Article
Nutrition & Dietetics
Jin-Ho Lee, Keun-Jung Woo, Min-Ah Kim, Joonpyo Hong, Jihee Kim, Sun-Hong Kim, Kwon-Il Han, Masahiro Iwasa, Tack-Joong Kim
Summary: The increased consumption of high-calorie foods and sedentary lifestyles have contributed to the global rise in obesity. This study found that dried heat-killed Enterococcus faecalis (EF-2001) can reduce the degree of obesity in rats fed a high-fat diet (HFD) and decrease cholesterol and triglyceride levels.
Article
Medicine, Research & Experimental
Ju-Hyoung Park, Eun-Kyung Ahn, Hye-Jin Ko, Min Hee Hwang, Young-Rak Cho, Dong-Ryung Lee, Bong-Keun Choi, Dong-Wan Seo, Joa Sub Oh
Summary: Spiraea prunifolia has been traditionally used in Korean medicine for its anti-malaria, anti-fever, and anti-emetic effects. This study investigated the effects of Spiraea prunifolia leaves extract (SPE) on obesity using a high-fat diet-induced obese mouse model. The results showed that oral administration of SPE significantly reduced body weight, serum levels of cholesterol and triglycerides, adipose tissue weight, and adipocyte cell size. SPE also inhibited the expression of adipogenesis and lipogenesis related genes, while promoting beta-oxidation through AMP-activated protein kinase signaling. These findings demonstrate the anti-adipogenic, anti-lipogenic, and beta-oxidation effects of SPE in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Agriculture, Multidisciplinary
Md Shamim Rahman, Inseok Kang, Youri Lee, Md Ahasun Habib, Byeong Jo Choi, Jong Soon Kang, Doo-Sang Park, Yong-Sik Kim
Summary: The study demonstrates the role of Bifidobacterium longum subsp. infantis YB0411 in inhibiting adipogenesis by reducing triglyceride accumulation and related gene expression, lowering levels of autophagic markers, and exerting anti-obesity effects through AMP-activated protein kinase. YB supplementation also significantly reduced body weight and fat accretion in mice with high-fat-diet-induced obesity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biology
Seul Gi Lee, Dong Se Kim, Jongbeom Chae, Eunbi Lee, Dongyup Hahn, Il-Kwon Kim, Chang-Jun Kim, Moon Bo Choi, Ju-Ock Nam
Summary: This study provides the first evidence of the anti-obesity effects of Nidus vespae, showing that it can inhibit adipose tissue expansion and preadipocyte differentiation, which could be valuable for the development of new drugs for obesity prevention and treatment.
Article
Multidisciplinary Sciences
Woongjae Yoo, Jacob K. Zieba, Nora J. Foegeding, Teresa P. Torres, Catherine D. Shelton, Nicolas G. Shealy, Austin J. Byndloss, Stephanie A. Cevallos, Erik Gertz, Connor R. Tiffany, Julia D. Thomas, Yael Litvak, Henry Nguyen, Erin E. Olsan, Brian J. Bennett, Jeffrey C. Rathmell, Amy S. Major, Andreas J. Baumler, Mariana X. Byndloss
Summary: It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.
Article
Biochemistry & Molecular Biology
Haiyan He, Chong Chen, Wei Zhao
Summary: Soybean soluble polysaccharide (SSPS) was found to have therapeutic effects on high-fat diet-induced obesity, reducing body weight, improving lipid metabolism abnormalities, and decreasing inflammatory cytokine levels. The study also uncovered the impact of SSPS on the liver proteome and proposed the existence of different lipid metabolism mechanisms between in vivo and in vitro.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Benjarat Janson, Janjira Prasomthong, Wachirawadee Malakul, Tantip Boonsong, Sakara Tunsophon
Summary: This study demonstrated that roselle extract can reduce body weight, food intake, lipid profiles, inflammatory cytokines, lipid peroxidation, serum leptin, insulin, and duodenal glucose absorption, while significantly increasing glucose uptake of adipose tissue and muscle compared to a high-fat diet group. Roselle can prevent lipid accumulation by suppressing differentiation of 3T3-L1 adipocyte through downregulating adipogenic gene expression, providing an alternative approach for preventing obesity-related insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Yanjun Liu, Ziwei Li, Junyi Liu, Jie Xu, Yuanfa Liu, Changhu Xue
Summary: Emerging evidence suggests that dietary D-mannose, enriched naturally in many plants and fruits, show benefits in patients with bacterial urinary tract infection, diabetes, and obesity. However, it is noteworthy that the physiological level of D-mannose in the blood is relatively low. Based on the study that D-mannose could be a safe and beneficial dietary supplement to obese, here phosphatidylation of mannose was proposed as a way to increase the physiological level of D-mannose and enhance the modulatory effect of mannose on obesity.
