Article
Chemistry, Analytical
Georgi Petrov, Rajan Arora, Vladoslav V. Yakovlev
Summary: The study demonstrated chemical imaging of calcifications in tissues using long wavelength excitation, with imaging and analysis performed 2 mm below the skin level in a model system. Applications to breast cancer diagnostics and imaging were discussed, along with methods to extend depth and improve spatial resolution in chemical imaging.
Article
Biochemical Research Methods
Margaux Bouzin, Mario Marini, Giuseppe Chirico, Francesca Granucci, Francesca Mingozzi, Roberto Colombo, Laura D'Alfonso, Laura Sironi, Maddalena Collini
Summary: This study proposes a non-destructive photo-thermal imaging method that can characterize the distribution and concentration of melanin pigments in excised melanoma biopsies. It provides a label-free super-resolution far-infrared thermal imaging of tissue sections, allowing for the quantitative analysis of melanin content. The proposed method could complement traditional histopathology in the characterization of pigmented lesions ex-vivo.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Multidisciplinary Sciences
Yang Luo, Alberto Martin-Jimenez, Michele Pisarra, Fernando Martin, Manish Garg, Klaus Kern
Summary: The motion of atoms is crucial for chemical and structural transformations. This study demonstrates the detection of vibrational coherences induced by broadband laser pulses on a single graphene nanoribbon using femtosecond coherent anti-Stokes Raman spectroscopy. This suggests a potential breakthrough in tracking and controlling vibrational coherences at the atomic and molecular scales.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Qingqing Li, Hongqi Huo, Ying Wu, Lanlan Chen, Lichao Su, Xuan Zhang, Jibin Song, Huanghao Yang
Summary: Surface-enhanced Raman scattering (SERS) is a feasible and ultra-sensitive method for biomedical imaging and disease diagnosis. The recent developments in SERS active materials and their in vivo imaging and biosensing applications are overviewed, including various SERS substrates and their successful utilization in in vivo imaging, as well as the role of highly sensitive SERS biosensors in disease detection and prevention. Additionally, the review highlights the use of SERS in the identification and resection of microtumors, as well as its potential as a diagnostic and therapeutic platform.
Article
Oncology
Christoph Krafft, Juergen Popp, Peter Bronsert, Arkadiusz Miernik
Summary: Raman spectroscopy allows for label-free assessment of bladder tissue in intraoperative applications. In a retrospective study, Raman microspectroscopic images were used to identify different components of bladder tissue, including normal bladder, bladder cancer, necrosis, epithelium, and lipid inclusions. Additionally, foreign materials such as microplastic particles and pigments were detected in the specimens. This study demonstrates the potential of Raman spectroscopy for tumor detection and material identification in complex matrices.
Article
Medicine, Research & Experimental
Jakub Boguslawski, Grazyna Palczewska, Slawomir Tomczewski, Jadwiga Milkiewicz, Piotr Kasprzycki, Dorota Stachowiak, Katarzyna Komar, Marcin J. Marzejon, Bartosz L. Sikorski, Arkadiusz Hudzikowski, Aleksander Gluszek, Zbigniew Laszczych, Karol Karnowski, Grzegorz Sobon, Krzysztof Palczewski, Maciej Wojtkowski
Summary: Researchers have developed a new method for noninvasive metabolic assessment of the human retina. Using a compact 2-photon-excited fluorescence scanning laser ophthalmoscope and near-infrared light, they were able to obtain spectrally resolved images of the human retina. This approach provides the possibility of monitoring eye diseases in the earliest stages before structural damage occurs to the retina.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Damien Boildieu, Tiffany Guerenne-Del Ben, Ludovic Duponchel, Vincent Sol, Jean-Michel Petit, Eric Champion, Hideaki Kano, David Helbert, Amandine Magnaudeix, Philippe Leproux, Philippe Carre
Summary: In this study, the combination of MCARS imaging technique with unsupervised data analysis based on multivariate curve resolution (MCR) is introduced for hyperspectral cell imaging and segmentation. The robustness, applicability, and sensitivity of this method are evaluated through experiments, and imaging results of different cell types and states are presented.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Zhen Du, Yuchen Qi, Jian He, Danni Zhong, Min Zhou
Summary: This article discusses the recent advances of surface-enhanced Raman scattering (SERS) nanoparticles for in vivo imaging, focusing on their applications in cancer imaging and treatment, as well as exploring the challenges and opportunities of nanoparticles in SERS in vivo imaging.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Biochemical Research Methods
Marko Rodewald, Hyeonsoo Bae, Sophie Huschke, Tobias Meyer-Zedler, Michael Schmitt, Adrian Tibor Press, Stephanie Schubert, Michael Bauer, Juergen Popp
Summary: The microscope setup presented in this study is tailored to address challenges in in vivo experiments, showcasing its use in identifying vitamin A accumulations in the liver and marking the positions of hepatic stellate cells. These cells, being the main source of extracellular matrix protein after hepatic injury, are key targets for novel nanomedical strategies in liver fibrosis treatment and their role in vitamin A metabolism makes them ideal for a CARS-based approach.
