Article
Urology & Nephrology
Kirtishri Mishra, Ilaha Isali, Mohit Sindhani, Megan Prunty, Spencer Bell, Amr Mahran, Giovanni Damiani, Mahmoud Ghannoum, Mauricio Retuerto, Alexander Kutikov, Jonathan Ross, Lynn L. Woo, Philip H. Abbosh, Laura Bukavina
Summary: This study aimed to analyze the changes in penile microbiome before and after circumcision in pediatric population and evaluate the pathways related to inflammation, barrier protection, and energy metabolism. The results showed a significant reduction in bacteria and fungi after circumcision, especially anaerobic bacteria, which are potential inducers of inflammation and cancer. This is the first study to demonstrate the changes in microbiome after circumcision and provide explanations for the differences in cancer and inflammatory disorders in adulthood among healthy infants after circumcision.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Biochemistry & Molecular Biology
Rui Huang, Pan Liu, Yiguang Bai, Jieqiong Huang, Rui Pan, Huihua Li, Yeping Su, Quan Zhou, Ruixin Ma, Shaohui Zong, Gaofeng Zeng
Summary: This study aimed to investigate the relationship between gut microbiota and osteoporosis by reviewing previous research findings. Through comprehensive analysis, changes in gut microbiota were found to be correlated with osteoporosis, with potential regional differences.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Medicine, Research & Experimental
Linfan Su, Yixian Qiao, Jinmei Luo, Rong Huang, Zhiwei Li, Hongbing Zhang, Hongmei Zhao, Jing Wang, Yi Xiao
Summary: This study analyzed the changes in the sputum microbiome of AECOPD patients and found correlations with clinical indices. The results suggest that microbial dysbiosis may contribute to disease progression and provide potential microbial biomarkers for the diagnosis of AECOPD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Lili Chen, Xinhua Xu, Xiaoqi Wu, Huizhen Cao, Xiuli Li, Zhaoyi Hou, Bixia Wang, Jinxiu Liu, Xinli Ji, Ping Zhang, Hong Li
Summary: This study compares the composition and functions of the oral and gut microbiotas in patients with mild and moderate AD. The results indicate differences in the microbiotas between different stages of AD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Muhong Wei, Can Li, Yu Dai, Haolong Zhou, Yuan Cui, Yun Zeng, Qin Huang, Qi Wang
Summary: Collective research indicates that gut microbiota play a significant role in bone remodeling and maintaining bone health. This study found that specific bacterial genera in the gut microbiota of osteoporosis patients may be associated with decreased bone density. After controlling for potential confounders, the associations of certain bacterial genera with the risk of osteoporosis were not significant.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hubiao Jiang, Luqiong Lv, Temoor Ahmed, Shaomin Jin, Muhammad Shahid, Muhammad Noman, Hosam-Eldin Hussein Osman, Yanli Wang, Guochang Sun, Xuqing Li, Bin Li
Summary: This study found that metal oxide nanoparticles can reduce the incidence of tomato bacterial wilt and alter the composition and structure of the rhizosphere bacterial community. Among them, the application of CuO nanoparticles significantly affected the abundance of beneficial Streptomyces bacteria. This research provides evidence and strategies for using metal oxide nanoparticles to prevent and control soil-borne disease tomato bacterial wilt.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yeon Bee Kim, Tae Woong Whon, Joon Yong Kim, Juseok Kim, Yujin Kim, Se Hee Lee, Seong-Eun Park, Eun-Ju Kim, Hong-Seok Son, Seong Woon Roh
Summary: Although little is known about the urogenital archaeome, several reports have indicated its association with health in other body sites. This study aimed to determine the presence and diversity of archaeomes in the human urogenital tract. Analysis of urine samples from 373 asymptomatic individuals revealed the presence of diverse archaea, including Methanobacteriota, Thermoproteota, and Halobacteriota. The urogenital archaeome showed partial taxonomic compositional similarities with archaeomes from other body sites. These findings provide new insights into the role of archaea in urinary tract health.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Jason A. Rothman, Jenna L. Riis, Katrina R. Hamilton, Clancy Blair, Douglas A. Granger, Katrine L. Whiteson
Summary: Human oral microbial communities have significant implications for oral and systemic health due to their diversity. Understanding the differences between healthy and dysbiotic oral microbiomes is important, especially within and between families. This study investigates the changes in oral microbiome composition within individuals and the impact of factors such as environmental tobacco smoke exposure, metabolic regulation, inflammation, and antioxidant potential. The findings reveal differences in oral microbiomes between children and caregivers, with shared diversity but distinct differences, and highlight the associations between the oral microbiome and various salivary markers.
