Article
Chemistry, Organic
Ali Sadatnabi, Niloofar Mohamadighader, Davood Nematollahi
Summary: Researchers have successfully developed a convergent paired electrochemical method for the synthesis of azoxy and azo compounds from nitroarenes, proposing a unique mechanism for their electrosynthesis. It was found that both anodic and cathodic reactions are responsible for the synthesis of these compounds. The synthesis was carried out in an undivided cell using carbon rod electrodes at room temperature.
Article
Chemistry, Analytical
Mahmood Masoudi Khoram, Niloofar Mohamadighader, Davood Nematollahi, Sadegh Khazalpour, Hossein Masoumi, Hojjat Alizadeh
Summary: A green electrochemical method was developed for the synthesis of new spiro and dispiro pyrimidine derivatives. The reactivity of the nucleophile (barbituric acids) was found to be crucial in determining the type of product. The synthesized compounds showed good antibacterial performance against gram-positive bacteria.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Pouria Patoghi, Ali Sadatnabi, Davood Nematollahi
Summary: In this study, a new convergent paired electro-organic synthesis method for sulfonamide derivatives was introduced, which follows the principles of green chemistry and does not require catalysts, oxidants, halogens, or amines. Instead of using toxic amine compounds, an innovative mechanism based on the reduction of nitro compounds and in-situ production of amine compounds was used. The mechanism involves cathodic reduction of nitro compounds to hydroxylamine compounds and anodic oxidation of hydroxylamine compounds to nitroso compounds.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Sheng Zhang, Lijun Li, Jingjing Li, Jianxue Shi, Kun Xu, Wenchao Gao, Luyi Zong, Guigen Li, Michael Findlater
Summary: The electrochemical arylation is an effective method for arylating alcohols, providing structurally diverse alcohols under mild conditions with good functional group tolerance and readily available starting materials. Research also suggests that there are two possible pathways involved in the alpha-arylation of benzylic alcohols.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Xiaoyu Zhan, Hongyu Liu, Rui Liu, Yanmin Huang, Yungui Peng
Summary: Here, a green and sustainable electrochemical strategy is reported for the a-alkylation of tertiary amines using halogenated alkanes under undivided electrolytic conditions. The reaction proceeds through an organozinc reagent produced at the cathode and an iminium ion produced at the anode, resulting in the formation of a-alkylated amines. The reaction shows wide-ranging functional-group and substrate compatibilities, and utilizes the challenging technique of convergent pair electrolysis.
Article
Agricultural Engineering
Jia Yun Chang, Taufiq Ahmad Syauqi, Kumar Sudesh, Si Ling Ng
Summary: Polyhydroxyalkanoates (PHAs) serve as effective biocarriers for biofilm development, showing excellent attachment performance and stable biofilm structure in acid orange 7 treatment.
BIORESOURCE TECHNOLOGY
(2024)
Article
Chemistry, Inorganic & Nuclear
Izzeddine Sameut Bouhaik, Mohammed Hadj Meliani, Rami K. Suleiman, Tawfik A. Saleh
Summary: This study predicted the redox potential of azo-dye chemicals using the DFT method and proposed a reaction mechanism for the biological degradation of the selected dye. The results showed that the DFT method was effective in predicting the redox potential, and the proposed mechanism was consistent with other mechanisms in the literature.
Article
Chemistry, Physical
Eleana Mundaray, Alfonso Saez, Jose Solla-Gullon, Vicente Montiel
Summary: The development of environmentally friendly Acid-Base Electrochemical Flow Battery (ABEFB) using high NaCl concentration electrolyte has been reported in this study. Under optimal conditions, this battery can provide a high power density, coulombic efficiency, and round-trip efficiency.
JOURNAL OF POWER SOURCES
(2021)
Article
Chemistry, Physical
Nicolas Schlueter, Petr Novak, Daniel Schroeder
Summary: The review presents various methods for investigating electrochemical energy storage and conversion systems and energy materials, including operando methods, standard electrochemical methods, and nonlinear electrochemical methods. Each method has its own advantages and limitations, making it a challenge for new scientists to select appropriate methods.
ADVANCED ENERGY MATERIALS
(2022)
Review
Medicine, Research & Experimental
Sameen Zafar, Muhammad Armaghan, Khushbukhat Khan, Nazia Hassan, Javad Sharifi-Rad, Solomon Habtemariam, Marek Kieliszek, Monica Butnariu, Iulia-Cristina Bagiu, Radu Vasile Bagiu, William C. Cho
Summary: Maytansine is an active drug derived from medicinal plants and microorganisms. Its pharmacological activities primarily include anticancer and antibacterial effects. The anticancer mechanism of maytansine is achieved through interaction with tubulin, inhibiting microtubule assembly and leading to cell cycle arrest and apoptosis. However, its non-selective cytotoxicity limits its clinical applications. Researchers have developed derivatives of maytansine with improved pharmacological activities. This review provides valuable insights into maytansine and its synthetic derivatives as anticancer agents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Environmental
Fangyuan Xiao, Yuruo Qi, Hao Wang, Yijun Liu, Shujuan Bao, Maowen Xu
Summary: This study investigates the electrochemical behavior of maleic acid and its contribution to lithium storage. The results suggest that the capacity is mainly derived from the corroded product of maleic acid rather than the acid itself.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Cell Biology
Yiming Yang, Nandini Nagarajan Margam
Summary: Membrane fusion, from lifeless viral particles to complex multicellular organisms, is a crucial biological phenomenon with protein mediators called fusogens at its core. Despite their functional independence and lack of sequence identity, fusogens share structural similarity, suggesting a potential common mechanism for membrane fusion. This review focuses on the structural characteristics of small-molecular-weight fusogens, aiming to uncover the fundamental aspects of membrane-membrane interactions and pave the way for future research on novel fusogens in health and disease.
Article
Chemistry, Organic
Ana Da Lama, Beatrice Bartolomei, Cristian Rosso, Giacomo Filippini, M. Montserrat Martinez, Luis A. Sarandeses, Maurizio Prato
Summary: Boron-dipyrromethene complexes (BODIPYs) with notable photophysical properties have attracted increasing interest, particularly in organic photocatalysis. This study investigated the relationship between their chemical composition and photocatalytic activity through a rationally designed structure-activity relationship study using atom transfer radical addition (ATRA) reaction as a benchmark. It was demonstrated that the presence of heavy atoms in the chromophore's core is essential for achieving high reactivity levels, while electron-withdrawing groups at position 8 (meso) undermine the catalytic performances.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Dan Ren, Jing Gao, Shaik M. Zakeeruddin, Michael Gratzel
Summary: The study investigated the performance of copper layers with different thicknesses on gas diffusion electrodes for ethylene formation in 1M KOH. It illustrated the effects of bulk pH, local pH, and CO2 diffusion on C-C coupling by comparing geometric and specific current density for ethylene on four Cu catalysts. The study also revealed the flexible rotation of the Cu-C bond of the *CO intermediate adsorbed on Cu as a key factor for efficient C-C coupling in a flow cell.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Review
Pharmacology & Pharmacy
Jingxuan Zhou, Jiechen Wang, Xiaozhao Zhang, Qingming Tang
Summary: Circadian clocks play a vital role in maintaining homeostasis and are closely related to cancer development. Chronotherapy for cancer treatment should leverage circadian rhythms for higher efficacy, and an individualized approach is recommended due to interpatient differences in circadian functions. Understanding the specific association between circadian clocks and cancers will pave the way for more effective clinical treatments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Razzagh Rahimpoor, Abdulrahman Bahrami, Davood Nematollahi, Farshid Ghorbani Shahna, Maryam Farhadian
Summary: In this study, a magnetic-dispersive solid-phase extraction (DSPE) method was developed for the extraction and desorption of muconic acid from real urine samples. Fe3O4-SiO2-NH2@ UiO-66 was used as a Metal-Organic Framework (MOF) in the DSPE for extraction followed by HPLC analysis. The method showed good detection limit, wide linear dynamic range, and high correlation coefficient, indicating its efficiency for the extraction and analysis of muconic acid from urine samples.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Ali Sadatnabi, Niloofar Mohamadighader, Davood Nematollahi
Summary: Researchers have successfully developed a convergent paired electrochemical method for the synthesis of azoxy and azo compounds from nitroarenes, proposing a unique mechanism for their electrosynthesis. It was found that both anodic and cathodic reactions are responsible for the synthesis of these compounds. The synthesis was carried out in an undivided cell using carbon rod electrodes at room temperature.
Article
Multidisciplinary Sciences
Amir Mohammad Naseri, Mahmoud Zarei, Saber Alizadeh, Saeed Babaee, Mohammad Ali Zolfigol, Davood Nematollahi, Jalal Arjomandi, Hu Shi
Summary: A metal-organic framework with sulfonic acid tags was synthesized and applied in organic synthesis reactions; studies on the synthesis of pyridine derivatives were conducted using the newly synthesized mesoporous catalyst.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Mahmood Masoudi Khoram, Niloofar Mohamadighader, Davood Nematollahi, Sadegh Khazalpour, Hossein Masoumi, Hojjat Alizadeh
Summary: A green electrochemical method was developed for the synthesis of new spiro and dispiro pyrimidine derivatives. The reactivity of the nucleophile (barbituric acids) was found to be crucial in determining the type of product. The synthesized compounds showed good antibacterial performance against gram-positive bacteria.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Zahra Souri, Mahmood Masoudi Khoram, Davood Nematollahi, Mohammad Mazloum-Ardakani, Hojjat Alizadeh
Summary: Electrochemical oxidation of imipramine in aqueous solutions was studied, showing a complex behavior at different pH values. The oxidation of imipramine at a pH of about 5 led to the formation of a unique dimer, which was fully characterized. A possible reaction mechanism for the oxidation process was proposed. The synthesized dimer exhibited fluorescence activity and good antibacterial performance.
