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Cell Biology
Alison J. May, Aaron J. Mattingly, Eliza A. Gaylord, Nathan Griffin, Sonia Sudiwala, Noel Cruz-Pacheco, Elaine Emmerson, Seayar Mohabbat, Sara Nathan, Hanan Sinada, Isabelle M. A. Lombaert, Sarah M. Knox
Summary: Neuronal-epithelial cross-talk drives acinar specification through NRG1-ERBB3-mTORC2 signaling. NRG1-ERBB3 regulates the cellular programs of lineage progression, secretion, and polarization through the mTORC2 signaling pathway. This mechanism plays a crucial role in the formation of functional acini.
DEVELOPMENTAL CELL
(2022)
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Cell & Tissue Engineering
Ece Somuncular, Julia Hauenstein, Prajakta Khalkar, Anne-Sofie Johansson, Ozge Dumral, Nicolai S. Frengen, Charlotte Gustafsson, Giuseppe Mocci, Tsu-Yi Su, Hugo Brouwer, Christine L. Trautmann, Michael Vanlandewijck, Stuart H. Orkin, Robert Mansson, Sidinh Luc
Summary: This study reveals the heterogeneity of hematopoietic stem cells (HSCs) and provides insights into the functional differences and regulatory mechanisms of HSCs through transcriptional and epigenetic mechanisms.
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Multidisciplinary Sciences
Pengxiang Chen, Wei Wang, Rui Liu, Jiahui Lyu, Lei Zhang, Baizhou Li, Biying Qiu, Anhao Tian, Wenhong Jiang, Honggang Ying, Rui Jing, Qianqian Wang, Keqing Zhu, Ruiliang Bai, Linghui Zeng, Shumin Duan, Chong Liu
Summary: Animals receive sensory stimuli from the environment, which are essential for survival but can also impact physiological status and disease development. This study demonstrates that olfaction directly regulates the development of malignant glioma through olfactory neuronal circuits.
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Multidisciplinary Sciences
Yang Zhao, Chenxu Zhao, Han Guo, Zhaoqi Zhang, Huawen Xu, Mingpu Shi, Yanan Xu, Dong Wei, Yong Zhao
Summary: Rictor deletion leads to reduced production of granulocyte-monocyte progenitors (GMPs), monocytes, and macrophages, while neutrophil levels remain unaffected. Loss of Rictor inhibits monocyte differentiation while promoting neutrophil differentiation. The mTORC2 pathway regulates monocyte development through the AKT-Foxo4-ATF5-mtUPR pathway.
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Multidisciplinary Sciences
Elle Koren, Alona Feldman, Marianna Yusupova, Avihay Kadosh, Egor Sedov, Roi Ankawa, Yahav Yosefzon, Waseem Nasser, Stefanie Gerstberger, Liam B. Kimel, Noa Priselac, Samara Brown, Sam Sharma, Travis Gorenc, Ruby Shalom-Feuerstein, Hermann Steller, Tom Shemesh, Yaron Fuchs
Summary: Koren and Feldman et al. discovered a distinct population of Thy1-expressing stem cells in the basal layer of the mouse epidermis that contribute to epidermal replenishment and wound repair. These stem cells display unique transcriptional signatures and exhibit slower cell cycle kinetics compared to basal epidermal progenitors. The ablation of Thy1(+) cells impairs epidermal homeostasis and repair, highlighting the critical role of these stem cells in maintaining the integrity of the epidermis.
NATURE COMMUNICATIONS
(2022)
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Biology
Fan Zhang, Yuanyuan Wang, Ying Zhao, Manqi Wang, Bin Zhou, Xianpeng Ge, Di Chen
Summary: NFATc1 is a crucial regulator of articular chondrocyte differentiation, expressed in the early stage of joint development. It negatively regulates the transcriptional activity of the COL2A1 gene in articular cartilage progenitors, determining the differentiation of articular chondrocytes. These findings highlight the important role of NFATc1 in articular cartilage development.
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Cell & Tissue Engineering
Tiffany Ko, Rhea Choi, Khalil Issa, Rupali Gupta, Edward Llinas, Lluis Morey, John B. Finlay, Bradley J. Goldstein
Summary: In this study, the role of PRC2 in olfactory neurogenesis was investigated using mouse lesion models. The researchers found that PRC2 plays an important role in promoting lesion-induced neuron production and regulating histone modifications and lineage-specific transcription factors. Additionally, a previously unrecognized role of PRC2 in regulating gland versus neuron cell fate was discovered.
Review
Urology & Nephrology
Melissa H. Little, Sara E. Howden, Kynan T. Lawlor, Jessica M. Vanslambrouck
Summary: Studying lineage relationships in cells can offer valuable insights into their origins, differentiation, and development. With the use of genetic methods, Cre systems, single-cell transcriptional profiling, and CRISPR-Cas9 gene editing, researchers are now able to make predictions about cellular relationships across different developmental stages, leading to a better understanding of development and disease.