Article
Obstetrics & Gynecology
Congcong Jin, Lang Qin, Zheng Liu, Xiao Li, Xuan Gao, Yongzhi Cao, Shigang Zhao, Jiaojiao Wang, Ting Han, Lei Yan, Jialun Song, Fangfang Zhang, Feifei Liu, Yousheng Zhang, Yuzhen Huang, Yuping Song, Yanjun Liu, Zhina Yao, Honglei Chen, Zhenzhen Zhang, Shengrui Zhao, Yuhan Feng, Ya-nan Zhang, Yu Qian, Tianyong Sun, Qiang Feng, Han Zhao
Summary: This cross-sectional study aimed to compare the vaginal microbiome (VMB) features between patients with polycystic ovary syndrome (PCOS) and healthy women. The PCOS group showed higher alpha diversity and higher intra-group variability in VMB. In addition, the proportion of Lactobacillus decreased, while Gardnerella vaginalis and Ureaplasma increased in the PCOS group.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Health Care Sciences & Services
Rumi Higuchi, Taichiro Goto, Yosuke Hirotsu, Sotaro Otake, Toshio Oyama, Kenji Amemiya, Hitoshi Mochizuki, Masao Omata
Summary: This study aimed to identify mesothelioma-specific microbiota using resected or biopsied mesothelioma samples, and found Streptococcus australis and Ralstonia pickettii as abundant species in almost all tumor and lung samples, suggesting their involvement in tumor progression and potential as targets for mesothelioma prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rodrigo Rodrigues Amaral, Tiago Braga, Jose F. Siqueira Jr, Isabela N. Rocas, Caio Tavora Coelho da Costa Rachid, Anna Gabriella Guimaraes Oliveira, Maria Ilma de Souza Cortes, Robert Mattew Love
Summary: This study used high-throughput sequencing technology to analyze the endodontic microbiome of teeth with asymptomatic apical periodontitis. The results revealed a high bacterial diversity and species composition variability among root canal samples. Large lesions showed a higher number of species but did not significantly differ from small lesions in bacterial diversity.
JOURNAL OF ENDODONTICS
(2022)
Article
Biology
Ammara Manzoor, Saira Amir, Farzana Gul, Muhammad Abubakar Sidique, Masood Ur Rehman Kayani, Syed Shujaat Ali Zaidi, Sundus Javed, Syed Tahir Abbas Shah, Arshan Nasir
Summary: This study describes the microbial composition of the gastrointestinal and reproductive tracts of married Pakistani couples. It reveals differences in microbial diversity and composition between fertile and infertile couples, providing a foundation for future research on the association between the human microbiome and infertility.
Article
Parasitology
Danielle Beard, Hayley J. Stannard, Julie M. Old
Summary: This study on wombat ticks in Australia identified multiple tick species, with the wombat tick being the most prevalent. The research also revealed the various bacteria carried by ticks, highlighting the high bacterial diversity in native Australian ticks.
PARASITES & VECTORS
(2021)
Article
Microbiology
Marcia Melo Medeiros, Anna Cacilia Ingham, Line Moller Nanque, Claudino Correia, Marc Stegger, Paal Skyt Andersen, Ane Baerent Fisker, Christine Stabell Benn, Miguel Lanaspa, Henrique Silveira, Patricia Abrantes
Summary: This study found that revaccination with oral polio vaccine (OPV) led to changes in the composition of gut and upper respiratory bacterial microbiotas in infants. Two months after revaccination, OPV-revaccinated infants had a more abundant and diversified microbiome with a reduced proportion of potentially pathogenic/opportunistic bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alexander T. Neu, Eric E. Allen, Kaustuv Roy
Summary: The term core microbiome refers to a set of microbial taxa or attributes associated with those taxa that are characteristic of a host or environment, with little consensus on how it should be quantified in practice. Various metrics have been used, but many are susceptible to biases, highlighting the need for standardized metrics for studying core microbiomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pediatrics
Jelena Zestic, Helen Liley, Penelope Sanderson
Summary: The study explored the feasibility of using clinicians' degree of concordance as an approximation of a neonate's true physiological state. The results showed that neonatal experts' interpretations of newborn trajectories can achieve a high degree of concordance.
PEDIATRIC RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Myra H. Wyckoff, Eunice M. Singletary, Jasmeet Soar, Theresa M. Olasveengen, Robert Greif, Helen G. Liley, David Zideman, Farhan Bhanji, Lars W. Andersen, Suzanne R. Avis, Khalid Aziz, Jason C. Bendall, David C. Berry, Vere Borra, Bernd W. Boettiger, Richard Bradley, Janet E. Bray, Jan Breckwoldt, Jestin N. Carlson, Pascal Cassan, Maaret Castren, Wei-Tien Chang, Nathan P. Charlton, Adam Cheng, Sung Phil Chung, Julie Considine, Daniela T. Costa-Nobre, Keith Couper, Katie N. Dainty, Peter G. Davis, Maria Fernanda de Almeida, Allan R. de Caen, Edison F. de Paiva, Charles D. Deakin, Therese Djarv, Matthew J. Douma, Ian R. Drennan, Jonathan P. Duff, Kathryn J. Eastwood, Walid El-Naggar, Jonathan L. Epstein, Raffo Escalante, Jorge G. Fabres, Joe Fawke, Judith C. Finn, Elizabeth E. Foglia, Fredrik Folke, Karoline Freeman, Elaine Gilfoyle, Craig A. Goolsby, Amy Grove, Ruth Guinsburg, Tetsuo Hatanaka, Mary Fran Hazinski, George S. Heriot, Karen G. Hirsch, Mathias J. Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Kevin K. C. Hung, Cindy H. Hsu, Takanari Ikeyama, Tetsuya Isayama, Vishal S. Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, David A. Kloeck, Peter J. Kudenchuk, Anthony T. Lagina, Kasper G. Lauridsen, Eric J. Lavonas, Andrew S. Lockey, Carolina Malta Hansen, David Markenson, Tasuku Matsuyama, Christopher J. D. McKinlay, Amin Mehrabian, Raina M. Merchant, Daniel Meyran, Peter T. Morley, Laurie J. Morrison, Kevin J. Nation, Michael Nemeth, Robert W. Neumar, Tonia Nicholson, Susan Niermeyer, Nikolaos Nikolaou, Chika Nishiyama, Brian J. O'Neil, Aaron M. Orkin, Osokogu Osemeke, Michael J. Parr, Catherine Patocka, Jeffrey L. Pellegrino, Gavin D. Perkins, Jeffrey M. Perlman, Yacov Rabi, Joshua C. Reynolds, Giuseppe Ristagno, Charles C. Roehr, Tetsuya Sakamoto, Claudio Sandroni, Taylor Sawyer, Georg M. Schmolzer, Sebastian Schnaubelt, Federico Semeraro, Markus B. Skrifvars, Christopher M. Smith, Michael A. Smyth, Roger F. Soll, Takahiro Sugiura, Sian Taylor-Phillips, Daniele Trevisanuto, Christian Vaillancourt, Tzong-Luen Wang, Gary M. Weiner, Michelle Welsford, Jane Wigginton, Jonathan P. Wyllie, Joyce Yeung, Jerry P. Nolan, Katherine M. Berg
Summary: The latest annual summary from the International Liaison Committee on Resuscitation reviews recently published evidence on various topics related to cardiopulmonary resuscitation, including video-based dispatch systems, head-up CPR, early coronary angiography, and more. The summary includes consensus treatment recommendations and highlights priority knowledge gaps for further research.