JOURNAL OF BIOPHOTONICS
(2021)
Review
Genetics & Heredity
Nian Liu, Xiao Chen, Melanie A. Kimm, Matthias Stechele, Xueli Chen, Zhimin Zhang, Moritz Wildgruber, Xiaopeng Ma
Summary: Optical imaging technology has great potential in detecting inflammation, providing accurate molecular information and offering new insights into the diagnosis and therapeutic evaluation of inflammatory diseases. By using endogenous and exogenous contrast agents, optical imaging technology can accurately visualize sites of inflammation, enabling early disease detection and specific disease characterization.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemical Research Methods
X. U. Z. H. O. U. LI, W. E. Zhang, Y. A. N. X. I. U. LI, X. I. A. O. Q. I. N. Wu, M. I. N. G. Y. A. N. G. Wang, X. I. A. O. T. I. A. N. Tan, Yannis m. Paulus, X. U. D. O. N. G. Fan, X. U. E. D. I. N. G. Wang
Summary: Emerging cell-based regenerative medicine and stem cell therapies have become significant in the field of medical research and clinical practice. This study presents a multimodality imaging technology that successfully tracks the 3D migration trajectories of labeled therapeutic cells in the eyes of living rabbits, providing valuable insights for the development of cell-based therapies.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Chemistry, Multidisciplinary
Jung Ho Yu, Myeong Seon Jeong, Emma Olivia Cruz, Israt S. Alam, Spencer K. Tumbale, Aimen Zlitni, Song Yeul Lee, Yong Il Park, Katherine Ferrara, Seung-Hae Kwon, Sanjiv S. Gambhir, Jianghong Rao
Summary: Raman spectroscopy is used for in vivo preclinical imaging with high specificity. Metallic gold nanoparticles larger than 10 nm are employed to amplify Raman signals, but they cannot be excreted which limits the translation of Raman imaging. This study presents biodegradable and excretable Raman-active metallic gold supraclusters that exhibit bright Raman scattering and have great potential for clinical applications of in vivo Raman imaging.
Article
Chemistry, Multidisciplinary
Jerome Carnis, Felizitas Kirner, Dmitry Lapkin, Sebastian Sturm, Young Yong Kim, Igor A. Baburin, Ruslan Khubbutdinov, Alexandr Ignatenko, Ekaterina Iashina, Alexander Mistonov, Tristan Steegemans, Thomas Wieck, Thomas Gemming, Axel Lubk, Sergey Lazarev, Michael Sprung, Ivan A. Vartanyants, Elena Sturm
Summary: Mesocrystals are nanostructured materials made up of nanocrystals with a preferred crystallographic orientation. Structural heterogeneity greatly affects their properties, as shown in the detailed structural characterization of a faceted mesocrystal grain made from 60 nm gold nanocubes. Coherent X-ray diffraction imaging revealed intrinsic structural heterogeneity and internal defects, with the average superlattice structure closely matching the real multidomain structure.
Article
Chemistry, Multidisciplinary
Jung Ho Yu, Idan Steinberg, Ryan M. Davis, Andrey Malkovskiy, Aimen Zlitni, Rochelle Karina Radzyminski, Kyung Oh Jung, Daniel Tan Chung, Luis Dan Curet, Aloma L. D'Souza, Edwin Chang, Jarrett Rosenberg, Jos Campbell, Hadas Frostig, Seung-min Park, Guillem Pratx, Craig Levin, Sanjiv S. Gambhir
Summary: We demonstrate noninvasive and five-plex SERS imaging of nanoparticle accumulation in tumors of living mice using multispectral palettes of gold multicore-near-infrared (NIR) resonant Raman dyes-silica shell SERS (NIR-SERRS) nanoparticle oligomers. The method allows for ratiometric imaging of tumors by varying the administered ratio of nanoparticles, simulating the detection of multiple biomarkers with different expression levels in the tumor environment. This approach surpasses the multiplicity limit of previous preclinical tumor imaging methods while maintaining sufficient sensitivity for in vivo imaging, enabling noninvasive assessment of multiple biological targets within the tumor microenvironment in living subjects.
