Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model

Molecular Cytotoxicity Mechanisms of Allyl Alcohol (Acrolein) in Budding Yeast

(2015) Upendarrao Golla et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Perturbation of the Vacuolar ATPase

(2015) Rania M. Deranieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolonged starvation drives reversible sequestration of lipid biosynthetic enzymes and organelle reorganization in Saccharomyces cerevisiae

(2015) Harsha Garadi Suresh et al.   MOLECULAR BIOLOGY OF THE CELL

Poster Sessions

(2015)   YEAST

Improper protein trafficking contributes to artemisinin sensitivity in cells lacking the KDAC Rpd3p

(2014) Amornrat Naranuntarat Jensen et al.   FEBS LETTERS

Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Inhibitor Sml1 in Response to Iron Deficiency

(2014) N. Sanvisens et al.   MOLECULAR AND CELLULAR BIOLOGY

Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target

(2014) Gajendra Kumar Azad et al.   FEBS Open Bio

Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details

(2013) Caryn E Outten et al.   CURRENT OPINION IN MICROBIOLOGY

Valproic Acid Protects Motor Neuron Death by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Cytochrome C Release after Spinal Cord Injury

(2013) Jee Y. Lee et al.   JOURNAL OF NEUROTRAUMA

Separate enrichment analysis of pathways for up- and downregulated genes

(2013) G. Hong et al.   Journal of the Royal Society Interface

Genome-Wide Screening for Genes Associated with Valproic Acid Sensitivity in Fission Yeast

(2013) Lili Zhang et al.   PLoS One

Effect of valproic acid on mitochondrial epigenetics

(2012) Hu Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phosphatidylserine Decarboxylase 1 (Psd1) Promotes Mitochondrial Fusion by Regulating the Biophysical Properties of the Mitochondrial Membrane and Alternative Topogenesis of Mitochondrial Genome Maintenance Protein 1 (Mgm1)

(2012) Eliana Y. L. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trials with ‘epigenetic’ drugs: An update

(2012) Angela Nebbioso et al.   Molecular Oncology

Yeast: An Experimental Organism for 21st Century Biology

(2011) David Botstein et al.   GENETICS

Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy

(2011) S. Ounjaijean et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Controlling gene expression in response to stress

(2011) Eulàlia de Nadal et al.   NATURE REVIEWS GENETICS

Valproic Acid Increases Susceptibility to Endotoxin Shock Through Enhanced Release of High-Mobility Group Box 1

(2011) Shinsuke Sugiura et al.   SHOCK

Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity

(2011) Tony K.L. Kiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Valproic Acid in the Complex Therapy of Malignant Tumors

(2010) J. Hrebackova et al.   CURRENT DRUG TARGETS

Coordination of Storage Lipid Synthesis and Membrane Biogenesis

(2010) Maria L. Gaspar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular and Therapeutic Potential and Toxicity of Valproic Acid

(2010) Sébastien Chateauvieux et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The role of p38 MAPK in valproic acid induced microglia apoptosis

(2010) Nanchang Xie et al.   NEUROSCIENCE LETTERS

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage

(2010) Bethany L. Andreson et al.   NUCLEIC ACIDS RESEARCH

Iron–sulfur proteins in health and disease

(2010) Alex Sheftel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The G1 phase arrest and apoptosis by intrinsic pathway induced by valproic acid inhibit proliferation of BGC-823 gastric carcinoma cells

(2010) Xia Zhao et al.   TUMOR BIOLOGY

The high-osmolarity glycerol (HOG) and cell wall integrity (CWI) signalling pathways interplay: a yeast dialogue between MAPK routes

(2010) Jose Manuel Rodríguez-Peña et al.   YEAST

Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae

(2009) Christopher D. Putnam et al.   DNA REPAIR

Drug-induced apoptosis in yeast

(2008) B. Almeida et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Membrane phospholipid synthesis and endoplasmic reticulum function

(2008) Paolo Fagone et al.   JOURNAL OF LIPID RESEARCH

The Mood-Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase-3

(2003) Guang Chen et al.   JOURNAL OF NEUROCHEMISTRY