SCIENTIFIC REPORTS
(2022)
Article
Electrochemistry
Faezeh Zivari-Moshfegh, Davood Nematollahi
Summary: A new derivative of desloratadine (DQ-TBC complex) was synthesized for the first time using a green electrochemical method. The electrooxidation of 4-tert-butylcatechol (TBC) in the presence of desloratadine (DES) was investigated to optimize the synthesis conditions of DQ-TBC complex. The results suggest that the electrooxidation of TBC in the presence of DES leads to DQ through an ECE mechanism. The synthesized compound showed promising antibacterial activity against Bacillus cereus and Staphylococcus aureus.
ELECTROCHIMICA ACTA
(2022)
Article
Electrochemistry
Heydar Hameed Salman Arkwazee, Niloofar Mohamadighader, Davood Nematollahi, Arash Rabiee, Hojjat Alizadeh
Summary: This article describes a method for synthesizing new sulfonamide derivatives using electrochemical methods without toxic reagents, and finds that these products have good antibacterial performance against bacteria.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Electrochemistry
Niloofar Mohamadighader, Davood Nematollahi, Mahnaz Saraei
Summary: Electrochemical oxidation of phenothiazine in an acetonitrile/water mixture was investigated, revealing that the oxidation pathway varies with respect to pH. The results led to the synthesis of two new types of PTZ dimer and provided insights into the oxidation mechanism of PTZ.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Razzagh Rahimpoor, Ali Firoozichahak, Saber Alizadeh, Houman Serkan, Davood Nematollahi
Summary: This paper synthesized an aluminum-based metal-organic framework and utilized it in high-performance liquid chromatography for the reliable determination of cyclophosphamide in urine samples. By optimizing various parameters, satisfactory measurement results and recovery rates were obtained.
Article
Electrochemistry
Mohammad Reza Talebi, Davood Nematollahi, Ahmad Reza Massah
Summary: The electrochemical oxidation of N-(4-aminophenyl) and N-(4-hydroxyphenyl)benzenesulfonamide derivatives was investigated at different pH values and concentrations. The oxidation potential and mechanism of these compounds were found to be pH dependent. The oxidation products were found to undergo hydroxylation and/or dimerization reactions. The adsorption behavior and oxidation products under conditions similar to the human body were also studied.
ELECTROCHIMICA ACTA
(2023)
Article
Electrochemistry
Faezeh Zivari-Moshfegh, Fereshteh Javanmardi, Davood Nematollahi
Summary: The electrochemical behavior of rifampicin, an anti-tuberculosis drug, was studied in a water/ethanol mixture. The drug was found to undergo two-step oxidation, with the first step being a reversible oxidation of the hydroquinone moiety and the second step being an irreversible oxidation of the phenolic ring. The adsorption activity and diffusion coefficient of rifampicin were also determined, indicating that the first oxidation step is diffusion-controlled and the second step is a diffusion/adsorption control process. The oxidation of rifampicin was found to be complex and highly pH-dependent, with different rates of reaction observed for different drugs used in combination therapy.
ELECTROCHIMICA ACTA
(2023)
Article
Electrochemistry
Faezeh Zivari-Moshfegh, Davood Nematollahi
Summary: This study investigates the toxic metabolites formed from the oxidation of rifampicin and acetaminophen in the body. It provides strong evidence of a catalytic reaction between vitamin C and the oxidized form of rifampicin. Additionally, contrary to previous reports, this study discovers another catalytic reaction between oxidized acetaminophen and rifampicin.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Electrochemistry
Zahra Godini, Davood Nematollahi, Faezeh Zivari-Moshfegh
Summary: In this study, the electrochemical complexation of five azole antifungal drugs with silver, copper and zinc cations was conducted in an undivided electrolytic cell. Twenty complexes were synthesized using a simple method in water/ethanol mixtures with high yield and purity. The applied current and acid concentration were found to have no significant effects on the yield and purity of the complexes, but they did affect the cell voltage and energy consumption.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Pouria Patoghi, Ali Sadatnabi, Davood Nematollahi
Summary: In this study, a new convergent paired electro-organic synthesis method for sulfonamide derivatives was introduced, which follows the principles of green chemistry and does not require catalysts, oxidants, halogens, or amines. Instead of using toxic amine compounds, an innovative mechanism based on the reduction of nitro compounds and in-situ production of amine compounds was used. The mechanism involves cathodic reduction of nitro compounds to hydroxylamine compounds and anodic oxidation of hydroxylamine compounds to nitroso compounds.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Fatemeh Ghamari, Davood Raoufi, Saber Alizadeh, Jalal Arjomandi, Davood Nematollahi
Summary: Efficient new binder-free bimetallic metal-organic framework (bi-MMOF) symmetric supercapacitors were fabricated, with surface statistical and morphological studies used to predict superior electrochemical performance. The studies showed that the bi-MMOF electrodes demonstrated excellent electrochemical performance and stability compared to mono-metallic MOF electrodes.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)