HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses

A Potential Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression

(2016) Elias A. Said et al.   PLoS One

TGF-β1 inhibits the production of IFN in response to CpG DNA via ubiquitination of TNF receptor-associated factor (TRAF) 6

(2015) Yoshikazu Naiki et al.   Innate Immunity

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism

(2015) Jiyoung Lee et al.   PLoS Pathogens

Global distribution and prevalence of hepatitis C virus genotypes

(2014) Jane P. Messina et al.   HEPATOLOGY

Activation and Evasion of Antiviral Innate Immunity by Hepatitis C Virus

(2013) Stacy M. Horner   JOURNAL OF MOLECULAR BIOLOGY

Regulation of hepatic innate immunity by hepatitis C virus

(2013) Stacy M Horner et al.   NATURE MEDICINE

Class A Scavenger Receptor 1 (MSR1) Restricts Hepatitis C Virus Replication by Mediating Toll-like Receptor 3 Recognition of Viral RNAs Produced in Neighboring Cells

(2013) Hiromichi Dansako et al.   PLoS Pathogens

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Evaluate the relationship between polymorphisms of OAS1 gene and susceptibility to chronic hepatitis C with high resolution melting analysis

(2012) Yan Zhao et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The ribonucleasel-dependent antiviral roles of human 2′,5′-oligoadenylate synthetase family members against hepatitis C virus

(2012) Young-Chan Kwon et al.   FEBS LETTERS

Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I

(2012) Gretja Schnell et al.   PLoS Pathogens

Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV

(2011) J. F. Bergmann et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Delayed Induction, Not Impaired Recruitment, of Specific CD8+ T Cells Causes the Late Onset of Acute Hepatitis C

(2011) Eui–Cheol Shin et al.   GASTROENTEROLOGY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients

(2011) Loubna Jouan et al.   JOURNAL OF HEPATOLOGY

ISG56 and IFITM1 Proteins Inhibit Hepatitis C Virus Replication

(2011) A. Raychoudhuri et al.   JOURNAL OF VIROLOGY

TLR7 and TLR8 Gene Variations and Susceptibility to Hepatitis C Virus Infection

(2011) Chiou-Huey Wang et al.   PLoS One

Inhibition of Hepatitis C Virus Replication by IFN-Mediated ISGylation of HCV-NS5A

(2010) M.-J. Kim et al.   JOURNAL OF IMMUNOLOGY

HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells

(2010) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis C Virus Core Protein Subverts the Antiviral Activities of Human Kupffer Cells

(2009) Zhengkun Tu et al.   GASTROENTEROLOGY

Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes

(2009) J A Mengshol et al.   GUT

Hepatitis C virus single-stranded RNA induces innate immunity via Toll-like receptor 7

(2009) Yi-Liang Zhang et al.   JOURNAL OF HEPATOLOGY

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

(2009) D. Uzri et al.   JOURNAL OF VIROLOGY

The history of the “natural history” of hepatitis C (1968-2009)

(2009) Leonard B. Seeff   LIVER INTERNATIONAL

The global burden of hepatitis C

(2009) Daniel Lavanchy   LIVER INTERNATIONAL

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

Functional characterization of ex vivo blood myeloid and plasmacytoid dendritic cells after infection with dengue virus

(2008) Peifang Sun et al.   VIROLOGY