Article
Nutrition & Dietetics
Hwa-Young Lee, Geum-Hwa Lee, Young Yoon, The-Hiep Hoang, Han-Jung Chae
Summary: Research shows that IBF-R, an extract from Rhus verniciflua, can effectively regulate weight gain, reduce adipogenic gene expression in white adipose tissue, and enhance genes related to fatty acid oxidation in diet-induced obese mice. Additionally, IBF-R administration inhibits obesity-related inflammations linked to redox-based post-translational modifications of IRE1 alpha.
Article
Biotechnology & Applied Microbiology
Chul Sang Lee, Mi Hyun Park, Byoung Kook Kim, Sae Hun Kim
Summary: Obesity is a major cause of metabolic diseases, and inhibiting adipogenic differentiation can prevent and suppress obesity. Oral administration of Lactobacillus strains can improve serum lipid profile and normalize gut microbiota, effectively preventing obesity and improving metabolic health.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Engineering, Chemical
Seung-Min Lee, So-Hyeon Bok, Min-Hee Kim, Ki Sun Lee, Dae-Hun Park
Summary: In 2016, 13% of the global adult population was obese. By 2030, this number is projected to reach 34%. Obesity is a non-communicable disease that can lead to various health problems. Study results showed that P. erosus effectively controls obesity by regulating leptin-C/EBPa-PPARgamma and FAS levels, and preventing lipid droplet accumulation.
Article
Food Science & Technology
Narongsuk Munkong, Piyanuch Lonan, Wirinya Mueangchang, Narissara Yadyookai, Vaiphot Kanjoo, Bhornprom Yoysungnoen
Summary: This study demonstrates that red rice bran extract (RRBE) has anti-adipogenic, anti-hypertrophic, and anti-inflammatory activities in mice. RRBE effectively attenuates high-fat diet-induced pathological adipose tissue remodeling by suppressing adipogenesis, lipid dysmetabolism, and inflammation. It may emerge as an alternative food product for combating obesity-associated adipose tissue dysfunction.
Article
Food Science & Technology
Yangmian Yuan, Chengyu Liu, Xingrui Chen, Yuyan Sun, Mingrui Xiong, Yu Fan, Robert B. Petersen, Hong Chen, Kun Huang, Ling Zheng
Summary: The study suggests that Tet1 plays a crucial role in obesity by promoting lipolysis and reducing obesity. Vitamin C can treat obesity by enhancing Tet1 activity, thus decreasing hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jessica Latorre, Aina Lluch, Francisco J. Ortega, Aleix Gavalda-Navarro, Ferran Comas, Samantha Moron-Ros, Amaia Rodriguez, Sara Becerril, Francesc Villarroya, Gema Fruhbeck, Wifredo Ricart, Marta Giralt, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: The study found that lysozyme is highly expressed in adipose tissue of obese individuals, associated with chronic inflammation, adipose tissue inflammation, and metabolic disturbances. Knocking down the lysozyme gene in experimental models improved adipose tissue inflammation and reduced weight gain.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Su-Min Woo, Ngoc Anh Nguyen, Jeong-Eun Seon, Jin Jang, Su-Min Yee, Ngoc Tan Cao, Harim Choi, Chul-Ho Yun, Hyung-Sik Kang
Summary: This study investigated the anti-obesity effects of phloretin and its metabolite 3-OH phloretin in mice fed a high-fat diet. 3-OH phloretin was found to be more effective than phloretin in inhibiting weight gain, reducing fat accumulation, and suppressing inflammation. Furthermore, 3-OH phloretin showed potential in alleviating obesity-induced insulin resistance.