NATURE REVIEWS NEPHROLOGY
(2022)
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Cell Biology
Jose Antonio de Mera-Rodriguez, Guadalupe Alvarez-Hernan, Yolanda Ganan, Ana Santos-Almeida, Gervasio Martin-Partido, Joaquin Rodriguez-Leon, Javier Francisco-Morcillo
Summary: The histochemical detection of beta-galactosidase enzymatic activity in the developing postnatal olfactory epithelium in mice suggests a correlation with olfactory marker protein, indicating a potential link to neuronal differentiation rather than cellular senescence.
Article
Cell Biology
Dapeng Yang, Hyunwoo Cho, Zakieh Tayyebi, Abhijit Shukla, Renhe Luo, Gary Dixon, Valeria Ursu, Stephanie Stransky, Daniel M. Tremmel, Sara D. Sackett, Richard Koche, Samuel J. Kaplan, Qing Li, Jiwoon Park, Zengrong Zhu, Bess P. Rosen, Julian Pulecio, Zhong-Dong Shi, Yaron Bram, Robert E. Schwartz, Jon S. Odorico, Simone Sidoli, Christopher Wrights, Christina S. Leslie, Danwei Huangfu
Summary: The pancreas and liver originate from a common pool of progenitors. The transcription factor HHEX plays a key role in pancreatic lineage specification, cooperating with other pioneer factors to promote pancreas development and restrict activation of alternative lineages.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Bieluszewska, Phillip Wulfridge, John Doherty, Wenqing Ren, Kavitha Sarma
Summary: This study investigates how ATRX mutations affect neurodifferentiation using engineered mouse embryonic stem cells. The results show that ATRX mutations lead to delayed and compromised neurodifferentiation through separate regulatory pathways, highlighting the important roles of ATRX in neurodevelopment.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Shaili D. D. Patel, Deepti Anand, Hozumi Motohashi, Fumiki Katsuoka, Masayuki Yamamoto, Salil A. A. Lachke
Summary: Deficiency of Mafg and Mafk proteins causes lens development defects and abnormal cell morphology. Loss of Mafg and Mafk leads to multilayered lens epithelium and misexpression of genes associated with cytoskeleton, cell cycle, and extracellular matrix.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Wuming Gong, Satyabrata Das, Javier E. Sierra-Pagan, Erik Skie, Nikita Dsouza, Thijs A. Larson, Mary G. Garry, Edgar Luzete-Monteiro, Kenneth S. Zaret, Daniel J. Garry
Summary: Gong et al. report that ETV2 functions as a pioneer factor in regulating endothelial genes and remodeling chromatin, which provides potential therapeutic applications for cardiovascular diseases and solid tumors.
NATURE CELL BIOLOGY
(2022)
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Immunology
Rumi Ueha, Toshihiro Ito, Satoshi Ueha, Ryutaro Furukawa, Masahiro Kitabatake, Noriko Ouji-Sageshima, Tsukasa Uranaka, Hirotaka Tanaka, Hironobu Nishijima, Kenji Kondo, Tatsuya Yamasoba
Summary: The study found that SARS-CoV-2 can be transmitted even after brief contact, and damage to the olfactory epithelium and lungs occurs more than 3 days after infection. The research also indicated that SARS-CoV-2 damages all olfactory receptor neuron lineage cells, but recovery can begin approximately 14 days post infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ami Shah, Madison Ratkowski, Alessandro Rosa, Paul Feinstein, Thomas Bozza
Summary: The study reveals that TAAR gene expression requires two cooperative cis-acting enhancers, deletion of either one or both elements can affect the expression of TAAR genes, and the similarity exists in the expression mechanisms between ORs and TAARs.
NATURE COMMUNICATIONS
(2021)
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Oncology
Huey-Huey Chua, Chiun-Sheng Huang, Pei-Lun Weng, Te-Huei Yeh
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Hematology
Ya-Ching Chou, Sue-Jane Lin, Jean Lu, Te-Huei Yeh, Chi-Long Chen, Pei-Lun Weng, Jiun-Han Lin, Ming Yao, Ching-Hwa Tsai
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Virology
Huey-Huey Chua, Hsin-Yi Chiu, Sue-Jane Lin, Pei-Lun Weng, Jiun-Han Lin, Shao-Wen Wu, Shu-Chun Tsai, Ching-Hwa Tsai
JOURNAL OF MEDICAL VIROLOGY
(2012)
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Virology
Pei-Fang Tsai, Sue-Jane Lin, Pei-Lun Weng, Shu-Chun Tsai, Jiun-Han Lin, Ya-Ching Chou, Ching-Hwa Tsai
JOURNAL OF VIROLOGY
(2011)
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Cell Biology
Pei-Lun Weng, Marit H. Aure, Takamitsu Maruyama, Catherine E. Ovitt