Article
Immunology
Lenka A. Vodstrcil, Erica L. Plummer, Michelle Doyle, Gerald L. Murray, Kaveesha Bodiyabadu, Jorgen S. Jensen, David Whiley, Emma Sweeney, Deborah A. Williamson, Eric P. F. Chow, Christopher K. Fairley, Catriona S. Bradshaw
Summary: This study evaluated the efficacy and tolerability of resistance-guided combination antimicrobial therapy for Mycoplasma genitalium (MG) infection. The combination of doxycycline and azithromycin achieved high cure rates for macrolide-susceptible infections, while the combination of doxycycline and moxifloxacin had a lower cure rate for macrolide-resistant infections. Sequencing revealed that mutations in the parC gene were associated with treatment failure.
CLINICAL INFECTIOUS DISEASES
(2022)
Editorial Material
Critical Care Medicine
Helen G. Liley, Stuart B. Hooper, Firdose L. Nakwa
Review
Environmental Sciences
Barne Willie, Emma L. Sweeney, Steven G. Badman, Mark Chatfield, Andrew J. Vallely, Angela Kelly-Hanku, David M. Whiley
Summary: NG AMR has become a global concern, with a lack of surveillance data in resource-limited settings like Papua New Guinea. There is a need to improve resistance-testing methods and enhance NG AMR surveillance, particularly in regions where traditional culture-based testing is unreliable.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Obstetrics & Gynecology
Poliana de Barros Medeiros, Cheryl Bailey, Christine Andrews, Helen Liley, Adrienne Gordon, Vicki Flenady
Summary: Neonatal near miss (NNM) refers to a newborn who almost died in the neonatal period. NNM audits can improve recognition of risk factors and substandard care, benchmarking, and prevention strategies for better perinatal outcomes. However, the current NNM definitions are inconsistent and varied, requiring expert opinions to establish a consensus for more meaningful data.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Review
Pediatrics
Ruth Guinsburg, Maria Fernanda B. de Almeida, Emer Finan, Jeffrey M. Perlman, Jonathan Wyllie, Helen G. Liley, Myra H. Wyckoff, Tetsuya Isayama
Summary: Tactile stimulation may have potential benefits in the initial management of term and preterm infants, but the certainty of evidence is very low. Further research is needed to evaluate the effectiveness and optimal duration of tactile stimulation.
Article
Pediatrics
Kristy P. Robledo, William O. Tarnow-Mordi, Ingrid Rieger, Preeti Suresh, Andrew Martin, Carbo Yeung, Alpana Ghadge, Helen G. Liley, David Osborn, Jonathan Morris, Wendy Hague, Martin Kluckow, Kei Lui, Roger Soll, Melinda Cruz, Anthony Keech, Adrienne Kirby, John Simes
Summary: The study indicates that delaying cord clamping for at least 60 seconds can reduce the risk of mortality or major disability in very preterm infants at 2 years of age. The results show that infants in the delayed clamping group had lower rates of mortality and major disability compared to the immediate clamping group.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Engineering, Industrial
Kelly Hinckfuss, Penelope M. Sanderson, Birgit Brecknell, Robert G. Loeb, David Liu, Helen Liley
Summary: Standard pulse oximeter auditory tones do not clearly indicate departures from the target range of oxygen saturation in preterm neonates. Acoustically enhanced tones significantly improve clinicians' and non-clinicians' ability to identify the SpO2 range. The accuracy of range identification was higher in the enhanced conditions compared to the standard condition, with the tremolo-enhanced tones showing the highest accuracy.