Article
Multidisciplinary Sciences
Di Wu, Yudong Feng, Rui Wang, Jin Jiang, Quanquan Guan, Xu Yang, Hongcheng Wei, Yankai Xia, Yongming Luo
Summary: This study aimed to investigate the accumulation of environmental particles in thrombus and their effects on the blood circulation system. Non-soluble microparticles, including synthetic material microparticles and iron compounds, were found in a large number in thrombi. The study also revealed a significant positive correlation between microparticle number and blood platelet levels. These findings suggest that the risk of microparticle exposure has been underestimated and further research is urgently needed to assess its health effects.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Psychiatry
David Baumeister, Emmanuelle Peters, Jens Pruessner, Oliver Howes, Paul Chadwick
Summary: Negative voice content is more associated with increased subjective stress-reactivity compared to other voices or auditory stimuli. Mindful voice-appraisals may partially moderate this effect. These findings highlight the importance of voice content for the impact of voice-hearing and the potential value of mindfulness training in treating voice distress in psychosis.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Behavioral Sciences
Maria Meier, Lisa Wirz, Philip Dickinson, Jens C. Pruessner
Summary: Stress is a major contributor to psychiatric diseases, and laughter yoga may help buffer the negative effects of stress. However, empirical evidence for beneficial effects of laughter yoga is still lacking.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Behavioral Sciences
Anja Richter, Mohammad Al-Bayati, Foteini Paraskevopoulou, Bernd Kraemer, Jens C. Pruessner, Elisabeth B. Binder, Oliver Gruber
Summary: The psychosocial stress effects of urban living are associated with increased risk for schizophrenia, mood and anxiety disorders due to alterations in stress-induced activity in the amygdala and pregenual anterior cingulate cortex. Genetic factors, such as FKBP5, may modulate the impact of city living on stress processing. The interaction between city living and genetic variation in FKBP5 (rs3800373) was found to modulate responses in the subgenual and pregenual ACC, potentially increasing the risk for developing stress-related mental disorders in city dwellers carrying the FKBP5 minor risk allele.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Psychology, Clinical
Annika B. E. Benz, Liliane Vanessa Kloker, Tim Kuhlmann, Maria Meier, Eva Unternaehrer, Ulrike U. Bentele, Stephanie J. Dimitroff, Bernadette F. Denk, Ulf-Dietrich Reips, Jens C. Pruessner
Summary: The German translation of the PBI showed good psychometric properties and demonstrated significant differences in reported parenting styles among different groups of individuals. The use of a 3-factor structure provided additional value, such as improved differentiation between normal-weight and overweight individuals.
PSYCHOTHERAPIE PSYCHOSOMATIK MEDIZINISCHE PSYCHOLOGIE
(2022)
Article
Psychiatry
Xi Ren, Xiaolin Zhao, Jiwen Li, Yadong Liu, Yipeng Ren, Jens C. Pruessner, Juan Yang
Summary: Higher daily stress levels are associated with lower salivary cortisol secretion and lower activation of the left hippocampus in response to a stress task. In addition, higher daily stress levels are associated with stronger functional connectivity between the left hippocampus and the ventral medial prefrontal cortex.
PSYCHOSOMATIC MEDICINE
(2022)
Article
Psychiatry
Angelina Gideon, Christine Sauter, Jens C. Pruessner, Damien R. Farine, Petra H. Wirtz
Summary: Acute psychosocial stress can activate the renin-angiotensin-aldosterone system, and cognitive stress appraisal processes seem to modulate this stress reactivity.
PSYCHOSOMATIC MEDICINE
(2022)
Review
Biology
Hanja B. Brandl, Jens C. Pruessner, Damien R. Farine
Summary: The stress systems play a crucial role in mediating the physiological responses to stress in animals. While the individual-level effects of stress on behavior and performance have been well studied, it remains largely unknown how stressed individuals can influence the stress systems of other group members and subsequently affect collective behavior. This article proposes that understanding the extent to which stress transmission modulates animal collectives is an important research avenue.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Hanna M. T. Edebol Carlman, Julia Rode, Julia Konig, Dirk Repsilber, Ashley N. Hutchinson, Per Thunberg, Jonas Persson, Andrey Kiselev, Jens C. Pruessner, Robert J. Brummer
Summary: In this study, the impact of a probiotic product containing different strains of probiotics on stress processing was investigated. The results showed that probiotic intervention subtly altered brain activity and functional connectivity in specific brain regions and had a greater effect on the initial stress response. These findings support the potential of probiotics as a non-pharmaceutical treatment modality for stress-related disorders.
Article
Endocrinology & Metabolism
Maria Meier, Kristina Haub, Marie-Luise Schramm, Marc Hamma, Ulrike U. Bentele, Stephanie J. Dimitroff, Raphaela Gartner, Bernadette F. Denk, Annika B. E. Benz, Eva Unternaehrer, Jens C. Pruessner
Summary: The study focused on the effects of an online version of the Trier Social Stress Test (TSST) on cortisol, alpha amylase, pleasure, and arousal levels in adults. It also compared the cortisol responses between men and women. The results showed that the online TSST successfully induced psychophysiological stress in adults, with significant increases in cortisol, alpha amylase, and arousal levels, and a decrease in pleasure. Moreover, cortisol responses were found to be stronger in males compared to females.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Cherie Strikwerda-Brown, Diana A. Hobbs, Julie Gonneaud, Frederic St-Onge, Alexa Pichet Binette, Hazal Ozlen, Karine Provost, Jean-Paul Soucy, Rachel F. Buckley, Tammie L. S. Benzinger, John C. Morris, Victor L. Villemagne, Vincent Dore, Reisa A. Sperling, Keith A. Johnson, Christopher C. Rowe, Brian A. Gordon, Judes Poirier, John C. S. Breitner, Sylvia Villeneuve
Summary: The study confirmed the clinical value of NIA-AA biological research criteria in predicting whether older individuals with no cognitive impairment will develop AD symptoms in the near future, with most A+T+(N+) individuals developing AD symptoms within 2 to 3 years.
Article
Psychology, Multidisciplinary
Annika B. E. Benz, Raphaela J. Gaertner, Maria Meier, Eva Unternaehrer, Simona Scharndke, Clara Jupe, Maya Wenzel, Ulrike U. Bentele, Stephanie J. Dimitroff, Bernadette F. Denk, Jens C. Pruessner
Summary: Growing evidence suggests that natural environments contribute to psychological health and physiological relaxation. This study investigates the effects of nature-based relaxation videos on heart rate variability (HRV) and heart rate (HR), revealing a decrease in HR and an increase in HRV during video interventions. The findings suggest that aspects of early life adversity and trait mindfulness may influence individual responses to relaxation videos.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Alexandra Barnabe, Karine Gamache, Joao Vitor Paes de Camargo, Erin Allen-Flanagan, Mathilde Rioux, Jens Pruessner, Marco Leyton, Karim Nader
Summary: Tobacco use is a leading cause of preventable death globally. This study examined the potential of stress to enhance the effects of a memory updating intervention on smoking cessation. The findings showed that individuals exposed to stress had greater psychophysiological responses during the intervention and experienced greater reductions in cigarette use.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Multidisciplinary
Jonas P. Nitschke, Jens C. Pruessner, Jennifer A. Bartz
Summary: This study suggests that acute psychosocial stress enhances empathic accuracy in men, related to their glucocorticoid response, while it has no effect on women, who also show a smaller cortisol response to stress.
PSYCHOLOGICAL SCIENCE
(2022)
Review
Endocrinology & Metabolism
Tobias Stalder, Sonia J. Lupien, Brigitte M. Kudielka, Emma K. Adam, Jens C. Pruessner, Stefan Wuest, Samantha Dockray, Nina Smyth, Phil Evans, Clemens Kirschbaum, Robert Miller, Mark A. Wetherell, Johannes B. Finke, Tim Klucken, Angela Clow
Summary: This article reports a critical evaluation and update of current cortisol awakening response (CAR) methodology, presenting an updated and streamlined version of the CAR consensus guidelines. A quantitative evaluation of CAR research shows limited improvement in implementing core recommendations, but evidence confirms the accuracy of the original guidelines. Furthermore, recent technological advances offer potential cost-saving methods for CAR assessment in future research.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Sarah E. M. Stoll, Leonie Mack, Jean P. P. Scheib, Jens Pruessner, Jennifer Randerath
Summary: Efficient movement selection is crucial in everyday activities. This study suggests that our stress system might influence this function, particularly for plan-based approaches. Variations in parasympathetic activity appear to be disadvantageous for improving plan-based movement selection, while performance in rule-based movement selection tasks remains relatively unaffected.
SCIENTIFIC REPORTS
(2022)