagh, Margaret J. Morris, Mohammadreza Mohebbi, Alyna Turner, Laura Gray, Lesley Berk, Ken Walder, Michael Berk, Olivia M. Dean
Summary: Minocycline has been found to have anti-inflammatory, antioxidant, and anti-apoptotic properties, which has led to a renewed interest in using it as an adjunctive treatment for psychiatric and neurological conditions. A systematic review and meta-analysis of the available data from clinical trials using minocycline was conducted, showing limited and difficult to interpret results for most conditions, but suggesting an overall benefit for using minocycline as an adjunctive treatment for schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Michael D. Kendig, Sarah-Jane Leigh, Kyoko Hasebe, Nadeem O. Kaakoush, R. Fred Westbrook, Margaret J. Morris
Summary: This study aimed to investigate the effects of diet cycling on cognition and fecal microbiota. The results showed that switching to a regular diet for at least 11 days could reduce the impairment in place recognition memory caused by a high-fat, high-sugar cafeteria diet. Moreover, longer cycles of unhealthy diet exposure worsened cognitive deficits and led to larger shifts in gut microbiota composition. The results suggest that at least a week of healthy diet is necessary for recovery of cognitive deficits.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Correction
Genetics & Heredity
Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson
Article
Endocrinology & Metabolism
Sing -Young Chen, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Derek Y. H. Wong, Stephanie J. Alexopoulos, Isabella Aleksovska, Joseph M. Salamoun, Christopher J. Garcia, Blake J. Cochran, Kerry-Anne Rye, Greg C. Smith, Frances L. Byrne, Margaret J. Morris, Webster L. Santos, James Cantley, Kyle L. Hoehn
Summary: This study compares the metabolic effects of calorie restriction and the mitochondrial uncoupler BAM15 in a mouse model with severe hyperglycemia, obesity, hypertriglyceridemia, and fatty liver. The results showed that BAM15 was more effective than calorie restriction in improving glucose control, and its effects were independent of weight loss.
MOLECULAR METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Yue Huang, Jun Wei, Antony Cooper, Margaret J. Morris
Summary: Parkinson's disease (PD) is a common neurodegenerative movement disorder in the elderly. The pathogenesis of PD is not fully understood, and there are currently no medications available to halt disease progression. Identification of causative genes and those associated with susceptibility to PD is crucial for the development of new therapeutic approaches. By reviewing relevant data, this study explores the roles of different genes and molecular pathways in the pathogenesis of PD, with the aim of improving consultation and personalized medicine for PD patients in the future.
Letter
Gastroenterology & Hepatology
John David Chetwood, Sudarshan Paramsothy, Craig Haifer, Rupert W. Leong, Nadeem O. Kaakoush
Meeting Abstract
Endocrinology & Metabolism
M. J. Hossain, M. D. Kendig, M. J. Morris, R. Arnold
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Microbiology
Kyoko Hasebe, Michael D. Kendig, Nadeem O. Kaakoush, Aynaz Tajaddini, R. Frederick Westbrook, Margaret J. Morris
Summary: This study investigates the effects of maternal diet quality on the longitudinal maturation of gut microbiota in offspring. The results show that introducing solid food at weaning triggers the maturation of gut microbiota in rats, and a western-style, high-choice cafeteria diet has a significant impact on offspring gut microbiota. However, this impact is modulated by maternal diet history.