APPLIED ERGONOMICS
(2023)
Article
Obstetrics & Gynecology
Poliana de Barros Medeiros, Helen Liley, Christine Andrews, Adrienne Gordon, Alexander E. P. Heazell, Alison L. Kent, Susannah H. Leisher, Vicki Flenady
Summary: Neonatal near-miss (NNM) audit is viewed as a valuable tool to reduce adverse neonatal outcomes. The survey results showed that the main characteristics of NNM according to most participants include birth asphyxia needing therapeutic hypothermia, unexpected resuscitation at birth, need for intubation/chest compression/adrenaline, and metabolic acidosis at birth. Despite the importance of NNM for identifying cases for perinatal morbidity audits, only a few institutions used a NNM definition.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Neurosciences
Alex M. Pagnozzi, Liza van Eijk, Kerstin Pannek, Roslyn N. Boyd, Susmita Saha, Joanne George, Samudragupta Bora, DanaKai Bradford, Michael Fahey, Michael Ditchfield, Atul Malhotra, Helen Liley, Paul B. Colditz, Stephen Rose, Jurgen Fripp
Summary: Infants born very preterm face neurodevelopmental challenges and early identification through clinical assessment and MRI can enable targeted interventions. This study used a prospective cohort of preterm infants and identified early MRI biomarkers for neurodevelopmental outcomes using advanced imaging techniques. The results demonstrated the utility of MRI prior to term equivalent age for predicting outcomes and initiating early interventions.
Review
Critical Care Medicine
V. V. Ramaswamy, J. A. Dawson, M. F. de Almeida, D. Trevisanuto, F. L. Nakwa, C. O. F. Kamlin, J. Trang, M. H. Wyckoff, G. M. Weiner, H. G. Liley
Summary: This study evaluated delivery room interventions to prevent hypothermia and improve outcomes in preterm newborn infants. The findings suggest that increasing the delivery room temperature, using a radiant warmer in manual mode, using a plastic bag or wrap, and covering the head can improve temperature outcomes in preterm infants. However, some interventions may also increase the risk of hyperthermia.
Review
Pediatrics
P. B. Medeiros, C. Bailey, D. Pollock, H. Liley, A. Gordon, C. Andrews, V. Flenady
Summary: This review evaluates the effectiveness of neonatal near-miss (NNM) audits for reducing perinatal mortality and morbidity and explores related contextual factors. The available data on NNM audits are limited, and further research is needed to determine their effectiveness and influencing factors.
Article
Infectious Diseases
Emma L. Sweeney, Kym Lowry, Mandy Seel, Frashta Rahimi, Julian Langton-Lockton, Cheryl Bletchly, Graeme R. Nimmo, David M. Whiley
Summary: An ongoing syphilis outbreak in Queensland, Australia has resulted in increasing cases of congenital syphilis, including deaths. A study found that the most common strains of Treponema pallidum were ST 1 and ST 100, accounting for the majority of infections in both males and females. These strains were mainly observed among men who have sex with men (MSM), with potential transmission to heterosexual networks. Further investigation and targeted public health interventions are needed to control the spread of syphilis in Queensland.
COMMUNICABLE DISEASES INTELLIGENCE
(2022)
Review
Public, Environmental & Occupational Health
Emma L. Sweeney, David M. Whiley, Gerald L. Murray, Catriona S. Bradshaw
Summary: This article discusses the emergence of antimicrobial resistance in Mycoplasma genitalium and its implications for treatment practices. It emphasizes the recommendations for testing rather than screening for M. genitalium and the expansion of individualized treatment strategies to curb the emergence of resistance and improve patient outcomes.