A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus

Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus

(2016) Stephen C. Becker et al.   Scientific Reports

Phage therapy redux--What is to be done?

(2015) R. Young et al.   SCIENCE

Staphylococcus aureus forms spreading dendrites that have characteristics of active motility

(2015) Eric J. G. Pollitt et al.   Scientific Reports

Molecular dissection of phage lysin PlySs2: integrity of the catalytic and cell wall binding domains is essential for its broad lytic activity

(2015) Yanling Huang et al.   VIROLOGICA SINICA

A chimeolysin with extended-spectrum streptococcal host range found by an induced lysis-based rapid screening method

(2015) Hang Yang et al.   Scientific Reports

Optimized polymeric film-based nitric oxide delivery inhibits bacterial growth in a mouse burn wound model

(2014) Elizabeth J. Brisbois et al.   Acta Biomaterialia

Biochemical and biophysical characterization of PlyGRCS, a bacteriophage endolysin active against methicillin-resistant Staphylococcus aureus

(2014) Sara B. Linden et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Clinical Management ofStaphylococcus aureusBacteremia

(2014) Thomas L. Holland et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Crystal structure of the lytic CHAPK domain of the endolysin LysK from Staphylococcus aureus bacteriophage K

(2014) Marta Sanz-Gaitero et al.   Virology Journal

Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin

(2014) Jingmin Gu et al.   PLoS Pathogens

Construction of a chimeric lysin Ply187N-V12C with extended lytic activity against staphylococci and streptococci

(2014) Qiuhua Dong et al.   Microbial Biotechnology

Novel Chimeric Lysin with High-Level Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus In Vitro andIn Vivo

(2013) Hang Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

(2013) Daniel B. Gilmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chimeric Ply187 endolysin killsStaphylococcus aureusmore effectively than the parental enzyme

(2013) Jinzhe Mao et al.   FEMS MICROBIOLOGY LETTERS

Combination Therapy With Lysin CF-301 and Antibiotic Is Superior to Antibiotic Alone for Treating Methicillin-Resistant Staphylococcus aureus–Induced Murine Bacteremia

(2013) Raymond Schuch et al.   JOURNAL OF INFECTIOUS DISEASES

Lysins: the arrival of pathogen-directed anti-infectives

(2013) M. Pastagia et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Asia

(2013) Yu-Yu Chuang et al.   LANCET INFECTIOUS DISEASES

Serverification of Molecular Modeling Applications: The Rosetta Online Server That Includes Everyone (ROSIE)

(2013) Sergey Lyskov et al.   PLoS One

Staphylococcal Infections: Mechanisms of Biofilm Maturation and Detachment as Critical Determinants of Pathogenicity

(2012) Michael Otto   Annual Review of Medicine

Existence of Separate Domains in Lysin PlyG for Recognizing Bacillus anthracis Spores and Vegetative Cells

(2012) Hang Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroActivities of Antibiotics and Antimicrobial Cationic Peptides Alone and in Combination against Methicillin-Resistant Staphylococcus aureus Biofilms

(2012) Emel Mataraci et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus

(2012) Piotr Szweda et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antistaphylococcal activity of bacteriophage derived chimeric protein P128

(2012) Aradhana A Vipra et al.   BMC MICROBIOLOGY

MRSA virulence and spread

(2012) Michael Otto   CELLULAR MICROBIOLOGY

Wall Teichoic Acids Restrict Access of Bacteriophage Endolysin Ply118, Ply511, and PlyP40 Cell Wall Binding Domains to the Listeria monocytogenes Peptidoglycan

(2012) Marcel R. Eugster et al.   JOURNAL OF BACTERIOLOGY

Novel Chimerical Endolysins with Broad Antimicrobial Activity Against Methicillin-Resistant Staphylococcus aureus

(2012) Sofia Fernandes et al.   Microbial Drug Resistance

X-ray crystal structure of the streptococcal specific phage lysin PlyC

(2012) S. McGowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In VitroActivity against Staphylococcus aureus of a Novel Antimicrobial Agent, PRF-119, a Recombinant Chimeric Bacteriophage Endolysin

(2011) Evgeny A. Idelevich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial activity of Acinetobacter baumannii phage ϕAB2 endolysin (LysAB2) against both Gram-positive and Gram-negative bacteria

(2011) Meng-Jiun Lai et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A stable phage lysin (Cpl-1) dimer with increased antipneumococcal activity and decreased plasma clearance

(2011) Gregory Resch et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies

(2011) M. Fauvart et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus

(2010) A. Daniel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prevalence of multidrug-resistant organisms recovered at a military burn center

(2010) Edward F. Keen et al.   BURNS

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Staphylococcus aureus biofilm formation at the physiologic glucose concentration depends on the S. aureus lineage

(2009) Sander Croes et al.   BMC MICROBIOLOGY

Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase

(2009) Kimberly Payne et al.   MOLECULAR MICROBIOLOGY

Lytic activity of the recombinant staphylococcal bacteriophage ΦH5 endolysin active against Staphylococcus aureus in milk

(2008) José María Obeso et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Structural elucidation of the Cys-His-Glu-Asn proteolytic relay in the secreted CHAP domain enzyme from the human pathogenStaphylococcus saprophyticus

(2008) Paolo Rossi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS