Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout

Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages

(2016) Sang Hyeon Yeon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet

(2016) Gabsik Yang et al.   Scientific Reports

Interleukin-1 as a therapeutic target in gout

(2015) Alexandre Dumusc et al.   CURRENT OPINION IN RHEUMATOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome Assembly

(2014) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation

(2014) Soo Jin Yang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Structural and Dynamics Aspects of ASC Speck Assembly

(2014) Ali Can Sahillioglu et al.   STRUCTURE

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

iGLuc: a luciferase-based inflammasome and protease activity reporter

(2013) Eva Bartok et al.   NATURE METHODS

Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2

(2012) So Young Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular Adaptation to Anthrax Lethal Toxin-Induced Mitochondrial Cholesterol Enrichment, Hyperpolarization, and Reactive Oxygen Species Generation through Downregulating MLN64 in Macrophages

(2012) S.-D. Ha et al.   MOLECULAR AND CELLULAR BIOLOGY

Quercetin and Allopurinol Ameliorate Kidney Injury in STZ-Treated Rats with Regulation of Renal NLRP3 Inflammasome Activation and Lipid Accumulation

(2012) Chuang Wang et al.   PLoS One

Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008

(2011) Yanyan Zhu et al.   ARTHRITIS AND RHEUMATISM

NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout

(2011) Flávio A. Amaral et al.   ARTHRITIS AND RHEUMATISM

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gout. Epidemiology of gout

(2011) Edward Roddy et al.   ARTHRITIS RESEARCH & THERAPY

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

(2010) S. M. Joung et al.   JOURNAL OF IMMUNOLOGY

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

(2009) Pamela Gasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

(2009) Eva de Alba   JOURNAL OF BIOLOGICAL CHEMISTRY

Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication

(2009) Daekyu Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE